{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:10:21Z","timestamp":1790021421207,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023\\u201300248157"],"award-info":[{"award-number":["RS-2023\\u201300248157"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010418","name":"Institute for Information and Communications Technology Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["IITP-2024-RS-2024\\u201300438239"],"award-info":[{"award-number":["IITP-2024-RS-2024\\u201300438239"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.psychres.2025.116587","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T10:08:01Z","timestamp":1749377281000},"page":"116587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Global burden of insomnia medication-associated suicidality, 1967\u20132024: A disproportionality analysis of the global pharmacovigilance database"],"prefix":"10.1016","volume":"351","author":[{"given":"Tae Hyeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-4367","authenticated-orcid":false,"given":"Suhyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7463-4094","authenticated-orcid":false,"given":"Hanseul","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-2799","authenticated-orcid":false,"given":"Eun Kyoung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9948","authenticated-orcid":false,"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2025.116587_bib0001","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fpsyt.2020.00097","article-title":"Dexamethasone suppression test may predict more severe\/violent suicidal behavior","volume":"11","author":"Alacreu-Crespo","year":"2020","journal-title":"Front. Psychiatry"},{"issue":"8","key":"10.1016\/j.psychres.2025.116587_bib0002","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"issue":"suppl_1","key":"10.1016\/j.psychres.2025.116587_bib0003","doi-asserted-by":"crossref","first-page":"A353","DOI":"10.1093\/sleep\/zsy061.951","article-title":"Sleep, suicide risk, and the protective role of Sleep medicine","volume":"41","author":"Bishop","year":"2018","journal-title":"Sleep."},{"issue":"Supplement_1","key":"10.1016\/j.psychres.2025.116587_bib0004","doi-asserted-by":"crossref","first-page":"A371","DOI":"10.1093\/sleep\/zsz067.921","article-title":"Insomnia and suicide attempts following discharge from residential treatment","volume":"42","author":"Bishop","year":"2019","journal-title":"Sleep."},{"key":"10.1016\/j.psychres.2025.116587_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109815","article-title":"Clinical usefulness of dual orexin receptor antagonism beyond insomnia: neurological and psychiatric comorbidities","volume":"245","author":"Carpi","year":"2024","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.psychres.2025.116587_bib0006","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s40264-020-00911-w","article-title":"Disproportionality analysis for pharmacovigilance signal detection in small databases or subsets: recommendations for limiting false-positive associations","volume":"43","author":"Caster","year":"2020","journal-title":"Drug Saf."},{"issue":"3","key":"10.1016\/j.psychres.2025.116587_bib0007","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/bjd.18042","article-title":"A multiyear cross-sectional study of U.S. national prescribing patterns of first-generation sedating antihistamines in older adults with skin disease","volume":"182","author":"Cenzer","year":"2020","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0008","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/pds.5548","article-title":"Methods for drug safety signal detection using routinely collected observational electronic health care data: a systematic review","volume":"32","author":"Coste","year":"2023","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"11","key":"10.1016\/j.psychres.2025.116587_bib0009","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S1474-4422(23)00363-0","article-title":"Sleep, melatonin, and cardiovascular disease","volume":"22","author":"Covassin","year":"2023","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.psychres.2025.116587_bib0010","article-title":"Over-the-counter agents for the treatment of occasional disturbed sleep or transient insomnia: a systematic review of efficacy and safety","volume":"17","author":"Culpepper","year":"2015","journal-title":"Prim. Care Companion. CNS. Disord."},{"issue":"10347","key":"10.1016\/j.psychres.2025.116587_bib0011","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(22)00878-9","article-title":"Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis","volume":"400","author":"De Crescenzo","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70866-6","article-title":"Sleep disturbances as risk factors for suicidal thoughts and behaviours: a meta-analysis of longitudinal studies","volume":"10","author":"Harris","year":"2020","journal-title":"Sci. Rep."},{"issue":"S1","key":"10.1016\/j.psychres.2025.116587_bib0013","doi-asserted-by":"crossref","first-page":"S843","DOI":"10.1192\/j.eurpsy.2022.2185","article-title":"The association between melatonin and suicide: a nationwide cohort study","volume":"65","author":"H\u00f8ier","year":"2022","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.psychres.2025.116587_bib0014","doi-asserted-by":"crossref","unstructured":"H\u00f8ier Nikolaj, K., Madsen, T., Spira Adam, P., Hawton, K., Jennum, P., Nordentoft, M., Erlangsen, A., Associations between treatment with melatonin and suicidal behavior: a nationwide cohort study. J. Clin. Sleep. Med. 18 (10), 2451\u20132458.","DOI":"10.5664\/jcsm.10118"},{"issue":"10","key":"10.1016\/j.psychres.2025.116587_bib0015","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.5664\/jcsm.10118","article-title":"Associations between treatment with melatonin and suicidal behavior: a nationwide cohort study","volume":"18","author":"H\u00f8ier","year":"2022","journal-title":"J. Clin. Sleep. Med."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0016","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74729-2","article-title":"Global burden of vaccine-associated Guillain-Barr\u00e9 syndrome over 170 countries from 1967 to 2023","volume":"14","author":"Jeong","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0017","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74729-2","article-title":"Global burden of vaccine-associated Guillain-Barr\u00e9 syndrome over 170 countries from 1967 to 2023","volume":"14","author":"Jeong","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.psychres.2025.116587_bib0018","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/jamapsychiatry.2020.3436","article-title":"Dissecting the association between inflammation, metabolic dysregulation, and specific depressive symptoms: a genetic correlation and 2-sample mendelian randomization study","volume":"78","author":"Kappelmann","year":"2021","journal-title":"JAMa Psychiatry"},{"key":"10.1016\/j.psychres.2025.116587_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114777","article-title":"Zolpidem use and risk of suicide: a systematic review and meta-analysis","volume":"316","author":"Khan","year":"2022","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.psychres.2025.116587_bib0020","doi-asserted-by":"crossref","first-page":"zsz235","DOI":"10.1093\/sleep\/zsz235","article-title":"Risks of suicide attempts after prescription of zolpidem in people with depression: a nationwide population study in South Korea","volume":"43","author":"Kim","year":"2020","journal-title":"Sleep."},{"issue":"11","key":"10.1016\/j.psychres.2025.116587_bib0021","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1111\/dom.15864","article-title":"Association between glucagon-like peptide-1 receptor agonists and risk of suicidality: a comprehensive analysis of the global pharmacovigilance database","volume":"26","author":"Kim","year":"2024","journal-title":"Diabetes. Obes. Metab."},{"issue":"2","key":"10.1016\/j.psychres.2025.116587_bib0022","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/02698811241309619","article-title":"Associations of treatment with hypnotics with suicide and attempted suicide: a nationwide cohort study","volume":"39","author":"Kj\u00e6r H\u00f8ier","year":"2025","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psychres.2025.116587_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105656","article-title":"Worldwide burden of antidiabetic drug-induced sarcopenia: an international pharmacovigilance study","volume":"129","author":"Kong","year":"2025","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.psychres.2025.116587_bib0024","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.sleep.2023.08.016","article-title":"Associations between insomnia medications and risk of death by suicide","volume":"111","author":"Lavigne","year":"2023","journal-title":"Sleep. Med."},{"key":"10.1016\/j.psychres.2025.116587_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113276","article-title":"Association between anxiolytic\/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students","volume":"291","author":"Lecat","year":"2020","journal-title":"Psychiatry Res."},{"issue":"20","key":"10.1016\/j.psychres.2025.116587_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39401","article-title":"National trends in thyroid disease and COVID-19 pandemic-related factors, 1998\u20132021: a nationwide representative study in South Korea","volume":"10","author":"Lee","year":"2024","journal-title":"Heliyon."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0027","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12888-018-1702-2","article-title":"Insomnia as an independent predictor of suicide attempts: a nationwide population-based retrospective cohort study","volume":"18","author":"Lin","year":"2018","journal-title":"BMC. Psychiatry"},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0028","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1176\/appi.ajp.2016.16030336","article-title":"Hypnotic medications and suicide: risk, mechanisms, mitigation, and the FDA","volume":"174","author":"McCall","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psychres.2025.116587_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2023.115576","article-title":"The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: lessons learned","volume":"330","author":"McCall","year":"2023","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psychres.2025.116587_bib0030","first-page":"1","article-title":"Association between dual orexin receptor antagonists (DORAs) and suicidality: reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS)","author":"McIntyre","year":"2024","journal-title":"Expert. Opin. Drug Saf."},{"key":"10.1016\/j.psychres.2025.116587_bib0031","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.54724\/lc.2022.e13","article-title":"The importance of a World Health Organization international pharmacovigilance database (VigiBase): novel methods for safety monitoring and surveillance of medical products","volume":"2","author":"Min","year":"2022","journal-title":"Life. Cycle"},{"issue":"3","key":"10.1016\/j.psychres.2025.116587_bib0032","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1056\/NEJMcp2305655","article-title":"Management of insomnia","volume":"391","author":"Morin","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.psychres.2025.116587_bib0033","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13902","article-title":"The orexin story and orexin receptor antagonists for the treatment of insomnia","volume":"32","author":"Muehlan","year":"2023","journal-title":"J. Sleep. Res."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0034","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.14267","article-title":"Trends in hypnotic drug use in depression 2007-2017: a Swedish population-based study","volume":"34","author":"Nygren","year":"2025","journal-title":"J. Sleep. Res."},{"issue":"S1","key":"10.1016\/j.psychres.2025.116587_bib0035","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.2105\/AJPH.2011.300470","article-title":"Sleep disturbance preceding suicide among veterans","volume":"102","author":"Pigeon","year":"2012","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.psychres.2025.116587_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.964399","article-title":"Analysis of pharmacovigilance databases for spontaneous reports of adverse drug reactions related to substandard and falsified medical products: a descriptive study","volume":"13","author":"Pozsgai","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.psychres.2025.116587_bib0037","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.23br14923","article-title":"Dual orexin receptor antagonists and suicide risk: findings from the WHO spontaneous reporting database","volume":"84","author":"Salvo","year":"2023","journal-title":"J. Clin. Psychiatry"},{"issue":"3","key":"10.1016\/j.psychres.2025.116587_bib0038","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/acps.13582","article-title":"Risk of suicide attempt and suicide associated with benzodiazepine: a nationwide case crossover study","volume":"148","author":"Tournier","year":"2023","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.psychres.2025.116587_bib0039","article-title":"Reported adverse drug reactions in women and men: aggregated evidence from globally collected individual case reports during half a century","volume":"17","author":"Watson","year":"2019","journal-title":"E Clin. Med."},{"issue":"1","key":"10.1016\/j.psychres.2025.116587_bib0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40360-025-00858-7","article-title":"An exploratory study evaluating the 20 medications most commonly associated with suicidal ideation and self-injurious behavior in the FAERS database","volume":"26","author":"Xie","year":"2025","journal-title":"BMC. Pharmacol. Toxicol."},{"key":"10.1016\/j.psychres.2025.116587_bib0041","article-title":"Psychiatric disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database","volume":"59","author":"Zhou","year":"2023","journal-title":"E Clin. Med."}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178125002355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178125002355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:33:21Z","timestamp":1778945601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178125002355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":41,"alternative-id":["S0165178125002355"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2025.116587","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global burden of insomnia medication-associated suicidality, 1967\u20132024: A disproportionality analysis of the global pharmacovigilance database","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2025.116587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116587"}}