{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:39:25Z","timestamp":1789389565301,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.psyneuen.2010.02.003","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T05:27:47Z","timestamp":1267162067000},"page":"1178-1186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3"],"prefix":"10.1016","volume":"35","author":[{"given":"Akihiro","family":"Asakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Fujimiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Niijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nanba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Laviano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Meguid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2010.02.003_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.22158","article-title":"Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin","volume":"120","author":"Asakawa","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0163-1047(83)91145-7","article-title":"Relative potency of foods and drinks as targets in aversion conditioning","volume":"37","author":"Bernstein","year":"1983","journal-title":"Behav. Neural. Biol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib3","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1016\/S0021-9258(18)48217-8","article-title":"Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy","volume":"262","author":"Burtis","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib4","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199004193221603","article-title":"Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer","volume":"322","author":"Burtis","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.gastro.2005.04.015","article-title":"Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats","volume":"129","author":"Chen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib6","first-page":"G511","article-title":"Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats","volume":"290","author":"Czimmer","year":"2006","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-6147(02)01946-6","article-title":"The CRF peptide family and their receptors: yet more partners discovered","volume":"23","author":"Dautzenberg","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1126\/science.3511527","article-title":"Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions","volume":"231","author":"Duggan","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80937-X","article-title":"Obesity and the hypothalamus: novel peptides for new pathways","volume":"92","author":"Flier","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.seminoncol.2003.10.002","article-title":"History of antibody therapy for non-Hodgkin's lymphoma","volume":"30","author":"Forero","year":"2003","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.2003.040600","article-title":"Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats","volume":"550","author":"Fujino","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib12","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1210\/endo-127-3-1444","article-title":"Measurement of circulating parathyroid hormone-related protein in rats with humoral hypercalcemia of malignancy using a two-site immunoradiometric assay","volume":"127","author":"Gaich","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib13","first-page":"R116","article-title":"Glucagon acts in the liver to control spontaneous meal size in rats","volume":"264","author":"Geary","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib14","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/1097-0142(197905)43:5+<2065::AID-CNCR2820430714>3.0.CO;2-1","article-title":"Nutritional assessment and patient outcome during oncological therapy","volume":"43","author":"Harvey","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/87936","article-title":"Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor","volume":"7","author":"Hsu","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00774-005-0640-5","article-title":"Effects of anti-parathyroid hormone-related protein monoclonal antibody and osteoprotegerin on PTHrP-producing tumor-induced cachexia in nude mice","volume":"24","author":"Iguchi","year":"2006","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3322\/canjclin.52.2.72","article-title":"Cancer anorexia-cachexia syndrome: current issues in research and management","volume":"52","author":"Inui","year":"2002","journal-title":"C. A. Cancer J. Clin."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1096\/fj.03-0641rev","article-title":"Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ","volume":"18","author":"Inui","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib20","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/en.2004-1266","article-title":"The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats","volume":"146","author":"Koda","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib21","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.84.14.5048","article-title":"Parathyroid hormone-related protein purified from a human lung cancer cell line","volume":"84","author":"Moseley","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib22","doi-asserted-by":"crossref","first-page":"741S","DOI":"10.1002\/j.1550-8528.1995.tb00494.x","article-title":"An electrophysiological study on amino acid sensors in the hepato-portal system in the rat","volume":"3","author":"Niijima","year":"1995","journal-title":"Obes. Res."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib23","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.peptides.2004.05.023","article-title":"Effects of urocortin 2 and 3 on motor activity and food intake in rats","volume":"25","author":"Ohata","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ijc.21038","article-title":"Parathyroid hormone-related protein (PTHrP) as a causative factor of cancer-associated wasting: possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts","volume":"116","author":"Onuma","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib25","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/cncr.20689","article-title":"Parathyroid hormone-related protein expression is correlated with clinical course in patients with glial tumors","volume":"101","author":"Pardo","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1053\/j.seminoncol.2003.08.019","article-title":"Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody","volume":"30","author":"Sato","year":"2003","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1634\/theoncologist.8-2-187","article-title":"Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control","volume":"28","author":"Schnell","year":"2003","journal-title":"The Oncologist"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib29","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI113275","article-title":"Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone","volume":"80","author":"Strewler","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1056\/NEJM200001203420306","article-title":"The physiology of parathyroid hormone-related protein","volume":"342","author":"Strewler","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2010.02.003_bib31","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/1097-0142(19951215)76:12<2418::AID-CNCR2820761204>3.0.CO;2-C","article-title":"Mechanisms mediating cancer cachexia","volume":"76","author":"Toomey","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/378287a0","article-title":"Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor","volume":"378","author":"Vaughan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.psyneuen.2010.02.003_bib33","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"5750","author":"Zhang","year":"2005","journal-title":"Science"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645301000034X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645301000034X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:34:49Z","timestamp":1759682089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645301000034X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S030645301000034X"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2010.02.003","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2010.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}