{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:33:04Z","timestamp":1793115184560,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psj.2026.107967","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:40:06Z","timestamp":1792046406000},"page":"107967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating gut microbiome and serum metabolomes to investigate the hepatoprotective effects of Lactiplantibacillus Plantarum PA01 against deoxynivalenol-induced liver injury in broilers"],"prefix":"10.1016","volume":"105","author":[{"given":"Huimei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-6599","authenticated-orcid":false,"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2026.107967_bib0001","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/s41423-021-00639-2","article-title":"Inflammation processes in the liver: divergent roles in homeostasis and pathology","volume":"18","author":"Ahmed","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"6","key":"10.1016\/j.psj.2026.107967_bib0002","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/03079457.2021.1983153","article-title":"Hepatoprotective effects of Lactobacillus plantarum 299v supplementation via drinking water against aflatoxin-induced liver damage","volume":"50","author":"Allameh","year":"2021","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2026.107967_bib0003","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.rvsc.2023.04.003","article-title":"Effect of Lactobacillus sp. and yeast supplementation on performance and some blood attributes in deoxynivalenol-challenged broiler chickens","volume":"159","author":"Azizi","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0004","article-title":"Polysaccharides of atracylodes macrocephala koidz alleviate lipopolysaccharide-stimulated liver inflammation injury of goslings through miR-223\/NLRP3 axis","volume":"102","author":"Chen","year":"2023","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.psj.2026.107967_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101651","article-title":"Effects of Lactobacillus salivarius supplementation on the growth performance, liver function, meat quality, immune responses and salmonella pullorum infection resistance of broilers challenged with Aflatoxin B1","volume":"101","author":"Chen","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0006","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","article-title":"Contribution of the intestinal microbiota and gut barrier to hepatic disorder","volume":"159","author":"Chopyk","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2026.107967_bib0007","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1021\/acs.jafc.3c02020","article-title":"Deoxynivalenol: emerging toxic mechanisms and control strategies, current and future perspectives","volume":"71","author":"Deng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2026.107967_bib0008","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.18632\/aging.203006","article-title":"Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration","volume":"13","author":"Deng","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.psj.2026.107967_bib0009","first-page":"43","article-title":"Deoxynivalenol in food and feed: occurrence and exposure","volume":"11","year":"2013","journal-title":"EFSA J."},{"key":"10.1016\/j.psj.2026.107967_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153689","article-title":"Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2\/ppar\u03b3-GPX4-ferroptosis pathway in mice","volume":"501","author":"Fan","year":"2024","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.psj.2026.107967_bib0011","article-title":"Lactiplantibacillus plantarum Lp05 protects against ethanol-induced liver injury in zebrafish through metabolic and microbiota modulation","volume":"15","author":"Fan","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2026.107967_bib0012","doi-asserted-by":"crossref","unstructured":"Guo, F., F. Wang, H. Ma, Z. Ren, X. Yang, and X. Yang. 2021. Study on the interactive effect of deoxynivalenol and Clostridium perfringens on the jejunal health of broiler chickens.","DOI":"10.1016\/j.psj.2020.10.061"},{"key":"10.1016\/j.psj.2026.107967_bib0013","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s00484-024-02674-w","article-title":"Deoxynivalenol and T-2 toxin cause liver damage and egg quality degradation through endoplasmic reticulum stress in summer laying hens","volume":"68","author":"Guo","year":"2024","journal-title":"Int. J. Biometeorol."},{"issue":"6","key":"10.1016\/j.psj.2026.107967_bib0014","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1080\/10408398.2021.1954598","article-title":"The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies","volume":"63","author":"Hou","year":"2023","journal-title":"Crit Rev Food Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104066","article-title":"Protective effect of honokiol on cadmium-induced liver injury in chickens","volume":"103","author":"Huang","year":"2024","journal-title":"Poult. Sci."},{"issue":"24","key":"10.1016\/j.psj.2026.107967_bib0016","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.3390\/cells12242831","article-title":"The emerging roles of \u03b3-glutamyl peptides by \u03b3-glutamyltransferase and the glutathione synthesis system","volume":"12","author":"Ikeda","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.psj.2026.107967_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114705","article-title":"Dietary taurine supplementation counteracts deoxynivalenol-induced liver injury via alleviating oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation in piglets","volume":"253","author":"Ji","year":"2023","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.psj.2026.107967_bib0018","article-title":"Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs","volume":"451","author":"Jia","year":"2023","journal-title":"J. Hazard. Master."},{"key":"10.1016\/j.psj.2026.107967_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134319","article-title":"18\u03b2-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control","volume":"471","author":"Jiang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.psj.2026.107967_bib0020","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.70047","article-title":"TCA cycle intermediate mitigates Di(2-ethylhexyl) phthalate-induced cholestatic liver injury through modulation of the Nrf2\/NQO1 signalling axis","volume":"136","author":"Jiang","year":"2025","journal-title":"Basic Clin. Pharmacol."},{"key":"10.1016\/j.psj.2026.107967_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2026.106501","article-title":"Effects of probiotic supplementation on growth performance, intestinal barrier function, and oxidative stress in broiler chickens fed a deoxynivalenol-contaminated diet","volume":"105","author":"Kpodo","year":"2026","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2026.107967_bib0022","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4014\/jmb.2310.10006","article-title":"Lactobacillus plantarum and bifidobacterium longum alleviate liver injury and fibrosis in mice by regulating NF-kappaB and AMPK signaling","volume":"34","author":"Lee","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2026.107967_bib0023","article-title":"The protective effects of Lactobacillus SNK-6 on growth, organ health, and intestinal function in geese exposed to low concentration aflatoxin B1","volume":"103","author":"Li","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104291","article-title":"Lactiplantibacillus plantarum JM113 alleviates deoxynivalenol induced intestinal damage by microbial modulation in broiler chickens","volume":"103","author":"Liang","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106390","article-title":"Compound probiotics and glycyrrhizic acid alleviate DON-induced liver damage linked to the alteration of lipid metabolism in piglets","volume":"120","author":"Liu","year":"2024","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.psj.2026.107967_bib0026","first-page":"2024","article-title":"Evaluating renal injury characteristics in different rat models of hyperuricemia and elucidating pathological molecular mechanisms via serum metabolomics","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.psj.2026.107967_bib0028","first-page":"1","article-title":"Descriptive anatomy of hepatic and portal veins with special reference to biliary duct system in broilers chickens (Gallus gallus domesticus): a recent illustration","volume":"21","author":"Maher","year":"2019","journal-title":"Braz. J. Poultry. Sci."},{"issue":"12","key":"10.1016\/j.psj.2026.107967_bib0029","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.4315\/JFP-22-077","article-title":"Lactobacillus plantarum and deoxynivalenol detoxification: a concise review","volume":"85","author":"Maidana","year":"2022","journal-title":"J. Food Prot."},{"key":"10.1016\/j.psj.2026.107967_bib0030","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s11033-018-4323-4","article-title":"Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2\/HO-1 signaling pathway","volume":"45","author":"Muhammad","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.psj.2026.107967_bib0031","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.toxicon.2018.08.010","article-title":"Multi-trichothecene mycotoxin exposure activates glutathione-redox system in broiler chicken","volume":"153","author":"Pelyhe","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.psj.2026.107967_bib0032","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/toxins13030217","article-title":"Biomarkers of deoxynivalenol toxicity in chickens with special emphasis on metabolic and welfare parameters","volume":"13","author":"Riahi","year":"2021","journal-title":"Toxins (Basel)"},{"issue":"9","key":"10.1016\/j.psj.2026.107967_bib0033","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1080\/10408398.2021.1960794","article-title":"Hepatotoxicity of food-borne mycotoxins: molecular mechanism, anti-hepatotoxic medicines and target prediction","volume":"62","author":"Ruan","year":"2022","journal-title":"Crit. Rev. Food Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0047","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.33761","article-title":"The influence of liver transplant on serum cholinesterase levels: A case report","author":"Stancu","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.psj.2026.107967_bib0034","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12917-022-03392-4","article-title":"Deoxynivalenol damages the intestinal barrier and biota of the broiler chickens","volume":"18","author":"Wan","year":"2022","journal-title":"BMC Vet. Res."},{"issue":"12","key":"10.1016\/j.psj.2026.107967_bib0035","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3390\/toxins14120830","article-title":"Dietary catalase supplementation alleviates deoxynivalenol-induced oxidative stress and gut microbiota dysibosis in broiler chickens","volume":"14","author":"Wang","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.psj.2026.107967_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156747","article-title":"Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS\/P53\/PGC-1\u03b1-mediated disruption of mitochondrial dynamics and PANoptosis","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.psj.2026.107967_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104280","article-title":"Beneficial effects of Lactobacillus plantarum on growth performance, immune status, antioxidant function and intestinal microbiota in broilers","volume":"103","author":"Xiao","year":"2024","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.psj.2026.107967_bib0038","first-page":"837","article-title":"Antioxidant activity of JM113 in vitro and its protective effect on broiler chickens challenged with deoxynivalenol","volume":"95","author":"Yang","year":"2017","journal-title":"J. Anim. Sci."},{"issue":"5","key":"10.1016\/j.psj.2026.107967_bib0039","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.psj.2019.10.034","article-title":"Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens","volume":"99","author":"Yang","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0040","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1080\/09540105.2019.1631261","article-title":"Antiallergic activity of Lactobacillus plantarum against peanut allergy in a balb\/c mouse model","volume":"30","author":"Yang","year":"2019","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.psj.2026.107967_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2026.106768","article-title":"Lactobacillus salivarius D5 improves growth performance and immune function in broilers by reducing Escherichia coli abundance and regulating the gut microbiota","volume":"105","author":"You","year":"2026","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2026.107967_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.104952","article-title":"Bamboo leaf flavonoids ameliorate cyclic heat stress-induced oxidative damage in broilers liver through activation of Keap1-Nrf2 signaling pathway","volume":"104","author":"Yuan","year":"2025","journal-title":"Poult. Sci."},{"issue":"10","key":"10.1016\/j.psj.2026.107967_bib0043","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/toxins14100682","article-title":"Possible toxic mechanisms of deoxynivalenol (DON) exposure to intestinal barrier damage and dysbiosis of the gut microbiota in laying hens","volume":"14","author":"Zhai","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.psj.2026.107967_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.110027","article-title":"Deoxynivalenol: occurrence, toxicity, and degradation","volume":"155","author":"Zhang","year":"2024","journal-title":"Food Control"},{"issue":"12","key":"10.1016\/j.psj.2026.107967_bib0045","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14469","article-title":"In vitro immunomodulatory and antioxidant effects of oligopeptides and four characteristic peptides in black-bone silky fowl (Gallus gallus domesticus Brisson)","volume":"46","author":"Zhang","year":"2022","journal-title":"J. Food Biochem."},{"issue":"3","key":"10.1016\/j.psj.2026.107967_bib0046","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/antiox13030295","article-title":"Selenomethionine supplementation mitigates liver dysfunction, oxidative injury and apoptosis through enhancing antioxidant capacity and inhibiting JNK MAPK pathway in piglets fed deoxynivalenol-contaminated diets","volume":"13","author":"Zhong","year":"2024","journal-title":"Antioxidants"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126016019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579126016019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:43:05Z","timestamp":1793112185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579126016019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0032579126016019"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2026.107967","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating gut microbiome and serum metabolomes to investigate the hepatoprotective effects of Lactiplantibacillus Plantarum PA01 against deoxynivalenol-induced liver injury in broilers","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2026.107967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"107967"}}