{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:45:45Z","timestamp":1778323545309,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","award":["CARS-42-17"],"award-info":[{"award-number":["CARS-42-17"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.psj.2025.105848","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T09:45:10Z","timestamp":1757843110000},"page":"105848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The UL24 gene affects duck plague virus replication, and its deletion attenuates virulence, enabling use as a vaccine"],"prefix":"10.1016","volume":"104","author":[{"given":"Huijun","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilin","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linjiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-353X","authenticated-orcid":false,"given":"Anchun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0001","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1261\/rna.1935610","article-title":"Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection","volume":"16","author":"Belin","year":"2010","journal-title":"RNA"},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/JVI.01428-09","article-title":"Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin","volume":"84","author":"Bertrand","year":"2010","journal-title":"J. Virol."},{"issue":"Pt 5","key":"10.1016\/j.psj.2025.105848_bib0003","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1099\/vir.0.83573-0","article-title":"The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin","volume":"89","author":"Bertrand","year":"2008","journal-title":"J. Gen. Virol."},{"issue":"6","key":"10.1016\/j.psj.2025.105848_bib0004","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0168-9525(00)02015-1","article-title":"Forward with BACs: new tools for herpesvirus genomics","volume":"16","author":"Brune","year":"2000","journal-title":"Trend. Genet."},{"issue":"3","key":"10.1016\/j.psj.2025.105848_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006937","article-title":"The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein","volume":"14","author":"Bussey","year":"2018","journal-title":"PLoS Pathog."},{"issue":"41","key":"10.1016\/j.psj.2025.105848_bib0006","doi-asserted-by":"crossref","first-page":"70006","DOI":"10.18632\/oncotarget.19549","article-title":"Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells","volume":"8","author":"Cai","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.psj.2025.105848_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198276","article-title":"Pseudorabies virus UL24 antagonizes OASL-mediated antiviral effect","volume":"295","author":"Chen","year":"2021","journal-title":"Virus Res."},{"issue":"5","key":"10.1016\/j.psj.2025.105848_bib0008","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s12250-021-00380-0","article-title":"Host interferon-stimulated gene 20 inhibits pseudorabies virus proliferation","volume":"36","author":"Chen","year":"2021","journal-title":"Virol. Sin."},{"issue":"1\u20132","key":"10.1016\/j.psj.2025.105848_bib0009","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-1135(01)00492-8","article-title":"Evolution of the herpesviruses","volume":"86","author":"Davison","year":"2002","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/01652176.2017.1298885","article-title":"Duck virus enteritis (duck plague) - a comprehensive update","volume":"37","author":"Dhama","year":"2017","journal-title":"Vet. Q."},{"key":"10.1016\/j.psj.2025.105848_bib0011","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.rvsc.2017.01.011","article-title":"Comparative pathogenicity and immunogenicity of triple and double gene-deletion pseudorabies virus vaccine candidates","volume":"115","author":"Dong","year":"2017","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105848_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.12703\/P5-41","article-title":"Stimulated nuclear import by \u03b2-like importins","volume":"5","author":"Flores","year":"2013","journal-title":"F1000Prime Rep."},{"issue":"24","key":"10.1016\/j.psj.2025.105848_bib0013","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01578-22","article-title":"Duck enteritis virus inhibits the cGAS-STING DNA-sensing pathway to evade the innate immune response","volume":"96","author":"Gao","year":"2022","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0014","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12985-017-0830-5","article-title":"Duck enteritis virus (DEV) UL54 protein, a novel partner, interacts with DEV UL24 protein","volume":"14","author":"Gao","year":"2017","journal-title":"Virol. J."},{"key":"10.1016\/j.psj.2025.105848_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1743-422X-6-71","article-title":"Development of TaqMan MGB fluorescent real-time PCR assay for the detection of anatid herpesvirus 1","volume":"6","author":"Guo","year":"2009","journal-title":"Virol. J."},{"key":"10.1016\/j.psj.2025.105848_bib0016","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-319-53168-7_6","article-title":"Herpesvirus capsid assembly and DNA packaging","volume":"223","author":"Heming","year":"2017","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"issue":"4","key":"10.1016\/j.psj.2025.105848_bib0017","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1128\/CVI.00605-13","article-title":"An attenuated duck plague virus (DPV) vaccine induces both systemic and mucosal immune responses to protect ducks against virulent DPV infection","volume":"21","author":"Huang","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"issue":"8","key":"10.1016\/j.psj.2025.105848_bib0018","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1128\/JVI.79.8.4819-4827.2005","article-title":"Role of the varicella-zoster virus gene product encoded by open reading frame 35 in viral replication in vitro and in differentiated human skin and T cells in vivo","volume":"79","author":"Ito","year":"2005","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0019","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/viro.1997.9012","article-title":"Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice","volume":"242","author":"Jacobson","year":"1998","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.psj.2025.105848_bib0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.virol.2010.02.012","article-title":"The ORF37 (UL24) is a neuropathogenicity determinant of equine herpesvirus 1 (EHV-1) in the mouse encephalitis model","volume":"400","author":"Kasem","year":"2010","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.psj.2025.105848_bib0021","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/JVI.80.5.2575-2577.2006","article-title":"Human herpesvirus 1 UL24 gene encodes a potential PD-(D\/E)XK endonuclease","volume":"80","author":"Knizewski","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2025.105848_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.979368","article-title":"Pathogenicity and transmissibility studies on live attenuated duck enteritis virus vaccine in non-target species","volume":"13","author":"Kong","year":"2022","journal-title":"Front. Microbiol."},{"issue":"D1","key":"10.1016\/j.psj.2025.105848_bib0023","doi-asserted-by":"crossref","first-page":"D708","DOI":"10.1093\/nar\/gkx932","article-title":"Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)","volume":"46","author":"Lefkowitz","year":"2018","journal-title":"Nucl. Acid. Res."},{"issue":"Pt 5","key":"10.1016\/j.psj.2025.105848_bib0024","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1099\/vir.0.017921-0","article-title":"Differential importance of highly conserved residues in UL24 for herpes simplex virus 1 replication in vivo and reactivation","volume":"91","author":"Leiva-Torres","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.psj.2025.105848_bib0025","article-title":"Development and immunogenicity evaluation of a quadruple-gene-deleted pseudorabies virus strain","volume":"15","author":"Li","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.105848_bib0026","article-title":"Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.psj.2025.105848_bib0027","doi-asserted-by":"crossref","first-page":"11562","DOI":"10.1128\/JVI.01568-13","article-title":"Human cytomegalovirus UL76 elicits novel aggresome formation via interaction with S5a of the ubiquitin proteasome system","volume":"87","author":"Lin","year":"2013","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13567-017-0456-z","article-title":"RNA-seq comparative analysis of Peking ducks spleen gene expression 24 h post-infected with duck plague virulent or attenuated virus","volume":"48","author":"Liu","year":"2017","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2025.105848_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109023","article-title":"Inhibition of the DNA-sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7","volume":"255","author":"Liu","year":"2021","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12964-021-00741-y","article-title":"Types of nuclear localization signals and mechanisms of protein import into the nucleus","volume":"19","author":"Lu","year":"2021","journal-title":"Cell Commun. Signal."},{"issue":"2","key":"10.1016\/j.psj.2025.105848_bib0031","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.virol.2011.01.016","article-title":"Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress","volume":"412","author":"Lymberopoulos","year":"2011","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.psj.2025.105848_bib0032","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.virol.2007.01.028","article-title":"Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin","volume":"363","author":"Lymberopoulos","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.psj.2025.105848_bib0033","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1146\/annurev-biochem-060208-104626","article-title":"Virus entry by endocytosis","volume":"79","author":"Mercer","year":"2010","journal-title":"Annu. Rev. Biochem."},{"issue":"Pt 5","key":"10.1016\/j.psj.2025.105848_bib0034","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1099\/vir.0.82589-0","article-title":"Murine gammaherpesvirus 68 ORF20 induces cell-cycle arrest in G2 by inhibiting the Cdc2-cyclin B complex","volume":"88","author":"Nascimento","year":"2007","journal-title":"J. Gen. Virol."},{"issue":"7","key":"10.1016\/j.psj.2025.105848_bib0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2183\/pjab.94.018","article-title":"Importin \u03b1: functions as a nuclear transport factor and beyond","volume":"94","author":"Oka","year":"2018","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"issue":"9","key":"10.1016\/j.psj.2025.105848_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/v16091418","article-title":"KSHV ORF20 promotes coordinated lytic reactivation for increased infectious particle production","volume":"16","author":"Orbaum-Harel","year":"2024","journal-title":"Viruses"},{"issue":"9","key":"10.1016\/j.psj.2025.105848_bib0037","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.3390\/v7092861","article-title":"Tegument assembly and secondary envelopment of alphaherpesviruses","volume":"7","author":"Owen","year":"2015","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0038","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.rvsc.2008.05.001","article-title":"Replication kinetics of duck virus enteritis vaccine virus in ducklings immunized by the mucosal or systemic route using real-time quantitative PCR","volume":"86","author":"Qi","year":"2009","journal-title":"Res. Vet. Sci."},{"issue":"12","key":"10.1016\/j.psj.2025.105848_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104378","article-title":"Duck plague virus UL24 protein initiates K48\/K63-linked IRF7 polyubiquitination to antagonize the innate immune response","volume":"103","author":"Ruan","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105848_bib0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.virol.2016.05.006","article-title":"Regulation of viral gene expression by the herpes simplex virus 1UL24 protein (HSV-1UL24 inhibits accumulation of viral transcripts)","volume":"495","author":"Sanabria-Solano","year":"2016","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.psj.2025.105848_bib0041","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/JVI.01716-07","article-title":"Intracellular localization map of human herpesvirus 8 proteins","volume":"82","author":"Sander","year":"2008","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0042","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00418-007-0359-6","article-title":"Nucleolus: the fascinating nuclear body","volume":"129","author":"Sirri","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.psj.2025.105848_bib0043","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-60761-652-8_30","article-title":"En passant mutagenesis: a two step markerless red recombination system","volume":"634","author":"Tischer","year":"2010","journal-title":"Method. Mol. Biol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/v12010051","article-title":"Pseudorabies virus UL24 abrogates tumor necrosis factor alpha-induced NF-\u03bab activation by degrading P65","volume":"12","author":"Wang","year":"2020","journal-title":"Viruses"},{"issue":"10","key":"10.1016\/j.psj.2025.105848_bib0045","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1128\/JVI.00529-12","article-title":"Complete genomic sequence of Chinese virulent duck enteritis virus","volume":"86","author":"Wu","year":"2012","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0046","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12985-017-0748-y","article-title":"Preliminary study of the UL55 gene based on infectious Chinese virulent duck enteritis virus bacterial artificial chromosome clone","volume":"14","author":"Wu","year":"2017","journal-title":"Virol. J."},{"issue":"6","key":"10.1016\/j.psj.2025.105848_bib0047","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01140-22","article-title":"Deletion of double copies of the US1 gene reduces the infectivity of recombinant duck plague virus In vitro and In vivo","volume":"10","author":"Wu","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"7","key":"10.1016\/j.psj.2025.105848_bib0048","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00025-17","article-title":"Herpes Simplex Virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-\u03bab activation","volume":"91","author":"Xu","year":"2017","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.psj.2025.105848_bib0049","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11262-018-1619-3","article-title":"Functional analysis of the UL24 protein of suid herpesvirus 1","volume":"55","author":"Ye","year":"2019","journal-title":"Virus Gene."},{"issue":"7","key":"10.1016\/j.psj.2025.105848_bib0050","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00705-020-04594-7","article-title":"Complete genome sequence of an isolate of duck enteritis virus from China","volume":"165","author":"Zhang","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.psj.2025.105848_bib0051","article-title":"Nuclear and nucleolar localization of bovine Adenovirus-3 protein V","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.psj.2025.105848_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102358","article-title":"Research note: duck plague virus pUL48 is a late protein that plays an important role in viral replication","volume":"102","author":"Zhou","year":"2023","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125010892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125010892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:32:27Z","timestamp":1772839947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125010892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0032579125010892"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105848","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The UL24 gene affects duck plague virus replication, and its deletion attenuates virulence, enabling use as a vaccine","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105848"}}