{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:13:38Z","timestamp":1789683218935,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["psy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.psychres.2014.03.022","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T08:01:07Z","timestamp":1396080067000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of antipsychotic drugs on insight in schizophrenia"],"prefix":"10.1016","volume":"218","author":[{"given":"Oriana","family":"Bianchini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Porcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nespeca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Cannav\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Trappoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Aguglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"De Ronchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.psychres.2014.03.022_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5498\/wjp.v2.i5.74","article-title":"Medication adherence in schizophrenia","volume":"2","author":"Acosta","year":"2012","journal-title":"World Journal of Psychiatry"},{"issue":"7\u20138","key":"10.1016\/j.psychres.2014.03.022_bib2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0278-5846(02)00242-7","article-title":"Insight in persons with schizophrenia: effects of switching from conventional neuroleptics to atypical antipsychotics","volume":"26","author":"Aguglia","year":"2002","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.psychres.2014.03.022_bib3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1192\/bjp.189.3.204","article-title":"Insight in psychosis and neuropsychological function: meta-analysis","volume":"189","author":"Aleman","year":"2006","journal-title":"British Journal of Psychiatry"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0193-953X(05)70359-2","article-title":"Psychopathologic domains and insight in schizophrenia","volume":"21","author":"Amador","year":"1998","journal-title":"Psychiatric Clinics of North America"},{"issue":"6","key":"10.1016\/j.psychres.2014.03.022_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1176\/ajp.150.6.873","article-title":"Assessment of insight in psychosis","volume":"150","author":"Amador","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.psychres.2014.03.022_bib6","series-title":"Scale to Assess Unawareness of Mental Disorder SUMD","author":"Amador","year":"1990"},{"issue":"4","key":"10.1016\/j.psychres.2014.03.022_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.eurpsy.2008.12.010","article-title":"Dissociating self-reported cognitive complaint from clinical insight in schizophrenia","volume":"24","author":"Bayard","year":"2009","journal-title":"European Psychiatry"},{"key":"10.1016\/j.psychres.2014.03.022_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1192\/bjp.161.5.599","article-title":"The assessment of insight in psychosis","volume":"161","author":"David","year":"1992","journal-title":"British Journal of Psychiatry: The Journal of Mental Science"},{"key":"10.1016\/j.psychres.2014.03.022_bib9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1192\/bjp.156.6.798","article-title":"Insight and psychosis","volume":"156","author":"David","year":"1990","journal-title":"British Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.psychres.2014.03.022_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.comppsych.2011.02.010","article-title":"The relationship between cognitive insight, clinical insight, and depression in patients with schizophrenia","volume":"53","author":"Ekinci","year":"2012","journal-title":"Comprehensive Psychiatry"},{"issue":"2","key":"10.1016\/j.psychres.2014.03.022_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/YCO.0b013e3282f33f76","article-title":"Predictors of long-term outcome in schizophrenia","volume":"21","author":"Emsley","year":"2008","journal-title":"Current Opinion in Psychiatry"},{"issue":"4","key":"10.1016\/j.psychres.2014.03.022_bib13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/schbul\/23.4.637","article-title":"Determinants of medication compliance in schizophrenia: empirical and clinical findings","volume":"23","author":"Fenton","year":"1997","journal-title":"Schizophrenia Bulletin"},{"issue":"12","key":"10.1016\/j.psychres.2014.03.022_bib14","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.4088\/JCP.11r06927","article-title":"Mid-term and long-term efficacy and effectiveness of antipsychotic medications for schizophrenia: a data-driven, personalized clinical approach","volume":"72","author":"Glick","year":"2011","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.psychres.2014.03.022_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.clinpsy.3.022806.091529","article-title":"Stimulating the development of drug treatments to improve cognition in schizophrenia","volume":"3","author":"Green","year":"2007","journal-title":"Annual Review of Clinical Psychology"},{"issue":"7","key":"10.1016\/j.psychres.2014.03.022_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7326\/0003-4819-157-7-201210020-00525","article-title":"Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis","volume":"157","author":"Hartling","year":"2012","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1016\/j.psychres.2014.03.022_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0010-440X(99)90144-X","article-title":"Awareness of being a patient and its relevance to insight into illness in patients with schizophrenia","volume":"40","author":"Hayashi","year":"1999","journal-title":"Comprehensive Psychiatry"},{"key":"10.1016\/j.psychres.2014.03.022_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1192\/S0007125000291514","article-title":"The Positive and Negative Syndrome Scale (PANSS): rationale and standardisation","volume":"7","author":"Kay","year":"1989","journal-title":"British Journal of Psychiatry \u2013 Supplement"},{"issue":"2","key":"10.1016\/j.psychres.2014.03.022_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/oxfordjournals.schbul.a033374","article-title":"The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis","volume":"25","author":"Keefe","year":"1999","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.psychres.2014.03.022_bib21","unstructured":"Kemp, R.A., David, A.S., 1997. Extended version of the Schedule for the Assessment of Insight Treatment Compliance and the Treatment Alliance in Serious Mental Illness."},{"issue":"2","key":"10.1016\/j.psychres.2014.03.022_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0010-440X(97)90091-2","article-title":"Insight and clinical correlates in schizophrenia","volume":"38","author":"Kim","year":"1997","journal-title":"Comprehensive Psychiatry"},{"issue":"3","key":"10.1016\/j.psychres.2014.03.022_bib23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.psychres.2013.02.016","article-title":"Is insight in schizophrenia multidimensional? Internal structure and associations of the Greek version of the Schedule for the Assessment of Insight-Expanded","volume":"209","author":"Konstantakopoulos","year":"2013","journal-title":"Psychiatry Research"},{"issue":"10","key":"10.1016\/j.psychres.2014.03.022_bib24","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4088\/JCP.v63n1007","article-title":"Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature","volume":"63","author":"Lacro","year":"2002","journal-title":"Journal of Clinical Psychiatry"},{"issue":"10","key":"10.1016\/j.psychres.2014.03.022_bib25","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1017\/S0033291709005455","article-title":"Second-generation antipsychotics for schizophrenia: can we resolve the conflict?","volume":"39","author":"Leucht","year":"2009","journal-title":"Psychological Medicine"},{"issue":"10","key":"10.1016\/j.psychres.2014.03.022_bib26","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1017\/S0033291709990882","article-title":"Second-generation antipsychotics: a therapeutic downturn?","volume":"39","author":"Lewis","year":"2009","journal-title":"Psychological Medicine"},{"issue":"5","key":"10.1016\/j.psychres.2014.03.022_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0010-440X(95)90118-3","article-title":"Insight in clinical psychiatry revisited","volume":"36","author":"Markova","year":"1995","journal-title":"Comprehensive Psychiatry"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00005053-198901000-00007","article-title":"Insight in schizophrenia. Its relationship to acute psychopathology","volume":"177","author":"McEvoy","year":"1989","journal-title":"Journal of Nervous and Mental Disease"},{"issue":"10","key":"10.1016\/j.psychres.2014.03.022_bib29","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1017\/S0033291706007793","article-title":"Insight in first-episode psychosis","volume":"36","author":"McEvoy","year":"2006","journal-title":"Psychological Medicine"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/14737175.2014.864237","article-title":"Current and future treatment modalities in schizophrenia: novel antipsychotic drugs and cognitive therapy","volume":"14","author":"McKenna","year":"2014","journal-title":"Expert Review of Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0920-9964(02)00316-X","article-title":"Insight in schizophrenia: a meta-analysis","volume":"61","author":"Mintz","year":"2003","journal-title":"Schizophrenia Research"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/08039488.2011.598556","article-title":"The influence of therapeutic alliance and insight on medication adherence in schizophrenia","volume":"66","author":"Misdrahi","year":"2012","journal-title":"Nordic Journal of Psychiatry"},{"issue":"9","key":"10.1016\/j.psychres.2014.03.022_bib32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00005053-199909000-00001","article-title":"Insight in schizophrenia: its relationship to measures of executive functions","volume":"187","author":"Mohamed","year":"1999","journal-title":"Journal of Nervous and Mental Disease"},{"issue":"1 Suppl. 1","key":"10.1016\/j.psychres.2014.03.022_bib33","first-page":"S29","article-title":"Use of ziprasidone in patients with schizophrenia in four European countries","volume":"26","author":"Montes","year":"2012","journal-title":"European Psychiatry"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1176\/appi.ajp.158.1.122","article-title":"Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features","volume":"158","author":"Pini","year":"2001","journal-title":"American Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.psychres.2014.03.022_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.comppsych.2007.08.013","article-title":"Correlations of attitudes toward antipsychotic drugs with insight and objective psychopathology in schizophrenia","volume":"49","author":"Rocca","year":"2008","journal-title":"Comprehensive Psychiatry"},{"issue":"5","key":"10.1016\/j.psychres.2014.03.022_bib36","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1371\/journal.pmed.0020141","article-title":"A systematic review of the prevalence of schizophrenia","volume":"2","author":"Saha","year":"2005","journal-title":"PLoS Medicine"},{"issue":"10","key":"10.1016\/j.psychres.2014.03.022_bib37","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1176\/appi.ps.53.10.1319","article-title":"Insight into illness and attitudes toward medications among inpatients with schizophrenia","volume":"53","author":"Sajatovic","year":"2002","journal-title":"Psychiatric Services"},{"issue":"5","key":"10.1016\/j.psychres.2014.03.022_bib38","first-page":"405","article-title":"Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives","volume":"27","author":"Semkovska","year":"2001","journal-title":"L\u05f3Enc\u00e9phale"},{"issue":"1","key":"10.1016\/j.psychres.2014.03.022_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eurpsy.2008.07.009","article-title":"The socio-economical burden of schizophrenia: a simulation of cost-offset of early intervention program in Italy","volume":"24","author":"Serretti","year":"2009","journal-title":"European Psychiatry"},{"issue":"4","key":"10.1016\/j.psychres.2014.03.022_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.eurpsy.2008.10.004","article-title":"The relation between neurocognitive dysfunction and impaired insight in patients with schizophrenia","volume":"24","author":"Simon","year":"2009","journal-title":"European Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.psychres.2014.03.022_bib10","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.clinthera.2010.01.021","article-title":"Aripiprazole in schizophrenia and schizoaffective disorder: a review","volume":"32","author":"Stip","year":"2010","journal-title":"Clinical Therapeutics"},{"issue":"6","key":"10.1016\/j.psychres.2014.03.022_bib41","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.comppsych.2007.06.003","article-title":"Clinical and neuropsychological correlates of insight in schizophrenia and bipolar I disorder: does diagnosis matter?","volume":"48","author":"Varga","year":"2007","journal-title":"Comprehensive Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.psychres.2014.03.022_bib42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.schres.2011.11.017","article-title":"Are there specific neuropsychological deficits underlying poor insight in first episode psychosis?","volume":"135","author":"Wiffen","year":"2012","journal-title":"Schizophrenia Research"},{"issue":"3","key":"10.1016\/j.psychres.2014.03.022_bib43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S146114570500516X","article-title":"A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia","volume":"8","author":"Woodward","year":"2005","journal-title":"International Journal of Neuropsychopharmacology"}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178114002285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178114002285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T01:55:59Z","timestamp":1565315759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178114002285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0165178114002285"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2014.03.022","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of antipsychotic drugs on insight in schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2014.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}