{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:30:21Z","timestamp":1761489021223},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"The Swedish Research Council for Medicine","award":["2009-S266"],"award-info":[{"award-number":["2009-S266"]}]},{"name":"European Commission 7th Framework","award":["FP7-HEALTH-2009-241592","FP7-KBBE-2009-3-245009","FP7-KBBE-2010-4-266408"],"award-info":[{"award-number":["FP7-HEALTH-2009-241592","FP7-KBBE-2009-3-245009","FP7-KBBE-2010-4-266408"]}]},{"name":"FOU\/ALF G\u00f6teborg","award":["ALFGBG-138741"],"award-info":[{"award-number":["ALFGBG-138741"]}]},{"name":"Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research","award":["A305-188"],"award-info":[{"award-number":["A305-188"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.psychres.2012.09.051","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T08:02:19Z","timestamp":1350460939000},"page":"22-25","source":"Crossref","is-referenced-by-count":21,"title":["A possible association between panic disorder and a polymorphism in the preproghrelingene"],"prefix":"10.1016","volume":"206","author":[{"given":"Caroline","family":"Hansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Annerbrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Bah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Allgulander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Andersch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar","family":"Sj\u00f6din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2012.09.051_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cccn.2005.04.038","article-title":"Pyrosequencing: history, biochemistry and future","volume":"363","author":"Ahmadian","year":"2006","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.psychres.2012.09.051_bib2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.biopsych.2009.03.012","article-title":"The serotonin-1A receptor in anxiety disorders","volume":"66","author":"Akimova","year":"2009","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib3","series-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-IV","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.psychres.2012.09.051_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ajcn\/86.1.25","article-title":"Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women","volume":"86","author":"Ando","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.psychres.2012.09.051_bib5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ajmg.b.30387","article-title":"Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa","volume":"141B","author":"Ando","year":"2006","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.psychres.2009.11.022","article-title":"Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication","volume":"178","author":"Annerbrink","year":"2010","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000054680","article-title":"A role of ghrelin in neuroendocrine and behavioral responses to stress in mice","volume":"74","author":"Asakawa","year":"2001","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.psychres.2012.09.051_bib8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.psychres.2012.09.051_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/hr.2009.194","article-title":"Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease","volume":"33","author":"Berthold","year":"2010","journal-title":"Hypertension Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2010.08.042","article-title":"Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): association and interaction with childhood trauma and parenting","volume":"485","author":"Blaya","year":"2010","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.psychres.2012.09.051_bib11","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0006-291X(02)02740-7","article-title":"Ghrelin increases anxiety-like behavior and memory retention in rats","volume":"299","author":"Carlini","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.psychres.2012.09.051_bib12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbrc.2006.11.112","article-title":"Obestatin improves memory performance and causes anxiolytic effects in rats","volume":"352","author":"Carlini","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.psychres.2012.09.051_bib13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbrc.2003.11.150","article-title":"Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin","volume":"313","author":"Carlini","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.psychres.2012.09.051_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S146114570400416X","article-title":"Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women","volume":"7","author":"Domschke","year":"2004","journal-title":"The International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2012.09.051_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.ypg.0000199443.69668.b1","article-title":"Interaction of serotonergic and noradrenergic gene variants in panic disorder","volume":"16","author":"Freitag","year":"2006","journal-title":"Psychiatric Genetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/oby.2008.589","article-title":"Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity","volume":"17","author":"Gueorguiev","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.psychres.2012.09.051_bib17","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/jc.2006-2657","article-title":"Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2diabetes","volume":"92","author":"Gueorguiev","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.psychres.2012.09.051_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.biopsych.2009.10.015","article-title":"Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder","volume":"67","author":"Gyawali","year":"2010","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0006-3223(01)01322-1","article-title":"Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22","volume":"51","author":"Hamilton","year":"2002","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2011.02.002","article-title":"Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence","volume":"180","author":"Hansson","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.psychres.2012.09.051_bib21","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib22","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1210\/jcem.87.6.8672","article-title":"Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students","volume":"87","author":"Hinney","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.psychres.2012.09.051_bib23","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.psyneuen.2004.01.005","article-title":"Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women","volume":"29","author":"Ho","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psychres.2012.09.051_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/YPG.0b013e32832a9bbd","article-title":"Association between the obestatin and BDNF gene polymorphism and panic disorder, and depressive disorder","volume":"19","author":"Ishii","year":"2009","journal-title":"Psychiatric Genetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neures.2011.12.002","article-title":"Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats","volume":"72","author":"Ishitobi","year":"2012","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib26","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.pnpbp.2006.05.005","article-title":"Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats","volume":"30","author":"Kanehisa","year":"2006","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/08039488.2010.525258","article-title":"No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders","volume":"65","author":"Kindler","year":"2011","journal-title":"Nordic Journal of Psychiatry"},{"key":"10.1016\/j.psychres.2012.09.051_bib28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2012.09.051_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00008571-199606000-00007","article-title":"Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders","volume":"6","author":"Lachman","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib30","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/j.1530-0277.2010.01236.x","article-title":"Genetic variation of the ghrelin signaling system in females with severe alcohol dependence","volume":"34","author":"Landgren","year":"2010","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clinbiochem.2005.01.008","article-title":"Mutation analysis of the preproghrelin gene: no association with obesity and type 2diabetes","volume":"38","author":"Larsen","year":"2005","journal-title":"Clinical Biochemistry"},{"key":"10.1016\/j.psychres.2012.09.051_bib32","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn.2139","article-title":"The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress","volume":"11","author":"Lutter","year":"2008","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.psychres.2012.09.051_bib33","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/oby.2007.125","article-title":"Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles","volume":"16","author":"Martin","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.psychres.2012.09.051_bib34","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3346\/jkms.2011.26.6.701","article-title":"The genetic basis of panic disorder","volume":"26","author":"Na","year":"2011","journal-title":"Journal of Korean Medical Science"},{"key":"10.1016\/j.psychres.2012.09.051_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/YPG.0b013e328306c979","article-title":"Ghrelin gene polymorphism is associated with depression, but not panic disorder","volume":"18","author":"Nakashima","year":"2008","journal-title":"Psychiatric Genetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajmg.b.20164","article-title":"Angiotensin-related genes in patients with panic disorder","volume":"127B","author":"Olsson","year":"2004","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.psychres.2012.09.051_bib37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/j.1550-8528.1998.tb00361.x","article-title":"Psychiatric ill-health of women and its relationship to obesity and body fat distribution","volume":"6","author":"Rosmond","year":"1998","journal-title":"Obesity Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib38","first-page":"1853","article-title":"Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities","volume":"83","author":"Rosmond","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.psychres.2012.09.051_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S1461145703004061","article-title":"Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia","volume":"7","author":"Rothe","year":"2004","journal-title":"The International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2012.09.051_bib40","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1038\/sj.npp.1301048","article-title":"Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder","volume":"31","author":"Rothe","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2012.09.051_bib41","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1460-9568.2011.07640.x","article-title":"Gastrectomy alters emotional reactivity in rats: neurobiological mechanisms","volume":"33","author":"Salome","year":"2011","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.psychres.2012.09.051_bib42","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1210\/jc.2005-0549","article-title":"Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish","volume":"90","author":"Steinle","year":"2005","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.psychres.2012.09.051_bib43","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2012.09.051_bib44","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/oby.2002.106","article-title":"Role of ghrelin polymorphisms in obesity based on three different studies","volume":"10","author":"Ukkola","year":"2002","journal-title":"Obesity Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib45","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1210\/endo.141.11.7873","article-title":"The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion","volume":"141","author":"Wren","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.psychres.2012.09.051_bib46","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neures.2005.08.013","article-title":"Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population","volume":"53","author":"Yoon","year":"2005","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.psychres.2012.09.051_bib47","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178112005525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178112005525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T18:46:15Z","timestamp":1562265975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178112005525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0165178112005525"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2012.09.051","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}