{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:33:12Z","timestamp":1793115192962,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1000201"],"award-info":[{"award-number":["2022YFF1000201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["NK2022100102"],"award-info":[{"award-number":["NK2022100102"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","award":["CARS-40"],"award-info":[{"award-number":["CARS-40"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107872","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:20:24Z","timestamp":1790954424000},"page":"107872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["WGCNA-based analysis of the plasma metabolome and identification of metabolic markers associated with meat production traits in broilers"],"prefix":"10.1016","volume":"105","author":[{"given":"Zhiyong","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-3094","authenticated-orcid":false,"given":"Xue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107872_bib0001","series-title":"Arbor Acres Plus Broiler Performance Objectives","year":"2022"},{"key":"10.1016\/j.psj.2026.107872_bib0002","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2156-13-90","article-title":"Analysis of a slow-growing line reveals wide genetic variability of carcass and meat quality-related traits","volume":"13","author":"Chabault","year":"2012","journal-title":"BMC Genet."},{"key":"10.1016\/j.psj.2026.107872_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51655-2","article-title":"Relationship of the blood metabolome to subsequent carcass traits at slaughter in feedlot Wagyu crossbred steers","volume":"9","author":"Connolly","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.107872_bib0004","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1016\/j.psj.2020.06.066","article-title":"Characterization of chicken muscle disorders through metabolomics, pathway analysis, and water relaxometry: a pilot study","volume":"99","author":"C\u00f4nsolo","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103994","article-title":"Integrative metabolomics and transcriptomics analysis revealed specific genes and metabolites affecting meat quality of chickens under different rearing systems","volume":"103","author":"Cui","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0006","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/foods11030483","article-title":"The effect of breed and age on the growth performance, carcass traits and metabolic profile in breast muscle of Chinese indigenous chickens","volume":"11","author":"Deng","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.psj.2026.107872_bib0007","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.3382\/ps.2010-00710","article-title":"Digestible lysine requirements of male broilers from 28 to 42 days of age","volume":"89","author":"Dozier","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0008","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","article-title":"Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain","volume":"137","author":"Fernstrom","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2026.107872_bib0009","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3382\/ps.2010-00863","article-title":"Comparison of adipose tissue cellularity in chicken lines divergently selected for fatness","volume":"90","author":"Guo","year":"2011","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0010","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s00018-017-2582-1","article-title":"Experimental design and reporting standards for metabolomics studies of mammalian cell lines","volume":"74","author":"Hayton","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0011","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/s41597-025-06116-z","article-title":"Temporal RNA-seq atlas of breast muscle development in purebred and crossbred broilers","volume":"12","author":"Huang","year":"2025","journal-title":"Sci. Data"},{"key":"10.1016\/j.psj.2026.107872_bib0012","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1515\/hsz-2013-0271","article-title":"Citrate\u2014new functions for an old metabolite","volume":"395","author":"Iacobazzi","year":"2014","journal-title":"Biol. Chem."},{"key":"10.1016\/j.psj.2026.107872_bib0013","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2015.08.014","article-title":"Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands\u2014a review","volume":"70","author":"Jongkees","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psj.2026.107872_bib0014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4167\/jbv.2022.52.4.184","article-title":"Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice suppresses B cell activation","volume":"52","author":"Kim","year":"2022","journal-title":"J. Bacteriol. Virol."},{"key":"10.1016\/j.psj.2026.107872_bib0015","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.bbalip.2016.09.020","article-title":"Lysophosphatidylcholines activate PPAR\u03b4 and protect human skeletal muscle cells from lipotoxicity","volume":"1861","author":"Klingler","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psj.2026.107872_bib0016","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.psj.2026.107872_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.102790","article-title":"Unsaturated fatty acids in natural edible resources, a systematic review of classification, resources, biosynthesis, biological activities and application","volume":"53","author":"Liu","year":"2023","journal-title":"Food Biosci."},{"key":"10.1016\/j.psj.2026.107872_bib0018","doi-asserted-by":"crossref","first-page":"2548S","DOI":"10.1093\/jn\/nxaa224","article-title":"Review of lysine metabolism with a focus on humans","volume":"150","author":"Matthews","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2026.107872_bib0019","article-title":"Effects of sulfur amino acid supplementation on broiler chickens exposed to acute and chronic cyclic heat stress","volume":"101","author":"Sarsour","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0020","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/foods11244005","article-title":"Plasma metabolomic profiling reveals preliminary biomarkers of pork quality based on pH value","volume":"11","author":"Shen","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.psj.2026.107872_bib0021","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aninu.2021.06.011","article-title":"Comparisons of carcass traits, meat quality, and serum metabolome between Shaziling and Yorkshire pigs","volume":"8","author":"Song","year":"2022","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2026.107872_bib0022","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s40104-022-00775-3","article-title":"Identification of biomarkers associated with the feed efficiency by metabolomics profiling: results from the broiler lines divergent for high or low abdominal fat content","volume":"13","author":"Su","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107872_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2023.02.016","article-title":"Large-scale genomic and transcriptomic analyses elucidate the genetic basis of high meat yield in chickens","volume":"55","author":"Tan","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.psj.2026.107872_bib0024","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3390\/ani15101425","article-title":"Quantitative proteomics revealed the molecular regulatory network of lysine and the effects of lysine supplementation on Sunit skeletal muscle satellite cells","volume":"15","author":"Wang","year":"2025","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.psj.2026.107872_bib0025","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.3390\/ani14182743","article-title":"Non-targeted metabolomics of serum reveals biomarkers associated with body weight in Wumeng black-bone chickens","volume":"14","author":"Wang","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.psj.2026.107872_bib0026","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.foodchem.2018.09.008","article-title":"1H NMR-based metabolic characterization of Chinese Wuding chicken meat","volume":"274","author":"Xiao","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2026.107872_bib0027","article-title":"Integrating microbial 16S rRNA sequencing and non-targeted metabolomics to reveal sexual dimorphism of the chicken cecal microbiome and serum metabolome","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2026.107872_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118889","article-title":"Aminoacyl-tRNA synthetases and amino acid signaling","volume":"1868","author":"Yu","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.psj.2026.107872_bib0029","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/ps\/83.4.521","article-title":"Estimation of genetic parameters for fat deposition and carcass traits in broilers","volume":"83","author":"Zerehdaran","year":"2004","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0030","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.psj.2026.107872_bib0031","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40104-024-01026-3","article-title":"Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits","volume":"15","author":"Zhao","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2026.107872_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104433","article-title":"Single-cell transcriptomics and tissue metabolomics uncover mechanisms underlying wooden breast disease in broilers","volume":"103","author":"Zhao","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0033","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/ps\/85.10.1712","article-title":"Genome-wide linkage analysis to identify chromosomal regions affecting phenotypic traits in the chicken. II. Body composition","volume":"85","author":"Zhou","year":"2006","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107872_bib0034","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.3382\/ps.2014-04291","article-title":"Growth, efficiency, and yield of commercial broilers from 1957, 1978, and 2005","volume":"93","author":"Zuidhof","year":"2014","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126015063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126015063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:44:41Z","timestamp":1793112281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126015063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0032579126015063"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107872","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"WGCNA-based analysis of the plasma metabolome and identification of metabolic markers associated with meat production traits in broilers","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107872"}}