{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:33:19Z","timestamp":1793133199983,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025JCQY004"],"award-info":[{"award-number":["2025JCQY004"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["L2025-CXNL-KCPT-GNYZZX-01"],"award-info":[{"award-number":["L2025-CXNL-KCPT-GNYZZX-01"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.psj.2026.107493","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:10:01Z","timestamp":1785132601000},"page":"107493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative multi-omics reveals comprehensive gut-liver-adipose metabolic changes in peak laying hens with high or low egg production"],"prefix":"10.1016","volume":"105","author":[{"given":"Junjie","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-5011","authenticated-orcid":false,"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107493_bib0001","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.3390\/ani11102986","article-title":"Hens that exhibit poorer feed efficiency produce eggs with lower albumen quality and are prone to being overweight","volume":"11","author":"Anene","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107493_bib0002","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.molp.2023.09.010","article-title":"TBtools-II: A \"one for all, all for one\" bioinformatics platform for biological big-data mining","volume":"16","author":"Chen","year":"2023","journal-title":"Mol. Plant"},{"key":"10.1016\/j.psj.2026.107493_bib0003","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107493_bib0004","article-title":"Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens","volume":"104","author":"Chen","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0005","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/antiox13020140","article-title":"Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via regulating the ROS\/GPX4\/ferroptosis pathway","volume":"13","author":"Cheng","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2026.107493_bib0006","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41467-023-36256-y","article-title":"Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases","volume":"14","author":"Deng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.107493_bib0007","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/biolre\/ioaf227","article-title":"Characterization of persistency of lay in laying hens","volume":"113","author":"Francoeur","year":"2025","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2026.107493_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103785","article-title":"Quantitative lipidomics reveals the changes of lipids and antioxidant capacity in egg yolk from laying hens with fatty liver hemorrhagic syndrome","volume":"103","author":"Guo","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.vas.2026.100603","article-title":"Impact of lactic acid bacteria and Bifidobacterium intervention on pathogenic bacteria and short-chain fatty acid production in diarrheic calves: an in vitro fermentation study","volume":"32","author":"He","year":"2026","journal-title":"Vet. Anim. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0010","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.psj.2026.107493_bib0011","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/microorganisms10010068","article-title":"Physiological role of bile acids modified by the gut microbiome","volume":"10","author":"Kiriyama","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.psj.2026.107493_bib0012","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2013.04.055","article-title":"The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation","volume":"153","author":"Leprivier","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.psj.2026.107493_bib0013","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.theriogenology.2014.05.003","article-title":"Estrogen stimulates expression of chicken hepatic vitellogenin II and very low-density apolipoprotein II through ER-\u03b1","volume":"82","author":"Li","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.psj.2026.107493_bib0014","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aca.2017.07.058","article-title":"An alignment algorithm for LC-MS-based metabolomics dataset assisted by MS\/MS information","volume":"990","author":"Li","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.psj.2026.107493_bib0015","article-title":"Study on changes in egg quality traits and genetic parameters of white leghorn hens from 35 to 100 weeks of age","volume":"104","author":"Li","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.736739","article-title":"Biological function of short-chain fatty acids and its regulation on intestinal health of poultry","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102593","article-title":"Alterations in hepatic transcriptome and cecum microbiota underlying potential ways to prevent early fatty liver in laying hens","volume":"102","author":"Liu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0018","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40104-024-01001-y","article-title":"Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens","volume":"15","author":"Liu","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107493_bib0019","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.psj.2026.107493_bib0020","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.psj.2026.107493_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.japr.2023.100357","article-title":"Estimating energy utilization in laying hens: What are the best response criteria?","volume":"32","author":"Lyons","year":"2023","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2026.107493_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103250","article-title":"Comparative analyses of laying performance and follicular development characteristics between fat and lean broiler lines","volume":"103","author":"Ma","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0023","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-023-06780-4","article-title":"mRNA reading frame maintenance during eukaryotic ribosome translocation","volume":"625","author":"Milicevic","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.psj.2026.107493_bib0024","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/s41598-020-62886-z","article-title":"Transcriptome analysis reveals differentially expressed genes associated with high rates of egg production in chicken hypothalamic-pituitary-ovarian axis","volume":"10","author":"Mishra","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.107493_bib0025","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12864-021-07688-x","article-title":"Transcriptome analysis of ovary tissues from low- and high-yielding Changshun green-shell laying hens","volume":"22","author":"Mu","year":"2021","journal-title":"BMC Genomics"},{"key":"10.1016\/j.psj.2026.107493_bib0026","series-title":"Egg formation and chemistry. Pages 83-132 in Improving the Safety and Quality of Eggs and Egg Products","author":"Nys","year":"2011"},{"key":"10.1016\/j.psj.2026.107493_bib0027","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/bioinformatics\/btac166","article-title":"Analysing high-throughput sequencing data in Python with HTSeq 2.0","volume":"38","author":"Putri","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107493_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2023.101015","article-title":"Update and evaluation of the egg production model in laying hens","volume":"17","author":"Reis","year":"2023","journal-title":"Animal."},{"key":"10.1016\/j.psj.2026.107493_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102756","article-title":"Yolk precursor synthesis and deposition in hierarchical follicles and effect on egg production performance of hens","volume":"102","author":"Song","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0030","doi-asserted-by":"crossref","first-page":"skad334","DOI":"10.1093\/jas\/skad334","article-title":"Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens","volume":"101","author":"Sun","year":"2023","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0031","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s40104-025-01280-z","article-title":"Taurochenodeoxycholic acid promotes abdominal fat deposition by modulating the crosstalk between bile acid metabolism and intestinal microbiota in broilers","volume":"16","author":"Sun","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107493_bib0032","first-page":"47","article-title":"Vitellogenesis: a versatile model for hormonal regulation of gene expression","volume":"35","author":"Tata","year":"1979","journal-title":"Recent. Prog. Horm. Res."},{"key":"10.1016\/j.psj.2026.107493_bib0033","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.111.093757","article-title":"Vitellogenin expression in white adipose tissue in female teleost fish","volume":"86","author":"Tingaud-Sequeira","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2026.107493_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104124","article-title":"The influence of breed, dietary energy and lysine on laying persistency and body composition of laying hens","volume":"103","author":"van Eck","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.106131","article-title":"Feeding a persistent laying hen: Effect of dietary amino acid levels in rearing and dietary energy source and level in laying on body composition and metabolism","volume":"105","author":"van Eck","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0036","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.3390\/ani15223300","article-title":"Integrative transcriptome analysis across follicles highlights key regulatory pathways in low and high-egg-laying hens","volume":"15","author":"Wadood","year":"2025","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107493_bib0037","series-title":"Developmental Biology: A Comprehensive Synthesis","first-page":"127","article-title":"Vitellogenesis and oocyte growth in nonmammalian vertebrates","volume":"Vol. 1","author":"Wallace","year":"1985"},{"key":"10.1016\/j.psj.2026.107493_bib0038","doi-asserted-by":"crossref","first-page":"467S","DOI":"10.1093\/jn\/129.2.467S","article-title":"Estrogen induction of VLDLy assembly in egg-laying hens","volume":"129","author":"Walzem","year":"1999","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2026.107493_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417304","article-title":"Berberine protects against high-energy and low-protein diet-induced hepatic steatosis: Modulation of gut microbiota and bile acid metabolism in laying hens","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0040","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1038\/s41467-024-50809-9","article-title":"Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.107493_bib0041","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fmicb.2020.00600","article-title":"Supplemental Clostridium butyricum modulates lipid metabolism through shaping gut microbiota and bile acid profile of aged laying hens","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.107493_bib0042","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.psj.2026.107493_bib0043","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/ani12111467","article-title":"Effect of heat stress on egg production, steroid hormone synthesis, and related gene expression in chicken preovulatory follicular granulosa cells","volume":"12","author":"Yan","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107493_bib0044","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-026-01035-2","article-title":"Gut commensal Parabacteroides goldsteinii-derived CDCA mediates FXR signalling to improve mucosal barrier function","author":"Yang","year":"2026","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.psj.2026.107493_bib0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s40104-024-01060-1","article-title":"Astragalus polysaccharides-induced gut microbiota play a predominant role in enhancing of intestinal barrier function of broiler chickens","volume":"15","author":"Yang","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107493_bib0046","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3390\/ani14070992","article-title":"Exploring bile-acid changes and microflora profiles in chicken fatty liver disease model","volume":"14","author":"Yang","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107493_bib0047","article-title":"Multi-omics reveals co-regulation of hepatic bile acid metabolism in laying hens by host genetics and the cecal Anaerostipes","volume":"105","author":"Yang","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101610","article-title":"Effects of dietary dimethylglycine supplementation on laying performance, egg quality, and tissue index of hens during late laying period","volume":"101","author":"Yao","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0049","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1038\/s41467-023-41817-2","article-title":"Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress","volume":"14","author":"Ye","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.107493_bib0050","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1002\/imt2.261","article-title":"Gut Bifidobacterium pseudocatenulatum protects against fat deposition by enhancing secondary bile acid biosynthesis","volume":"3","author":"Zha","year":"2024","journal-title":"Imeta"},{"key":"10.1016\/j.psj.2026.107493_bib0051","article-title":"Exploring the metabolic patterns and response mechanisms of bile acids during fasting: a study with poultry as an example","volume":"104","author":"Zhang","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107493_bib0052","first-page":"1396","article-title":"Multi-omics reveals key cell types and gene families regulating eggshell strength in chicken uteri","volume":"46","author":"Zhang","year":"2025","journal-title":"Zool. Res."},{"key":"10.1016\/j.psj.2026.107493_bib0053","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1017\/S1751731117002658","article-title":"Genetic selection on abdominal fat content alters the reproductive performance of broilers","volume":"12","author":"Zhang","year":"2018","journal-title":"Animal"},{"key":"10.1016\/j.psj.2026.107493_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104422","article-title":"Bile acid disorders and intestinal barrier dysfunction are involved in the development of fatty liver in laying hens","volume":"103","author":"Zhao","year":"2024","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126011260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126011260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:59:42Z","timestamp":1793131182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126011260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0032579126011260"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107493","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative multi-omics reveals comprehensive gut-liver-adipose metabolic changes in peak laying hens with high or low egg production","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107493","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107493"}}