{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:16:12Z","timestamp":1788894972528,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.psj.2026.106816","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:21:34Z","timestamp":1773825694000},"page":"106816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of dietary saponin and polyphenol supplementation in broiler chickens exposed to multiple mild stressors of cyclic elevated ambient temperature, feed withdrawal, and coccidiosis infection"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7775-1949","authenticated-orcid":false,"given":"Laney E.","family":"Froebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rincker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-2845","authenticated-orcid":false,"given":"Ryan N.","family":"Dilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.106816_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.rvsc.2023.105057","article-title":"Review: the role of heat shock proteins in chicken: insights into stress adaptation and health","volume":"165","author":"Abare","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0002","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1016\/j.psj.2020.09.012","article-title":"Dietary supplementation with anti-IL-10 antibody during a severe Eimeria challenge in broiler chickens","volume":"99","author":"Abdul Rasheed","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0003","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jpn.12688","article-title":"Effect of dietary polyphenol-rich grape seed on growth performance, antioxidant capacity and ileal microflora in broiler chicks","volume":"102","author":"Abu Hafsa","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.psj.2026.106816_bib0004","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.japr.2019.11.005","article-title":"An approach to alternative strategies to control avian coccidiosis and necrotic enteritis","volume":"29","author":"Adhikari","year":"2020","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2026.106816_bib0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/01652176.2014.991048","article-title":"The effect of infection with mixed Eimeria species on hematology and immune responses following Newcastle disease and infectious bursal disease booster vaccination in broilers","volume":"35","author":"Akhtar","year":"2015","journal-title":"Vet. Q."},{"key":"10.1016\/j.psj.2026.106816_bib0006","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/00071660310001618334","article-title":"Effect of heat stress on oxidative stress, lipid peroxidation and some stress parameters in broilers","volume":"44","author":"Altan","year":"2003","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0007","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/PL00000664","article-title":"The glutathione peroxidases","volume":"57","author":"Arthur","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-020-00837-2","article-title":"Re-calculating the cost of coccidiosis in chickens","volume":"51","author":"Blake","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2026.106816_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.934381","article-title":"A review of heat stress in chickens. Part I: insights into physiology and gut health","volume":"13","author":"Brugaletta","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2026.106816_bib0010","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fvets.2019.00463","article-title":"Effects of dietary direct fed microbial supplementation on performance, intestinal morphology and immune response of broiler chickens challenged with coccidiosis","volume":"6","author":"Calik","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.japr.2023.100347","article-title":"Raising broiler chickens without ionophore anticoccidials","volume":"32","author":"Cervantes","year":"2023","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2026.106816_bib0012","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.3382\/ps\/pex127","article-title":"Oral administration of tea saponins to relive oxidative stress and immune suppression in chickens","volume":"96","author":"Chi","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0013","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.3390\/molecules28165979","article-title":"Malondialdehyde as a potential oxidative stress marker for allergy-oriented diseases: an update","volume":"28","author":"Cordiano","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2026.106816_bib0014","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/ani13091447","article-title":"Comparison of the effects of Yucca saponin, Yucca shidigera, and Quillaja saponaria on growth performance, immunity, antioxidant capacity, and intestinal flora in broilers","volume":"13","author":"Dai","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.106816_bib0015","series-title":"Methods in Neurosciences","doi-asserted-by":"crossref","DOI":"10.1016\/S1043-9471(13)70013-2","article-title":"Behavioral effects of cytokines: an insight into mechanisms of sickness behavior. Pages 130\u2013150","author":"Dantzer","year":"1993"},{"key":"10.1016\/j.psj.2026.106816_bib0016","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0034-5288(18)32266-5","article-title":"Effects of dietary corticosterone on peripheral blood lymphocyte and granulocyte populations in immature domestic fowl","volume":"34","author":"Davison","year":"1983","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0017","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.numecd.2005.05.003","article-title":"A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress","volume":"15","author":"Del Rio","year":"2005","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.psj.2026.106816_bib0018","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fmicb.2014.00282","article-title":"Antibiotics in Canadian poultry productions and anticipated alternatives","volume":"5","author":"Diarra","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.106816_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101542","article-title":"Phytochemical control of poultry coccidiosis: a review","volume":"101","author":"El-Shall","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.707757","article-title":"Heat stress and feed restriction distinctly affect performance, carcass and meat yield, intestinal integrity, and inflammatory (chemo)cytokines in broiler chickens","volume":"12","author":"Emami","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2026.106816_bib0021","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jtherbio.2018.07.012","article-title":"Physiological alterations of poultry to the high environmental temperature","volume":"76","author":"Farag","year":"2018","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.psj.2026.106816_bib0022","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2307\/3278782","article-title":"Mucosal morphology and cellular renewal in the intestine of chickens following a single infection of Eimeria acervulina","volume":"59","author":"Fernando","year":"1973","journal-title":"J. Parasitol."},{"key":"10.1016\/j.psj.2026.106816_bib0023","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1079\/BJN2002725","article-title":"The biological action of saponins in animal systems: a review","volume":"88","author":"Francis","year":"2002","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2026.106816_bib0024","article-title":"Establishing an experimental challenge model in broiler chickens exposed to multiple mild stressors of cyclic elevated ambient temperature, feed withdrawal, and coccidiosis infection","volume":"105","author":"Froebel","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103021","article-title":"Coccidiosis infection and growth performance of broilers in experimental trials: insights from a meta-analysis including modulating factors","volume":"102","author":"Freitas","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0026","doi-asserted-by":"crossref","first-page":"972","DOI":"10.2307\/1590198","article-title":"Evaluation of the heterophil\/lymphocyte ratio as a measure of stress in chickens","volume":"27","author":"Gross","year":"1983","journal-title":"Avian Dis"},{"key":"10.1016\/j.psj.2026.106816_bib0027","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3382\/ps.0590516","article-title":"Some effects of feeding corticosterone to chickens","volume":"59","author":"Gross","year":"1980","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0028","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0705776","article-title":"Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?","volume":"142","author":"Halliwell","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.psj.2026.106816_bib0029","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1079\/WPS20037","article-title":"Modulation of nutrient metabolism and homeostasis by the immune system","volume":"60","author":"Humphrey","year":"2004","journal-title":"Worlds Poult. Sci. J."},{"key":"10.1016\/j.psj.2026.106816_bib0030","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/bfgp\/elt028","article-title":"The IL-10\/STAT3-mediated anti-inflammatory response: recent developments and future challenges","volume":"12","author":"Hutchins","year":"2013","journal-title":"Brief. Funct. Genomics."},{"key":"10.1016\/j.psj.2026.106816_bib0031","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0043933916000787","article-title":"The potential of antioxidant rich essential oils against avian coccidiosis","volume":"73","author":"Idris","year":"2016","journal-title":"Worlds Poult. Sci. J."},{"key":"10.1016\/j.psj.2026.106816_bib0032","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/0115426503018006461","article-title":"Gut immunology and the differential response to feeding and starvation","volume":"18","author":"Jabbar","year":"2003","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.psj.2026.106816_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103335","article-title":"Defining optimal dietary starch, oil, and amino acid inclusion levels for broilers experiencing a coccidiosis challenge","volume":"103","author":"Jespersen","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103502","article-title":"Effects of a coccidiosis challenge on dietary methionine recommendations in broilers","volume":"103","author":"Jespersen","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3181\/00379727-176-41872","article-title":"Changes in protein synthesis due to an inflammatory challenge","volume":"176","author":"Klasing","year":"1984","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.psj.2026.106816_bib0036","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/ani10030481","article-title":"Dietary encapsulated essential oils improve production performance of coccidiosis-vaccine-challenged broiler chickens","volume":"10","author":"Lee","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.106816_bib0037","first-page":"143","article-title":"Progressive increases in serum catalase activity in advancing human immunodeficiency virus infection. Free Radic","volume":"13","author":"Leff","year":"1992","journal-title":"Biol. Med."},{"key":"10.1016\/j.psj.2026.106816_bib0038","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.3390\/ijms20163896","article-title":"Causative links between protein aggregation and oxidative stress: a review","volume":"20","author":"L\u00e9vy","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0039","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/antiox12020441","article-title":"Comparison of the effects between tannins extracted from different natural plants on growth performance, antioxidant capacity, immunity, and intestinal flora of broiler chickens","volume":"12","author":"Liu","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2026.106816_bib0040","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u0394\u0394CT method","volume":"2","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.psj.2026.106816_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103996","article-title":"Effects of oregano and\/or rosemary extracts on growth performance, digestive enzyme activities, cecal bacteria, tight junction proteins, and antioxidants-related genes in heat-stressed broiler chickens","volume":"103","author":"Madkour","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0042","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1017\/S1751731119000600","article-title":"Effect of functional oils on the immune response of broilers challenged with Eimeria spp","volume":"13","author":"Moraes","year":"2019","journal-title":"Animal"},{"key":"10.1016\/j.psj.2026.106816_bib0043","doi-asserted-by":"crossref","first-page":"277S","DOI":"10.1093\/ajcn\/81.1.277S","article-title":"Polyphenols and glutathione synthesis regulation","volume":"81","author":"Moskaug","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.psj.2026.106816_bib0044","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3382\/ps\/pex364","article-title":"Inhibition of corticosterone synthesis and its effect on acute phase proteins, heat shock protein 70, and interleukin-6 in broiler chickens subjected to feed restriction","volume":"97","author":"Najafi","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10495-008-0301-y","article-title":"Cell death: protein misfolding and neurodegenerative diseases","volume":"14","author":"Nakamura","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.psj.2026.106816_bib0046","series-title":"Nutrient Requirements of Poultry. 9th Rev. Ed. Natl","year":"1994"},{"key":"10.1016\/j.psj.2026.106816_bib0047","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3382\/ps.0341100","volume":"34","author":"Natt","year":"1955","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0048","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3390\/ph6121451","article-title":"Effect of essential oils on pathogenic bacteria","volume":"6","author":"Nazzaro","year":"2013","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.psj.2026.106816_bib0049","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0306-4565(86)90032-X","article-title":"Influence of feather cover on heat balance in laying hens (Gallus domesticus)","volume":"11","author":"Nichelmann","year":"1986","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.psj.2026.106816_bib0050","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/gerona\/55.8.M477","article-title":"Autonomic and neurohumoral control of postprandial blood pressure in healthy aging","volume":"55","author":"Oberman","year":"2000","journal-title":"J. Gerontol."},{"key":"10.1016\/j.psj.2026.106816_bib0051","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.3382\/ps\/pez051","article-title":"Effects of Yucca schidigera-derived saponin supplementation during a mixed Eimeria challenge in broilers","volume":"98","author":"Oelschlager","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104003","article-title":"Oxidative stress in poultry production","volume":"103","author":"Oke","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0053","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1469-185X.1970.tb01631.x","article-title":"The biology and comparative physiology of thermal panting","volume":"45","author":"Richards","year":"1970","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.psj.2026.106816_bib0054","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.psj.2026.106816_bib0055","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/ani12101273","article-title":"Experimental cyclic heat stress on intestinal permeability, bone mineralization, leukocyte proportions and meat quality in broiler chickens","volume":"12","author":"Rocchi","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.106816_bib0056","doi-asserted-by":"crossref","first-page":"skaa090","DOI":"10.1093\/jas\/skaa090","article-title":"Effects of heat stress on the gut health of poultry","volume":"98","author":"Rostagno","year":"2020","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0057","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.psj.2019.10.075","article-title":"Research note: evaluation of a heat stress model to induce gastrointestinal leakage in broiler chickens","volume":"99","author":"Ruff","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0058","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/03079457.2014.988122","article-title":"Quantitative histo-morphometric analysis of heat-stress-related damage in the small intestines of broiler chickens","volume":"44","author":"Santos","year":"2015","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.106816_bib0059","first-page":"5","article-title":"Effects of dietary supplementation of dried distillers grain with solubles (DDGS) and yucca (Yucca schidigera) on broiler performance, carcass traits, intestinal viscosity and marketing","volume":"12","author":"Sariozkan","year":"2015","journal-title":"J. Poult. Res."},{"key":"10.1016\/j.psj.2026.106816_bib0060","series-title":"Tributyrin Supplementation and Colitis in Young Pigs","author":"Sommer","year":"2022"},{"key":"10.1016\/j.psj.2026.106816_bib0061","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.3168\/jds.S0022-0302(03)74040-5","article-title":"Economic losses from heat stress by US livestock industries","volume":"86","author":"St-Pierre","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1678-4324-2016150035","article-title":"Effects of Yucca extract on feed efficiency, immune and antioxidative functions in broilers","volume":"59","author":"Su","year":"2016","journal-title":"Brazil. Arch. of Biol. Technol."},{"key":"10.1016\/j.psj.2026.106816_bib0063","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.17582\/journal.pjz\/20221012161058","article-title":"Yucca schidigera liquid extract enhances growth performance, nutrient utilization, liver antioxidative function, and welfare indices of broilers","volume":"56","author":"Sultan","year":"2024","journal-title":"Pak. J. Zool."},{"key":"10.1016\/j.psj.2026.106816_bib0064","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21767\/2572-5459.100008","article-title":"Antioxidant systems in poultry biology: superoxide dismutase","volume":"1","author":"Surai","year":"2016","journal-title":"J. Anim. Res. Nutr."},{"key":"10.1016\/j.psj.2026.106816_bib0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/antiox8070235","article-title":"Antioxidant defence systems and oxidative stress in poultry biology: an update","volume":"8","author":"Surai","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2026.106816_bib0066","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00534-002-0824-5","article-title":"Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication","volume":"10","author":"Szymonik-Lesiuk","year":"2003","journal-title":"J Hepatobiliary Pancreat. Surg."},{"key":"10.1016\/j.psj.2026.106816_bib0067","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1017\/S0007114514001846","article-title":"Supplemental dietary L-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens","volume":"112","author":"Tan","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2026.106816_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101963","article-title":"Constant and cyclic chronic heat stress models differentially influence growth performance, carcass traits and meat quality of broilers","volume":"101","author":"Teyssier","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0069","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/ps\/85.9.1535","article-title":"Feed withdrawal alters small-intestinal morphology and mucus of broilers","volume":"85","author":"Thompson","year":"2006","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0070","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0020-7519(98)00066-6","article-title":"Epidemiological aspects of the use of live anticoccidial vaccines for chickens","volume":"28","author":"Williams","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.psj.2026.106816_bib0071","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/00071669608417922","article-title":"Effects of fasting and refeeding on structures of the intestinal villi and epithelial cells in White Leghorn hens","volume":"37","author":"Yamauchi","year":"1996","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0072","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3382\/ps\/pex408","article-title":"Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens","volume":"97","author":"Zhang","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.106816_bib0073","article-title":"ROS and ROS-mediated cellular signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Long."},{"key":"10.1016\/j.psj.2026.106816_bib0074","article-title":"Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: a review","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Pharmacol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126004451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126004451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:12:15Z","timestamp":1782601935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126004451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0032579126004451"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.106816","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of dietary saponin and polyphenol supplementation in broiler chickens exposed to multiple mild stressors of cyclic elevated ambient temperature, feed withdrawal, and coccidiosis infection","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.106816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"106816"}}