{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:33:03Z","timestamp":1793115183754,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025QCY-KXJ-132"],"award-info":[{"award-number":["2025QCY-KXJ-132"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025NC-YBXM-356"],"award-info":[{"award-number":["2025NC-YBXM-356"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573274"],"award-info":[{"award-number":["32573274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172776"],"award-info":[{"award-number":["32172776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107726","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:59:44Z","timestamp":1788537584000},"page":"107726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PCYT2 inhibits lipid accumulation via the notch signaling pathway in chicken primary hepatocytes"],"prefix":"10.1016","volume":"105","author":[{"given":"Huimei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-6599","authenticated-orcid":false,"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107726_bib0001","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1021\/acs.jafc.5c15705","article-title":"A dual-regulatory mechanism of estrogen on MTTPL-mediated hepatic lipid transport in chickens: involvement of ppar\u03b1 and miR-7439-3p","volume":"74","author":"Cao","year":"2026","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.psj.2026.107726_bib0002","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.psj.2020.10.028","article-title":"Estimation of the genetic parameters of traits relevant to feed efficiency: result from broilers lines divergent for high or low abdominal fat content","volume":"100","author":"Chen","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107726_bib0003","article-title":"Bushen Huoxue prescription inhibits ferroptosis of HUVEC cells by regulating FABP1-mediated lipid metabolism","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psj.2026.107726_bib0004","article-title":"PCYT2 mediates ovarian epithelial cancer metastasis by regulating cell membrane fluidity through the AMPK\/FOXO1 signaling pathway","volume":"15","author":"Chen","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.psj.2026.107726_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104175","article-title":"Supplemental l-arginine promotes hepatocyte proliferation and alters liver fatty acid metabolism in the late embryonic phase: an RNA-seq analysis","volume":"103","author":"Chen","year":"2024","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.psj.2026.107726_bib0006","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s42255-023-00766-2","article-title":"PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing","volume":"5","author":"Cikes","year":"2023","journal-title":"Nat. Metab."},{"issue":"6","key":"10.1016\/j.psj.2026.107726_bib0007","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.7150\/ijbs.80122","article-title":"Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice","volume":"19","author":"Ding","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.psj.2026.107726_bib0008","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.metabol.2010.03.022","article-title":"Complementation of the metabolic defect in CTP:phosphoethanolamine cytidylytransferase (pcyt2)-deficient primary hepatocyte","volume":"59","author":"Fullerton","year":"2010","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.psj.2026.107726_bib0009","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E21-11-0558-T","article-title":"ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation","volume":"33","author":"Gok","year":"2022","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.psj.2026.107726_bib0010","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41598-022-05140-y","article-title":"Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphonoethylamine","volume":"12","author":"Grapentine","year":"2022","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.psj.2026.107726_bib0011","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3724\/abbs.2022121","article-title":"ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer","volume":"54","author":"Hong","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.psj.2026.107726_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103200","article-title":"miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells","volume":"103","author":"Jia","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107726_bib0013","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41420-022-00899-5","article-title":"FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.psj.2026.107726_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106741","article-title":"ANGPTL4-mediated microglial lipid droplet accumulatopn: bridging Alzheimer\u2019s disease and obesity","volume":"203","author":"Li","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.psj.2026.107726_bib0015","doi-asserted-by":"crossref","unstructured":"Madduma Hewage, S., K. K. W. Au-Yeung, S. Prashar, C. U. B. Wijerathne, K. O, and Y. L. Siow. 2022. Lingonberry improves hepatic lipid metabolism by targeting Notch1 signaling. Antioxidants. 11(3):472.","DOI":"10.3390\/antiox11030472"},{"issue":"9","key":"10.1016\/j.psj.2026.107726_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105476","article-title":"Sodium butyrate attenuates lipid metabolism disorder via improving mitochondrial function and activating autophagy in LMH cells","volume":"104","author":"Miao","year":"2025","journal-title":"Poult. Sci."},{"issue":"5","key":"10.1016\/j.psj.2026.107726_bib0017","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/ps\/86.5.1043","article-title":"Nutrition of the developing embryo and hatching","volume":"86","author":"Moran","year":"2007","journal-title":"Poult. Sci."},{"issue":"8","key":"10.1016\/j.psj.2026.107726_bib0018","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nm.3259","article-title":"Inhibition of Notch uncouples akt activation from hepatic lipid accumulation by decreasing mTorc1 stability","volume":"19","author":"Pajvani","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.psj.2026.107726_bib0019","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/thno.118755","article-title":"Downregulation of PCYT2 by increased portal pressure safeguards liver regeneration after partial hepatectomy","volume":"16","author":"Pu","year":"2026","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.psj.2026.107726_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105857","article-title":"Developmental programming in chickens including transgenerational nutrition, chemosensory mechanisms and in ovo essential oils, organic acids, and pre-pro-syn-biotics; role of epigenetic modifications","volume":"104","author":"Roura","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107726_bib0021","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo7958","article-title":"JAG1-NOTCH4 mechanosensing drives atherosclerosis","volume":"8","author":"Souilhol","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.psj.2026.107726_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1094273","article-title":"Phosphatidylethanolamine homeostasis under conditions of impaired CDP-ethanolamine pathway or phosphatidylserine decarboxylation","volume":"9","author":"St Germain","year":"2023","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.psj.2026.107726_bib0023","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1139\/bcb-2016-0105","article-title":"Adaptations to excess choline in insulin resistant and pcyt2 deficient skeletal muscle","volume":"95","author":"Taylor","year":"2017","journal-title":"Biochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.psj.2026.107726_bib0024","article-title":"Single-nucleus transcriptome reveals cell dynamic response of liver during the late chick embryonic development","volume":"103","author":"Wang","year":"2024","journal-title":"Pout. Sci."},{"issue":"7","key":"10.1016\/j.psj.2026.107726_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105218","article-title":"Lipidomics reveals lipid changes in the hepatic during the late chick embryonic development","volume":"104","author":"Wang","year":"2025","journal-title":"Poult. Sci."},{"issue":"11","key":"10.1016\/j.psj.2026.107726_bib0026","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1097\/JS9.0000000000003049","article-title":"Fatty acid-binding proteins in cancers","volume":"111","author":"Wu","year":"2025","journal-title":"Int. J. Surg."},{"issue":"3","key":"10.1016\/j.psj.2026.107726_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100337","article-title":"Phosphoethanolamine cytidylytransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro","volume":"64","author":"Xu","year":"2023","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.psj.2026.107726_bib0028","article-title":"Transcriptome and metabolite profiling reveals the mechanism of hepatic lipid metabolism during fasting in chicken","volume":"39","author":"Xu","year":"2026","journal-title":"Anim. Biotechnol."},{"issue":"4","key":"10.1016\/j.psj.2026.107726_bib0030","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s11259-024-10420-1","article-title":"Development of fatty liver disease model using high cholesterol and low choline diet in white leghorn chickens","volume":"48","author":"Yadav","year":"2024","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.psj.2026.107726_bib0031","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.psj.2026.107726_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103023","article-title":"Transcriptome analysis of healthy and fatty liver revealed that inhibition of SLCO1B3 induces abnormal liver metabolism and lipid synthesis","volume":"102","author":"Zhu","year":"2023","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912601360X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912601360X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:43:07Z","timestamp":1793112187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257912601360X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S003257912601360X"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107726","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PCYT2 inhibits lipid accumulation via the notch signaling pathway in chicken primary hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107726"}}