{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T15:21:50Z","timestamp":1794151310941,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060057"],"award-info":[{"award-number":["2023B1212060057"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515110384"],"award-info":[{"award-number":["2025A1515110384"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20440"],"award-info":[{"award-number":["U24A20440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107851","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:32:36Z","timestamp":1790749956000},"page":"107851","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbial dysbiosis is associated with altered splenic immune homeostasis in chickens"],"prefix":"10.1016","volume":"105","author":[{"given":"Yunpeng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-4324","authenticated-orcid":false,"given":"Yibin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107851_bib0001","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41577-023-00857-x","article-title":"Splenic stromal niches in homeostasis and immunity","volume":"23","author":"Alexandre","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00253-015-7077-0","article-title":"Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation","volume":"100","author":"Aparicio","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2026.107851_bib0003","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s13304-021-01112-5","article-title":"Oral neomycin and bacitracin are effective in preventing surgical site infections in elective colorectal surgery: a multicentre, randomized, parallel, single-blinded trial (COLORAL-1)","volume":"73","author":"Arezzo","year":"2021","journal-title":"Updates. Surg."},{"key":"10.1016\/j.psj.2026.107851_bib0004","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-024-07336-w","article-title":"Paternal microbiome perturbations impact offspring fitness","volume":"629","author":"Argaw-Denboba","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.psj.2026.107851_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s44385-025-00010-4","article-title":"Inflammation: a matter of immune cell life and death","volume":"2","author":"Bender","year":"2025","journal-title":"npj Biomed. Innov."},{"key":"10.1016\/j.psj.2026.107851_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117177","article-title":"The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds","volume":"178","author":"Bhol","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.psj.2026.107851_bib0007","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The Spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.psj.2026.107851_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2025.112518","article-title":"The spleen-liver axis supports obesity-induced systemic and fatty liver inflammation via MDSC and NKT cell enrichment","volume":"601","author":"Brummer","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.psj.2026.107851_bib0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.humimm.2019.01.001","article-title":"CD3CD20 T cells and their roles in human diseases++","volume":"80","author":"Chen","year":"2019","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0011","doi-asserted-by":"crossref","first-page":"D27","DOI":"10.1093\/nar\/gkab951","article-title":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022","volume":"50","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.psj.2026.107851_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29686","article-title":"Monocytes and macrophages: origin, homing, differentiation, and functionality during inflammation","volume":"10","author":"Dash","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.psj.2026.107851_bib0029","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41579-023-00936-9","article-title":"Antibiotic-induced collateral damage to the microbiota and associated infections","volume":"21","author":"de Nies","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.psj.2026.107851_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1277102","article-title":"The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective","volume":"14","author":"Fu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0014","doi-asserted-by":"crossref","first-page":"8872","DOI":"10.1038\/s41598-019-45467-7","article-title":"Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans","volume":"9","author":"Guinan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.107851_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2026.1785607","article-title":"Host\u2013gut microbiota interactions in health and disease: mechanisms and intervention strategies","volume":"17","author":"Han","year":"2026","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.107851_bib0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Sig Transduct. Target Ther."},{"key":"10.1016\/j.psj.2026.107851_bib0017","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41579-024-01106-1","article-title":"Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential","volume":"23","author":"Ioannou","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.psj.2026.107851_bib0018","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0923-2494(91)90090-6","article-title":"Structure and function of the chicken spleen","volume":"142","author":"Jeurissen","year":"1991","journal-title":"Res. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0019","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s44324-025-00066-1","article-title":"Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes","volume":"3","author":"Jyoti","year":"2025","journal-title":"npj Metab. Health Dis."},{"key":"10.1016\/j.psj.2026.107851_bib0020","article-title":"Rewired neuroactive ligand-receptor signaling confers adaptive resistance to BCL-2 inhibition in AML","author":"Koyama","year":"2026","journal-title":"Res. Sq."},{"key":"10.1016\/j.psj.2026.107851_bib0021","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/trstmh\/trad059","article-title":"Clinical and laboratory factors associated with splenic dysfunction among patients with sickle cell disease in a malaria endemic region","volume":"117","author":"Ladu","year":"2023","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.psj.2026.107851_bib0022","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure-function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0023","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.chom.2011.10.004","article-title":"Role of the commensal microbiota in normal and pathogenic host immune responses","volume":"10","author":"Littman","year":"2011","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.psj.2026.107851_bib0024","article-title":"Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells","volume":"15","author":"Liu","year":"2026","journal-title":"Front. Oncol."},{"key":"10.1016\/j.psj.2026.107851_bib0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aninu.2021.09.012","article-title":"The interaction among gut microbes, the intestinal barrier and short chain fatty acids","volume":"9","author":"Ma","year":"2022","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107851_bib0026","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0027","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3390\/cancers15041189","article-title":"Modulating T cell responses by targeting CD3","volume":"15","author":"Menon","year":"2023","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.psj.2026.107851_bib0028","doi-asserted-by":"crossref","first-page":"R375","DOI":"10.1152\/ajpregu.00151.2022","article-title":"Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments","volume":"323","author":"Mota","year":"2022","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.psj.2026.107851_bib0030","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.3390\/ijms27125432","article-title":"Oxidative stress biomarkers and systemic inflammatory indices in metabolic dysfunction-associated steatotic liver disease with type 2 diabetes mellitus: a comparative and longitudinal analysis","volume":"27","author":"P\u0103dureanu","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2026.107851_bib0031","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s41423-025-01333-3","article-title":"Beyond the gut: decoding the gut\u2013immune\u2013brain axis in health and disease","volume":"22","author":"Park","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0032","first-page":"103","article-title":"Composition and function of chicken gut microbiota","volume":"10","author":"Rychlik","year":"2020","journal-title":"Anim. (Basel)"},{"key":"10.1016\/j.psj.2026.107851_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2025.128317","article-title":"Akkermansia muciniphila: a key player in gut microbiota-based disease modulation","volume":"301","author":"Shaheen","year":"2025","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.psj.2026.107851_bib0034","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.psj.2026.107851_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2019.00099","article-title":"Antibiotic-induced disruption of gut microbiota alters local metabolomes and immune responses","volume":"9","author":"Sun","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.psj.2026.107851_bib0036","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13099-026-00795-8","article-title":"Broad-spectrum antibiotic treatment reshapes the gut microbiome, resistome, and colonization potential of opportunistic pathogens: a metagenomics study","volume":"18","author":"Tigabu","year":"2026","journal-title":"Gut. Pathog."},{"key":"10.1016\/j.psj.2026.107851_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178509","article-title":"Spleen-derived immune cells potentiate cerebral ischemia-reperfusion injury through brain-spleen communication","volume":"1013","author":"Wang","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.psj.2026.107851_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113570","article-title":"Gut microbiota contributes to the intestinal and extraintestinal immune homeostasis by balancing Th17\/treg cells","volume":"143","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.psj.2026.107851_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108864","article-title":"The lysosome-phagosome pathway mediates immune regulatory mechanisms in Mesocentrotus nudus against Vibrio coralliilyticus infection","volume":"139","author":"Wang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1449657","article-title":"The anti-inflammatory and tolerogenic potential of small spleen peptides","volume":"15","author":"Wixler","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2026.107851_bib0041","article-title":"The roles of CCR9\/CCL25 in inflammation and inflammation-associated diseases","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.psj.2026.107851_bib0042","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41522-021-00228-1","article-title":"Improved functionality of ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation","volume":"7","author":"Yao","year":"2021","journal-title":"NPJ. Biofilms. Microbiomes."},{"key":"10.1016\/j.psj.2026.107851_bib0044","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/19490976.2015.1031946","article-title":"Control of commensal microbiota by the adaptive immune system","volume":"6","author":"Zhang","year":"2015","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.psj.2026.107851_bib0043","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1111\/brv.12325","article-title":"IgY: a key isotype in antibody evolution","volume":"92","author":"Zhang","year":"2017","journal-title":"Biol. Rev."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126014835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126014835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T14:22:42Z","timestamp":1794147762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126014835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0032579126014835"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107851","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbial dysbiosis is associated with altered splenic immune homeostasis in chickens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107851"}}