{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:33:48Z","timestamp":1793082828730,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["DN95-420"],"award-info":[{"award-number":["DN95-420"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WU 324\/3-(1-3"],"award-info":[{"award-number":["WU 324\/3-(1-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRH 1389\/1"],"award-info":[{"award-number":["GRH 1389\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.psyneuen.2009.07.006","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T03:06:13Z","timestamp":1249959973000},"page":"339-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone"],"prefix":"10.1016","volume":"35","author":[{"given":"Nienke","family":"van Leeuwen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kumsta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Entringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ronald","family":"de Kloet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans G.","family":"Zitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel H.","family":"DeRijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"W\u00fcst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0306-4530(93)90053-N","article-title":"Oral contraceptives and the dexamethasone suppression test","volume":"18","author":"Ansseau","year":"1993","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib2","first-page":"3176","article-title":"Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans","volume":"86","author":"Arvat","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.psyneuen.2009.07.006_bib3","doi-asserted-by":"crossref","first-page":"E1011","DOI":"10.1152\/ajpendo.00721.2007","article-title":"Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor","volume":"294","author":"Atkinson","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.psyneuen.2009.07.006_bib4","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.psyneuen.2004.01.010","article-title":"Sleep disturbances are correlated with decreased morning awakening salivary cortisol","volume":"29","author":"Backhaus","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0306-4530(02)00003-3","article-title":"Heritability of cortisol levels: review and simultaneous analysis of twin studies","volume":"28","author":"Bartels","year":"2003","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.psyneuen.2009.07.006_bib7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1176\/appi.ajp.160.10.1890","article-title":"Increase in concentration of waking salivary cortisol in recovered patients with depression","volume":"160","author":"Bhagwagar","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.psyneuen.2009.07.006_bib8","first-page":"1106","article-title":"Blocking of central nervous mineralocorticoid receptors counteracts inhibition of pituitary\u2013adrenal activity in human sleep","volume":"82","author":"Born","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.psyneuen.2009.07.006_bib9","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1210\/endo.134.3.8119168","article-title":"Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation","volume":"134","author":"Bradbury","year":"1994","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.psyneuen.2009.07.006_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0306-4530(03)00093-3","article-title":"Salivary cortisol sampling compliance: comparison of patients and healthy volunteers","volume":"29","author":"Broderick","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"8\u201310","key":"10.1016\/j.psyneuen.2009.07.006_bib11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.psyneuen.2007.05.016","article-title":"The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls","volume":"32","author":"Buckley","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/joe.0.1440311","article-title":"The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat","volume":"144","author":"Carey","year":"1995","journal-title":"J. Endocrinol."},{"issue":"5613","key":"10.1016\/j.psyneuen.2009.07.006_bib13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/bmj.3.5613.285","article-title":"Resistance to suppression by dexamethasone of Plasma 11-Ohcs levels in severe depressive illness","volume":"3","author":"Carroll","year":"1968","journal-title":"Br. Med. J."},{"issue":"9","key":"10.1016\/j.psyneuen.2009.07.006_bib14","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1210\/endo.136.9.7649087","article-title":"Regulation of rat mineralocorticoid receptor expression in neurons by progesterone","volume":"136","author":"Castren","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2009.07.006_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biopsycho.2008.10.004","article-title":"Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis","volume":"80","author":"Chida","year":"2009","journal-title":"Biol. Psychol."},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/10253890410001667205","article-title":"The awakening cortisol response: methodological issues and significance","volume":"7","author":"Clow","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.psyneuen.2009.07.006_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1210\/endo-96-3-598","article-title":"Differences in corticosterone and dexamethasone binding to rat brain and pituitary","volume":"96","author":"de Kloet","year":"1975","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.psyneuen.2009.07.006_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"12","key":"10.1016\/j.psyneuen.2009.07.006_bib19","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1210\/jc.2006-0915","article-title":"A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness","volume":"91","author":"DeRijk","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.psyneuen.2009.07.006_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000054384","article-title":"Mineralocorticoid receptor also modulates basal activity of hypothalamus-pituitary-adrenocortical system in humans","volume":"68","author":"Deuschle","year":"1998","journal-title":"Neuroendocrinology"},{"issue":"5","key":"10.1016\/j.psyneuen.2009.07.006_bib21","first-page":"570","article-title":"Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humans","volume":"58","author":"Dodt","year":"1993","journal-title":"Neuroendocrinology"},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0960-0760(92)90294-S","article-title":"Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement","volume":"43","author":"Dressendorfer","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib23","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1210\/en.2008-0103","article-title":"Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress","volume":"149","author":"Droste","year":"2008","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijpsycho.2008.03.014","article-title":"The cortisol awakening response (CAR) facts and future directions","volume":"72","author":"Fries","year":"2008","journal-title":"Int. J. Psychophysiol."},{"issue":"3","key":"10.1016\/j.psyneuen.2009.07.006_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/eje.0.1510397","article-title":"Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells, a comparison of their glucocorticoid and mineralocorticoid properties","volume":"151","author":"Grossmann","year":"2004","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.psyneuen.2006.10.005","article-title":"Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components","volume":"32","author":"Hellhammer","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.psyneuen.2009.07.006_bib27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0197-4580(00)00145-7","article-title":"The role of mineralocorticoid receptors in the circadian activity of the human hypothalamus-pituitary-adrenal system: effect of age","volume":"21","author":"Heuser","year":"2000","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.psyneuen.2009.07.006_bib28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2007.10.005","article-title":"The coming out of the brain mineralocorticoid receptor","volume":"31","author":"Joels","year":"2008","journal-title":"Trends Neurosci."},{"issue":"12","key":"10.1016\/j.psyneuen.2009.07.006_bib30","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1210\/en.2005-0501","article-title":"Low doses of dexamethasone can produce a hypocorticosteroid state in the brain","volume":"146","author":"Karssen","year":"2005","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.psyneuen.2009.07.006_bib31","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1152\/jn.00143.2005","article-title":"Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells","volume":"94","author":"Karst","year":"2005","journal-title":"J. Neurophysiol."},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006842-199903000-00006","article-title":"Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis","volume":"61","author":"Kirschbaum","year":"1999","journal-title":"Psychosom. Med."},{"issue":"10","key":"10.1016\/j.psyneuen.2009.07.006_bib33","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1523\/JNEUROSCI.20-10-03843.2000","article-title":"Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons","volume":"20","author":"Kovacs","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.PSY.0000058374.50240.BF","article-title":"Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects","volume":"65","author":"Kudielka","year":"2003","journal-title":"Psychosom. Med."},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.biopsycho.2004.11.009","article-title":"Sex differences in HPA axis responses to stress: a review","volume":"69","author":"Kudielka","year":"2005","journal-title":"Biol. Psychol."},{"issue":"8","key":"10.1016\/j.psyneuen.2009.07.006_bib36","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.biopsych.2007.04.013","article-title":"Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress","volume":"62","author":"Kumsta","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.psyneuen.2009.07.006_bib37","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/sj.npp.1301260","article-title":"Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors","volume":"32","author":"Kuningas","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.psyneuen.2009.07.006_bib38","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1210\/endo.139.4.5917","article-title":"Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice","volume":"139","author":"Meijer","year":"1998","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.psyneuen.2009.07.006_bib39","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ije\/dym234","article-title":"How should we use information about HWE in the meta-analyses of genetic association studies?","volume":"37","author":"Minelli","year":"2008","journal-title":"Int. J. Epidemiol."},{"issue":"14","key":"10.1016\/j.psyneuen.2009.07.006_bib41","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0024-3205(03)00513-7","article-title":"The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre-treatment with metyrapone","volume":"73","author":"Otte","year":"2003","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.psyneuen.2009.07.006_bib42","doi-asserted-by":"crossref","first-page":"B900","DOI":"10.1093\/gerona\/58.10.B900","article-title":"Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans","volume":"58","author":"Otte","year":"2003","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"issue":"4","key":"10.1016\/j.psyneuen.2009.07.006_bib43","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/eje.0.1500585","article-title":"Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities","volume":"150","author":"Pascual-Le Tallec","year":"2004","journal-title":"Eur. J. Endocrinol."},{"issue":"4","key":"10.1016\/j.psyneuen.2009.07.006_bib44","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1176\/appi.ajp.162.4.807","article-title":"Enhanced early morning salivary cortisol in neuroticism","volume":"162","author":"Portella","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.psyneuen.2009.07.006_bib45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.PSY.0000040950.22044.10","article-title":"Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening","volume":"65","author":"Pruessner","year":"2003","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib46","first-page":"117","article-title":"On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation","volume":"50","author":"Ratka","year":"1989","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.psyneuen.2009.07.006_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1192\/bjp.184.2.136","article-title":"Salivary cortisol response to awakening in chronic fatigue syndrome","volume":"184","author":"Roberts","year":"2004","journal-title":"Br. J. Psychiatry"},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2003.11.018","article-title":"Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder","volume":"55","author":"Rohleder","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.psy.0000116715.78238.56","article-title":"Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response","volume":"66","author":"Schlotz","year":"2004","journal-title":"Psychosom. Med."},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib51","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1210\/endo.140.7.6755","article-title":"Prenatal dexamethasone treatment does not prevent alterations of the hypothalamic pituitary adrenal axis in steroid 21-hydroxylase deficient mice","volume":"140","author":"Tajima","year":"1999","journal-title":"Endocrinology"},{"issue":"19","key":"10.1016\/j.psyneuen.2009.07.006_bib52","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0024-3205(90)90340-W","article-title":"Sex difference in glucocorticoid binding in rat pituitary is estrogen dependent","volume":"46","author":"Turner","year":"1990","journal-title":"Life Sci."},{"issue":"15","key":"10.1016\/j.psyneuen.2009.07.006_bib53","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1523\/JNEUROSCI.19-15-06684.1999","article-title":"Independent and overlapping effects of corticosterone and testosterone on corticotropin-releasing hormone and arginine vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus and stress-induced adrenocorticotropic hormone release","volume":"19","author":"Viau","year":"1999","journal-title":"J. Neurosci."},{"issue":"09","key":"10.1016\/j.psyneuen.2009.07.006_bib54","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1055\/s-2005-872838","article-title":"Kontrazeption","volume":"65","author":"von Have","year":"2005","journal-title":"Geburtsh Frauenheilk"},{"issue":"10","key":"10.1016\/j.psyneuen.2009.07.006_bib55","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1210\/jc.2004-0086","article-title":"Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans","volume":"89","author":"Wellhoener","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib56","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.psyneuen.2005.06.010","article-title":"Altered cortisol awakening response in posttraumatic stress disorder","volume":"31","author":"Wessa","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2009.07.006_bib57","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1055\/s-2007-972392","article-title":"Is the cortisol awakening rise a response to awakening?","volume":"115","author":"Wilhelm","year":"2007","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib58","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0306-4530(00)00021-4","article-title":"Genetic factors, perceived chronic stress, and the free cortisol response to awakening","volume":"25","author":"W\u00fcst","year":"2000","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"10.1016\/j.psyneuen.2009.07.006_bib59","first-page":"79","article-title":"The cortisol awakening response\u2014normal values and confounds","volume":"2","author":"W\u00fcst","year":"2000","journal-title":"Noise Health"},{"issue":"2","key":"10.1016\/j.psyneuen.2009.07.006_bib60","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1056\/NEJMra012941","article-title":"Post-traumatic stress disorder","volume":"346","author":"Yehuda","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.psyneuen.2009.07.006_bib61","first-page":"3339","article-title":"The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans","volume":"83","author":"Young","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453009002194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453009002194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:24:47Z","timestamp":1778509487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453009002194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0306453009002194"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2009.07.006","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2009.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}