{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:52:50Z","timestamp":1789638770243,"version":"4.0.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychosomatics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.psym.2015.10.001","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T17:09:38Z","timestamp":1445792978000},"page":"71-81","source":"Crossref","is-referenced-by-count":66,"title":["Nonalcoholic Thiamine-Related Encephalopathy (Wernicke-Korsakoff Syndrome) Among Inpatients With Cancer: A Series of 18 Cases"],"prefix":"10.1016","volume":"57","author":[{"given":"Elie","family":"Isenberg-Grzeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesne","family":"Alici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaios","family":"Hatzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Breitbart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psym.2015.10.001_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/alcalc\/37.6.513","article-title":"Royal College of Physicians, London: The Royal College of Physicians report on alcohol: guidelines for managing Wernicke\u2019s encephalopathy in the accident and Emergency Department","volume":"37","author":"Thomson","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.psym.2015.10.001_bib2","article-title":"Thyrotoxicosis-associated Wernicke\u2019s encephalopathy","volume":"23:897","author":"Sechi","year":"2008","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.psym.2015.10.001_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.psym.2012.04.008","article-title":"Wernicke-Korsakoff-syndrome: under-recognized and under-treated","volume":"53","author":"Isenberg-Grzeda","year":"2012","journal-title":"Psychosomatics"},{"key":"10.1016\/j.psym.2015.10.001_bib4","doi-asserted-by":"crossref","first-page":"E84","DOI":"10.3174\/ajnr.A1142","article-title":"Metronidazole-induced and Wernicke encephalopathy: two different entities sharing the same metabolic pathway?","volume":"29","author":"Zuccoli","year":"2008","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.psym.2015.10.001_bib5","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0014-2964(80)90251-0","article-title":"Thiamine status of patients treated with drug combinations containing 5-fluorouracil","volume":"16","author":"Aksoy","year":"1980","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.psym.2015.10.001_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3346\/jkms.2009.24.4.747","article-title":"A case of Wernicke\u2019s encephalopathy following fluorouracil-based chemotherapy","volume":"24","author":"Cho","year":"2009","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.psym.2015.10.001_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/oxfordjournals.jjco.a023220","article-title":"Severe acute metabolic acidosis and Wernicke\u2019s encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature","volume":"26","author":"Kondo","year":"1996","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.psym.2015.10.001_bib8","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1007\/s00125-007-0771-4","article-title":"High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease","volume":"50","author":"Thornalley","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.psym.2015.10.001_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0303-8467(99)00014-1","article-title":"Wernicke\u2019s encephalopathy associated with hemodialysis: report of two cases and review of the literature","volume":"101","author":"Ihara","year":"1999","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.psym.2015.10.001_bib10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1527-5299.2007.06260.x","article-title":"Loop diuretic therapy, thiamine balance, and heart failure","volume":"13","author":"Sica","year":"2007","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.psym.2015.10.001_bib11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke\u2019s encephalopathy: new clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.psym.2015.10.001_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3174\/ajnr.A1280","article-title":"MR imaging findings in 56 patients with Wernicke encephalopathy: nonalcoholics may differ from alcoholics","volume":"30","author":"Zuccoli","year":"2009","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.psym.2015.10.001_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2014-309598","article-title":"Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review","author":"Scalzo","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.psym.2015.10.001_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/alcalc\/agn101","article-title":"Molecular genetics of alcohol-related brain damage","volume":"44","author":"Guerrini","year":"2009","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.psym.2015.10.001_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/104.1.1","article-title":"Cerebral disorder in alcoholism: syndromes of impairment","volume":"104","author":"Lishman","year":"1981","journal-title":"Brain"},{"key":"10.1016\/j.psym.2015.10.001_bib16","first-page":"381","article-title":"Wernicke\u2019s encephalopathy\u2014prevalence and clinical spectrum","volume":"1","author":"Torvik","year":"1991","journal-title":"Alcohol Alcohol Suppl"},{"key":"10.1016\/j.psym.2015.10.001_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnnp.49.4.341","article-title":"Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy","volume":"49","author":"Harper","year":"1986","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.psym.2015.10.001_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.62.1.51","article-title":"Operational criteria for the classification of chronic alcoholics: identification of Wernicke\u2019s encephalopathy","volume":"62","author":"Caine","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.psym.2015.10.001_bib19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2214\/ajr.171.4.9763009","article-title":"Usefulness of CT and MR imaging in the diagnosis of acute Wernicke\u2019s encephalopathy","volume":"171","author":"Antunez","year":"1998","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.psym.2015.10.001_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/alcalc\/agq004","article-title":"Biomarkers for detecting thiamine deficiency\u2014improving confidence and taking a comprehensive history are also important","volume":"45","author":"Thomson","year":"2010","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.psym.2015.10.001_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ADM.0000435320.72857.c8","article-title":"Prescribing thiamine to inpatients with alcohol use disorders: how well are we doing?","volume":"8","author":"Isenberg-Grzeda","year":"2014","journal-title":"J Addict Med"},{"key":"10.1016\/j.psym.2015.10.001_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/jnnp.46.7.593","article-title":"The incidence of Wernicke\u2019s encephalopathy in Australia\u2014a neuropathological study of 131 cases","volume":"46","author":"Harper","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.psym.2015.10.001_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/alcalc\/agh249","article-title":"The natural history and pathophysiology of Wernicke\u2019s Encephalopathy and Korsakoff\u2019s Psychosis","volume":"41","author":"Thomson","year":"2006","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.psym.2015.10.001_bib24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/pmj.77.911.582","article-title":"Thiamine deficiency in patients with B-chronic lymphocytic leukemia: a pilot study","volume":"77","author":"Seligmann","year":"2001","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.psym.2015.10.001_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.bmt.1702140","article-title":"Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases","volume":"25","author":"Bleggi-Torres","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.psym.2015.10.001_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/978-3-642-81553-9_101","article-title":"Prospective neuropathologic study on the occurrence of Wernicke\u2019s encephalopathy in patients with tumours of the lymphoid-hemopoietic systems","volume":"7","author":"De Reuck","year":"1981","journal-title":"Acta Neuropathol Suppl"},{"key":"10.1016\/j.psym.2015.10.001_bib27","first-page":"1","article-title":"Palliative treatment of thiamine-related encephalopathy (Wernicke\u2019s encephalopathy) in cancer: a case series and review of the literature","author":"Isenberg-Grzeda","year":"2014","journal-title":"Palliat Support Care"},{"key":"10.1016\/j.psym.2015.10.001_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000174951","article-title":"Wernicke\u2019s encephalopathy: an underrecognized and reversible cause of confusional state in cancer patients","volume":"76","author":"Kuo","year":"2009","journal-title":"Oncology"},{"key":"10.1016\/j.psym.2015.10.001_bib29","first-page":"169","article-title":"The role of thiamine in cancer: possible genetic and cellular signaling mechanisms","volume":"10","author":"Lu\u2019o\u2019ng","year":"2013","journal-title":"Cancer Genomics Proteomics"},{"key":"10.1016\/j.psym.2015.10.001_bib30","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1468-1331.2010.03153.x","article-title":"EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy","volume":"17","author":"Galvin","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.psym.2015.10.001_bib31","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2215\/CJN.02470312","article-title":"Onco-nephrology: the pathophysiology and treatment of malignancy-associated hypercalcemia","volume":"7","author":"Rosner","year":"2012","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033318215001589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033318215001589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T08:55:05Z","timestamp":1537260905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0033318215001589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0033318215001589"],"URL":"https:\/\/doi.org\/10.1016\/j.psym.2015.10.001","relation":{},"ISSN":["0033-3182"],"issn-type":[{"value":"0033-3182","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}