{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:41:49Z","timestamp":1772901709822,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-41-G11"],"award-info":[{"award-number":["CARS-41-G11"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202724"],"award-info":[{"award-number":["32202724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","award":["2022YFD1300403"],"award-info":[{"award-number":["2022YFD1300403"]}],"id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.psj.2025.105745","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:29:16Z","timestamp":1756362556000},"page":"105745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary N-acetylcysteine supplementation improves antioxidant capacity and production performance of breeder hens and offspring"],"prefix":"10.1016","volume":"104","author":[{"given":"Shu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingkun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlou","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingkun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-6949","authenticated-orcid":false,"given":"Zengpeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.psj.2025.105745_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103313","article-title":"Impact of broiler breeder hens' age and egg storage on egg quality, embryonic development, and hatching traits of FUNAAB-alpha chickens","volume":"103","author":"Alo","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105745_bib0003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbi.2021.01.007","article-title":"Maternal oxidative stress during pregnancy and offspring neurodevelopment","volume":"93","author":"Buss","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.psj.2025.105745_bib0004","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11250-022-03315-3","article-title":"Age and sex related changes in fattening performance, dermatitis, intestinal histomorphology, and serum IgG level of slow- and fast-growing broilers under the intensive system","volume":"54","author":"\u00c7apar Aky\u00fcz","year":"2022","journal-title":"Trop. Anim. Health Prod."},{"issue":"4","key":"10.1016\/j.psj.2025.105745_bib0005","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1017\/S0043933908000160","article-title":"Important metabolic pathways in poultry embryos prior to hatch","volume":"64","author":"De Oliveira","year":"2008","journal-title":"World's Poult. Sci. J."},{"issue":"5","key":"10.1016\/j.psj.2025.105745_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103420","article-title":"Effects of puerarin as a feed additive on the laying performance, egg quality, endocrine hormones, antioxidant capacity, and intestinal morphology of aged laying hens","volume":"103","author":"Du","year":"2024","journal-title":"Poult. Sci."},{"issue":"5","key":"10.1016\/j.psj.2025.105745_bib0007","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.3382\/ps\/pey609","article-title":"Effects of in ovo injection of sulfur-containing amino acids on heat shock protein 70, corticosterone hormone, antioxidant indices, and lipid profile of newly hatched broiler chicks exposed to heat stress during incubation","volume":"98","author":"Elnesr","year":"2019","journal-title":"Poult. Sci."},{"issue":"7","key":"10.1016\/j.psj.2025.105745_bib0008","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/life13071468","article-title":"Supplementing Genistein for breeder hens alters the growth performance and intestinal health of offspring","volume":"13","author":"Gao","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.psj.2025.105745_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70044","article-title":"Soyasaponin and vertical microbial transmission: maternal effect on the intestinal development and health of early chicks","author":"Gao","year":"2025","journal-title":"iMeta"},{"issue":"12","key":"10.1016\/j.psj.2025.105745_bib0010","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.3390\/ijms21124293","article-title":"N-acetylcysteine reduces skeletal muscles oxidative stress and improves grip strength in dysferlin-deficient bla\/J mice","volume":"21","author":"Garc\u00eda-Campos","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0001","doi-asserted-by":"crossref","first-page":"045","DOI":"10.53771\/ijlsra.2021.1.1.0054","article-title":"Oxidative stress in broiler chicken and its consequences on meat quality","volume":"1","author":"Hassan Nawaz","year":"2021","journal-title":"Int. J. Life Sci. Res. Arch."},{"issue":"3","key":"10.1016\/j.psj.2025.105745_bib0012","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/antiox13030312","article-title":"Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.psj.2025.105745_bib0013","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-0436-x","article-title":"The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2\/ARE signaling pathway","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.psj.2025.105745_bib0014","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","article-title":"Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy","volume":"72","author":"Jiang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"24","key":"10.1016\/j.psj.2025.105745_bib0015","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.3390\/ani12243574","article-title":"Feed supplemented with Aronia melanocarpa (AM) relieves the oxidative stress caused by ovulation in peak laying hens and increases the content of yolk precursors","volume":"12","author":"Jing","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105745_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102497","article-title":"NAC, NAC, knockin\u2019 on heaven's door: interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells","volume":"57","author":"Kalyanaraman","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.psj.2025.105745_bib0017","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s40263-015-0300-9","article-title":"Mechanisms of antioxidant induction with high-dose N-acetylcysteine in childhood cerebral adrenoleukodystrophy","volume":"29","author":"Kartha","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.psj.2025.105745_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2025.100138","article-title":"Oxidative stress-induced cytotoxicity and the role of dietary antioxidants in farm animals: a review","volume":"16","author":"Khan","year":"2025","journal-title":"Adv. Redox Res."},{"issue":"1-2","key":"10.1016\/j.psj.2025.105745_bib0019","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2006.03.001","article-title":"Mitochondrial glutathione transport: physiological, pathological and toxicological implications","volume":"163","author":"Lash","year":"2006","journal-title":"Chem.-Biol. Interact."},{"issue":"16","key":"10.1016\/j.psj.2025.105745_bib0020","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.3390\/ijms20163896","article-title":"Causative links between protein aggregation and oxidative stress: a review","volume":"20","author":"L\u00e9vy","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0021","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40360-019-0323-9","article-title":"Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study","volume":"20","author":"Li","year":"2019","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.psj.2025.105745_bib0022","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2022.05.024","article-title":"NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2\/Gpx4 pathway","volume":"187","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.psj.2025.105745_bib0023","article-title":"Effects of N-acetyl-L-cysteine on serum indices and hypothalamic AMPK-related gene expression under chronic heat stress","volume":"9","author":"Li","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"3","key":"10.1016\/j.psj.2025.105745_bib0024","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5772\/58253","article-title":"A fast approach to arm blind grasping and placing for mobile robot transportation in laboratories","volume":"11","author":"Liu","year":"2014","journal-title":"Int. J. Adv. Robot. Syst."},{"key":"10.1016\/j.psj.2025.105745_bib0025","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ijbiomac.2019.10.115","article-title":"Proteome-based identification of chicken egg yolk proteins associated with antioxidant activity on the Qinghai-Tibetan Plateau","volume":"150","author":"Liu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.psj.2025.105745_bib0026","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1096\/fj.201701457R","article-title":"Dietary genistein supplementation in laying broiler breeder hens alters the development and metabolism of offspring embryos as revealed by hepatic transcriptome analysis","volume":"32","author":"Lv","year":"2018","journal-title":"FASEB J."},{"issue":"28","key":"10.1016\/j.psj.2025.105745_bib0027","doi-asserted-by":"crossref","first-page":"20416","DOI":"10.1074\/jbc.M609582200","article-title":"Glutathione is recruited into the nucleus in early phases of cell proliferation","volume":"282","author":"Markovic","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0028","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12917-018-1743-2","article-title":"N-acetylcysteine addition after vitrification improves oocyte mitochondrial polarization status and the quality of embryos derived from vitrified murine oocytes","volume":"15","author":"Matilla","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.psj.2025.105745_bib0029","series-title":"China National Feeding Standard of Chicken (NY\/T 33-2004)","year":"2004"},{"key":"10.1016\/j.psj.2025.105745_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2019.00060","article-title":"Oxidative stress in the poultry gut: potential challenges and interventions","volume":"6","author":"Mishra","year":"2019","journal-title":"Front. Vet. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0031","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1071\/AN17269","article-title":"Histomorphometric analysis of the small intestine of broiler chick embryos injected in ovo with methionine","volume":"59","author":"Nazem","year":"2017","journal-title":"Anim. Prod. Sci."},{"issue":"6","key":"10.1016\/j.psj.2025.105745_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253810","article-title":"Effects of maternal gestational diet, with or without methionine, on muscle transcriptome of Bos indicus-influenced beef calves following a vaccine-induced immunological challenge","volume":"16","author":"Palmer","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2025.105745_bib0033","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2018.02.002","article-title":"Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: involvement of the crosstalk between Nrf2 and NF-\u03bab pathways regulated by MAPKs","volume":"288","author":"Pan","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.japr.2024.100500","article-title":"Alleviating heat stress on broiler breeder hens: effect of dietary antioxidant supplementation on reproductive performance, egg quality, offspring growth, and antioxidant capacity","volume":"34","author":"Pasri","year":"2025","journal-title":"J. Appl. Poult. Res."},{"issue":"7","key":"10.1016\/j.psj.2025.105745_bib0036","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.3382\/ps\/pez068","article-title":"Productive performance and surface temperatures of Japanese quail exposed to different environment conditions at start of lay","volume":"98","author":"Santos","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105745_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110078","article-title":"Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: implication of oxidative stress and apoptosis","volume":"190","author":"Shah","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0038","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75885-x","article-title":"Chronic heat stress regulates the relation between heat shock protein and immunity in broiler small intestine","volume":"10","author":"Siddiqui","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105745_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742868","article-title":"Vitamin E alleviates ammonia\u2011nitrogen and hypoxia co-exposure-induced intestinal damage in grass carp (Ctenopharyngodon idella) by modulating mitochondrial function, cellular autophagy and apoptosis","volume":"609","author":"Su","year":"2025","journal-title":"Aquaculture"},{"issue":"7","key":"10.1016\/j.psj.2025.105745_bib0041","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/antiox8070235","article-title":"Antioxidant defence systems and oxidative stress in poultry biology: an update","volume":"8","author":"Surai","year":"2019","journal-title":"Antioxid. (Basel)"},{"issue":"10","key":"10.1016\/j.psj.2025.105745_bib0040","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.3382\/ps\/pey406","article-title":"Kochish, I. I. Nutritional modulation of the antioxidant capacities in poultry: the case of selenium","volume":"98","author":"Surai","year":"2019","journal-title":"Poult. Sci."},{"issue":"4","key":"10.1016\/j.psj.2025.105745_bib0042","doi-asserted-by":"crossref","DOI":"10.1007\/s13593-016-0398-2","article-title":"Breeding for efficiency in the broiler chicken: a review","volume":"36","author":"Tallentire","year":"2016","journal-title":"Agron. Sustain. Dev."},{"issue":"11","key":"10.1016\/j.psj.2025.105745_bib0043","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1007\/s11356-019-04585-5","article-title":"Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats","volume":"26","author":"Turkmen","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"11","key":"10.1016\/j.psj.2025.105745_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102717","article-title":"The effect of theabrownins on the amino acid composition and antioxidant properties of hen eggs","volume":"102","author":"Wang","year":"2023","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105745_bib0044","first-page":"1644","article-title":"Mechanisms of oxidative stress-induced sperm dysfunction","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.psj.2025.105745_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101142","article-title":"The impacts of egg storage time and maternal dietary vitamin E on the growth performance and antioxidant capacity of progeny chicks","volume":"100","author":"Yang","year":"2021","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.psj.2025.105745_bib0049","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00726-015-2105-z","article-title":"N-acetylcysteine stimulates protein synthesis in enterocytes independently of glutathione synthesis","volume":"48","author":"Yi","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.psj.2025.105745_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ecoenv.2018.07.069","article-title":"Protective effects of zinc and N-acetyl-L-cysteine supplementation against cadmium induced erythrocyte cytotoxicity in Arbor Acres broiler chickens (Gallus gallus domesticus)","volume":"163","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.psj.2025.105745_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103382","article-title":"Effects of dietary methionine supplementation on the growth performance, immune responses, antioxidant capacity, and subsequent development of layer chicks","volume":"103","author":"Zhang","year":"2024","journal-title":"Poult. Sci."},{"issue":"7","key":"10.1016\/j.psj.2025.105745_bib0052","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/acs.chemrestox.9b00152","article-title":"N-acetylcysteine: antioxidant, aldehyde scavenger, and more","volume":"32","author":"Zhitkovich","year":"2019","journal-title":"Chem. Res. Toxicol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:39:20Z","timestamp":1772836760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125009861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0032579125009861"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105745","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary N-acetylcysteine supplementation improves antioxidant capacity and production performance of breeder hens and offspring","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105745"}}