{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:33:07Z","timestamp":1793133187306,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2021-67015-34533"],"award-info":[{"award-number":["2021-67015-34533"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.psj.2026.107565","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:55:32Z","timestamp":1785995732000},"page":"107565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host immunological response of Ross 308 broilers fed an anti-IL-10 antibody to Eimeria and Clostridium perfringens challenge"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2335-3994","authenticated-orcid":false,"given":"Michael","family":"Carroll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-8166","authenticated-orcid":false,"given":"Krysten","family":"Fries-Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-2888","authenticated-orcid":false,"given":"Melissa","family":"Monson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-0709","authenticated-orcid":false,"given":"Stephan","family":"Schmitz-Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-9074","authenticated-orcid":false,"given":"Elizabeth A.","family":"Bobeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107565_bib0001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-4017(84)90117-1","article-title":"The effects of Eimeria acervuline infection on the metabolism of chick duodenal tissue","volume":"14","author":"Allen","year":"1984","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.psj.2026.107565_bib0002","author":"Andrews"},{"key":"10.1016\/j.psj.2026.107565_bib0003","first-page":"234","article-title":"Evaluating the resistance of Eimeria spp. Field isolates to anticoccidial drugs using three different indices","volume":"8","author":"Arabkhazaeli","year":"2013","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.psj.2026.107565_bib0004","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3382\/ps\/pev365","article-title":"Interleukin-10 neutralizing antibody for detection of intestinal luminal levels and as a dietary additive in Eimeria challenged broiler chicks","volume":"95","author":"Arendt","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.01357-19","article-title":"Draft genome sequence of clostridium perfringens strain TAMU, which causes necrotic enteritis in broiler chickens","volume":"9","author":"Ausland","year":"2020","journal-title":"Microbiol. Resour. Announc."},{"key":"10.1016\/j.psj.2026.107565_bib0006","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/molbev\/msi198","article-title":"Gene conversion drives the evolution of HINTW, an ampliconic gene on the female-specific avian W chromosome","volume":"22","author":"Backstr\u00f6m","year":"2005","journal-title":"Mol. Bio. Evol."},{"key":"10.1016\/j.psj.2026.107565_bib0007","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/bmj.321.7258.424","article-title":"Th1 and Th2 responses: what are they?","volume":"321","author":"Berger","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.psj.2026.107565_bib0008","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13567-020-00837-2","article-title":"Recalculating the cost of coccidiosis in chickens","volume":"51","author":"Blake","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2026.107565_bib0009","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107565_bib0010","article-title":"Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens","volume":"104","author":"Chen","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0011","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/ani11041111","article-title":"Assessment of Lippia origanoides essential oils in a Salmonella typhimurium, Eimeria maxima, and Clostridium perfringens challenge model to induce necrotic enteritis in broiler chickens","volume":"11","author":"Coles","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2026.107565_bib0012","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2007.10.014","article-title":"Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth","volume":"122","author":"Collier","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2026.107565_bib0013","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2026.107565_bib0014","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14760584.5.1.143","article-title":"Poultry coccidiosis: recent advancements in control measures and vaccine development","volume":"5","author":"Dalloul","year":"2006","journal-title":"Exp. Rev. Vacc."},{"key":"10.1016\/j.psj.2026.107565_bib50","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1186\/s12864-017-4380-4","article-title":"Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome","volume":"18","author":"Deist","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.psj.2026.107565_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107565_bib0016","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13567-020-00792-y","article-title":"Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection","volume":"51","author":"Elsheimer-Matulova","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2026.107565_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103187","article-title":"Early Salmonella Typhimurium inoculation may obscure anti-interleukin-10 protective effects on broiler performance during coccidiosis and necrotic enteritis challenge","volume":"103","author":"Fries-Craft","year":"2024","journal-title":"Poult. Sci."},{"issue":"4","key":"10.1016\/j.psj.2026.107565_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103551","article-title":"Coccidiosis and necrotic enteritis model may have a greater impact than dietary anti-interleukin-10 on broiler chicken systemic immunometabolic responses","volume":"103","author":"Fries-Craft","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0019","article-title":"Broiler chicken distal jejunum microbial communities are more responsive to coccidiosis or necrotic enteritis challenge than dietary anti-interleukin-10 in a model using Salmonella Typhimurium- Emeria maxima- Clostridium perfringens coinfection","volume":"103","author":"Fries-Craft","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0020","article-title":"Sequencing approaches to identify distal jejunum microbial community composition and function in broiler chickens fed anti-interleukin-10 during coccidiosis and necrotic enteritis challenge","volume":"103","author":"Fries-Craft","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.106046","article-title":"Individual and combined effects of butyric acid glycerides and a multicomponent phytogenic supplement on growth performance, intestinal mucosal health, and immune response of broiler chickens under coccidiosis challenge","volume":"104","author":"Ghasemi","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0022","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fvets.2019.00108","article-title":"Impact of a bacillus direct-fed microbial on growth performance, intestinal barrier integrity, necrotic enteritis lesions, and ileal microbiota in broiler chickens using a laboratory challenge model","volume":"6","author":"Hernandez-Patlan","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0023","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vetimm.2006.07.007","article-title":"Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections","volume":"114","author":"Hong","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2026.107565_bib0024","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.dci.2009.11.006","article-title":"Comparison of global transcriptional responses to primary and secondary Eimeria acervulina infections in chickens","volume":"34","author":"Kim","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.psj.2026.107565_bib0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vetpar.2013.01.013","article-title":"Meta-analysis of the performance variation in broilers experimentally challenged by Eimeria spp","volume":"196","author":"Kipper","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.psj.2026.107565_bib0026","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fimmu.2017.00372","article-title":"Immunometabolic phenotype alternations associated with the induction of disease tolerance and persistent asymptomatic infection of Salmonella in chicken intestine","volume":"8","author":"Kogut","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107565_bib0027","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome. Biol."},{"key":"10.1016\/j.psj.2026.107565_bib0028","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107565_bib0029","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.actatropica.2006.05.001","article-title":"Osteopontin is involved in Th1-mediated immunity against plasmodium falciparum infection in holoendemic malaria region in Vietnam","volume":"98","author":"Maeno","year":"2006","journal-title":"Acta. Trop."},{"key":"10.1016\/j.psj.2026.107565_bib0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0020-7519(97)00027-1","article-title":"Analysis of immunological cross-protection and sensitivities to anticoccidial drugs among five geographical and temporal strains of Eimeria maxima","volume":"27","author":"Martin","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.psj.2026.107565_bib0031","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0165-2427(97)00152-9","article-title":"Characterisation of chicken monocytes, macrophages and interdigitating cells by the monoclonal antibody KUL01","volume":"61","author":"Mast","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2026.107565_bib0032","doi-asserted-by":"crossref","first-page":"D394","DOI":"10.1093\/nar\/gkaa1106","article-title":"PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API","volume":"49","author":"Mi","year":"2021","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.psj.2026.107565_bib0033","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.dci.2013.04.003","article-title":"Recent progress in host immunity to avian coccidiosis: IL-17 family cytokines and sentinels of the intestinal mucosa","volume":"41","author":"Min","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.psj.2026.107565_bib0034","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s00436-019-06343-5","article-title":"Anticoccidial drugs of the livestock industry","volume":"118","author":"Noack","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.psj.2026.107565_bib0035","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1016\/j.psj.2020.09.046","article-title":"Effects of methylsulfonylmethane and neutralizing anti-IL-10 antibody supplementation during a mild Eimeria challenge infection in broiler chickens","volume":"99","author":"Rasheed","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0036","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1016\/j.psj.2020.09.012","article-title":"Dietary supplementation with anti-IL-10 antibody during a severe Eimeria challenge in broiler chickens","volume":"99","author":"Rasheed","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0037","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0304-4017(82)90079-6","article-title":"Changes in liver glycogen of broilers during coccidiosis","volume":"10","author":"Ruff","year":"1982","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.psj.2026.107565_bib0038","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3382\/ps\/pev352","article-title":"Oral antibody to interleukin-10 reduces growth rate depression due to Eimeria spp. Infection in broiler chickens","volume":"95","author":"Sand","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0039","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1637\/9604-112910-ResNote.1","article-title":"The role of an early Salmonella Typhimurium infection as a predisposing factor for necrotic enteritis in a laboratory challenge model","volume":"55","author":"Shivaramaiah","year":"2011","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107565_bib0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40104-025-01234-5","article-title":"Research advances in intramuscular fat deposition and chicken meat quality: genetics and nutrition","volume":"16","author":"Song","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107565_bib0041","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.immunol.26.021607.090316","article-title":"Interleukin-21: basic biology and implications for cancer and autoimmunity","volume":"26","author":"Spolski","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.psj.2026.107565_bib0042","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/10495398.2021.1935981","article-title":"Role and function of Hintw in early sex differentiation in chicken (Gallus gallus) embryo","volume":"34","author":"Sun","year":"2023","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.psj.2026.107565_bib0043","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13567-025-01519-7","article-title":"Comprehensive analysis of blood proteome response to necrotic enteritis in broiler chicken","volume":"56","author":"Tretiak","year":"2025","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2026.107565_bib0044","doi-asserted-by":"crossref","first-page":"36","DOI":"10.11613\/BM.2015.004","article-title":"Pathologic patterns of interleukin 10 expression-a review","volume":"25","author":"Trifunovic","year":"2015","journal-title":"Biochem. Med."},{"issue":"2","key":"10.1016\/j.psj.2026.107565_bib0046","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/00071668.2024.2410367","article-title":"Consensus gene co-expression analysis across multiple intestinal tissues to identify key genes and pathways associated with abdominal fat deposition in broilers","volume":"66","author":"Wang","year":"2025","journal-title":"Brit. Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.104823","article-title":"Comprehensive analysis of gene expressions in ileal mucosa of chickens fed paddy rice and their IgA response to oral vaccination","volume":"104","author":"Yamamoto","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107565_bib0048","article-title":"Evolution, dynamic expression changes and regulatory characteristics of gene families involved in the glycerophosphate pathway of triglyceride synthesis in chicken (Gallus gallus)","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.107565_bib0049","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/ps\/79.5.619","article-title":"Analysis of disease resistance-associated parameters in broiler chickens challenged with Eimeria maxima","volume":"79","author":"Zhu","year":"2000","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126011983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126011983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:54:59Z","timestamp":1793130899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126011983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0032579126011983"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107565","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host immunological response of Ross 308 broilers fed an anti-IL-10 antibody to Eimeria and Clostridium perfringens challenge","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107565"}}