{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:32:42Z","timestamp":1790292762262,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Health (NIH)"},{"DOI":"10.13039\/100000026","name":"NIDA","doi-asserted-by":"publisher","award":["P50 DA018197-10"],"award-info":[{"award-number":["P50 DA018197-10"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.psychres.2015.07.073","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T20:24:41Z","timestamp":1438201481000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans"],"prefix":"10.1016","volume":"230","author":[{"given":"Thomas F.","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin N.","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"James J.","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Verrico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Richard","family":"De La Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Kosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2015.07.073_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2011.06077.x","article-title":"Fundamentals of PET and PET\/CT imaging","volume":"1228","author":"Basu","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.psychres.2015.07.073_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-510X(98)00307-4","article-title":"Pramipexole\u2014a new dopamine agonist for the treatment of Parkinson\u2019s disease","volume":"163","author":"Bennett","year":"1999","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.psychres.2015.07.073_bib3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1523\/JNEUROSCI.4371-11.2012","article-title":"Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study","volume":"32","author":"Boileau","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psychres.2015.07.073_bib4","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1097\/00001756-199707070-00054","article-title":"D3 receptor test in vitro predicts decreased cocaine self-administration in rats","volume":"8","author":"Caine","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.psychres.2015.07.073_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/npp.2008.114","article-title":"Sustained administration of pramipexole modifies the spontaneous firing of dopamine, norepinephrine, and serotonin neurons in the rat brain","volume":"34","author":"Chernoloz","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2015.07.073_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1503\/jpn.110038","article-title":"Long-term administration of the dopamine D3\/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain","volume":"37","author":"Chernoloz","year":"2012","journal-title":"J. Psychiatry Neurosci: JPN"},{"issue":"Suppl 1","key":"10.1016\/j.psychres.2015.07.073_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1360-0443.2005.00985.x","article-title":"Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence","volume":"100","author":"Ciraulo","year":"2005","journal-title":"Addiction"},{"key":"10.1016\/j.psychres.2015.07.073_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00213-011-2382-5","article-title":"Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats","volume":"219","author":"Collins","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.psychres.2015.07.073_bib9","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.4088\/JCP.12m08093","article-title":"A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder","volume":"74","author":"Cusin","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2015.07.073_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(74)90109-5","article-title":"Rating the behavioral effects of amphetamine","volume":"28","author":"Ellinwood","year":"1974","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0924-977X(02)00055-X","article-title":"Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens","volume":"12","author":"Ellinwood","year":"2002","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2012.01.010","article-title":"Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate","volume":"134","author":"Haile","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.psychres.2015.07.073_bib13","doi-asserted-by":"crossref","first-page":"e47702","DOI":"10.1371\/journal.pone.0047702","article-title":"The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial","volume":"7","author":"Haile","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.psychres.2015.07.073_bib14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0006-3223(03)00241-5","article-title":"Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats","volume":"54","author":"Haile","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2015.07.073_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00210-012-0803-6","article-title":"Rationale in support of the use of selective dopamine D(3) receptor antagonists for the pharmacotherapeutic management of substance use disorders","volume":"386","author":"Heidbreder","year":"2013","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.euroneuro.2011.10.002","article-title":"Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment","volume":"22","author":"Kelleher","year":"2012","journal-title":"Eur. Neuropsychopharmacol.:\u00a0J. Eur. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib17","first-page":"603631","article-title":"Dopamine agonists and pathologic behaviors","volume":"2012","author":"Kelley","year":"2012","journal-title":"Parkinson\u2019s Dis."},{"key":"10.1016\/j.psychres.2015.07.073_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0033-3182(10)70695-2","article-title":"Impact of dopamine agonists on compulsive behaviors: a case series of pramipexole-induced pathological gambling","volume":"51","author":"Kolla","year":"2010","journal-title":"Psychosomatics"},{"key":"10.1016\/j.psychres.2015.07.073_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0922-4106(95)90013-6","article-title":"Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors","volume":"290","author":"Mierau","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib20","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bcp.2012.06.023","article-title":"Medication discovery for addiction: translating the dopamine D3 receptor hypothesis","volume":"84","author":"Newman","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.psychres.2015.07.073_bib21","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1046\/j.1471-4159.1996.67031078.x","article-title":"Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement","volume":"67","author":"Parsons","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.psychres.2015.07.073_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/npp.2013.192","article-title":"Heightened D dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [C]-(+)-PHNO","volume":"39","author":"Payer","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2015.07.073_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/22560","article-title":"Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist","volume":"400","author":"Pilla","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2015.07.073_bib24","first-page":"659","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.psychres.2015.07.073_bib25","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1176\/ajp.156.11.1834","article-title":"Pramipexole treatment for cocaine cravings","volume":"156","author":"Rosenbaum","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psychres.2015.07.073_bib26","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1038\/npp.2010.127","article-title":"Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine beta-hydroxylase","volume":"35","author":"Schroeder","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psychres.2015.07.073_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0169-328X(97)00025-9","article-title":"Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities. Brain Research","volume":"45","author":"Segal","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.psychres.2015.07.073_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/347146a0","article-title":"Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics","volume":"347","author":"Sokoloff","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2015.07.073_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1369-1600.2011.00317.x","article-title":"YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice","volume":"17","author":"Song","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.psychres.2015.07.073_bib30","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1523\/JNEUROSCI.16-19-06100.1996","article-title":"Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities","volume":"16","author":"Staley","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psychres.2015.07.073_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1254\/jphs.12096SC","article-title":"Pramipexole upregulates dopamine receptor D2 and D3 expression in rat striatum","volume":"120","author":"Tokunaga","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.psychres.2015.07.073_bib32","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1523\/JNEUROSCI.22-21-09595.2002","article-title":"Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats","volume":"22","author":"Vorel","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psychres.2015.07.073_bib33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archneurol.2010.65","article-title":"Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients","volume":"67","author":"Weintraub","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.psychres.2015.07.073_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1126\/science.276.5309.122","article-title":"A general model for the origin of allometric scaling laws in biology","volume":"276","author":"West","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.psychres.2015.07.073_bib35","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1111\/j.1460-9568.2005.04159.x","article-title":"Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats","volume":"21","author":"Xi","year":"2005","journal-title":"Eur. J. Neurosci."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178115005338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178115005338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T16:51:06Z","timestamp":1691859066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178115005338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0165178115005338"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2015.07.073","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2015.07.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}