{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:59Z","timestamp":1791434999975,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CFB310"],"award-info":[{"award-number":["2020CFB310"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705505"],"award-info":[{"award-number":["2023YFC2705505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001524"],"award-info":[{"award-number":["82001524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82672162"],"award-info":[{"award-number":["82672162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.psychres.2026.117446","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:42:56Z","timestamp":1788565376000},"page":"117446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between age at menopause and depressive symptoms among postmenopausal women with depressive symptoms at baseline: results from SHARE and ELSA"],"prefix":"10.1016","volume":"366","author":[{"given":"Na","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-8704","authenticated-orcid":false,"given":"Hengwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psychres.2026.117446_bib0001","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/ije\/dyt088","article-title":"Data resource profile: the survey of health, ageing and retirement in Europe (SHARE)","volume":"42","author":"B\u00f6rsch-Supan","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.psychres.2026.117446_bib0002","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tips.2008.12.006","article-title":"Estrogen-induced plasticity from cells to circuits: predictions for cognitive function","volume":"30","author":"Brinton","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.psychres.2026.117446_bib0003","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1196\/annals.1347.005","article-title":"Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action","volume":"1052","author":"Brinton","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.psychres.2026.117446_bib0004","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ogc.2018.07.007","article-title":"Depression during and after the perimenopause: impact of hormones, genetics, and environmental determinants of disease","volume":"45","author":"Bromberger","year":"2018","journal-title":"Obstet. Gynecol. Clin. North Am."},{"key":"10.1016\/j.psychres.2026.117446_bib0005","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jad.2007.01.034","article-title":"Depressive symptoms during the menopausal transition","volume":"103","author":"Bromberger","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2026.117446_bib0006","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.bp.107.036772","article-title":"Prevalence of depressive symptoms and syndromes in later life in ten european countries: the SHARE study","volume":"191","author":"Castro-Costa","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0007","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/endrev\/bnac017","article-title":"Estrogen receptor signaling in the immune system","volume":"44","author":"Chakraborty","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.psychres.2026.117446_bib0008","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/mpr.1489","article-title":"Are different measures of depressive symptoms in old age comparable? An analysis of the CES-D and euro-D scales in 13 countries","volume":"24","author":"Courtin","year":"2015","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.psychres.2026.117446_bib0009","article-title":"Application of psychobiotics in clinical treatment of mental disorders: neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety","volume":"3","author":"Cui","year":"2025","journal-title":"Interdiscip. Med."},{"key":"10.1016\/j.psychres.2026.117446_bib0010","unstructured":"Depressive disorder (depression) [WWW Document], 2026 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression (accessed 11.7.25)."},{"key":"10.1016\/j.psychres.2026.117446_bib0011","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat. Med."},{"key":"10.1016\/j.psychres.2026.117446_bib0012","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","article-title":"Late-life depression and risk of vascular dementia and alzheimer\u2019s disease: systematic review and meta-analysis of community-based cohort studies","volume":"202","author":"Diniz","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0013","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0014","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1741-7015-11-131","article-title":"Depression as a risk factor for adverse outcomes in coronary heart disease","volume":"11","author":"Freedland","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.psychres.2026.117446_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40695-015-0002-y","article-title":"Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population","volume":"1","author":"Freeman","year":"2015","journal-title":"Womens Midlife Health"},{"key":"10.1016\/j.psychres.2026.117446_bib0016","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/gme.0b013e3181db9f8b","article-title":"Associations of depression with the transition to menopause","volume":"17","author":"Freeman","year":"2010","journal-title":"Menopause"},{"key":"10.1016\/j.psychres.2026.117446_bib0017","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/jamapsychiatry.2013.2819","article-title":"The longitudinal pattern of depressive symptoms around natural menopause","volume":"71","author":"Freeman","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0018","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/jamapsychiatry.2015.2653","article-title":"Association of age at menopause and duration of reproductive period with depression after menopause: a systematic review and meta-analysis","volume":"73","author":"Georgakis","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0019","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/geriatrics2040035","article-title":"The gender difference in depression: are elderly women at greater risk for depression than elderly men?","volume":"2","author":"Girgus","year":"2017","journal-title":"Geriatrics"},{"key":"10.1016\/j.psychres.2026.117446_bib0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12888-015-0390-4","article-title":"Psychometric properties of EURO-D, a geriatric depression scale: a cross-cultural validation study","volume":"15","author":"Guerra","year":"2015","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0021","article-title":"Age at menopause and cognitive function and decline among middle-aged and older women in the China health and retirement longitudinal study, 2011\u20132018","volume":"21","author":"Guo","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.psychres.2026.117446_bib0022","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12916-025-04175-y","article-title":"Cross-national differences in the association between estimated cardiorespiratory fitness and depressive symptoms among older adults: findings from three nationwide cohort studies","volume":"23","author":"He","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.psychres.2026.117446_bib0023","article-title":"Prevalence of depression in older adults: a systematic review and meta-analysis","volume":"311","author":"Hu","year":"2022","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.psychres.2026.117446_bib0024","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2026.117446_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S2215-0366(16)30263-2","article-title":"Why is depression more common among women than among men?","volume":"4","author":"Kuehner","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0026","article-title":"Gut microbial 3\u03b1-hydroxysteroid dehydrogenase promotes depression in males via degrading testosterone","volume":"3","author":"Li","year":"2025","journal-title":"Interdiscip. Med."},{"key":"10.1016\/j.psychres.2026.117446_bib0027","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/med4.70057","article-title":"Mental health and corresponding interventions for persons with physical disabilities: a scoping review","volume":"4","author":"Li","year":"2026","journal-title":"Med. Adv."},{"key":"10.1016\/j.psychres.2026.117446_bib0028","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/s12888-024-05875-0","article-title":"Prevalence and associated factors of depression in postmenopausal women: a systematic review and meta-analysis","volume":"24","author":"Li","year":"2024","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0029","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/GME.0000000000000929","article-title":"Lifelong estradiol exposure and risk of depressive symptoms during the transition to menopause and postmenopause","volume":"24","author":"Marsh","year":"2017","journal-title":"Menopause N. Y. N"},{"key":"10.1016\/j.psychres.2026.117446_bib0030","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2337\/dc08-0985","article-title":"Depression and type 2 diabetes over the lifespan","volume":"31","author":"Mezuk","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.psychres.2026.117446_bib0031","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psychres.2026.117446_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1442991","article-title":"Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study","volume":"15","author":"Moon","year":"2024","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0033","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.bbagen.2009.11.001","article-title":"Underlying mechanisms mediating the antidepressant effects of estrogens","volume":"1800","author":"\u00d6sterlund","year":"2010","journal-title":"Biochim. Biophys. Acta BBA - Gen. Subj., Estrogen Actions in the Brain"},{"key":"10.1016\/j.psychres.2026.117446_bib0034","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2011.1282","article-title":"Depression and the risk of stroke morbidity and mortality: a meta-analysis and systematic review","volume":"306","author":"Pan","year":"2011","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"10.1016\/j.psychres.2026.117446_bib0035","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae065","article-title":"Evidence-based guideline: premature ovarian insufficiency\u2020,\u2021","volume":"2024","author":"Panay","year":"2024","journal-title":"Hum. Reprod. OPEN"},{"key":"10.1016\/j.psychres.2026.117446_bib0036","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1177\/10731911221138930","article-title":"The eight-item center for epidemiological studies depression scale in the english longitudinal study of aging: longitudinal and gender invariance, sum score models, and external associations","volume":"30","author":"Schlechter","year":"2023","journal-title":"Assessment"},{"key":"10.1016\/j.psychres.2026.117446_bib0037","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.2009.04982.x","article-title":"Sex hormones and mood in the perimenopause","volume":"1179","author":"Schmidt","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.psychres.2026.117446_bib0038","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.psychres.2026.117446_bib0039","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1741-7015-8-79","article-title":"Can depression be a menopause-associated risk?","volume":"8","author":"Soares","year":"2010","journal-title":"BMC Med"},{"key":"10.1016\/j.psychres.2026.117446_bib0040","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/ije\/dys168","article-title":"Cohort profile: the English longitudinal study of ageing","volume":"42","author":"Steptoe","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.psychres.2026.117446_bib0041","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5152\/alphapsychiatry.2024.231501","article-title":"Premature ovarian insufficiency is associated with increased risk of depression, anxiety, and poor life quality: a systematic review and meta-analysis","volume":"25","author":"Tian","year":"2024","journal-title":"Alpha Psychiatry"},{"key":"10.1016\/j.psychres.2026.117446_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119588","article-title":"Specific types of depressive symptoms trajectories and risk of chronic lung diseases events in middle-aged and older adults: result from two prospective cohort studies","volume":"388","author":"Wang","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2026.117446_bib0043","doi-asserted-by":"crossref","first-page":"daaf005","DOI":"10.1093\/heapro\/daaf005","article-title":"Women\u2019s experiences and expectations during the menopause transition: a systematic qualitative narrative review","volume":"40","author":"Wood","year":"2025","journal-title":"Health Promot. Int."},{"key":"10.1016\/j.psychres.2026.117446_bib0044","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jad.2024.04.077","article-title":"Association of reproductive lifespan and age at menopause with depression: data from NHANES 2005\u20132018","volume":"356","author":"Wu","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psychres.2026.117446_bib0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0306-4530(96)00034-0","article-title":"A meta-analysis of the effect of hormone replacement therapy upon depressed mood","volume":"22","author":"Zweifel","year":"1997","journal-title":"Psychoneuroendocrinology"}],"container-title":["Psychiatry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178126005068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165178126005068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:08:54Z","timestamp":1791432534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165178126005068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":45,"alternative-id":["S0165178126005068"],"URL":"https:\/\/doi.org\/10.1016\/j.psychres.2026.117446","relation":{},"ISSN":["0165-1781"],"issn-type":[{"value":"0165-1781","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between age at menopause and depressive symptoms among postmenopausal women with depressive symptoms at baseline: results from SHARE and ELSA","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psychres.2026.117446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117446"}}