{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:03:12Z","timestamp":1785322992850,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["104-2410-H-030-014-MY2"],"award-info":[{"award-number":["104-2410-H-030-014-MY2"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["MOST 105-2410-H-431-005"],"award-info":[{"award-number":["MOST 105-2410-H-431-005"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["MOST 106-2410-H-431-006"],"award-info":[{"award-number":["MOST 106-2410-H-431-006"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.psychres.2018.07.031","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T02:49:54Z","timestamp":1532573394000},"page":"508-513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Motor function in an animal model with ouabain-induced bipolar disorder and comorbid anxiety behavior"],"prefix":"10.1016","volume":"268","author":[{"given":"Ying-Chou","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Li","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-7302","authenticated-orcid":false,"given":"Andrew Chih Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2018.07.031_bib0001","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0278-5846(99)00111-6","article-title":"Open field is more sensitive than automated activity monitor in documenting ouabain-induced hyperlocomotion in the development of an animal model for bipolar illness","volume":"24","author":"Decker","year":"2000","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0002","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1034\/j.1399-5618.2003.00053.x","article-title":"Intracerebroventricular administration of ouabain as a model of mania in rats","volume":"5","author":"El-Mallakh","year":"2003","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0003","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11126-008-9071-5","article-title":"Comorbid anxiety in bipolar disorder alters treatment and prognosis","volume":"79","author":"El-Mallakh","year":"2008","journal-title":"Psychiatr. Q."},{"key":"10.1016\/j.psychres.2018.07.031_bib0004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-3223(94)00201-D","article-title":"The Na,K-ATPase hypothesis for bipolar illness","volume":"37","author":"El-Mallakh","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0005","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0165-0327(95)00023-G","article-title":"Complex and rapid-cycling in bipolar children and adolescents: a preliminary study","volume":"34","author":"Geller","year":"1995","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11920-014-0540-2","article-title":"The importance of anxiety states in bipolar disorder","volume":"17","author":"Goes","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psychres.2018.07.031_bib0007","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.neubiorev.2007.04.001","article-title":"Mimicking human bipolar ion dysregulation models mania in rats","volume":"31","author":"Herman","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psychres.2018.07.031_bib0008","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11920-008-0022-5","article-title":"Anxiety symptoms and syndromes in bipolar children and adolescents","volume":"10","author":"Jolin","year":"2008","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psychres.2018.07.031_bib0009","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.chc.2008.12.005","article-title":"Comorbidity in pediatric bipolar disorder","volume":"18","author":"Joshi","year":"2009","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.psychres.2018.07.031_bib0010","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1586\/ern.09.31","article-title":"Clinical implications of a staging model for bipolar disorders","volume":"9","author":"Kapczinski","year":"2009","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.psychres.2018.07.031_bib0011","first-page":"5","article-title":"Prevalence and impact of comorbid anxiety and bipolar disorder","volume":"67","author":"Keller","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0012","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.pnpbp.2008.05.027","article-title":"Dose-dependent effect of intracerebroventricular injection of ouabain on the phosphorylation of the MEK1\/2-ERK1\/2-p90RSK pathway in the rat brain related to locomotor activity","volume":"32","author":"Kim","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0013","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1423-0127-17-29","article-title":"Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder","volume":"17","author":"Kung","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.psychres.2018.07.031_bib0014","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuroscience.2015.08.041","article-title":"Animal models of bipolar mania: the past, present and future","volume":"321","author":"Logan","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.psychres.2018.07.031_bib0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1399-2406.2003.00061.x","article-title":"The role of atypical antipsychotics in bipolar depression and anxiety disorders","volume":"2","author":"McIntyre","year":"2003","journal-title":"Bipolar. Disord"},{"key":"10.1016\/j.psychres.2018.07.031_bib0016","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1399-5618.2006.00355.x","article-title":"Anxiety disorders and bipolar disorder: a review","volume":"8","author":"McIntyre","year":"2006","journal-title":"Bipolar. Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0017","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jad.2009.04.018","article-title":"The quantitative assessment of motor activity in mania and schizophrenia","volume":"120","author":"Minassian","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0018","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ebiom.2015.09.006","article-title":"A lifetime prevalence of comorbidity between bipolar affective disorder and anxiety disorders: a meta-analysis of 52 interview-based studies of psychiatric population","volume":"2","author":"Nabavi","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.psychres.2018.07.031_bib0019","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.psychres.2018.07.031_bib0020","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/eb-2016-102412","article-title":"Prevalence, impact and treatment of generalised anxiety disorder in bipolar disorder: a systematic review and meta-analysis","volume":"19","author":"Preti","year":"2016","journal-title":"Evid. Based. Ment. Health"},{"key":"10.1016\/j.psychres.2018.07.031_bib0021","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0165-0327(02)00091-5","article-title":"Neuropsychology of bipolar disorder: a review","volume":"72","author":"Quraishi","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0022","first-page":"21","article-title":"Diagnosis and management of bipolar disorder with comorbid anxiety in the elderly","volume":"67 Suppl 1","author":"Sajatovic","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2005.09.009","article-title":"Distinct seasonality of depressive episodes differentiates unipolar depressive patients with and without depressive mixed states","volume":"90","author":"Sato","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2018.07.031_bib0024","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s11910-016-0706-x","article-title":"Mental health comorbidity in MS: depression, anxiety, and bipolar disorder","volume":"16","author":"Turner","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.psychres.2018.07.031_bib0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuropharm.2016.10.015","article-title":"Lithium and valproate act on the GSK-3beta signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain","volume":"117","author":"Valvassori","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.psychres.2018.07.031_bib0026","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.psyneuen.2007.02.008","article-title":"Opposite effects of maternal separation on intermale and maternal aggression in C57BL\/6 mice: link to hypothalamic vasopressin and oxytocin immunoreactivity","volume":"32","author":"Veenema","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psychres.2018.07.031_bib0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4088\/JCP.v67n0518","article-title":"Bipolar disorder and comorbid anxiety disorders in children and adolescents","volume":"67","author":"Wagner","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0028","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pbb.2013.02.004","article-title":"Effects of lithium and carbamazepine on spatial learning and depressive behavior in a rat model of bipolar disorder induced by ouabain","volume":"105","author":"Wang","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.psychres.2018.07.031_bib0029","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1176\/ajp.152.2.271","article-title":"Attention deficit hyperactivity disorder in adolescent mania","volume":"152","author":"West","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psychres.2018.07.031_bib0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/104454603322724887","article-title":"Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorder","volume":"13","author":"Wilens","year":"2003","journal-title":"J. Child Adolesc. Psychopharmacol."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178117319522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178117319522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T05:34:59Z","timestamp":1759037699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178117319522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":30,"alternative-id":["S0165178117319522"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2018.07.031","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor function in an animal model with ouabain-induced bipolar disorder and comorbid anxiety behavior","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2018.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}