{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:22:17Z","timestamp":1782224537127,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Intitutes of Health (NIH)\/National Institute of Mental Health","award":["P50 MH077138"],"award-info":[{"award-number":["P50 MH077138"]}]},{"DOI":"10.13039\/100000062","name":"NIH\/National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK097599"],"award-info":[{"award-number":["DK097599"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.psychres.2016.10.042","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T06:46:25Z","timestamp":1477377985000},"page":"803-807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Familial risk for bipolar disorder is not associated with impaired peroxisomal function: Dissociation from docosahexaenoic acid deficits"],"prefix":"10.1016","volume":"246","author":[{"given":"Robert K.","family":"McNamara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann B.","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Jandacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Rodrigo","family":"Patino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Strawn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Strakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"DelBello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2016.10.042_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1176\/appi.ajp.163.2.322","article-title":"Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study","volume":"163","author":"Adler","year":"2006","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1176\/appi.ajp.2014.14010035","article-title":"Diagnostic precursors to bipolar disorder in offspring of parents with bipolar disorder: a longitudinal study","volume":"172","author":"Axelson","year":"2015","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/bdi.12205","article-title":"The predictive validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospective study","volume":"16","author":"Bechdolf","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib4","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0022-2275(20)38802-7","article-title":"Simple diagnosis of the Zellweger syndrome by gas-liquid chromatography of dimethylacetals","volume":"27","author":"Bj\u00f6rkhem","year":"1986","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib5","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1997"},{"key":"10.1016\/j.psychres.2016.10.042_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/bdi.12194","article-title":"Type and duration of subsyndromal symptoms in youth with bipolar I disorder prior to their first manic episode","volume":"16","author":"Correll","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1542\/peds.66.6.918","article-title":"Adolescents' self-assessment of sexual maturation","volume":"66","author":"Duke","year":"1980","journal-title":"Pediatrics"},{"key":"10.1016\/j.psychres.2016.10.042_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jpsychires.2014.06.001","article-title":"Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism","volume":"57","author":"Evans","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib9","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0022-2275(20)31527-3","article-title":"Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid","volume":"42","author":"Ferdinandusse","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib10","unstructured":"First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W., 1995. Structured Clinical Interview for DSM-IV Axis I Disorders \u2013 Patient Edition (SCID-I\/P). Biometrics Research Department, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032."},{"key":"10.1016\/j.psychres.2016.10.042_bib11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00004583-200104000-00014","article-title":"Reliability of the Washington University in St. Louis Kiddie schedule for affective disorders and schizophrenia (WASH-U-KSADS) mania and rapid cycling sections","volume":"40","author":"Geller","year":"2001","journal-title":"J. Am. Acad. Child Adolesc. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib12","series-title":"Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin","year":"2007"},{"key":"10.1016\/j.psychres.2016.10.042_bib13","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/MCB.18.1.616","article-title":"Pex19p, a farnesylated protein essential for peroxisome biogenesis","volume":"18","author":"G\u00f6tte","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.psychres.2016.10.042_bib14","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1017\/S0033291710001790","article-title":"A comprehensive review and model of putative prodromal features of bipolar affective disorder","volume":"41","author":"Howes","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.psychres.2016.10.042_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-2275(20)32330-0","article-title":"Rapid and quantitative analysis of unconjugated C(27) bile acids in plasma and blood samples by tandem mass spectrometry","volume":"42","author":"Johnson","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.psychres.2012.02.019","article-title":"Impaired plasmalogens in patients with schizophrenia","volume":"198","author":"Kaddurah-Daouk","year":"2012","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.schres.2012.08.014","article-title":"A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia","volume":"141","author":"van der Kemp","year":"2012","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(87)90283-X","article-title":"Stable isotope dilution analysis of pipecolic acid in cerebrospinal fluid, plasma, urine and amniotic fluid using electron capture negative ion mass fragmentography","volume":"168","author":"Kok","year":"1987","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.psychres.2016.10.042_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/mgme.2001.3170","article-title":"Quantitative determination of plasma C8-C26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders","volume":"73","author":"Lagerstedt","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.psychres.2016.10.042_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jpsychires.2010.06.010","article-title":"Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder","volume":"45","author":"Liu","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(10)80021-6","article-title":"Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders","volume":"583","author":"Martinez","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF02536332","article-title":"Blood polyunsaturated fatty acids in patients with peroxisomal disorders. A multicenter study","volume":"29","author":"Martinez","year":"1994","journal-title":"Lipids"},{"key":"10.1016\/j.psychres.2016.10.042_bib23","series-title":"Family Interview for Genetics Studies","author":"Maxwell","year":"1999"},{"key":"10.1016\/j.psychres.2016.10.042_bib24","series-title":"Handbook of Lipids in Human Function: Fatty Acids","first-page":"423","article-title":"Role of dietary fatty acids in mood disorders","author":"McNamara","year":"2015"},{"key":"10.1016\/j.psychres.2016.10.042_bib25","series-title":"Nutrition for Brain Health and Cognitive Performance","first-page":"151","article-title":"Role of long-chain omega-3 fatty acids in cognitive and emotional development","author":"McNamara","year":"2015"},{"key":"10.1016\/j.psychres.2016.10.042_bib26","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/bdi.12386","article-title":"Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder","volume":"18","author":"McNamara","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jad.2010.03.015","article-title":"Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder","volume":"126","author":"McNamara","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.psychres.2015.09.035","article-title":"First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: dissociation from clinical response to lithium or quetiapine","volume":"230","author":"McNamara","year":"2015","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/eip.12282","article-title":"Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker","volume":"10","author":"McNamara","year":"2016","journal-title":"Early Interv. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib30","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/archpsyc.60.12.1209","article-title":"Individual and familial risk factors for bipolar affective disorders in Denmark","volume":"60","author":"Mortensen","year":"2003","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1022549618333","article-title":"Plasma and red blood cell fatty acids in peroxisomal disorders","volume":"24","author":"Moser","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/1531-8249(199901)45:1<100::AID-ART16>3.0.CO;2-U","article-title":"Plasma very long chain fatty acids in 3000 peroxisome disease patients and 29,000 controls","volume":"45","author":"Moser","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.psychres.2016.10.042_bib33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jad.2013.05.034","article-title":"Systematic review and voxel-based meta-analysis of diffusion tensor imaging studies in bipolar disorder","volume":"150","author":"Nortje","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-5618.2009.00686.x","article-title":"Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study","volume":"11","author":"Perlis","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1750-3639.1998.tb00139.x","article-title":"Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis","volume":"8","author":"Powers","year":"1998","journal-title":"Brain Pathol."},{"key":"10.1016\/j.psychres.2016.10.042_bib36","first-page":"200","article-title":"Use of the children's depression rating scale in an inpatient psychiatric population","volume":"44","author":"Poznanski","year":"1983","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.psychres.2016.10.042_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1176\/jnp.11.3.315","article-title":"The neuropsychiatry of adult-onset adrenoleukodystrophy","volume":"11","author":"Rosebush","year":"1999","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.psychres.2016.10.042_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2009.10.003","article-title":"Symptoms and signs of the initial prodrome of bipolar disorder: a systematic review","volume":"126","author":"Skjelstad","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2016.10.042_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.20013","article-title":"Family, twin, and adoption studies of bipolar disorder","volume":"123C","author":"Smoller","year":"2003","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.psychres.2016.10.042_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/0471142905.hg1706s58","article-title":"Investigational methods for peroxisomal disorders","author":"Steinberg","year":"2008","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.psychres.2016.10.042_bib41","doi-asserted-by":"crossref","first-page":"38115","DOI":"10.1074\/jbc.M106326200","article-title":"Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis","volume":"276","author":"Su","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psychres.2016.10.042_bib42","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2006.08.010","article-title":"Peroxisomal disorders: the single Peroxisomal enzyme deficiencies","volume":"1763","author":"Wanders","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psychres.2016.10.042_bib43","series-title":"Wechsler Adult Intelligence Scale-Third Edition: Administration and Scoring Manual","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.psychres.2016.10.042_bib44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.schres.2014.11.032","article-title":"Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia","volume":"161","author":"Wood","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psychres.2016.10.042_bib45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.euroneuro.2006.11.006","article-title":"Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial","volume":"17","author":"Wozniak","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.psychres.2016.10.042_bib46","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatr."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178116308927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178116308927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T04:53:31Z","timestamp":1657515211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178116308927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":46,"alternative-id":["S0165178116308927"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2016.10.042","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Familial risk for bipolar disorder is not associated with impaired peroxisomal function: Dissociation from docosahexaenoic acid deficits","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2016.10.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}