{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:23:44Z","timestamp":1787574224734,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008771","name":"Animal and Plant Quarantine Agency","doi-asserted-by":"publisher","award":["M-1543084-2023-25-01"],"award-info":[{"award-number":["M-1543084-2023-25-01"]}],"id":[{"id":"10.13039\/501100008771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008771","name":"Animal and Plant Quarantine Agency","doi-asserted-by":"publisher","award":["B-1543084-2025-28-01"],"award-info":[{"award-number":["B-1543084-2025-28-01"]}],"id":[{"id":"10.13039\/501100008771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.psj.2026.107139","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:27:40Z","timestamp":1778858860000},"page":"107139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel chicken infectious anemia virus vaccine candidate: complete attenuation, strong immunogenicity, and a built-in DIVA marker"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-7464","authenticated-orcid":false,"given":"HyeSoon","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-7534","authenticated-orcid":false,"given":"HyeonSu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6684-7170","authenticated-orcid":false,"given":"Moon","family":"Her","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-2298","authenticated-orcid":false,"given":"HyeRyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107139_bib0001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-7-9","article-title":"Interleukin 18 in the CNS","volume":"7","author":"Alboni","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.psj.2026.107139_bib0002","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1439-0450.1986.tb00071.x","article-title":"Attenuierung des erregers der avi\u00e4ren infekti\u00f6sen an\u00e4mie (CAA) durch serienpassagen in zellkulturen","volume":"33","author":"B\u00fclow","year":"1986","journal-title":"J. Vet. Med. B"},{"key":"10.1016\/j.psj.2026.107139_bib0003","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2011.04.007","article-title":"Immune responses of chickens inoculated with a recombinant fowlpox vaccine coexpressing HA of H9N2 avian influenza virus and chicken IL-18","volume":"91","author":"Chen","year":"2011","journal-title":"Antiviral Res."},{"key":"10.1016\/j.psj.2026.107139_bib0004","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1007\/s00705-003-0189-3","article-title":"Pathogenicity, sequence and phylogenetic analysis of Malaysian chicken anemia virus obtained after low and high passages in MSB-1 cells","volume":"148","author":"Chowdhury","year":"2003","journal-title":"Arch. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0005","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1016\/j.vaccine.2007.01.113","article-title":"The use of vaccination to combat multiple introductions of notifiable avian influenza viruses of the H5 and H7 subtypes between 2000 and 2006 in Italy","volume":"25","author":"Capua","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2026.107139_bib0006","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-6749(99)70518-X","article-title":"IL-18: a Th1-inducing, proinflammatory cytokine and new member of the IL-1 family","volume":"103","author":"Dinarello","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.psj.2026.107139_bib0007","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3390\/v14071456","article-title":"Design of a multiepitope vaccine against chicken anemia virus disease","volume":"14","author":"Fatoba","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.psj.2026.107139_bib0008","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/pathogens9040294","article-title":"The role of apoptin in chicken anemia virus replication","volume":"9","author":"Feng","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.psj.2026.107139_bib0009","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1637\/11841-041318-Review.1","article-title":"Virus-induced immunosuppression in chickens","volume":"62","author":"Gimeno","year":"2018","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107139_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134866","article-title":"Transcriptomic profiling of virus-host cell interactions following chicken anemia virus (CAV) infection in an in vivo model","volume":"10","author":"Giotis","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2026.107139_bib0011","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/v15040870","article-title":"Development and validation of a new DIVA real-time PCR allowing to differentiate wild-type lumpy skin disease virus strains, including the Asian recombinant strains, from neethling-based vaccine strains","volume":"15","author":"Haegeman","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.psj.2026.107139_bib0012","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.vaccine.2009.11.042","article-title":"Adjuvant effects of chicken interleukin-18 in avian Newcastle disease vaccine","volume":"28","author":"Hung","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2026.107139_bib0013","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1292\/jvms.60.175","article-title":"Development of an enzyme-linked immunosorbent assay using recombinant chicken anemia virus proteins expressed in a baculovirus vector system","volume":"60","author":"Iwata","year":"1998","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.psj.2026.107139_bib0014","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/03079450701812965","article-title":"Evaluation of chicken anemia virus mutants as potential vaccine strains in 1-day-old chickens","volume":"37","author":"Kaffashi","year":"2008","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107139_bib0015","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.3382\/ps.2010-00911","article-title":"Molecular characterization of chicken infectious anemia viruses detected from breeder and broiler chickens in South Korea","volume":"89","author":"Kim","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107139_bib0017","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.vaccine.2013.01.056","article-title":"Adjuvant effects of interleukin-18 in DNA vaccination against infectious bursal disease virus in chickens","volume":"31","author":"Li","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2026.107139_bib0018","article-title":"Genomic characterization of CIAV detected in contaminated attenuated NDV vaccine: epidemiological evidence of source and vertical transmission from SPF chicken embryos in China","volume":"9","author":"Li","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107139_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/v14102115","article-title":"DNA prime and recombinant protein boost vaccination confers chickens with enhanced protection against chicken infectious anemia virus","volume":"14","author":"Liu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.psj.2026.107139_bib0020","article-title":"Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases","volume":"16","author":"Ma","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107139_bib0021","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.1365-2567.2003.01643.x","article-title":"Infection with chicken anemia virus impairs the generation of pathogen-specific cytotoxic T lymphocytes","volume":"109","author":"Markowski-Grimsrud","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.psj.2026.107139_bib0022","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2307\/1591750","article-title":"Economic effects of clinical chicken anemia agent infection on profitable broiler production","volume":"36","author":"McIlroy","year":"1992","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107139_bib0023","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/03079459108418756","article-title":"Chicken anemia agent: a review","volume":"20","author":"McNulty","year":"1991","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107139_bib0024","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1128\/JVI.79.5.2859-2868.2005","article-title":"Positive and negative regulation of chicken anemia virus transcription","volume":"79","author":"Miller","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","article-title":"Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu","volume":"12","author":"Nakanishi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.psj.2026.107139_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2025.115200","article-title":"Development of an ORF154-DIVA ELISA for serological differentiation of LSDV-infected and vaccinated animals","volume":"338","author":"Nokhwal","year":"2025","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.psj.2026.107139_bib0027","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1128\/jvi.68.1.346-351.1994","article-title":"A single chicken anemia virus protein induces apoptosis","volume":"68","author":"Noteborn","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0028","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1099\/0022-1317-79-12-3073","article-title":"Simultaneous expression of recombinant baculovirus-encoded chicken anemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope","volume":"79","author":"Noteborn","year":"1998","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.613170","article-title":"Alternative pathways of IL-1 activation, and its role in health and disease","volume":"11","author":"Pyrillou","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107139_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ani11040944","article-title":"Genetic heterogeneity among chicken infectious anemia viruses detected in Italian fowl","volume":"11","author":"Quaglia","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107139_bib0031","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00705-017-3247-y","article-title":"Revisiting the taxonomy of the family circoviridae: establishment of the genus cyclovirus and removal of the genus gyrovirus","volume":"162","author":"Rosario","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0032","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4614-8289-5_4","article-title":"Gadd45 proteins in immunity","volume":"793","author":"Schmitz","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.psj.2026.107139_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1333596","article-title":"Genetic characterization of chicken infectious anemia viruses isolated in Korea and their pathogenicity in chicks","volume":"14","author":"Song","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.psj.2026.107139_bib0034","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s42770-023-01223-8","article-title":"Subclinical circulation of chicken infectious anemia virus - a sero-molecular study","volume":"55","author":"Sreekala","year":"2024","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.psj.2026.107139_bib0035","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1074-7613(00)80543-9","article-title":"Defective NK cell activity and Th1 response in IL-18-deficient mice","volume":"8","author":"Takeda","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.psj.2026.107139_bib0036","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/03079457.2021.1919289","article-title":"Origin, spreading and genetic variability of chicken anemia virus","volume":"50","author":"Techera","year":"2021","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107139_bib0037","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/03079459808419277","article-title":"Effect of multiple cell culture passages on the biological behaviour of chicken anemia virus","volume":"27","author":"Todd","year":"1998","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107139_bib0038","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1128\/JVI.76.16.8472-8474.2002","article-title":"Molecular basis of the attenuation exhibited by molecularly cloned highly passaged chicken anemia virus isolates","volume":"76","author":"Todd","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2026.107139_bib0039","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/pathogens8020048","article-title":"Persistent infection with chicken anemia virus in 3-week-old chickens induced by inoculation of the virus by the natural route","volume":"8","author":"Tongkamsai","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.psj.2026.107139_bib0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/pathogens8030141","article-title":"Oral inoculation of specific-pathogen-free chickens with chicken anemia virus induces dose-dependent viremia and transient anemia","volume":"8","author":"Tongkamsai","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.psj.2026.107139_bib0041","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/pathogens8040262","article-title":"Preparation of chicken anemia virus (CAV) virus-like particles and chicken interleukin-12 for vaccine development using a baculovirus expression system","volume":"8","author":"Tseng","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.psj.2026.107139_bib0042","article-title":"Molecular epidemiology and pathogenic characterization of novel chicken infectious anemia viruses in Henan province of China","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107139_bib0043","article-title":"Advances in chicken infectious anemia vaccines","volume":"13","author":"Wang","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.psj.2026.107139_bib0044","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02180-19","article-title":"Generation of DelNS1 influenza viruses: a strategy for optimizing live attenuated influenza vaccines","volume":"10","author":"Wang","year":"2019","journal-title":"MBio"},{"key":"10.1016\/j.psj.2026.107139_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/ani13172709","article-title":"Molecular characteristics of chicken infectious anemia virus in central and eastern China from 2020 to 2022","volume":"13","author":"Xu","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107139_bib0046","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2307\/1589567","article-title":"Isolation and some characteristics of an agent inducing anemia in chicks","volume":"23","author":"Yuasa","year":"1979","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107139_bib0047","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/vetsci10070481","article-title":"Isolation, identification, and whole genome analysis of chicken infectious anemia virus in an outbreak of disease in adult layer hens","volume":"10","author":"Zeng","year":"2023","journal-title":"Vet. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126007686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126007686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:43:18Z","timestamp":1787571798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126007686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0032579126007686"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107139","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel chicken infectious anemia virus vaccine candidate: complete attenuation, strong immunogenicity, and a built-in DIVA marker","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107139"}}