{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:19:03Z","timestamp":1778581143086,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.psyneuen.2004.01.002","type":"journal-article","created":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T05:16:02Z","timestamp":1077599762000},"page":"1119-1128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":140,"title":["Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women"],"prefix":"10.1016","volume":"29","author":[{"given":"Edward C","family":"Suarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranga R","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2004.01.002_BIB1","series-title":"Anger, Hostility and the Heart","first-page":"43","article-title":"The assessment of anger and hostility","author":"Barefoot","year":"1994"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/oxfordjournals.aje.a117663","article-title":"Hostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women","volume":"142","author":"Barefoot","year":"1995","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB3","series-title":"Depression: Causes and Treatment","author":"Beck","year":"1967"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB4","first-page":"757","article-title":"Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation","volume":"89","author":"Beck","year":"1999","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB5","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/01.ATV.0000029781.31325.66","article-title":"Interrelationships among circulating interleukin-6, C-reactive protein, and traditional risk factors in women","volume":"22","author":"Bermudez","year":"2002","journal-title":"Arterioscler. Thromb. Vas. Biol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/1040-3590.7.1.59","article-title":"Assessing depression in primary care practice with the Beck Depression Inventory and the Hamilton Rating Scale for Depression","volume":"7","author":"Brown","year":"1995","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB54","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1016\/S0889-1591(02)00078-8","article-title":"Cytokines and depression: the need for a new paradigm","volume":"17","author":"Capuron","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/aje\/kwf158","article-title":"Hostility predicts recurrent events among postmenopausal women with coronary heart disease","volume":"156","author":"Chaput","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1037\/h0060667","article-title":"Proposed hostility and pharisaic-virtue scales for the MMPI","volume":"38","author":"Cook","year":"1954","journal-title":"J Appl. Psych."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB9","article-title":"Application of Adult Treatment Panel III (ATPIII) guidelines to a multi-ethnic cohort of perimenopausal women: inclusion of age>55 will produce an important shift in the proportions requiring intervention","author":"Derby","year":"2003"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1037\/1040-3590.10.2.83","article-title":"The psychometric evaluation of the Beck Depression Inventory\u2014II","volume":"10","author":"Dozois","year":"1998","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0021-9150(96)06077-7","article-title":"Leukocyte activation in atherosclerosis: correlation with risk factors","volume":"131","author":"Elneihoum","year":"1997","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0191-8869(96)00097-9","article-title":"Hostility, stress, and symptoms of depression","volume":"21","author":"Felsten","year":"1996","journal-title":"Person. Indiv. Differ."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/archinte.160.9.1261","article-title":"Depression as an antecedent to heart disease among women and men in the NHANES I study","volume":"160","author":"Ferketich","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB14","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1001\/archinte.158.13.1422","article-title":"Depression is a risk factor for coronary artery disease in men: the precursors study","volume":"158","author":"Ford","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB15","first-page":"181","article-title":"The role of the monocyte in atherogenesis. I Transition of blood-borne monocytes into foam cells in fatty lesions","volume":"103","author":"Gerrity","year":"1981","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB16","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3956(99)00021-7","article-title":"Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis","volume":"33","author":"Haack","year":"1999","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/oxfordjournals.aje.a112873","article-title":"The relationship of psychosocial factors to coronary heart disease in the Framingham Study. III. Eight-year incidence of coronary heart disease","volume":"111","author":"Haynes","year":"1980","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB18","series-title":"Cardiovascular Health and Disease in Women","first-page":"33","article-title":"Cardiovascular disease in women as a public health problem","author":"Higgins","year":"1993"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11920-003-0009-1","article-title":"Depression and ischemic heart disease: overview of the evidence and treatment implication","volume":"5","author":"Jiang","year":"2003","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0892-0354(92)90016-J","article-title":"Uptake, distribution, and fate of bacterial lipopolysaccharides in monocytes and macrophages: an ultrastructural and functional correlation","volume":"5","author":"Kang","year":"1992","journal-title":"Electron Microsc. Rev."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB21","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1161\/01.ATV.20.8.1976","article-title":"Polymerase chain reaction-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tumor necrosis factor-alpha and interluekin-1 beta","volume":"20","author":"Kim","year":"2000","journal-title":"Arterioscler. Thromb. Vas. Biol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB22","series-title":"Experimental Design: Procedures for the Behavioral Sciences","author":"Kirk","year":"1968"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0002-9149(98)00599-2","article-title":"Hostility, social support, and coronary heart disease in the National Heart, Lung and Blood Institute Family Heart Study","volume":"82","author":"Knox","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0002-9149(01)02264-0","article-title":"Inflammation and coagulation factors in persons>65 years of age with symptoms of depression but without evidence of myocardial ischemia","volume":"89","author":"Kop","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB25","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0002-9440(10)61163-7","article-title":"Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model","volume":"160","author":"Lessner","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB26","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1161\/01.CIR.0000055323.57885.88","article-title":"Superparamagnetic iron oxide-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tissue necrosis factor-\u03b1, interleukin-1\u03b2, and interferon-\u03b3","volume":"107","author":"Litovsky","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB27","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1161\/01.CIR.103.18.2236","article-title":"Enhanced response of blood monocytes to in vitro lipopolysaccharide-challenge in patients with recurrent unstable angina","volume":"103","author":"Liuzzo","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/hrt.78.3.273","article-title":"Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease","volume":"78","author":"Mendall","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB29","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0002-9149(02)02863-1","article-title":"Clinical depression and inflammatory risk markers for coronary heart disease","volume":"90","author":"Miller","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0304-4157(90)90008-Z","article-title":"Alteration of intracellular traffice by monensin: mechanism, specificity and relation to toxicity","volume":"1031","author":"Mollenhauer","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archpsyc.55.7.580","article-title":"The relationship of depression to cardiovascular disease","volume":"55","author":"Musselman","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0167-5273(01)00441-7","article-title":"Meta-analyses of prospective studies on coronary heart disease, type A personality, and hostility","volume":"79","author":"Myrtek","year":"2001","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oxfordjournals.aje.a116601","article-title":"Monocyte count: a risk factor for coronary heart disease?","volume":"137","author":"Olivares","year":"1993","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/archpsyc.58.3.221","article-title":"Depression and cardiac mortality: results from a community-based longitudinal study","volume":"58","author":"Penninx","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men and women","volume":"336","author":"Ridker","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S8756-3282(01)00468-9","article-title":"The effect of 17beta-estradiol on production of cytokines in cultures of peripheral blood","volume":"29","author":"Rogers","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00005053-197408000-00003","article-title":"Depression and hostility","volume":"159","author":"Schless","year":"1974","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB39","first-page":"29","article-title":"Intracytoplasmic detection of proinflammatory cytokines and chemokines in monocytes by flow cytometry","volume":"215","author":"Schultz","year":"2003"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-0-585-37970-8_3","article-title":"Cytokine production in depressed patients","volume":"461","author":"Seidel","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-Z","article-title":"The macrophage theory of depression","volume":"35","author":"Smith","year":"1991","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB42","series-title":"Anger, Hostility and the Heart","first-page":"23","article-title":"Concepts and methods in the study of anger, hostility, and health","author":"Smith","year":"1994"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1037\/0278-6133.4.6.503","article-title":"What\u2019s so unhealthy about hostility? Construct validity and psychological correlates of the Cook and Medley Ho scale","volume":"4","author":"Smith","year":"1985","journal-title":"Health Psychol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB44","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.ATV.14.5.840","article-title":"A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council of Arteriosclerosis, American Heart Association","volume":"14","author":"Stary","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/01.PSY.0000062530.94551.EA","article-title":"The joint effect of hostility and depressive symptoms on plasma interleukin-6 in apparently healthy men","volume":"65","author":"Suarez","year":"2003","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0889-1591(03)00059-X","article-title":"Plasma interleukin-6 is associated with psychological risk factors of atherosclerotic cardiovascular disease: moderation by multivitamin supplementation","volume":"17","author":"Suarez","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB47","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/00006842-199009000-00008","article-title":"The relationships between dimensions of hostility and cardiovascular reactivity as a function of task characteristics","volume":"52","author":"Suarez","year":"1990","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1037\/0278-6133.12.6.459","article-title":"Cardiovascular and emotional responses in women: the role of hostility and harassment","volume":"12","author":"Suarez","year":"1993","journal-title":"Health Psychol."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02884449","article-title":"The relation of hostility to lipids and lipoproteins in women: evidence for the role of antagonistic hostility","volume":"20","author":"Suarez","year":"1998","journal-title":"Ann. Behav. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB50","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0889-1591(02)00019-3","article-title":"The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-\u03b1 by blood monocytes of normal men","volume":"16","author":"Suarez","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/01.PSY.0000035719.79068.2B","article-title":"The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men","volume":"65","author":"Suarez","year":"2003","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1176\/ajp.128.3.261","article-title":"Clinical evaluation of hostility in depression","volume":"128","author":"Weissman","year":"1971","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2004.01.002_BIB53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.PSY.0000058371.50240.E3","article-title":"Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review","volume":"65","author":"Wuslin","year":"2003","journal-title":"Psychosom. Med."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453004000034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453004000034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:25:41Z","timestamp":1759681541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453004000034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0306453004000034"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2004.01.002","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2004.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}