{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:32:30Z","timestamp":1793115150140,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107700","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:55:34Z","timestamp":1787727334000},"page":"107700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional GWAS analyses on longitudinal phenotypes reveal candidate genes regulating multi-stage egg production traits in Wannan yellow chicken"],"prefix":"10.1016","volume":"105","author":[{"given":"Qianyun","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-0473","authenticated-orcid":false,"given":"Xingyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107700_bib0001","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.psj.2026.107700_bib0002","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/biolre\/ioz114","article-title":"Prokineticin 1 is a new biomarker of human oocyte competence: expression and hormonal regulation throughout late folliculogenesis","volume":"101","author":"Alfaidy","year":"2019","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2026.107700_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2026.106657","article-title":"Nanopore long-read RNA sequencing reveals key genes regulating pre-hierarchical follicle development in the chicken ovary","volume":"105","author":"Cao","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0004","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107700_bib0005","doi-asserted-by":"crossref","unstructured":"Danecek, P., J. K. Bonfield, J. Liddle, J. Marshall, V. Ohan, M. O. Pollard, A. Whitwham, T. Keane, S. A. McCarthy, R. M. Davies, et al. 2021. Twelve years of SAMtools and BCFtools. GigaScience 10:giab008. https:\/\/doi.org\/10.1093\/gigascience\/giab008.","DOI":"10.1093\/gigascience\/giab008"},{"key":"10.1016\/j.psj.2026.107700_bib0006","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1672-0229(10)60027-7","article-title":"Scanning for genomic regions subject to selective sweeps using SNP-MaP strategy","volume":"8","author":"Deng","year":"2010","journal-title":"Genom. Proteom. Bioinf."},{"key":"10.1016\/j.psj.2026.107700_bib0007","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0008","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1139\/o00-015","article-title":"The role of glutamate and nitric oxide in the reproductive neuroendocrine system","volume":"78","author":"Dhandapani","year":"2000","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.psj.2026.107700_bib0009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrg2575","article-title":"Mapping genes for complex traits in domestic animals and their use in breeding programmes","volume":"10","author":"Goddard","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/REP-15-0018","article-title":"Effects of the mycotoxin deoxynivalenol on steroidogenesis and apoptosis in granulosa cells","volume":"149","author":"Guerrero-Netro","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.psj.2026.107700_bib0011","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3168\/jds.2008-1646","article-title":"Invited review: Genomic selection in dairy cattle: progress and challenges","volume":"92","author":"Hayes","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0012","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12864-020-6613-1","article-title":"Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals","volume":"21","author":"Hou","year":"2020","journal-title":"BMC Genom"},{"key":"10.1016\/j.psj.2026.107700_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105739","article-title":"Genome-wide association study reveals candidate genes associated with egg-laying performance in Wuhua yellow chicken","volume":"104","author":"Huang","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0014","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ajhg.2022.01.018","article-title":"GWAS of longitudinal trajectories at biobank scale","volume":"109","author":"Ko","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103705","article-title":"Genome-wide association studies of egg production traits by whole genome sequencing of Laiwu Black chicken","volume":"103","author":"Lei","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0016","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/sj.bjc.6604375","article-title":"Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance","volume":"98","author":"Leung","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.psj.2026.107700_bib0017","unstructured":"Li, H. 2013. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv Genom. https:\/\/doi.org\/10.48550\/arXiv.1303.3997."},{"key":"10.1016\/j.psj.2026.107700_bib0018","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00441-012-1361-4","article-title":"BMPRIB and BMPRII mRNA expression levels in goat ovarian follicles and the in vitro effects of BMP-15 on preantral follicle development","volume":"348","author":"Lima","year":"2012","journal-title":"Cell. Tissue. Res."},{"key":"10.1016\/j.psj.2026.107700_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028600","article-title":"A genome-wide SNP scan reveals novel loci for egg production and quality traits in white leghorn and brown-egg dwarf layers","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2026.107700_bib0021","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/rep.0.1230291","article-title":"Modulatory effects of gonadotrophins and insulin-like growth factor on the secretion of inhibin A and progesterone by granulosa cells from chicken preovulatory (F1-F3) follicles","volume":"123","author":"Lovell","year":"2002","journal-title":"Reproduction"},{"key":"10.1016\/j.psj.2026.107700_bib0022","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/genetics\/157.4.1819","article-title":"Prediction of total genetic value using genome-wide dense marker maps","volume":"157","author":"Meuwissen","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.psj.2026.107700_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110777","article-title":"RNA-modifying enzyme Alkbh8 is involved in mouse embryonic development","volume":"27","author":"Nakai","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.psj.2026.107700_bib0024","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1093\/bioinformatics\/btz304","article-title":"Efficient multivariate analysis algorithms for longitudinal genome-wide association studies","volume":"35","author":"Ning","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107700_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.anireprosci.2008.09.017","article-title":"Intra-ovarian growth factors regulating ovarian function in avian species: a review","volume":"111","author":"Onagbesan","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0026","doi-asserted-by":"crossref","first-page":"452","DOI":"10.17221\/8525-CJAS","article-title":"Tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds","volume":"60","author":"Pan","year":"2015","journal-title":"Czech J. Anim. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0027","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007989","article-title":"Genetics of adaptation in modern chicken","volume":"15","author":"Qanbari","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0029","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107700_bib0030","doi-asserted-by":"crossref","first-page":"msaf275","DOI":"10.1093\/molbev\/msaf275","article-title":"Fast and memory-efficient dynamic programming approach for large-scale EHH-based selection scans","volume":"42","author":"Rahman","year":"2025","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.psj.2026.107700_bib0031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/mrd.20127","article-title":"Expression of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and BMP receptors in the ovaries of goats","volume":"70","author":"Silva","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.psj.2026.107700_bib0032","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/sim.6323","article-title":"Generalized estimating equations for genome-wide association studies using longitudinal phenotype data","volume":"34","author":"Sitlani","year":"2014","journal-title":"Stat. Med."},{"key":"10.1016\/j.psj.2026.107700_bib0033","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and limitations of genome-wide association studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105280","article-title":"Genome-wide association studies on longitudinal phenotypes reveal genetic mechanisms of egg production in chickens","volume":"104","author":"Tan","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41588-017-0009-4","article-title":"Multi-trait analysis of genome-wide association summary statistics using MTAG","volume":"50","author":"Turley","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0036","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnins.2013.00038","article-title":"Neuroendocrine regulation of gonadotropin secretion in seasonally breeding birds","volume":"7","author":"Ubuka","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.psj.2026.107700_bib0037","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","article-title":"10 Years of GWAS discovery: biology, function, and translation","volume":"101","author":"Visscher","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0038","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41422-020-0349-y","article-title":"863 genomes reveal the origin and domestication of chicken","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.psj.2026.107700_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54483-9","article-title":"Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline","volume":"15","author":"Wiegrebe","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2026.107700_bib0040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/jbg.12086","article-title":"Genome-wide association study for egg production and quality in layer chickens","volume":"131","author":"Wolc","year":"2014","journal-title":"J. Anim. Breed. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0041","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaf032","article-title":"VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files","volume":"14","author":"Xu","year":"2025","journal-title":"GigaScience"},{"key":"10.1016\/j.psj.2026.107700_bib0042","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1186\/s12864-015-1945-y","article-title":"Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens","volume":"16","author":"Yi","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.psj.2026.107700_bib0043","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/bioinformatics\/bty875","article-title":"PopLDdecay: a fast and effective tool for linkage disequilibrium decay analysis based on variant call format files","volume":"35","author":"Zhang","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2026.107700_bib0044","article-title":"Genome-wide association study reveals candidate genes associated with key egg production traits in Langya chickens","volume":"105","author":"Zhang","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0045","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1186\/s12864-021-07755-3","article-title":"Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study","volume":"22","author":"Zhao","year":"2021","journal-title":"BMC Genom"},{"key":"10.1016\/j.psj.2026.107700_bib0046","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.theriogenology.2023.01.018","article-title":"Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis","volume":"199","author":"Zhao","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.psj.2026.107700_bib0047","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ng.2310","article-title":"Genome-wide efficient mixed-model analysis for association studies","volume":"44","author":"Zhou","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.psj.2026.107700_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2022.107091","article-title":"Insulin-like growth factor-1 regulates follicle selection of hens by promoting proliferation and inhibiting apoptosis of granulosa cells in prehierarchical follicles in vitro","volume":"247","author":"Zhu","year":"2022","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.psj.2026.107700_bib0049","first-page":"84","article-title":"High-throughput sequencing technology and its application","volume":"21","author":"Zhu","year":"2014","journal-title":"J. Northeast Agric. Univ. (Engl. Ed.)"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126013349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126013349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:33:50Z","timestamp":1793111630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126013349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0032579126013349"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107700","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidimensional GWAS analyses on longitudinal phenotypes reveal candidate genes regulating multi-stage egg production traits in Wannan yellow chicken","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107700"}}