{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:27:57Z","timestamp":1775309277405,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.psychres.2006.12.015","type":"journal-article","created":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T11:18:31Z","timestamp":1184671111000},"page":"103-109","source":"Crossref","is-referenced-by-count":17,"title":["Low baseline serotonin-2A receptors predict clinical response to olanzapine in first-episode schizophrenia patients"],"prefix":"10.1016","volume":"153","author":[{"given":"Bel\u00e9n","family":"Arranz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Rosel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"San","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Due\u00f1as","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Salavert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Centeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique del","family":"Moral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2006.12.015_bib1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF02244049","article-title":"Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenic patients","volume":"101","author":"Alfredsson","year":"1990","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.psychres.2006.12.015_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/schbul\/21.1.53","article-title":"Assessment of the central dopaminergic index of plasma HVA in schizophrenia","volume":"21","author":"Amin","year":"1995","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.psychres.2006.12.015_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/npp.1994.12","article-title":"Effect of clozapine treatment on serotonin-2 receptor binding in the blood platelets of schizophrenic patients","volume":"10","author":"Arora","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2006.12.015_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(95)92168-0","article-title":"Association between clozapine response and allelic variation in 5-HT2A receptor gene","volume":"346","author":"Arranz","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.psychres.2006.12.015_bib5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/alcalc\/34.5.726","article-title":"Platelet serotonergic binding sites in alcohol-dependent patients","volume":"34","author":"Arranz","year":"1999","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.psychres.2006.12.015_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-1781(03)00073-8","article-title":"Altered platelet serotonin 5-HT2A receptor density and second messenger inositol trisphosphate (IP3) levels in drug-free schizophrenic patients","volume":"118","author":"Arranz","year":"2003","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.psychres.2006.12.015_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02247327","article-title":"Effects of ceruletide on perioral movements and the dopamine receptor\u2013adenylate cyclase system in rats chronically treated with fluphenazine","volume":"125","author":"Ashizawa","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.psychres.2006.12.015_bib8","first-page":"248","article-title":"Plasma catecholamine metabolites and early response to haloperidol","volume":"45","author":"Bowers","year":"1984","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.psychres.2006.12.015_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0920-9964(98)00146-7","article-title":"Antagonism by olanzapine of dopamine D1, serotonin 2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro","volume":"37","author":"Bymaster","year":"1999","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.psychres.2006.12.015_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1192\/S0007125000293653","article-title":"Olanzapine: a basic science update","volume":"37","author":"Bymaster","year":"1999","journal-title":"British Journal of Psychiatry"},{"issue":"suppl 10","key":"10.1016\/j.psychres.2006.12.015_bib11","first-page":"28","article-title":"In vitro and in vivo biochemistry of olanzapine: a novel, atypical antipsychotic drug","volume":"58","author":"Bymaster","year":"1997","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.psychres.2006.12.015_bib12","series-title":"Psychopharmacology: The Fourth Generation of Progress","first-page":"1567","article-title":"The neuropsychopharmacology of personality disorders","author":"Coccaro","year":"1995"},{"key":"10.1016\/j.psychres.2006.12.015_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1471-4159.1994.63020465.x","article-title":"Primary structure of the human platelet serotonin 5-HT2A receptor: identity with the frontal cortex serotonin 5-HT2A receptor","volume":"63","author":"Cook","year":"1994","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.psychres.2006.12.015_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1099-1077(200003)15:2<113::AID-HUP150>3.0.CO;2-W","article-title":"5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response","volume":"15","author":"Cryan","year":"2000","journal-title":"Human Psychopharmacology Clinical and Experimental"},{"key":"10.1016\/j.psychres.2006.12.015_bib15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archpsyc.1988.01800300060007","article-title":"Plasma homovanillic acid as a predictor of response to neuroleptics","volume":"45","author":"Davila","year":"1988","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.psychres.2006.12.015_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1471-4159.1989.tb07313.x","article-title":"Comparison of [125I]lysergic-acid diethylamide binding in human frontal cortex and platelet tissue","volume":"53","author":"Elliot","year":"1989","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.psychres.2006.12.015_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00429-005-0036-2","article-title":"Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia","volume":"210","author":"Hurlemann","year":"2005","journal-title":"Anatomical Embryology"},{"key":"10.1016\/j.psychres.2006.12.015_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive and Negative Syndrome Scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophrenia Bulletin"},{"issue":"4","key":"10.1016\/j.psychres.2006.12.015_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4088\/JCP.v65n0416","article-title":"Effects of atypical antipsychotics on the syndromal profile in treatment-resistant schizophrenia","volume":"65","author":"Lindenmayer","year":"2004","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.psychres.2006.12.015_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0003-2697(78)90586-9","article-title":"A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples","volume":"87","author":"Markwell","year":"1978","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.psychres.2006.12.015_bib21","first-page":"238","article-title":"Classification of typical and atypical antipsychotic drugs on the basis of dopamine D1, D2 and serotonin2 pKi values","volume":"251","author":"Meltzer","year":"1989","journal-title":"Journal of Pharmacological and Experimental Therapeutics"},{"key":"10.1016\/j.psychres.2006.12.015_bib22","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.6310753","article-title":"Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus in schizophrenics","volume":"221","author":"Memo","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.psychres.2006.12.015_bib23","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0006-3223(96)00244-2","article-title":"First-episode neuroleptic-free schizophrenics: concentrations of monoamines and their metabolites in plasma and their correlations with clinical responses to haloperidol treatment","volume":"41","author":"Nagaoka","year":"1997","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.psychres.2006.12.015_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0006-8993(93)91112-6","article-title":"Increase in [3H]cAMP binding sites and decrease in Gi-alpha and Go-alpha immunoreactivities in left temporal cortices from patients with schizophrenia","volume":"615","author":"Nishino","year":"1993","journal-title":"Brain Research"},{"key":"10.1016\/j.psychres.2006.12.015_bib25","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1176\/appi.ajp.163.10.1826","article-title":"Effect of 5-HT1A receptor gene polymorphism on negative and depressive symptom response to antipsychotic treatment of drug-na\u00efve psychotic patients","volume":"163","author":"Reynolds","year":"2006","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"10.1016\/j.psychres.2006.12.015_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1520-6769(199911\/12)25:3<129::AID-NRC2>3.0.CO;2-#","article-title":"5-HT2A receptors and their second messenger IP3 are only correlated in human brain and not in platelets","volume":"25","author":"Rosel","year":"1999","journal-title":"Neuroscience Research Communications"},{"key":"10.1016\/j.psychres.2006.12.015_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000077365","article-title":"Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims","volume":"49","author":"Rosel","year":"2004","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.psychres.2006.12.015_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/plef.1999.0063","article-title":"What can the investigation of phosphoinositide signaling system in platelets of schizophrenic patients tell us?","volume":"61","author":"Strunecka","year":"1999","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"issue":"11","key":"10.1016\/j.psychres.2006.12.015_bib29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0006-3223(98)00093-6","article-title":"A double-blind, controlled comparison of the novel antipsychotic olanzapine versus haloperidol or placebo on anxious and depressive symptoms accompanying schizophrenia","volume":"43","author":"Tollefson","year":"1998","journal-title":"Biological Psychiatry"}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178106004057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178106004057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T07:42:12Z","timestamp":1556696532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178106004057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0165178106004057"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2006.12.015","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}