{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:24:37Z","timestamp":1783038277366,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["INFANT-12\/RC\/2272"],"award-info":[{"award-number":["INFANT-12\/RC\/2272"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["10\/RFP\/NES2786"],"award-info":[{"award-number":["10\/RFP\/NES2786"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.psychres.2017.05.013","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T17:02:24Z","timestamp":1494262944000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling"],"prefix":"10.1016","volume":"255","author":[{"given":"Katie L.","family":"Togher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimear","family":"Treacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard W.","family":"O\u2019Keeffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise C.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s10995-014-1637-2","article-title":"Prenatal depression and adverse birth outcomes: an updated systematic review","volume":"19","author":"Accortt","year":"2015","journal-title":"Matern Child Health J."},{"key":"10.1016\/j.psychres.2017.05.013_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.psyneuen.2014.11.004","article-title":"Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior","volume":"52","author":"Appleton","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.psychres.2017.05.013_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/jp.2015.18","article-title":"Racial\/ethnic differences in self-reported and biologic measures of chronic stress in pregnancy","volume":"35","author":"Borders","year":"2015","journal-title":"J. Perinatol."},{"key":"10.1016\/j.psychres.2017.05.013_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.dr.2015.04.001","article-title":"Maternal prenatal stress and infant birth weight and gestational age: a meta-analysis of prospective studies","volume":"36","author":"Bussi\u00e8res","year":"2015","journal-title":"Dev. Rev."},{"issue":"4","key":"10.1016\/j.psychres.2017.05.013_bib5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"10.1016\/j.psychres.2017.05.013_bib6","article-title":"Foetal and placental 11beta-HSD2: a hub for developmental programming","author":"Cottrell","year":"2013","journal-title":"Acta Physiol. (Oxf.)"},{"issue":"3","key":"10.1016\/j.psychres.2017.05.013_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ctcp.2015.06.005","article-title":"A randomized controlled trial of yoga for pregnant women with symptoms of depression and anxiety","volume":"21","author":"Davis","year":"2015","journal-title":"Complement. Ther. Clin. Pract."},{"key":"10.1016\/j.psychres.2017.05.013_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jad.2014.02.027","article-title":"Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies","volume":"159","author":"Ding","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2017.05.013_bib9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1089\/jwh.2008.0998","article-title":"High pregnancy-related anxiety and prenatal depressive symptoms as predictors of intention to breastfeed and breastfeeding initiation","author":"Fairlie","year":"2009","journal-title":"J. Women\u2019s Health (Larchmt)"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1095\/biolreprod.115.128066","article-title":"The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight","volume":"92","author":"Green","year":"2015","journal-title":"Biol. Reprod."},{"issue":"10","key":"10.1016\/j.psychres.2017.05.013_bib11","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archgenpsychiatry.2010.111","article-title":"A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction","volume":"67","author":"Grote","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.psychres.2017.05.013_bib12","doi-asserted-by":"crossref","first-page":"e0119018","DOI":"10.1371\/journal.pone.0119018","article-title":"Antenatal depressive symptoms and the risk of preeclampsia or operative deliveries: a meta-analysis","volume":"10","author":"Hu","year":"2015","journal-title":"PLoS One"},{"issue":"2 Pt 1","key":"10.1016\/j.psychres.2017.05.013_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/01.AOG.0000275284.24298.23","article-title":"Group prenatal care and perinatal outcomes: a randomized controlled trial","volume":"110","author":"Ickovics","year":"2007","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib14","doi-asserted-by":"crossref","first-page":"e39791","DOI":"10.1371\/journal.pone.0039791","article-title":"Epigenetic effects of prenatal stress on 11beta-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain","volume":"7","author":"Jensen Pena","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.psychres.2017.05.013_bib15","first-page":"1","article-title":"Second-trimester maternal distress increases the risk of small for gestational age","author":"Khashan","year":"2014","journal-title":"Psychol. Med"},{"issue":"2","key":"10.1016\/j.psychres.2017.05.013_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/humrep\/den418","article-title":"Rates of preterm birth following antenatal maternal exposure to severe life events: a population-based cohort study","volume":"24","author":"Khashan","year":"2009","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/PSY.0b013e318177940d","article-title":"Reduced infant birthweight consequent upon maternal exposure to severe life events","volume":"70","author":"Khashan","year":"2008","journal-title":"Psychosom. Med"},{"key":"10.1016\/j.psychres.2017.05.013_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.wombi.2016.04.003","article-title":"Immediate stress reduction effects of yoga during pregnancy: one group pre-post test","author":"Kusaka","year":"2016","journal-title":"Women Birth"},{"issue":"01","key":"10.1016\/j.psychres.2017.05.013_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1079\/PNS2005478","article-title":"Developmental programming of health and disease","volume":"65","author":"Langley-Evans","year":"2006","journal-title":"Proc. Nutr. Soc."},{"issue":"2","key":"10.1016\/j.psychres.2017.05.013_bib20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ajog.2006.03.078","article-title":"Timing of scheduled cesarean delivery in patients on a teaching versus private service: adherence to American College of Obstetricians and Gynecologists guidelines and neonatal outcomes","volume":"195","author":"Laye","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.psychres.2017.05.013_bib21","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/01.AOG.0000287065.59491.70","article-title":"Prevalence, course, and risk factors for antenatal anxiety and depression","volume":"110","author":"Lee","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.psychres.2017.05.013_bib22","doi-asserted-by":"crossref","first-page":"c4990","DOI":"10.1136\/bmj.c4990","article-title":"Association of cerebral palsy with Apgar score in low and normal birthweight infants: population based cohort study","volume":"341","author":"Lie","year":"2010","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.midw.2013.11.007","article-title":"Longitudinal study of perinatal maternal stress, depressive symptoms and anxiety","volume":"30","author":"Liou","year":"2013","journal-title":"Midwifery"},{"issue":"4","key":"10.1016\/j.psychres.2017.05.013_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"issue":"Pt 3","key":"10.1016\/j.psychres.2017.05.013_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.2044-8260.1992.tb00997.x","article-title":"The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI)","volume":"31","author":"Marteau","year":"1992","journal-title":"Br. J. Clin. Psychol."},{"issue":"13","key":"10.1016\/j.psychres.2017.05.013_bib26","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/1471-0528.13233","article-title":"Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy","volume":"122","author":"McCarthy","year":"2015","journal-title":"Bjog"},{"issue":"Suppl 1","key":"10.1016\/j.psychres.2017.05.013_bib27","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2393-13-S1-S2","article-title":"The All Our Babies pregnancy cohort: design, methods, and participant characteristics","volume":"13","author":"McDonald","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"issue":"7","key":"10.1016\/j.psychres.2017.05.013_bib28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1176\/appi.ajp.2015.15091171","article-title":"Distress during pregnancy: epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior","volume":"173","author":"Monk","year":"2016","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1067\/mpd.2001.114694","article-title":"The association of Apgar score with subsequent death and cerebral palsy: a population-based study in term infants","volume":"138","author":"Moster","year":"2001","journal-title":"J. Pediatr."},{"issue":"8","key":"10.1016\/j.psychres.2017.05.013_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4161\/epi.21180","article-title":"Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight","volume":"7","author":"Mulligan","year":"2012","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.psychres.2017.05.013_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/ppe.12051","article-title":"How to measure prenatal stress? A systematic review of psychometric instruments to assess psychosocial stress during pregnancy","volume":"27","author":"Nast","year":"2013","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib32","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.psyneuen.2011.09.014","article-title":"Maternal prenatal anxiety and downregulation of placental 11beta-HSD2","volume":"37","author":"O'Donnell","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.psychres.2017.05.013_bib33","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/15592294.2015.1088630","article-title":"Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis","volume":"10","author":"Palma-Gudiel","year":"2015","journal-title":"Epigenetics"},{"issue":"8","key":"10.1016\/j.psychres.2017.05.013_bib34","doi-asserted-by":"crossref","first-page":"e104913","DOI":"10.1371\/journal.pone.0104913","article-title":"Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort","volume":"9","author":"Paquette","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.psychres.2017.05.013_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2012.08.012","article-title":"Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis-2012 Curt Richter Award Winner","volume":"38","author":"Reynolds","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib36","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3109\/08039488.2011.590606","article-title":"The Swedish validation of Edinburgh Postnatal Depression Scale (EPDS) during pregnancy","volume":"65","author":"Rubertsson","year":"2011","journal-title":"Nord J. Psychiatry"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib37","first-page":"875","article-title":"Apgar scores and cognitive performance at 17 years of age","volume":"77","author":"Seidman","year":"1991","journal-title":"Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.psychres.2017.05.013_bib38","doi-asserted-by":"crossref","first-page":"27482","DOI":"10.3390\/ijms161126034","article-title":"Maternal prenatal mental health and placental 11beta-HSD2 gene expression: initial findings from the mercy pregnancy and emotional wellbeing study","volume":"16","author":"Seth","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1515\/jpm-2012-0295","article-title":"Psychosocial stress in pregnancy and preterm birth: associations and mechanisms","volume":"41","author":"Shapiro","year":"2013","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.psychres.2017.05.013_bib40","first-page":"10","article-title":"Methylation of the glucocorticoid receptor (NR3C1) in placenta is associated with infant cry acoustics","author":"Sheinkopf","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.psychres.2017.05.013_bib41","first-page":"28","article-title":"Heat loss prevention in neonates","author":"Soll","year":"2008","journal-title":"J. Perinatol."},{"issue":"1","key":"10.1016\/j.psychres.2017.05.013_bib42","first-page":"65","article-title":"Low 5-minute Apgar score: a population-based register study of 1 million term births","volume":"98","author":"Thorngren-Jerneck","year":"2001","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib43","doi-asserted-by":"crossref","DOI":"10.4161\/epi.28703","article-title":"Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal development","volume":"9","author":"Togher","year":"2014","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.psychres.2017.05.013_bib44","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/nur.20389","article-title":"The impact of miscarriage and parity on patterns of maternal distress in pregnancy","volume":"33","author":"Woods-Giscomb\u00e9","year":"2010","journal-title":"Res. Nurs. Health"},{"key":"10.1016\/j.psychres.2017.05.013_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/s12884-014-0369-z","article-title":"Antenatal mindfulness intervention to reduce depression, anxiety and stress: a pilot randomised controlled trial of the MindBabyBody program in an Australian tertiary maternity hospital","volume":"14","author":"Woolhouse","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"issue":"6","key":"10.1016\/j.psychres.2017.05.013_bib46","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ejhg.2013.226","article-title":"Site-specific methylation of placental HSD11B2 gene promoter is related to intrauterine growth restriction","volume":"22","author":"Zhao","year":"2014","journal-title":"Eur. J. Hum. Genet."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016517811631616X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016517811631616X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T09:03:12Z","timestamp":1655629392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016517811631616X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":46,"alternative-id":["S016517811631616X"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2017.05.013","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2017.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}