{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:33:36Z","timestamp":1782488016324,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["psy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.psychres.2017.12.062","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T18:07:03Z","timestamp":1514916423000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Thiol\/disulphide homeostasis in bipolar disorder"],"prefix":"10.1016","volume":"261","author":[{"given":"Gamze","family":"Erzin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahap Ozan","family":"Kotan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Top\u00e7uo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcven","family":"\u00d6zkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia Nazik","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"\u00dcrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makbule \u00c7i\u011fdem","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"G\u00f6ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2017.12.062_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/comp.2001.19756","article-title":"Reliability and validity of the Turkish version of the Hamilton Depression Rating Scale","volume":"42","author":"Akdemir","year":"2001","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib2","doi-asserted-by":"crossref","first-page":"e8508","DOI":"10.1136\/bmj.e8508","article-title":"Bipolar disorder","volume":"345","author":"Anderson","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.psychres.2017.12.062_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jad.2008.04.013","article-title":"Oxidative stress markers in bipolar disorder: a meta-analysis","volume":"111","author":"Andreazza","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2017.12.062_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jpsychires.2014.04.017","article-title":"Inflammatory mediators of cognitive impairment in bipolar disorder","volume":"56","author":"Bauer","year":"2014","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.psychres.2017.12.062_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/1871527315666160321104059","article-title":"Mood stabilizers, oxidative stress and antioxidative defense in euthymia of bipolar disorder","volume":"15","author":"Bengesser","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.psychres.2017.12.062_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00441-004-0976-5","article-title":"Redox imbalance","volume":"318","author":"Berg","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bcp.2005.10.044","article-title":"Redox modifications of protein-thiols: emerging roles in cell signaling","volume":"71","author":"Biswas","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.psychres.2017.12.062_bib8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neubiorev.2010.10.008","article-title":"Oxidative stress in schizophrenia: an integrated approach","volume":"35","author":"Bitanihirwe","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psychres.2017.12.062_bib9","first-page":"237","article-title":"Oxidative stress in schizophrenia - focusing on the main markers","volume":"23","author":"Ciobica","year":"2011","journal-title":"Psychiatr. Danub"},{"key":"10.1016\/j.psychres.2017.12.062_bib10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.psychres.2017.12.062_bib11","doi-asserted-by":"crossref","first-page":"26489","DOI":"10.1074\/jbc.R113.462929","article-title":"Oxidant sensing by reversible disulfide bond formation","volume":"288","author":"Cremers","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psychres.2017.12.062_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jsbmb.2013.07.007","article-title":"17\u03b2-estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease (Ape1) in the cerebral cortex of female mice following hypoxia","volume":"138","author":"Dietrich","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.psychres.2017.12.062_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01818955","article-title":"Parkinson's disease and weight loss: a study with anthropometric and nutritional assessment","volume":"2","author":"Durrieu","year":"1992","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4088\/JCP.v62n0614","article-title":"Determinants of overweight and obesity in patients with bipolar disorder","volume":"62","author":"Elmslie","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A novel and automated assay for thiol\/disulphide homeostasis","volume":"47","author":"Erel","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.psychres.2017.12.062_bib16","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1089\/ars.2006.8.2187","article-title":"Redox control of apoptosis: an update","volume":"8","author":"Filomeni","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.psychres.2017.12.062_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.biopsych.2013.03.018","article-title":"Meta-analysis of oxidative stress in schizophrenia","volume":"74","author":"Flatow","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/bdi.12151","article-title":"Sex hormones and biomarkers of neuroprotection and neurodegeneration: implications for female reproductive events in bipolar disorder","volume":"16","author":"Frey","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2017.12.062_bib19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.pnpbp.2005.11.009","article-title":"Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine","volume":"30","author":"Gama","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.pnpbp.2006.09.012","article-title":"Assessment of malondialdehyde levels in schizophrenia: a meta-analysis and some methodological considerations","volume":"31","author":"Grignon","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib21","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.jpsychires.2013.06.018","article-title":"Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects","volume":"47","author":"Gubert","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib22","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.freeradbiomed.2009.08.021","article-title":"Measuring the poise of thiol\/disulfide couples in vivo","volume":"47","author":"Jones","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.psychres.2017.12.062_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpsychires.2010.05.015","article-title":"Peripheral biomarkers and illness activity in bipolar disorder","volume":"45","author":"Kapczinski","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib24","first-page":"107","article-title":"Reliability and validity of Turkish translation of Young Mania Rating Scale","volume":"13","author":"Karada\u011f","year":"2002","journal-title":"Turk. Psikiyatr. Derg."},{"key":"10.1016\/j.psychres.2017.12.062_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1399-5618.2007.00386.x","article-title":"Nutrition and exercise behavior among patients with bipolar disorder","volume":"9","author":"Kilbourne","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2017.12.062_bib26","doi-asserted-by":"crossref","first-page":"9616593","DOI":"10.1155\/2016\/9616593","article-title":"Antipsychotic treatment reduces indices of oxidative stress in first-episode psychosis patients","volume":"2016","author":"Kriisa","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.psychres.2017.12.062_bib27","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.pnpbp.2008.07.001","article-title":"Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia","volume":"32","author":"Kunz","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib28","doi-asserted-by":"crossref","first-page":"899","DOI":"10.4088\/JCP.v68n0612","article-title":"Increased mortality among patients admitted with major psychiatric disorders: a register-based study comparing mortality in unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia","volume":"68","author":"Laursen","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2007.05.016","article-title":"Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects","volume":"421","author":"Machado-Vieira","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psychres.2017.12.062_bib30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1600-0447.2012.01908.x","article-title":"In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes","volume":"127","author":"Maes","year":"2013","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.psychres.2017.12.062_bib31","first-page":"7","article-title":"Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways","volume":"32","author":"Maes","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.psychres.2017.12.062_bib32","first-page":"157","article-title":"Oxidative stress as marker of positive symptoms in schizophrenia","volume":"9","author":"Pavlovi\u0107","year":"2002","journal-title":"Facta Univ. - Ser.: Med. Biol."},{"key":"10.1016\/j.psychres.2017.12.062_bib33","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1046\/j.1460-9568.2003.02590.x","article-title":"The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP +-induced apoptosis","volume":"17","author":"Qing","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.psychres.2017.12.062_bib34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pnpbp.2012.07.013","article-title":"Reduced antioxidant defense systems in schizophrenia and bipolar I disorder","volume":"39","author":"Raffa","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1196\/annals.1344.035","article-title":"The in vitro effect of estradiol and testosterone on iron-induced lipid peroxidation in rat brain and kidney tissues","volume":"1053","author":"Requintina","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.psychres.2017.12.062_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jad.2015.03.058","article-title":"Oxidative markers of myeloperoxidase and catalase and their diagnostic performance in bipolar disorder","volume":"181","author":"Selek","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2017.12.062_bib37","doi-asserted-by":"crossref","first-page":"653S","DOI":"10.1093\/ajcn\/72.2.653S","article-title":"Thiol homeostasis and supplements in physical exercise","volume":"72","author":"Sen","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.psychres.2017.12.062_bib38","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.biopsych.2005.04.052","article-title":"Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells","volume":"58","author":"Shao","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2013.05.001","article-title":"Glutathione metabolism and Parkinson's disease","volume":"62","author":"Smeyne","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.psychres.2017.12.062_bib40","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1523\/JNEUROSCI.0886-13.2013","article-title":"Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ER\u03b1 signaling on astrocytes but not through ER\u03b2 signaling on astrocytes or neurons","volume":"33","author":"Spence","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psychres.2017.12.062_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10571-012-9867-6","article-title":"Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells","volume":"33","author":"Steele","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.psychres.2017.12.062_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.psychres.2017.02.016","article-title":"Thiol\/disulfide homeostasis in untreated schizophrenia patients","volume":"251","author":"Topcuoglu","year":"2017","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.psychres.2015.12.005","article-title":"Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder","volume":"235","author":"Tsai","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2014.10.045","article-title":"Thiobarbituric acid reactive substances (TBARS) is a state biomarker of oxidative stress in bipolar patients in a manic phase","volume":"173","author":"Tsai","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2017.12.062_bib45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.psychres.2015.04.046","article-title":"Oxidative stress in bipolar and schizophrenia patients","volume":"228","author":"Tun\u00e7el","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psychres.2017.12.062_bib46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clineuro.2016.12.009","article-title":"Impairment of dynamic thiol-disulphide homeostasis in patients with idiopathic Parkinson's disease and its relationship with clinical stage of disease","volume":"153","author":"Vural","year":"2017","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.psychres.2017.12.062_bib47","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1001\/archpsyc.1988.01800320058007","article-title":"A structured interview guide for the Hamilton Depression Rating Scale","volume":"45","author":"Williams","year":"1988","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psychres.2017.12.062_bib48","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tins.2003.08.009","article-title":"Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics","volume":"26","author":"Zecca","year":"2003","journal-title":"Trends Neurosci."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178117306285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178117306285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T01:13:13Z","timestamp":1533345193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178117306285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":48,"alternative-id":["S0165178117306285"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2017.12.062","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiol\/disulphide homeostasis in bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2017.12.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}