{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:14Z","timestamp":1789571114224,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009329","name":"Guangxi Science and Technology Plan Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.psj.2026.107374","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:13:45Z","timestamp":1783008825000},"page":"107374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chicken viperin inhibits fowl adenovirus serotype 4 replication and affects related innate immune signaling pathways"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1740-3298","authenticated-orcid":false,"given":"Lijun","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houxun","family":"Ya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liji","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.psj.2026.107374_bib0001","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine","volume":"6","author":"Borden","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.psj.2026.107374_bib0002","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.vetmic.2016.11.005","article-title":"Characterization of fowl adenoviruses isolated between 2007 and 2014 in China","volume":"197","author":"Changjing","year":"2016","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0003","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12864-024-10566-x","article-title":"Unexpected regulatory functions of cyprinid viperin on inflammation and metabolism","volume":"25","author":"Chaumont","year":"2024","journal-title":"BMC Genom."},{"issue":"4","key":"10.1016\/j.psj.2026.107374_bib0004","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/tbed.12500","article-title":"Hydropericardium hepatitis syndrome emerged in Cherry Valley Ducks in China","volume":"64","author":"Chen","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0005","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2341144","article-title":"Viral strategies to antagonize the host antiviral innate immunity: an indispensable research direction for emerging virus-host interactions","volume":"13","author":"Chen","year":"2024","journal-title":"Emerg. Microbes Infec."},{"issue":"7","key":"10.1016\/j.psj.2026.107374_bib0006","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4049\/jimmunol.1900293","article-title":"IRF7 is involved in both STING and MAVS mediating IFN-beta signaling in IRF3-lacking chickens","volume":"203","author":"Cheng","year":"2019","journal-title":"J. Immunol."},{"issue":"26","key":"10.1016\/j.psj.2026.107374_bib0007","doi-asserted-by":"crossref","first-page":"15125","DOI":"10.1073\/pnas.011593298","article-title":"Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus","volume":"98","author":"Chin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.psj.2026.107374_bib0008","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/imcb.12420","article-title":"Viperin binds STING and enhances the type-I interferon response following dsDNA detection","volume":"99","author":"Crosse","year":"2021","journal-title":"Immunol. Cell Biol."},{"issue":"12","key":"10.1016\/j.psj.2026.107374_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002436","article-title":"Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes","volume":"21","author":"Culbertson","year":"2023","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.psj.2026.107374_bib0010","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrm1126","article-title":"The present view of the mechanism of protein folding","volume":"4","author":"Daggett","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.psj.2026.107374_bib0011","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1021\/acs.biochem.9b00741","article-title":"Structural basis of the substrate selectivity of viperin","volume":"59","author":"Fenwick","year":"2020","journal-title":"Biochem.-Us"},{"issue":"26","key":"10.1016\/j.psj.2026.107374_bib0012","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1073\/pnas.1705402114","article-title":"Structural studies of viperin, an antiviral radical SAM enzyme","volume":"114","author":"Fenwick","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.psj.2026.107374_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2025.157017","article-title":"Fowl adenovirus serotype 4 ORF1B protein suppresses type I interferon production by inhibiting IRF7 nuclear translocation","volume":"195","author":"Gao","year":"2025","journal-title":"Cytokine"},{"issue":"33","key":"10.1016\/j.psj.2026.107374_bib0014","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1074\/jbc.REV120.012784","article-title":"Viperin: an ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity","volume":"295","author":"Ghosh","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"7711","key":"10.1016\/j.psj.2026.107374_bib0015","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41586-018-0238-4","article-title":"A naturally occurring antiviral ribonucleotide encoded by the human genome","volume":"558","author":"Gizzi","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.psj.2026.107374_bib0016","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.molimm.2014.09.011","article-title":"Characterisation of chicken viperin","volume":"63","author":"Goossens","year":"2015","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0017","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/03079450050045440","article-title":"Detection and differentiation of avian adenoviruses: a review","volume":"29","author":"Hess","year":"2000","journal-title":"Avian Pathol."},{"issue":"6","key":"10.1016\/j.psj.2026.107374_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103741","article-title":"Differential innate immune responses to fowl adenovirus serotype 4 infection in Leghorn male hepatocellular and chicken embryo fibroblast cells","volume":"103","author":"Hou","year":"2024","journal-title":"Poultry Sci."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0019","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2172-11-22","article-title":"Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution","volume":"11","author":"Huang","year":"2010","journal-title":"BMC Immunol."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.psj.2026.107374_bib0021","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.psj.2026.107374_bib0022","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e33","article-title":"Viperin differentially induces interferon-stimulated genes in distinct cell types","volume":"19","author":"Kim","year":"2019","journal-title":"Immune Netw."},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0023","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/ijms25031681","article-title":"Chicken interferon-alpha and -lambda exhibit antiviral effects against fowl adenovirus serotype 4 in leghorn male hepatocellular cells","volume":"25","author":"Lai","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0024","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13567-020-00814-9","article-title":"Innate immune responses to duck Tembusu virus infection","volume":"51","author":"Li","year":"2020","journal-title":"Vet. Res."},{"issue":"11","key":"10.1016\/j.psj.2026.107374_bib0025","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1128\/MCB.22.11.3942-3957.2002","article-title":"A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein","volume":"22","author":"Nehyba","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.psj.2026.107374_bib0026","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetmic.2018.07.014","article-title":"Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver","volume":"223","author":"Niu","year":"2018","journal-title":"Vet. Microbiol."},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0027","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3382\/ps\/pey485","article-title":"Mechanism of fowl adenovirus serotype 4-induced heart damage and formation of pericardial effusion","volume":"98","author":"Niu","year":"2019","journal-title":"Poult. Sci."},{"issue":"9","key":"10.1016\/j.psj.2026.107374_bib0028","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.3382\/ps\/pez179","article-title":"Immunosuppressive potential of fowl adenovirus serotype 4","volume":"98","author":"Niu","year":"2019","journal-title":"Poultry Sci."},{"issue":"9","key":"10.1016\/j.psj.2026.107374_bib0029","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1016\/j.psj.2020.06.003","article-title":"Genetic characterization of fowl aviadenovirus 4 isolates from Guangxi, China, during 2017-2019","volume":"99","author":"Rashid","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107374_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1370414","article-title":"Biological features of fowl adenovirus serotype-4","volume":"14","author":"Rashid","year":"2024","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0031","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-virology-011720-095930","article-title":"Viperin reveals its true function","volume":"7","author":"Rivera-Serrano","year":"2020","journal-title":"Annu. Rev. Virol."},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0032","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.immuni.2011.03.010","article-title":"Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells","volume":"34","author":"Saitoh","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.psj.2026.107374_bib0033","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fimmu.2017.00049","article-title":"Avian interferons and their antiviral effectors","volume":"8","author":"Santhakumar","year":"2017","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.psj.2026.107374_bib0034","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.vaccine.2013.12.056","article-title":"Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS)","volume":"32","author":"Schachner","year":"2014","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0035","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.psj.2026.107374_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003497","article-title":"Viperin regulates cellular lipid metabolism during human cytomegalovirus infection","volume":"9","author":"Seo","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.psj.2026.107374_bib0037","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cyto.2019.04.007","article-title":"Chicken viperin inhibits Newcastle disease virus infection in vitro: a possible interaction with the viral matrix protein","volume":"120","author":"Shah","year":"2019","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0038","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.bbrc.2009.12.070","article-title":"Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme","volume":"391","author":"Shaveta","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.psj.2026.107374_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189532","article-title":"The soluble loop BC region guides, but not dictates, the assembly of the transmembrane cytochrome b6","volume":"12","author":"Tome-Stangl","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.psj.2026.107374_bib0040","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.molcel.2016.04.021","article-title":"Structural analysis of dsRNA binding to anti-viral pattern recognition receptors LGP2 and MDA5","volume":"62","author":"Uchikawa","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.psj.2026.107374_bib0041","article-title":"Chicken-derived pattern recognition receptor chLGP2 inhibits the replication and proliferation of infectious bronchitis virus","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Microbiol."},{"issue":"Pt 1","key":"10.1016\/j.psj.2026.107374_bib0042","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1099\/vir.0.033860-0","article-title":"Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33","volume":"93","author":"Wang","year":"2012","journal-title":"J. Gen. Virol."},{"issue":"10","key":"10.1016\/j.psj.2026.107374_bib0043","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41577-022-00705-4","article-title":"Bacterial origins of human cell-autonomous innate immune mechanisms","volume":"22","author":"Wein","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.psj.2026.107374_bib0044","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1637\/aviandiseases-D-20-00004","article-title":"Pathogenicity and immune responses in specific-pathogen-free chickens during fowl adenovirus serotype 4 infection","volume":"64","author":"Wu","year":"2020","journal-title":"Avian Dis."},{"issue":"6","key":"10.1016\/j.psj.2026.107374_bib0045","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01938-20","article-title":"Fowl adenovirus serotype 4 induces hepatic steatosis via activation of liver X receptor-alpha","volume":"95","author":"Yuan","year":"2021","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.psj.2026.107374_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104421","article-title":"TMT-based quantitative proteomic analysis of IBDV-infected CEF cells reveals a favorable role of chicken IRF10 in IBDV replication via suppressing type-I interferon expression","volume":"103","author":"Zhang","year":"2024","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2026.107374_bib0047","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13567-024-01368-w","article-title":"Increased viperin expression induced by avian infectious bronchitis virus inhibits viral replication by restricting cholesterol synthesis: an in vitro study","volume":"55","author":"Zhang","year":"2024","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2026.107374_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2019.101404","article-title":"Fowl adenoviruse-4 infection induces strong innate immune responses in chicken","volume":"68","author":"Zhao","year":"2020","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126010059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126010059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:39:51Z","timestamp":1789569591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126010059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0032579126010059"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107374","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chicken viperin inhibits fowl adenovirus serotype 4 replication and affects related innate immune signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107374"}}