{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:04:43Z","timestamp":1789571083107,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.psj.2026.107295","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:24:55Z","timestamp":1781454295000},"page":"107295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrating network pharmacology and in vivo evaluation reveals chicory (Cichorium intybus L.) extract activates autophagy to alleviate fatty liver hemorrhagic syndrome in laying hens"],"prefix":"10.1016","volume":"105","author":[{"given":"Zhaonian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-6362","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-7121","authenticated-orcid":false,"given":"Wanyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.psj.2026.107295_bib0001","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jphs.2022.07.007","article-title":"Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism","volume":"150","author":"Aibaidula","year":"2022","journal-title":"J. Pharmacol. Sci."},{"issue":"18","key":"10.1016\/j.psj.2026.107295_bib0002","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.psj.2026.107295_bib0003","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.meatsci.2007.09.009","article-title":"A sensory description of boar taint and the effects of crude and dried chicory roots (Cichorium intybus L.) and inulin feeding in male and female pork","volume":"79","author":"Byrne","year":"2008","journal-title":"Meat Sci."},{"issue":"11","key":"10.1016\/j.psj.2026.107295_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103042","article-title":"Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA","volume":"102","author":"Chen","year":"2023","journal-title":"Poult. Sci."},{"issue":"17","key":"10.1016\/j.psj.2026.107295_bib0005","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1021\/acs.jafc.6b00470","article-title":"Pharmacokinetics and biodistribution of aurantiamide and aurantiamide acetate in rats after oral administration of portulaca oleracea l. extracts","volume":"64","author":"Chen","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.psj.2026.107295_bib0006","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s10620-015-4025-x","article-title":"Function of autophagy in nonalcoholic fatty liver disease","volume":"61","author":"Czaja","year":"2016","journal-title":"Dig. Dis. Sci."},{"issue":"9","key":"10.1016\/j.psj.2026.107295_bib0007","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1002\/ptr.70043","article-title":"Luteolin treats obese rats with polycystic ovary syndrome by improving liver lipid metabolism and regulating the gut microbiota","volume":"39","author":"Dai","year":"2025","journal-title":"Phytother. Res."},{"issue":"5","key":"10.1016\/j.psj.2026.107295_bib0008","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jhep.2022.05.015","article-title":"Lack of hepatic autophagy promotes severity of liver injury but not steatosis","volume":"77","author":"Ding","year":"2022","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.psj.2026.107295_bib0009","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.apsb.2021.12.012","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.psj.2026.107295_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.765563","article-title":"Integrated metabolomics and network pharmacology to establish the action mechanism of qingrekasen granule for treating nephrotic syndrome","volume":"12","author":"Duan","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"27","key":"10.1016\/j.psj.2026.107295_bib0011","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3748\/wjg.v24.i27.2974","article-title":"Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: from \"two hit theory\" to \"multiple hit model\"","volume":"24","author":"Fang","year":"2018","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.psj.2026.107295_bib0012","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1080\/15548627.2023.2179781","article-title":"Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3\/calcineurin","volume":"19","author":"Fang","year":"2023","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.psj.2026.107295_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102487","article-title":"In ovo protective effects of chicoric and rosmarinic acids against Thiacloprid-induced cytotoxicity, oxidative stress, and growth retardation on newly hatched chicks","volume":"102","author":"Farag","year":"2023","journal-title":"Poult. Sci."},{"issue":"15","key":"10.1016\/j.psj.2026.107295_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/cssc.202500749","article-title":"Synthesis of 19-hydroxyarachidonic acid by fungal peroxygenases: an experimental and computational study","volume":"18","author":"Gonz\u00e1lez-Benjumea","year":"2025","journal-title":"ChemSusChem"},{"issue":"2","key":"10.1016\/j.psj.2026.107295_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102332","article-title":"End of lay postmortem findings in aviary housed laying hens","volume":"102","author":"Gretarsson","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107295_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104172","article-title":"Transcriptomics integrated with metabolomics unravels the interweaving of inflammatory response and 1-stearoyl-2-arachidonoyl-sn-glycerol metabolic disorder in chronic cadmium exposure-induced hepatotoxicity","volume":"101","author":"Hao","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"16","key":"10.1016\/j.psj.2026.107295_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/foods14162781","article-title":"Untargeted metabolomics uncovers food safety risks: polystyrene nanoplastics induce metabolic disorders in chicken liver","volume":"14","author":"Hu","year":"2025","journal-title":"Foods"},{"issue":"5","key":"10.1016\/j.psj.2026.107295_bib0018","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1080\/15548627.2023.2300922","article-title":"MCOLN\/TRPML channels in the regulation of MTORC1 and autophagy","volume":"20","author":"Huang","year":"2024","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.psj.2026.107295_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105573","article-title":"Phytogenic feed additives as an approach to prevent fatty liver hemorrhagic syndrome in laying hens","volume":"104","author":"Khodaei","year":"2025","journal-title":"Poult. Sci."},{"issue":"10","key":"10.1016\/j.psj.2026.107295_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101471","article-title":"Modulation of hepatic functions by chicory (cichorium intybus l.) extract: preclinical study in rats","volume":"16","author":"Krepkova","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.psj.2026.107295_bib0021","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13020-024-00983-1","article-title":"Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus","volume":"19","author":"Lan","year":"2024","journal-title":"Chin. Med."},{"issue":"8","key":"10.1016\/j.psj.2026.107295_bib0022","first-page":"2056","article-title":"[Serum metabolomics of Tibetan medicine Ershiwuwei Songshi Pills against chronic cholestasis in mice]","volume":"47","author":"Li","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1","key":"10.1016\/j.psj.2026.107295_bib0023","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40168-025-02083-0","article-title":"Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO\/TLR-4\/NF-\u03baB signaling pathway in laying hens","volume":"13","author":"Li","year":"2025","journal-title":"Microbiome"},{"issue":"6","key":"10.1016\/j.psj.2026.107295_bib0024","first-page":"129","article-title":"Calculation of equivalent dose conversion coefficients of chickens and other experimental animals based on body surface area","volume":"39","author":"Li","year":"2018","journal-title":"Progr. Veterin. Med."},{"issue":"4","key":"10.1016\/j.psj.2026.107295_bib0025","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3382\/ps.2010-01181","article-title":"Growth performance, digestibility, and gut development of broiler chickens on diets with inclusion of chicory (Cichorium intybus L.)","volume":"90","author":"Liu","year":"2011","journal-title":"Poult. Sci."},{"issue":"5","key":"10.1016\/j.psj.2026.107295_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103489","article-title":"Effects of 28 h ahemeral light cycle on production performance, egg quality, blood parameters, and uterine characteristics of hens during the late laying period","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107295_bib0027","first-page":"817","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"Excli j"},{"issue":"12","key":"10.1016\/j.psj.2026.107295_bib0028","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1017\/S1751731119000867","article-title":"The effect of cultivated mixed-species green fodder on intake, milk production and milk composition of housed dairy goats","volume":"13","author":"Murney","year":"2019","journal-title":"Animal"},{"issue":"1","key":"10.1016\/j.psj.2026.107295_bib0029","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1038\/s41467-021-26295-8","article-title":"Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates","volume":"12","author":"Peng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.107295_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127676","article-title":"Chicory (Cichorium intybus L.) as a food ingredient - nutritional composition, bioactivity, safety, and health claims: a review","volume":"336","author":"Perovi\u0107","year":"2021","journal-title":"Food Chem."},{"issue":"12","key":"10.1016\/j.psj.2026.107295_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210360","article-title":"Taurine protects against the fatty liver hemorrhagic syndrome in laying hens through the regulation of mitochondrial homeostasis","volume":"24","author":"San","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.psj.2026.107295_bib0032","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2021.11.009","article-title":"A new perspective on NAFLD: Focusing on lipid droplets","volume":"76","author":"Scorletti","year":"2022","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.psj.2026.107295_bib0033","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/03079457.2019.1682119","article-title":"Unravelling fatty liver haemorrhagic syndrome: 2. inflammation and pathophysiology","volume":"49","author":"Shini","year":"2020","journal-title":"Avian Pathol."},{"issue":"2","key":"10.1016\/j.psj.2026.107295_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103293","article-title":"Osteocalcin activates lipophagy via the ADPN-AMPK\/PPAR\u03b1-mTOR signaling pathway in chicken embryonic hepatocyte","volume":"103","author":"Tu","year":"2024","journal-title":"Poult. Sci."},{"issue":"7","key":"10.1016\/j.psj.2026.107295_bib0035","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1080\/10495398.2022.2130798","article-title":"The effects of peppermint (Mentha piperita L.) and chicory (Cichorium intybus L.) in comparison with a prebiotic on productive performance, blood constituents, immunity and intestinal microflora in broiler chickens","volume":"34","author":"Tufarelli","year":"2023","journal-title":"Anim. Biotechnol."},{"issue":"5","key":"10.1016\/j.psj.2026.107295_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105062","article-title":"Dietary Puerariae Lobatae Radix polysaccharides improve ovarian function and reproductive efficiency in laying hens with fatty liver hemorrhagic syndrome","volume":"104","author":"Wang","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107295_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157404","article-title":"Integrative gut microbiota and metabolomics reveals the mechanism of chicory extract in improving metabolic dysfunction-associated steatotic liver disease via gut-liver axis","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.psj.2026.107295_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156056","article-title":"Dioscin improves fatty liver hemorrhagic syndrome by promoting ER\u03b1-AMPK mediated mitophagy in laying hens","volume":"135","author":"Xing","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.psj.2026.107295_bib0039","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40104-023-00900-w","article-title":"Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota","volume":"14","author":"Yang","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107295_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107617","article-title":"AlphaFold-based AI docking reveals AMPK\/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease","volume":"212","author":"Zhang","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.psj.2026.107295_bib0041","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.aninu.2024.08.008","article-title":"Improving fatty liver hemorrhagic syndrome in laying hens through gut microbiota and oxylipin metabolism by Bacteroides fragilis: A potential involvement of arachidonic acid","volume":"20","author":"Zhang","year":"2025","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107295_bib0042","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jep.2017.01.038","article-title":"Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-\u03baB signaling pathway in Influenza A virus-infected cells","volume":"199","author":"Zhou","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.psj.2026.107295_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156458","article-title":"Polysaccharides from hawthorn fruit alleviate high-fat diet-induced NAFLD in mice by improving gut microbiota dysbiosis and hepatic metabolic disorder","volume":"139","author":"Zhou","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126009260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126009260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:31:03Z","timestamp":1789569063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126009260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0032579126009260"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107295","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating network pharmacology and in vivo evaluation reveals chicory (Cichorium intybus L.) extract activates autophagy to alleviate fatty liver hemorrhagic syndrome in laying hens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107295"}}