{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:45:24Z","timestamp":1782603924538,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007539","name":"Jiangsu Academy of Agricultural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD04064"],"award-info":[{"award-number":["2023ZD04064"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.psj.2026.106769","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:20:49Z","timestamp":1773418849000},"page":"106769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated multi-omics implicates the gut microbiota and bilirubin in abdominal fat deposition in Huainan yellow chickens"],"prefix":"10.1016","volume":"105","author":[{"given":"Yaxin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-3139","authenticated-orcid":false,"given":"Mingming","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.106769_bib0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejcb.2013.06.001","article-title":"Adipocyte and adipogenesis","volume":"92","author":"Ali","year":"2013","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.psj.2026.106769_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105107","article-title":"Dietary bile acid supplementation influences protein digestibility and alters plasma amino acid profiles in broiler chickens fed conventional and reduced-protein diets","volume":"104","author":"Bao","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106769_bib0003","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbpc.2009.04.005","article-title":"Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus)","volume":"150","author":"Cai","year":"2009","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.psj.2026.106769_bib0004","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/jn\/121.9.1486","article-title":"Adipose cellularity in Gallus domesticus: investigations to control body composition in growing chickens","volume":"121","author":"Cartwright","year":"1991","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2026.106769_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.595637","article-title":"miR-429-3p\/LPIN1 axis promotes chicken abdominal fat deposition via PPAR\u03b3 pathway","volume":"8","author":"Chao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.psj.2026.106769_bib0006","doi-asserted-by":"crossref","first-page":"E191","DOI":"10.1152\/ajpendo.00405.2020","article-title":"Bilirubin as a metabolic hormone: the physiological relevance of low levels","volume":"320","author":"Creeden","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.psj.2026.106769_bib0007","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.psj.2026.106769_bib0008","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nchembio.1864","article-title":"A biosynthetic pathway for a prominent class of microbiota-derived bile acids","volume":"11","author":"Devlin","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.psj.2026.106769_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1139800","article-title":"Research progress of gut microbiota and obesity caused by high-fat diet","volume":"13","author":"Fan","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.psj.2026.106769_bib0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ecl.2022.02.008","article-title":"Lipid and lipoprotein metabolism","volume":"51","author":"Feingold","year":"2022","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.psj.2026.106769_bib0011","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bst0320059","article-title":"Synthesis and function of hepatic very-low-density lipoprotein","volume":"32","author":"Gibbons","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.psj.2026.106769_bib0012","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tem.2018.01.002","article-title":"Bilirubin in the liver-gut signaling axis","volume":"29","author":"Hamoud","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.psj.2026.106769_bib0013","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/HYPERTENSIONAHA.118.11130","article-title":"Bilirubin, a cardiometabolic signaling molecule","volume":"72","author":"Hinds","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.psj.2026.106769_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.594574","article-title":"Bilirubin nanoparticles reduce diet-induced hepatic steatosis, improve fat utilization, and increase plasma beta-hydroxybutyrate","volume":"11","author":"Hinds","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psj.2026.106769_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105320","article-title":"Utilizing plasma biochemical indicators to improve prediction of economic traits in crossbred duck population","volume":"104","author":"Hu","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106769_bib0016","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/antiox12010170","article-title":"Bilirubin levels are negatively correlated with adiposity in obese men and women, and its catabolized product, urobilin, is positively associated with insulin resistance","volume":"12","author":"Kipp","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.psj.2026.106769_bib0017","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.3390\/ani13243860","article-title":"Age-related changes in hepatic lipid metabolism and abdominal adipose deposition in yellow-feathered broilers aged from 1 to 56 days","volume":"13","author":"Lan","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.psj.2026.106769_bib0018","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s40168-025-02190-y","article-title":"Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-alpha-linolenic and linoleic acid metabolism-enterohepatic circulation axis","volume":"13","author":"Lin","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.psj.2026.106769_bib0019","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/s41586-024-07929-5","article-title":"A brain-to-gut signal controls intestinal fat absorption","volume":"634","author":"Lyu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.psj.2026.106769_bib0020","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1017\/S0007114521000374","article-title":"Diets, nutrients, genes and the microbiome: recent advances in personalised nutrition","volume":"126","author":"Matusheski","year":"2021","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2026.106769_bib0021","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/age.12263","article-title":"Variant discovery in a QTL region on chromosome 3 associated with fatness in chickens","volume":"46","author":"Moreira","year":"2015","journal-title":"Anim. Genet."},{"key":"10.1016\/j.psj.2026.106769_bib0022","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00042737-200411000-00003","article-title":"Mitochondrial injury in steatohepatitis","volume":"16","author":"Pessayre","year":"2004","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2026.106769_bib0023","doi-asserted-by":"crossref","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.psj.2026.106769_bib0024","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gene.2011.12.022","article-title":"Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids","volume":"496","author":"Rodr\u00edguez-Cruz","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.psj.2026.106769_bib0025","article-title":"Effect of type of fiber and its physicochemical properties on performance, digestive transit time, and cecal fermentation in broilers from 1 to 23 d of age","volume":"103","author":"Rybicka","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106769_bib0026","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00041433-200104000-00008","article-title":"Very-low-density lipoprotein assembly and secretion","volume":"12","author":"Shelness","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.psj.2026.106769_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2023.09.002","article-title":"An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism","volume":"31","author":"Shelton","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.psj.2026.106769_bib0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00253-016-8006-6","article-title":"Interaction of gut microbiota with bile acid metabolism and its influence on disease states","volume":"101","author":"Staley","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2026.106769_bib0029","doi-asserted-by":"crossref","first-page":"25403","DOI":"10.1021\/acs.jafc.4c06867","article-title":"Deciphering mechanisms of adipocyte differentiation in abdominal fat of broilers","volume":"72","author":"Sun","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2026.106769_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2025.107412","article-title":"Bilirubin nanotechnology: an innovative approach in biomedicine","volume":"320-321","author":"Tatikolov","year":"2025","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.psj.2026.106769_bib0031","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S2468-1253(17)30147-4","article-title":"The microbiota-gut-brain axis in obesity","volume":"2","author":"Torres-Fuentes","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2026.106769_bib0032","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2004.10.012","article-title":"The impact of intestinal microflora on serum bilirubin levels","volume":"42","author":"V\u00edtek","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.psj.2026.106769_bib0033","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.psj.2026.106769_bib0034","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/gutjnl-2018-317609","article-title":"Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial","volume":"68","author":"Wan","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.psj.2026.106769_bib0035","article-title":"Dietary succinate reduces fat deposition through gut microbiota and lipid metabolism in broilers","volume":"103","author":"Wang","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106769_bib0036","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.2527\/jas2017.1706","article-title":"Identification of a potential functional single nucleotide polymorphism for fatness and growth traits in the 3\u2032-untranslated region of the PCSK1 gene in chickens","volume":"95","author":"Zhang","year":"2017","journal-title":"J. Anim. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126003962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126003962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:04:41Z","timestamp":1782601481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126003962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0032579126003962"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.106769","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated multi-omics implicates the gut microbiota and bilirubin in abdominal fat deposition in Huainan yellow chickens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.106769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"106769"}}