{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T15:21:53Z","timestamp":1794151313625,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800301"],"award-info":[{"award-number":["2023YFD1800301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373043"],"award-info":[{"award-number":["32373043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573402"],"award-info":[{"award-number":["32573402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072897"],"award-info":[{"award-number":["32072897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20261509KJ"],"award-info":[{"award-number":["JJKH20261509KJ"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107740","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:35:24Z","timestamp":1788849324000},"page":"107740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protection against necrotic enteritis in broiler chickens by co-administration of Enterococcus faecalis EF32 and recombinant Lactobacillus plantarum strain co-expressing FimA, FimB, NetB and Fba"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0792-0869","authenticated-orcid":false,"given":"Yao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhannan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-4301","authenticated-orcid":false,"given":"Yanlong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107740_bib0001","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4014\/jmb.1509.09030","article-title":"Surface-displayed IL-10 by recombinant Lactobacillus plantarum reduces Th1 responses of RAW264.7 cells stimulated with poly(I:C) or LPS","volume":"26","author":"Cai","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2026.107740_bib0002","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12934-015-0313-6","article-title":"Lactic acid bacteria: reviewing the potential of a promising delivery live vector for biomedical purposes","volume":"14","author":"Cano-Garrido","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.psj.2026.107740_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1481514","article-title":"A novel oral vaccine delivery system for enhancing stability and immune protection: bacterium-like particle with functional coating","volume":"15","author":"De","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.107740_bib0004","doi-asserted-by":"crossref","first-page":"19149","DOI":"10.1021\/acsnano.5c00563","article-title":"Tamibarotene-loaded nanoemulsion incorporating toll-like receptor 2\/6 agonist as an intramuscular adjuvant system enhances gastrointestinal mucosal immunity","volume":"19","author":"Deng","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.psj.2026.107740_bib0005","article-title":"Necrotic enteritis in broiler chickens: disease characteristics and prevention using organic antibiotic alternatives - a comprehensive review","volume":"101","author":"El-Hack","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107740_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101330","article-title":"Centennial review: recent developments in host-pathogen interactions during necrotic enteritis in poultry","volume":"100","author":"Emami","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107740_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2026.111130","article-title":"A Lactobacillus plantarum vaccine candidate with dendritic cell targeting and lysosome escape properities provides efficient protection against necrotic enteritis in broiler chickens","volume":"320","author":"Gao","year":"2026","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2026.107740_bib0008","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1637\/11973-092018-Reg.1","article-title":"Characterization of virulent netB(+)\/tpeL(+)clostridium perfringens strains from necrotic enteritis-affected broiler chicken farms","volume":"63","author":"Gu","year":"2019","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107740_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104401","article-title":"Positive impact of early-probiotic administration on performance parameters, intestinal health and microbiota populations in broiler chickens","volume":"103","author":"Hussain","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107740_bib0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1637\/8656-021109-Reg.1","article-title":"Immunization of broiler chickens against Clostridium perfringens-induced necrotic enteritis using purified recombinant immunogenic proteins","volume":"53","author":"Jiang","year":"2009","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107740_bib0011","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1637\/11094-041715-Reg","article-title":"Protection against necrotic enteritis in broiler chickens by regulated delayed lysis Salmonella vaccines","volume":"59","author":"Jiang","year":"2015","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2026.107740_bib0012","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/IAI.00806-06","article-title":"Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens","volume":"74","author":"Keyburn","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2026.107740_bib0013","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1128\/JVI.80.8.4079-4087.2006","article-title":"Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice","volume":"80","author":"Lee","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2026.107740_bib0014","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.vetmic.2019.01.005","article-title":"Immunization with subunits of a novel pilus produced by virulent Clostridium perfringens strains confers partial protection against necrotic enteritis in chickens","volume":"230","author":"Lepp","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2026.107740_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40104-025-01246-1","article-title":"Lonicerae flos and turmeric extracts alleviate necrotic enteritis in broilers by modulating gut-liver health and microbiota","volume":"16","author":"Liu","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107740_bib0016","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/03079457.2014.939942","article-title":"Progress and problems in vaccination against necrotic enteritis in broiler chickens","volume":"43","author":"Mot","year":"2014","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107740_bib0017","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12934-016-0570-z","article-title":"Display of a beta-mannanase and a chitosanase on the cell surface of Lactobacillus plantarum towards the development of whole-cell biocatalysts","volume":"15","author":"Nguyen","year":"2016","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.psj.2026.107740_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114645","article-title":"Development of a lymph node-homing peptide vaccine targeting C-C chemokine receptor 7-positive dendritic cells with enhanced antitumor immunity","volume":"391","author":"Pang","year":"2026","journal-title":"J. Control Release"},{"key":"10.1016\/j.psj.2026.107740_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210026","article-title":"Recombinant lactic acid bacteria as promising vectors for mucosal vaccination","volume":"1","author":"Qiao","year":"2021","journal-title":"Exploration"},{"key":"10.1016\/j.psj.2026.107740_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2021.102377","article-title":"Evaluation of different antigenic preparations against necrotic enteritis in broiler birds using a novel Clostridium perfringens type G strain","volume":"70","author":"Sarmah","year":"2021","journal-title":"Anaerobe"},{"key":"10.1016\/j.psj.2026.107740_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03079457.2024.2398028","article-title":"Necrotic enteritis in chickens: a comprehensive review of vaccine advancements over the last two decades","volume":"54","author":"Shamshirgaran","year":"2025","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107740_bib0022","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12602-019-09557-2","article-title":"Effect of a potential probiotic candidate Enterococcus faecalis-1 on growth performance, intestinal microbiota, and immune response of commercial broiler chickens","volume":"12","author":"Shehata","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.psj.2026.107740_bib0023","article-title":"Effects of dietary astragalus polysaccharide supplementation on the Th17\/Treg balance and the gut microbiota of broiler chickens challenged with necrotic enteritis","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107740_bib0024","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jam.13446","article-title":"Lactic acid bacteria - promising vaccine vectors: possibilities, limitations, doubts","volume":"123","author":"Szatraj","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.psj.2026.107740_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2024.102902","article-title":"Clostridium perfringens antigens and challenges for development of vaccines against necrotic enteritis in poultry","volume":"89","author":"Waller","year":"2024","journal-title":"Anaerobe"},{"key":"10.1016\/j.psj.2026.107740_bib0026","article-title":"A triple-sugar regulated Salmonella vaccine protects against Clostridium perfringens-induced necrotic enteritis in broiler chickens","volume":"101","author":"Wang","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107740_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197721","article-title":"Salmonella-vectored vaccine delivering three Clostridium perfringens antigens protects poultry against necrotic enteritis","volume":"14","author":"Wilde","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2026.107740_bib0028","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2567.2009.03129.x","article-title":"Generation and characterization of chicken bone marrow-derived dendritic cells","volume":"129","author":"Wu","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.psj.2026.107740_bib0029","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1472-765X.2011.03160.x","article-title":"Novel surface display system for heterogonous proteins on Lactobacillus plantarum","volume":"53","author":"Xu","year":"2011","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.psj.2026.107740_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10060979","article-title":"Immunization with pooled antigens for Clostridium perfringens conferred partial protection against experimental necrotic enteritis in broiler chickens","volume":"10","author":"Yuan","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.psj.2026.107740_bib0031","article-title":"Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers","volume":"12","author":"Zhang","year":"2025","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107740_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144179","article-title":"Trained immunity driven by Enterococcus faecalis ribosomal protein S11 enhances antigen presentation and boosts influenza vaccine efficacy via nanoparticle delivery","volume":"315","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912601374X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912601374X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T14:24:25Z","timestamp":1794147865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257912601374X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S003257912601374X"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107740","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against necrotic enteritis in broiler chickens by co-administration of Enterococcus faecalis EF32 and recombinant Lactobacillus plantarum strain co-expressing FimA, FimB, NetB and Fba","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107740","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107740"}}