{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:07:02Z","timestamp":1790928422298,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272953"],"award-info":[{"award-number":["32272953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372956"],"award-info":[{"award-number":["32372956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.psj.2026.106573","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T22:47:09Z","timestamp":1769986029000},"page":"106573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The adiponectin receptor agonist AdipoRon alleviates lipotoxic injury in LMH cells"],"prefix":"10.1016","volume":"105","author":[{"given":"Xinhong","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-1360","authenticated-orcid":false,"given":"Zhongzan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.106573_bib79","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70677","article-title":"Protective effects of COG133 on carbon tetrachloride-induced acute liver injury: modulation of inflammation, apoptosis and sphingolipid metabolism","volume":"29","author":"Aslan","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.psj.2026.106573_bib0001","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2337\/diabetes.52.5.1073","article-title":"Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: roles of MAPKerk and MAPKp38","volume":"52","author":"Au","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.psj.2026.106573_bib0002","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2009.02.131","article-title":"Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1\/LKB1\/AMPK dependent pathway","volume":"382","author":"Awazawa","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psj.2026.106573_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115871","article-title":"AdipoRon and ADP355, adiponectin receptor agonists, in metabolic-associated fatty liver disease (MAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"218","author":"Barbalho","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.psj.2026.106573_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.766737","article-title":"Mori Fructus polysaccharides attenuate alcohol-induced liver damage by regulating fatty acid synthesis, degradation and glycerophospholipid metabolism in mice","volume":"12","author":"Bian","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psj.2026.106573_bib63","doi-asserted-by":"crossref","first-page":"101708","DOI":"10.1016\/j.psj.2022.101708","article-title":"Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet","volume":"101","author":"Cao","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib72","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.1039\/D2FO01518H","article-title":"The important role of glycerophospholipid metabolism in the protective effects of polyphenol-enriched Tartary buckwheat extract against alcoholic liver disease","volume":"13","author":"Cao","year":"2022","journal-title":"Food. Funct."},{"key":"10.1016\/j.psj.2026.106573_bib0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jsbmb.2013.08.013","article-title":"Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes","volume":"138","author":"Chen","year":"2013","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.psj.2026.106573_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103968","article-title":"Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics","volume":"103","author":"Cheng","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2024.101056","article-title":"Expanding functions of the phosphatidylinositol\/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology","volume":"95","author":"Cockcroft","year":"2025","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.psj.2026.106573_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103482","article-title":"Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK\/PPAR\u03b1 pathway","volume":"103","author":"Ding","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0009","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1388-1981(00)00140-2","article-title":"Regulation of gene expression by SREBP and SCAP","volume":"1529","author":"Edwards","year":"2000","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.psj.2026.106573_bib0011","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/j.2040-4603.2018.tb00036.x","article-title":"Adiponectin regulation and function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.psj.2026.106573_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.970292","article-title":"The AMPK pathway in fatty liver disease","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2026.106573_bib0012","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14429","article-title":"Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity","volume":"24","author":"Fern\u00e0ndez-Bernal","year":"2025","journal-title":"Aging. Cell."},{"key":"10.1016\/j.psj.2026.106573_bib0013","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/biomedicines6020052","article-title":"Adiponectin signaling pathways in liver diseases","volume":"6","author":"Gamberi","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.psj.2026.106573_bib0014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbrc.2022.08.074","article-title":"Sphingomyelin: What is it good for?","volume":"633","author":"Go\u00f1i","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psj.2026.106573_bib69","doi-asserted-by":"crossref","first-page":"F5","DOI":"10.1083\/jcb.150.1.F5","article-title":"Apoptosis and sphingomyelin hydrolysis. The flip side","volume":"150","author":"Green","year":"2000","journal-title":"J.Cell. Biol."},{"key":"10.1016\/j.psj.2026.106573_bib0015","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3390\/jcm10040792","article-title":"Roles of ceramides in non-alcoholic fatty liver disease","volume":"10","author":"Hajduch","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.psj.2026.106573_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2023.12.003","article-title":"New advances of adiponectin in regulating obesity and related metabolic syndromes","volume":"14","author":"Han","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.psj.2026.106573_bib0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.plipres.2012.08.002","article-title":"Stearoyl-CoA desaturase: rogue or innocent bystander?","volume":"52","author":"Hodson","year":"2013","journal-title":"Prog. Lipid. Res."},{"key":"10.1016\/j.psj.2026.106573_bib0018","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.3390\/nu15224772","article-title":"Nuclear receptor PPAR\u03b1 as a therapeutic target in diseases associated with lipid metabolism disorders","volume":"15","author":"Hu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2026.106573_bib0019","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11154-019-09510-2","article-title":"Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease","volume":"20","author":"Ishtiaq","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.psj.2026.106573_bib71","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/09637486.2024.2437469","article-title":"Phosphatidylcholine ameliorates lipid accumulation and liver injury in high-fat diet mice by modulating bile acid metabolism and gut microbiota","volume":"76","author":"Jia","year":"2025","journal-title":"Int. J. Food. Sci. Nutr."},{"key":"10.1016\/j.psj.2026.106573_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103734","article-title":"Synergistic effect of genistein and adiponectin reduces fat deposition in chicken hepatocytes by activating the ER\u03b2-mediated SIRT1-AMPK signaling pathway","volume":"103","author":"Jiang","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0021","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.metabol.2010.03.006","article-title":"Plasma metabolomic profile in nonalcoholic fatty liver disease","volume":"60","author":"Kalhan","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.psj.2026.106573_bib0022","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cbin.10915","article-title":"Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism","volume":"42","author":"Ke","year":"2018","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.psj.2026.106573_bib0023","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR\u03b1","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.psj.2026.106573_bib0024","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3390\/ijms18061275","article-title":"Globular adiponectin inhibits lipopolysaccharide-primed inflammasomes activation in macrophages via autophagy induction: the critical role of AMPK signaling","volume":"18","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib76","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3892\/mmr.2015.3361","article-title":"Plasma sphingolipids: potential biomarkers for severe hepatic fibrosis in chronic hepatitis C","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/metabo9020036","article-title":"Function, detection and alteration of acylcarnitine metabolism in hepatocellular carcinoma","volume":"9","author":"Li","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.psj.2026.106573_bib0027","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.2147\/DDDT.S351092","article-title":"Didymin ameliorates liver fibrosis by alleviating endoplasmic reticulum stress and glycerophospholipid metabolism: Based on transcriptomics and metabolomics","volume":"16","author":"Li","year":"2022","journal-title":"Drug. Des. Devel. Ther."},{"key":"10.1016\/j.psj.2026.106573_bib0026","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.3390\/molecules27186117","article-title":"Targeting ceramides and adiponectin receptors in the islet of langerhans for treating diabetes","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2026.106573_bib0028","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14152","article-title":"AdipoRon prevents myostatin-induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line","volume":"7","author":"Liu","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00071668.2024.2393960","article-title":"Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver","volume":"66","author":"Ma","year":"2025","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0029","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1478-3231.2007.01475.x","article-title":"Sphingolipid signalling and liver diseases","volume":"27","author":"Mar\u00ed","year":"2007","journal-title":"Liver. Int."},{"key":"10.1016\/j.psj.2026.106573_bib0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7150\/ijms.13581","article-title":"Palmitate-induced regulation of PPAR\u03b3 via PGC1\u03b1: a mechanism for lipid accumulation in the liver in nonalcoholic fatty liver disease","volume":"13","author":"Maruyama","year":"2016","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0031","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.20282","article-title":"Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice","volume":"40","author":"Masaki","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.psj.2026.106573_bib73","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.psj.2026.106573_bib0032","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-0716-2128-8_22","article-title":"Analysis of the sphingolipidome in NAFLD","volume":"2455","author":"Montefusco","year":"2022","journal-title":"Methods. Mol. Biol."},{"key":"10.1016\/j.psj.2026.106573_bib0033","doi-asserted-by":"crossref","DOI":"10.1038\/srep11737","article-title":"Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria","volume":"5","author":"Morita","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib0034","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0305-0491(00)00171-1","article-title":"Role of hepatic lipogenesis in the susceptibility to fatty liver in the goose (Anser anser)","volume":"126","author":"Mourot","year":"2000","journal-title":"Comp. Biochem. Physiol. B. Biochem. Mol. Biol."},{"key":"10.1016\/j.psj.2026.106573_bib74","first-page":"4468","article-title":"Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells","volume":"60","author":"Nava","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.psj.2026.106573_bib0035","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1111\/dom.16542","article-title":"AdipoRon attenuates steatosis, inflammation and fibrosis in murine diet-induced NASH via inhibiting ER stress","volume":"27","author":"Nie","year":"2025","journal-title":"Diabetes. Obes. Metab."},{"key":"10.1016\/j.psj.2026.106573_bib0036","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","article-title":"A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity","volume":"503","author":"Okada-Iwabu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.psj.2026.106573_bib0037","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s13340-019-00409-6","article-title":"Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity","volume":"10","author":"Okada-Iwabu","year":"2019","journal-title":"Diabetol. Int."},{"key":"10.1016\/j.psj.2026.106573_bib0038","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2026.106573_bib0039","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tem.2012.04.005","article-title":"Role of ceramides in nonalcoholic fatty liver disease","volume":"23","author":"Pagadala","year":"2012","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.psj.2026.106573_bib0040","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40139-015-0094-y","article-title":"Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver","volume":"3","author":"Park","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib0041","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.psj.2026.106573_bib0043","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.psj.2026.106573_bib0042","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-020-63579-3","article-title":"Hepatocyte-specific deletion of PPAR\u03b1 promotes NAFLD in the context of obesity","volume":"10","author":"R\u00e9gnier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib77","doi-asserted-by":"crossref","first-page":"13739","DOI":"10.3390\/ijms252413739","article-title":"Metabolic biomarkers of liver failure in cell models and patient sera: toward liver damage evaluation in vitro","volume":"25","author":"Rentschler","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib66","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","article-title":"Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes","volume":"24","author":"Ricchi","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2026.106573_bib0044","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/BST20253042","article-title":"Ceramide homeostasis in hepatic lipid droplets","volume":"53","author":"Robles-Martinez","year":"2025","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.psj.2026.106573_bib0045","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.lfs.2008.07.022","article-title":"Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats","volume":"83","author":"Rodr\u00edguez","year":"2008","journal-title":"Life. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0046","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/1873-3468.14992","article-title":"The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases","volume":"598","author":"Santos","year":"2024","journal-title":"FEBS. Lett."},{"key":"10.1016\/j.psj.2026.106573_bib0047","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1467-789X.2009.00642.x","article-title":"Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome","volume":"11","author":"Schreurs","year":"2010","journal-title":"Obes. Rev."},{"key":"10.1016\/j.psj.2026.106573_bib0048","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1194\/jlr.M700033-JLR200","article-title":"SREBP-1-independent regulation of lipogenic gene expression in adipocytes","volume":"48","author":"Sekiya","year":"2007","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.psj.2026.106573_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106157","article-title":"Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice","volume":"79","author":"Sha","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.psj.2026.106573_bib0050","doi-asserted-by":"crossref","first-page":"27029","DOI":"10.1074\/jbc.M202638200","article-title":"The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression","volume":"277","author":"Stoeckman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psj.2026.106573_bib62","doi-asserted-by":"crossref","first-page":"105867","DOI":"10.1016\/j.psj.2025.105867","article-title":"Daidzein-betaine cocrystal alleviates high-energy and low-protein diet induced fatty liver hemorrhagic syndrome in laying hens through gut-liver axis","volume":"104","author":"Sun","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2025.1667501","article-title":"Adiponectin receptor agonist reduces broiler hepatic lipid deposition","volume":"12","author":"Tan","year":"2025","journal-title":"Front.Vet. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34835","article-title":"DHA-enriched phosphatidylserine alleviates bisphenol A-induced liver injury through regulating glycerophospholipid metabolism and the SIRT1-AMPK pathway","volume":"10","author":"Tian","year":"2024","journal-title":"Heliyon."},{"key":"10.1016\/j.psj.2026.106573_bib78","doi-asserted-by":"crossref","first-page":"103293","DOI":"10.1016\/j.psj.2023.103293","article-title":"Osteocalcin activates lipophagy via the ADPN-AMPK\/PPAR\u03b1-mTOR signaling pathway in chicken embryonic hepatocyte","volume":"103","author":"Tu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib70","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta. Biomembr."},{"key":"10.1016\/j.psj.2026.106573_bib0053","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1007\/s11010-025-05268-1","article-title":"Adiponectin mediated metabolic and sphingolipid alterations in preventing endothelial dysfunction","volume":"480","author":"Vincent","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.psj.2026.106573_bib65","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.3892\/mmr.2017.7450","article-title":"Adiponectin receptor agonist AdipoRon suppresses adipogenesis in C3H10T1\/2 cells through the adenosine monophosphate\u2011activated protein kinase signaling pathway","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.psj.2026.106573_bib75","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1038\/s41467-024-48954-2","article-title":"Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2\u03b1","volume":"15","author":"Xia","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.106573_bib0054","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1097\/CM9.0000000000000488","article-title":"Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice","volume":"132","author":"Xiao","year":"2019","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.psj.2026.106573_bib0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI200317797","article-title":"The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.psj.2026.106573_bib0056","article-title":"Adiponectin receptor agonist AdipoRon regulates glucose and lipid metabolism via PPAR\u03b3 signaling pathway in hepatocytes of large yellow croaker (Larimichthys crocea)","volume":"1870","author":"Xu","year":"2025","journal-title":"Biochim. Biophys. Acta. Mol. Cell. Biol. Lipids."},{"key":"10.1016\/j.psj.2026.106573_bib67","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.beem.2013.09.003","article-title":"Adiponectin receptors: a review of their structure, function and how they work","volume":"28","author":"Yamauchi","year":"2014","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psj.2026.106573_bib0057","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3390\/ijms20051190","article-title":"Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: Mechanisms and perspectives","volume":"20","author":"Yanai","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0058","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.2337\/db05-1322","article-title":"Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha","volume":"55","author":"Yoon","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.psj.2026.106573_bib0059","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1111\/jgh.15005","article-title":"Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats","volume":"35","author":"Yue","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2026.106573_bib0060","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1186\/s12885-024-13114-8","article-title":"Integrated bulk and single-cell profiling characterize sphingolipid metabolism in pancreatic cancer","volume":"24","author":"Zhang","year":"2024","journal-title":"BMC. Cancer."},{"key":"10.1016\/j.psj.2026.106573_bib68","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.3168\/jds.2022-22723","article-title":"AdipoRon alleviates fatty acid-induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy","volume":"106","author":"Zhao","year":"2023","journal-title":"J. Dairy. Sci."},{"key":"10.1016\/j.psj.2026.106573_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115427","article-title":"Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK","volume":"295","author":"Zhu","year":"2022","journal-title":"J. Ethnopharmacol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126002002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126002002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:19:51Z","timestamp":1775247591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126002002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0032579126002002"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.106573","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The adiponectin receptor agonist AdipoRon alleviates lipotoxic injury in LMH cells","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.106573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"106573"}}