{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:33:10Z","timestamp":1793133190845,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.psj.2026.107348","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:27:34Z","timestamp":1782491254000},"page":"107348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-omics analysis of the gut-liver axis reveals the health hazards of embryonic egg exposure to zearalenone in chicks"],"prefix":"10.1016","volume":"105","author":[{"given":"Tao","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107348_bib0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3382\/ps.0620282","article-title":"Effects of fusarium cultures, T-2 toxin, and zearalenone on reproduction of turkey females","volume":"62","author":"Allen","year":"1983","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107348_bib0002","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1111\/1541-4337.12974","article-title":"Roles of stress response-related signaling and its contribution to the toxicity of zearalenone in mammals","volume":"21","author":"Bai","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.psj.2026.107348_bib0003","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3390\/toxins5101872","article-title":"Aflatoxin, fumonisin and Shiga toxin-producing Escherichia coli infections in calves and the effectiveness of Celmanax\u00ae\/Dairyman's Choice\u2122 applications to eliminate morbidity and mortality losses","volume":"5","author":"Baines","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0004","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/17450390802190292","article-title":"Effects of deoxynivalenol and zearalenone on oxidative stress and blood phagocytic activity in broilers","volume":"62","author":"Borutova","year":"2008","journal-title":"Arch. Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107348_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110420","article-title":"Compound probiotics alleviating aflatoxin B1 and zearalenone toxic effects on broiler production performance and gut microbiota","volume":"194","author":"Chang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2026.107348_bib0006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/toxins9010021","article-title":"Gestational zearalenone exposure causes reproductive and developmental toxicity in pregnant rats and female offspring","volume":"9","author":"Gao","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fct.2018.04.011","article-title":"Prenatal exposure to zearalenone disrupts reproductive potential and development via hormone-related genes in male rats","volume":"116","author":"Gao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.psj.2026.107348_bib0008","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3920\/WMJ2008.x015","article-title":"Zearalenone and its metabolites: occurrence, detection, toxicity and guidelines","volume":"1","author":"Gromadzka","year":"2008","journal-title":"World Mycotoxin J"},{"key":"10.1016\/j.psj.2026.107348_bib0009","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/toxins14060386","article-title":"Research progress of safety of zearalenone: a review","volume":"14","author":"Han","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.575455","article-title":"Novel odoribacter splanchnicus strain and its outer membrane vesicles exert immunoregulatory effects in vitro","volume":"11","author":"Hiippala","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.107348_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118600","article-title":"Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc\u2013GSH-GPX4 signaling pathway","volume":"302","author":"Huangfu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2026.107348_bib0012","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.toxlet.2020.07.032","article-title":"Low doses of individual and combined deoxynivalenol and zearalenone in naturally moldy diets impair intestinal functions via inducing inflammation and disrupting epithelial barrier in the intestine of piglets","volume":"333","author":"Jia","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.psj.2026.107348_bib0013","doi-asserted-by":"crossref","first-page":"10374","DOI":"10.1039\/D2FO01545E","article-title":"Toxicity of zearalenone and its nutritional intervention by natural products","volume":"13","author":"Jing","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.psj.2026.107348_bib0014","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1002\/jsfa.6301","article-title":"Prospects of in ovo feeding and nutrient supplementation for poultry: the science and commercial applications\u2013a review","volume":"93","author":"Kadam","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.psj.2026.107348_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.metabol.2017.11.018","article-title":"The hypothalamus-pituitary-gonad axis: tales of mice and men","volume":"86","author":"Kaprara","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.psj.2026.107348_bib0016","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fcimb.2018.00060","article-title":"Mycotoxin: its impact on gut health and microbiota","volume":"8","author":"Liew","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.psj.2026.107348_bib0017","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3390\/toxins12060377","article-title":"Zearalenone (ZEN) in livestock and poultry: dose, toxicokinetics, toxicity and estrogenicity","volume":"12","author":"Liu","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.944891","article-title":"Effects of embryo injected with ochratoxins A on hatching quality and jejunum antioxidant capacity of ducks at hatching","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107348_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152957","article-title":"Zearalenone exposure mediated hepatotoxicity via mitochondrial apoptotic and autophagy pathways: associated with gut microbiome and metabolites","volume":"462","author":"Li","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2026.107348_bib0020","article-title":"Estrogen receptor (ER)-mediated activation by endocrine disrupting chemicals (EDCs)","volume":"1","author":"Li","year":"2013","journal-title":"Endocr. Disruptors"},{"key":"10.1016\/j.psj.2026.107348_bib0021","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/molecules30030505","article-title":"Reproductive toxicity of zearalenone and its molecular mechanisms: a review","volume":"30","author":"Lv","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2026.107348_bib0022","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.3390\/ijms9122570","article-title":"Zearalenone and reproductive function in farm animals","volume":"9","author":"Minervini","year":"2008","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.107348_bib0023","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1017\/S146625232400001X","article-title":"Minerals, serum metabolites, hormones, and bovine reproduction: a review","volume":"24","author":"Molefe","year":"2023","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.psj.2026.107348_bib0024","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/toxins13110790","article-title":"Exposure to zearalenone leads to metabolic disruption and changes in circulating adipokines concentrations in pigs","volume":"13","author":"Nagl","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/ijms22010217","article-title":"Kaempferol inhibits zearalenone-induced oxidative stress and apoptosis via the PI3K\/Akt-mediated Nrf2 signaling pathway: in vitro and in vivo studies","volume":"22","author":"Rajendran","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.107348_bib0026","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1080\/10408398.2019.1655388","article-title":"Occurrence and toxicity of a fusarium mycotoxin, zearalenone","volume":"60","author":"Rai","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.psj.2026.107348_bib0027","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/toxins11110665","article-title":"Fusarium mycotoxins disrupt the barrier and induce IL-6 release in a human placental epithelium cell line","volume":"11","author":"Seyed Toutounchi","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096404","article-title":"Gene expression profile and toxic effects in human bronchial epithelial cells exposed to zearalenone","volume":"9","author":"So","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2026.107348_bib0029","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/toxins14110732","article-title":"Zearalenone promotes uterine development of weaned gilts by interfering with serum hormones and up-regulating expression of estrogen and progesterone receptors","volume":"14","author":"Song","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0030","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3390\/toxins13090626","article-title":"The effects of zearalenone on the localization and expression of reproductive hormones in the ovaries of weaned gilts","volume":"13","author":"Wan","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0031","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.anireprosci.2010.10.002","article-title":"Interaction of zearalenone and soybean isoflavone on the development of reproductive organs, reproductive hormones and estrogen receptor expression in prepubertal gilts","volume":"122","author":"Wang","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.psj.2026.107348_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129978","article-title":"Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells","volume":"275","author":"Wang","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.psj.2026.107348_bib0033","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.aninu.2021.01.002","article-title":"The insensitive mechanism of poultry to zearalenone: a review","volume":"7","author":"Wu","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107348_bib0034","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3390\/foods13081217","article-title":"Resveratrol alleviates zearalenone-induced intestinal dysfunction in mice through the NF-\u03baB\/Nrf2\/HO-1 signalling pathway","volume":"13","author":"Xia","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.psj.2026.107348_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108097","article-title":"Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway","volume":"100","author":"Xu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.psj.2026.107348_bib0036","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.aninu.2016.04.008","article-title":"Effects of purified zearalenone on selected immunological measurements of blood in post-weaning gilts","volume":"2","author":"Yang","year":"2016","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107348_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116343","article-title":"Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway","volume":"277","author":"Yang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2026.107348_bib0038","doi-asserted-by":"crossref","first-page":"15570","DOI":"10.1021\/acs.jafc.2c06457","article-title":"Maternal zearalenone exposure affects gut microbiota and follicular development in suckled offspring","volume":"70","author":"Yan","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2026.107348_bib0039","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/toxins14100653","article-title":"Effects of zearalenone on production performance, egg quality, ovarian function and gut microbiota of laying hens","volume":"14","author":"Yuan","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.psj.2026.107348_bib0040","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40104-021-00603-0","article-title":"Occurrence of aflatoxin B1, deoxynivalenol and zearalenone in feeds in China during 2018-2020","volume":"12","author":"Zhao","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107348_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136637","article-title":"Characterization of zearalenone-induced hepatotoxicity and its mechanisms by transcriptomics in zebrafish model","volume":"309","author":"Zhang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.psj.2026.107348_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111072","article-title":"Changes in intestinal barrier functions and gut microbiota in rats exposed to zearalenone","volume":"204","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2026.107348_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139476","article-title":"Integrated multi-omics analysis uncovers zearalenone-induced ovarian and intestinal inflammation is mediated by the tumor necrosis factor-\u03b1","volume":"496","author":"Zhang","year":"2025","journal-title":"J. Hazard. Mater."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912600979X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912600979X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:57:09Z","timestamp":1793131029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257912600979X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S003257912600979X"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107348","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics analysis of the gut-liver axis reveals the health hazards of embryonic egg exposure to zearalenone in chicks","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107348"}}