{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:06:52Z","timestamp":1791860812304,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["psy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.psychres.2016.07.027","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T23:03:34Z","timestamp":1468883014000},"page":"19-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Altered serum levels of TNF-\u03b1, IL-6 and IL-18 in manic, depressive, mixed state of bipolar disorder patients"],"prefix":"10.1016","volume":"244","author":[{"given":"Yayan","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xini","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2016.07.027_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-7-9","article-title":"Interleukin 18 in the CNS","volume":"7","author":"Alboni","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.psychres.2016.07.027_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psychres.2016.07.027_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jad.2015.04.044","article-title":"IL-6, IL-18, sIL-2R, and TNF\u03b1 proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation","volume":"82","author":"Al-Hakeim","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jad.2014.05.009","article-title":"Comparison of inflammatory cytokine levels among type I\/type II and manic\/hypomanic\/euthymic\/depressive states of bipolar disorder","volume":"166","author":"Bai","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/360481","article-title":"Cytokines in bipolar disorder: paving the way for neuroprogression","volume":"360481","author":"Barbosa","year":"2014","journal-title":"Neural Plast."},{"key":"10.1016\/j.psychres.2016.07.027_bib6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","article-title":"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors","volume":"35","author":"Berk","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.psychres.2016.07.027_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S1461145708009498","article-title":"Neuroprogression: pathways to progressive brain changes in bipolar disorder","volume":"12","author":"Berk","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2016.07.027_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2008.12.001","article-title":"Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder","volume":"116","author":"Brietzke","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib9","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.pnpbp.2008.01.006","article-title":"TNF-alpha as a molecular target in bipolar disorder","volume":"32","author":"Brietzke","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.psychres.2016.07.027_bib11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00406-007-0797-0","article-title":"Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder","volume":"258","author":"Cunha","year":"2008","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.psychres.2016.07.027_bib12","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.pnpbp.2007.02.018","article-title":"Elevated serum levels of C-reactive protein are associated with mania symptoms in out-patients with bipolar disorder","volume":"31","author":"Dickerson","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1017\/S1461145710000799","article-title":"Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients","volume":"13","author":"Drexhage","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2016.07.027_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.tins.2005.06.008","article-title":"IL-18: a key player in neuroinflammation and neurodegeneration?","volume":"28","author":"Felderhoff-Mueser","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.psychres.2016.07.027_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.physbeh.2011.10.029","article-title":"Mediators of allostasis and systemic toxicity in bipolar disorder","volume":"106","author":"Grande","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psychres.2016.07.027_bib16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.pnpbp.2010.07.030","article-title":"Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders","volume":"35","author":"Gardner","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib17","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4088\/JCP.08r04505","article-title":"Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature","volume":"70","author":"Goldstein","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br. J. Soc. Clin. Psychol."},{"key":"10.1016\/j.psychres.2016.07.027_bib19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jpsychires.2011.08.003","article-title":"Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia","volume":"45","author":"Hope","year":"2011","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.psychres.2016.07.027_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-8993(99)02439-7","article-title":"Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB","volume":"857","author":"Ichiyama","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.psychres.2016.07.027_bib22","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1586\/ern.09.31","article-title":"Clinical implications of a staging model for bipolar disorders","volume":"9","author":"Kapczinski","year":"2009","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.psychres.2016.07.027_bib23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1017\/S1461145708009310","article-title":"Brain-derived neuro-trophic factor and inflammatory markers in patients with early-vs. late-stage bipolar disorder","volume":"12","author":"Kauer-Sant\u2019anna","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2016.07.027_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jad.2007.02.018","article-title":"Imbalance between pro- inflammatory and anti-inflammatory cytokines in bipolar disorder","volume":"104","author":"Kim","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1399-5618.2007.00444.x","article-title":"An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment","volume":"9","author":"Knijff","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0278-5846(01)00155-5","article-title":"The immune system, depression and the action of antidepressants","volume":"25","author":"Leonard","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.schres.2014.09.015","article-title":"Serum levels of TNF-\u03b1, IL-6 and IL-18 elevated in chronic schizophrenic patients","volume":"159","author":"Luo","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psychres.2016.07.027_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","article-title":"Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies","volume":"74","author":"Modabbernia","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2014.09.021","article-title":"Elevated levels of IL-6 and IL-18 in manic and hypomanic states in rapid cycling bipolar disorder patients","volume":"43","author":"Munkholm","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psychres.2016.07.027_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jad.2005.11.015","article-title":"Cytokine profiles in bipolar disorder: focus on acutely ill patients","volume":"90","author":"O\u2019Brien","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1399-5618.2007.00493.x","article-title":"Immune variations in bipolar disorder: phasic differences","volume":"9","author":"Ort\u00edz-Domingues","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/archpsyc.65.4.395","article-title":"A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes","volume":"65","author":"Padmos","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1742-2094-9-206","article-title":"Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia","volume":"9","author":"Palladino","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.psychres.2016.07.027_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0169-409X(98)00086-6","article-title":"Penetration of neurotrophins and cytokines across the blood-brain\/ blood-spinal cord barrier","volume":"36","author":"Pan","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.psychres.2016.07.027_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.biopsych.2010.10.014","article-title":"Association of plasma interleukin-18 levels with emotion regulation and mu-opioid neurotransmitter function in major depression and healthy volunteers","volume":"69","author":"Prossin","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib39","first-page":"12","article-title":"Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls","volume":"25","author":"Reale","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.psychres.2016.07.027_bib40","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1016\/S0006-3223(00)00950-1","article-title":"Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells","volume":"48","author":"Rajkowska","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jad.2010.11.008","article-title":"Glial pathology is modified by age in mood disorderse a systematic meta-analysis of serum S100B in vivo studies","volume":"134","author":"Schroeter","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.07.027_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0306-9877(95)90062-4","article-title":"The macrophage-T-lymphocyte theory of schizophrenia: additional evidence","volume":"45","author":"Smith","year":"1995","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.psychres.2016.07.027_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-1781(00)00196-7","article-title":"Serum interleukin-18 levels are elevated in schizophrenia","volume":"96","author":"Tanaka","year":"2000","journal-title":"Psychiatry Resid."},{"key":"10.1016\/j.psychres.2016.07.027_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1819.2010.02094.x","article-title":"Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models","volume":"64","author":"Watanabe","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.psychres.2016.07.027_bib45","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jpsychires.2012.04.026","article-title":"Elevated interleukin-18 serum levels in chronic schizophrenia: association with psychopathology","volume":"46","author":"Xiu","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psychres.2016.07.027_bib46","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psychres.2016.07.027_bib47","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4088\/JCP.v65n0710","article-title":"Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia","volume":"65","author":"Zhang","year":"2004","journal-title":"J. Clin. Psychiatry"}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178115301219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178115301219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T11:53:12Z","timestamp":1536580392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178115301219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":44,"alternative-id":["S0165178115301219"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2016.07.027","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered serum levels of TNF-\u03b1, IL-6 and IL-18 in manic, depressive, mixed state of bipolar disorder patients","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2016.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}