{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:29:34Z","timestamp":1788445774910,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20220202062NC"],"award-info":[{"award-number":["20220202062NC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.psj.2025.106248","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T07:58:40Z","timestamp":1765353520000},"page":"106248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anemoside B4 attenuates intestinal damage in chickens infected with Eimeria tenella: Mechanisms involving antioxidant defense, immune modulation, and barrier repair"],"prefix":"10.1016","volume":"105","author":[{"given":"Mohan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.106248_bib0001","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/CMR.15.1.58-65.2002","article-title":"Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry","volume":"15","author":"Allen","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.psj.2025.106248_bib0002","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/03079457.2018.1475724","article-title":"Re-thinking the chicken-Campylobacter jejuni interaction: a review","volume":"47","author":"Awad","year":"2018","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2025.106248_bib0003","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.pt.2013.10.003","article-title":"Securing poultry production from the ever-present Eimeria challenge","volume":"30","author":"Blake","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.psj.2025.106248_bib0005","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3382\/ps.2010-00931","article-title":"Forty years of monensin for the control of coccidiosis in poultry","volume":"89","author":"Chapman","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.106248_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1637\/7306-11150R","article-title":"Recent advances in immunomodulation and vaccination strategies against coccidiosis","volume":"49","author":"Dalloul","year":"2005","journal-title":"Avian Dis"},{"key":"10.1016\/j.psj.2025.106248_bib0007","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14760584.5.1.143","article-title":"Poultry coccidiosis: recent advancements in control measures and vaccine development","volume":"5","author":"Dalloul","year":"2006","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.psj.2025.106248_bib0008","series-title":"Advancements in Technology for Diagnosing and Controlling Coccidiosis in Poultry: a Review of the Eimeria Genus","author":"Franzo","year":"2025"},{"key":"10.1016\/j.psj.2025.106248_bib0009","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vetimm.2006.07.007","article-title":"Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections","volume":"114","author":"Hong","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2025.106248_bib0010","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70738","article-title":"Pulchinenoside C attenuates the development of osteoarthritis by inhibiting the PI3K\/AKT\/NF-\u03bab signalling pathway","volume":"29","author":"Hu","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.psj.2025.106248_bib0011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0014-4894(70)90063-9","article-title":"Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens","volume":"28","author":"Johnson","year":"1970","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.psj.2025.106248_bib0013","first-page":"582","article-title":"IPSE, an uracil-DNA glycosylase inhibitor, enhances antioxidant defense in chickens against Eimeria maxima infection","volume":"7","author":"Kim","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.106248_bib0016","first-page":"44","article-title":"Suppression of CD4+ and CD8+ T-cell function by Eimeria acervulina and Eimeria tenella","volume":"148","author":"Lillehoj","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2025.106248_bib0017","article-title":"Saponins regulate intestinal inflammation in colon cancer and IBD","volume":"174","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.psj.2025.106248_bib0019","series-title":"Diseases of Poultry","first-page":"1148","article-title":"Coccidiosis","author":"McDougald","year":"2013"},{"key":"10.1016\/j.psj.2025.106248_bib0021","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/01652176.2011.605247","article-title":"Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies","volume":"31","author":"Peek","year":"2011","journal-title":"Vet. Q."},{"key":"10.1016\/j.psj.2025.106248_bib0022","first-page":"660","article-title":"Effects of probiotics and antibiotic on performance and immune response of broiler chickens challenged with Eimeria tenella","volume":"95","author":"Ritzi","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.106248_bib0023","first-page":"48","article-title":"Combination of probiotics and coccidiosis vaccine enhances protection against Eimeria challenge","volume":"173","author":"Ritzi","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2025.106248_bib0024","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.4049\/jimmunol.173.4.2675","article-title":"Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima","volume":"173","author":"Rothwell","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2025.106248_bib0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0065-308X(05)60005-X","article-title":"The biology of avian eimeria with an emphasis on their control by vaccination","volume":"60","author":"Shirley","year":"2005","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.psj.2025.106248_bib0026","first-page":"6645","article-title":"Ginsenoside Rb1 attenuates intestinal barrier injury via mTOR signaling","volume":"68","author":"Song","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2025.106248_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aninu.2016.01.001","article-title":"Antioxidant systems in chick embryo development. Part 1. Vitamin E, carotenoids and selenium","volume":"2","author":"Surai","year":"2016","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2025.106248_bib0028","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0264-410X(95)98255-9","article-title":"Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens","volume":"13","author":"Wallach","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2025.106248_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103746","article-title":"Anemoside B4 alleviates ulcerative colitis by activating aryl hydrocarbon receptor to remodel gut microbiome and metabolites","volume":"85","author":"Wu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.psj.2025.106248_bib0031","first-page":"345","article-title":"Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function","volume":"73","author":"Xu","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.psj.2025.106248_bib0032","first-page":"501","article-title":"Antioxidant properties of triterpenoid saponins from Pulsatilla chinensis","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125014889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125014889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:47:35Z","timestamp":1771861655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125014889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0032579125014889"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.106248","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anemoside B4 attenuates intestinal damage in chickens infected with Eimeria tenella: Mechanisms involving antioxidant defense, immune modulation, and barrier repair","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.106248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"106248"}}