{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:03:09Z","timestamp":1792231389361,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018551","name":"Science and Technology Innovation Talents in Universities of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["CARS-34"],"award-info":[{"award-number":["CARS-34"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["244200510010"],"award-info":[{"award-number":["244200510010"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.psj.2025.105772","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T15:35:18Z","timestamp":1756913718000},"page":"105772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Zn glycine mitigates the LPS-induced hepatic injury and inflammation through NrF2\/NF\u03baB signaling in geese"],"prefix":"10.1016","volume":"104","author":[{"given":"Zeshan","family":"Zulfiqar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Arslan","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3027-2288","authenticated-orcid":false,"given":"Layla","family":"Al-Mitib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khawla","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1310-7602","authenticated-orcid":false,"given":"Tanzina","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105772_bib0001","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5194\/aab-63-125-2020","article-title":"Effects of organic zinc on the performance and gut integrity of broilers under heat stress conditions","volume":"63","author":"Abuajamieh","year":"2020","journal-title":"Arch. Anim. Breed."},{"key":"10.1016\/j.psj.2025.105772_bib0002","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1007\/s12011-023-04057-5","article-title":"The role of zinc on liver fibrosis by modulating ZIP14 expression throughout epigenetic regulatory mechanisms","volume":"202","author":"Aksoy-Ozer","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105772_bib0003","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.psj.2025.105772_bib0004","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3390\/antiox12091653","article-title":"Oxidative stress in liver pathophysiology and disease","volume":"12","author":"Allameh","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2025.105772_bib0005","article-title":"Mechanism of cytokine modulation of epithelial tight junction barrier","volume":"2765","author":"Al-Sadi","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.psj.2025.105772_bib0006","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/antibiotics10020186","article-title":"Protective effect of grape (Vitis vinifera) seed powder and zinc-glycine complex on growth traits and gut health of broilers following Eimeria tenella challenge","volume":"10","author":"Chand","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.psj.2025.105772_bib0007","doi-asserted-by":"crossref","first-page":"skad279","DOI":"10.1093\/jas\/skad279","article-title":"Organic zinc glycine chelate is better than inorganic zinc in improving growth performance of cherry valley ducks by regulating intestinal morphology, barrier function, and the gut microbiome","volume":"101","author":"Chang","year":"2023","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.793174","article-title":"Comparison of gut microbiota and metabolic status of sows with different litter sizes during pregnancy","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0009","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1021\/acschembio.8b00064","article-title":"Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases-3, -6, -7, and -8","volume":"13","author":"Eron","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.psj.2025.105772_bib0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.taap.2010.11.016","article-title":"Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice","volume":"251","author":"Ghatak","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.psj.2025.105772_bib0011","article-title":"The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD (J Pu, Ed.)","volume":"2021","author":"Hong","year":"2021","journal-title":"Oxidat. Med. Cell. Long."},{"key":"10.1016\/j.psj.2025.105772_bib0012","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.rvsc.2016.09.007","article-title":"The effect of feed supplementation with zinc chelate and zinc sulphate on selected humoral and cell-mediated immune parameters and cytokine concentration in broiler chickens","volume":"112","author":"Jarosz","year":"2017","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0013","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s12011-018-1346-6","article-title":"Effect of zinc sulfate and zinc glycine chelate on concentrations of acute phase proteins in chicken serum and liver tissue","volume":"187","author":"Jarosz","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105772_bib0014","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","article-title":"Intestinal goblet cells and mucins in health and disease: recent insights and progress","volume":"12","author":"Kim","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.psj.2025.105772_bib0016","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.3390\/ijms20092192","article-title":"Zinc attenuates the cytotoxicity of some stimuli by reducing endoplasmic reticulum stress in hepatocytes","volume":"20","author":"Kusanaga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0017","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s12011-010-8824-9","article-title":"Effects of zinc glycine chelate on oxidative stress, contents of trace elements, and intestinal morphology in broilers","volume":"142","author":"Ma","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105772_bib0018","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/antiox6020024","article-title":"Zinc and oxidative stress: current mechanisms","volume":"6","author":"Marreiro","year":"2017","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2025.105772_bib0019","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.clnesp.2022.08.003","article-title":"Effects of zinc supplementation on glycemic control and oxidative stress in experimental diabetes: a systematic review","volume":"51","author":"Martins","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.psj.2025.105772_bib0020","first-page":"81","article-title":"Dietary glycine is rate-limiting for glutathione synthesis and may have broad potential for health protection","volume":"18","author":"McCarty","year":"2018","journal-title":"Ochsner J."},{"key":"10.1016\/j.psj.2025.105772_bib0021","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0884533611433534","article-title":"Zinc and liver disease","volume":"27","author":"Mohammad","year":"2012","journal-title":"Nut Clin. Prac."},{"key":"10.1016\/j.psj.2025.105772_bib0022","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/cimb47020079","article-title":"Advances in understanding lipopolysaccharide-mediated Hepatitis: mechanisms and pathological features","volume":"47","author":"Nakadate","year":"2025","journal-title":"CIMB"},{"key":"10.1016\/j.psj.2025.105772_bib0023","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in Human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2025.105772_bib0024","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/antiox8060164","article-title":"Molecular mechanisms of zinc as a pro-antioxidant mediator: clinical therapeutic implications","volume":"8","author":"Prasad","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2025.105772_bib0025","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s12011-024-04220-6","article-title":"Growth performance of and liver function in heat-stressed Magang Geese fed the antioxidant zinc ascorbate and its potential mechanism of action","volume":"203","author":"Ren","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105772_bib0026","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.psj.2025.105772_bib0027","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/nu12061576","article-title":"Oxidative stress management in chronic liver diseases and hepatocellular carcinoma","volume":"12","author":"Uchida","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2025.105772_bib0028","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.3382\/ps\/pev211","article-title":"Effect of dexamethasone in feed on intestinal permeability, differential white blood cell counts, and immune organs in broiler chicks","volume":"94","author":"Vicu\u00f1a","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0029","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.179.6.4180","article-title":"Zinc-dependent suppression of TNF-\u03b1 production is mediated by protein kinase A-induced inhibition of raf-1, i\u03bab kinase \u03b2, and NF-\u03bab","volume":"179","author":"Von B\u00fclow","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2025.105772_bib0030","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/cells12131769","article-title":"TLR4 Overexpression aggravates bacterial lipopolysaccharide-induced apoptosis via excessive autophagy and NF-\u03bab\/MAPK signaling in transgenic mammal models","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.psj.2025.105772_bib0031","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2025.105772_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116111","article-title":"Zinc glycinate alleviates LPS-induced inflammation and intestinal barrier disruption in chicken embryos by regulating zinc homeostasis and TLR4\/NF-\u03bab pathway","volume":"272","author":"Xiao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2025.105772_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101462","article-title":"Effect of zinc supplementation on growth performance, intestinal development, and intestinal barrier function in Pekin ducks with lipopolysaccharide challenge","volume":"100","author":"Xie","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1517976","article-title":"Organic trace elements enhance growth performance, antioxidant capacity, and gut microbiota in finishing pigs","volume":"11","author":"Xu","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105772_bib0035","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/mco2.104","article-title":"NF-\u03bab signaling in inflammation and cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"MedComm"},{"key":"10.1016\/j.psj.2025.105772_bib0036","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12011-017-1028-9","article-title":"Effects of maternal zinc glycine on mortality, zinc concentration, and antioxidant status in a developing embryo and 1-day-old chick","volume":"181","author":"Zhang","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105772_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110208","article-title":"Pretreatment with zinc protects Kupffer cells following administration of microbial products","volume":"127","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.psj.2025.105772_bib0038","first-page":"229","article-title":"L-glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent","volume":"6","author":"Zhong","year":"2003","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.psj.2025.105772_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.104925","article-title":"Zinc glycine supplementation improves bone quality in meat geese by modulating gut microbiota, SCFA\u2019s, and gut barrier function through Wnt10b\/NF-\u03bab axis","volume":"104","author":"Zulfiqar","year":"2025","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125010132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125010132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:56:20Z","timestamp":1765540580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125010132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0032579125010132"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105772","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zn glycine mitigates the LPS-induced hepatic injury and inflammation through NrF2\/NF\u03baB signaling in geese","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105772"}}