{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:14:13Z","timestamp":1792293253983,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.psyneuen.2013.12.016","type":"journal-article","created":{"date-parts":[[2014,1,5]],"date-time":"2014-01-05T04:15:39Z","timestamp":1388895339000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":141,"special_numbering":"C","title":["Social support predicts inflammation, pain, and depressive symptoms: Longitudinal relationships among breast cancer survivors"],"prefix":"10.1016","volume":"42","author":[{"given":"Spenser","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Jaremka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Alfano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Povoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele M.","family":"Lipari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen M.","family":"Agnese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa D.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William E.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Malarkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice K.","family":"Kiecolt-Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2013.12.016_bib0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.psy.0000204851.15499.fc","article-title":"Comorbid depression, chronic pain, and disability in primary care","volume":"68","author":"Arnow","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0010","series-title":"Measuring Patient Changes in Mood, Anxiety, and Personality Disorders: Toward a Core Battery","article-title":"Outcome measures of depression","author":"Basco","year":"1997"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0304-3959(97)00126-7","article-title":"Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center","volume":"73","author":"Becker","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/aje\/kwm280","article-title":"Association of adult body mass index and height with anxiety, depression, and suicide in the general population","volume":"167","author":"Bjerkeset","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0025","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1200\/JCO.2007.14.3248","article-title":"Behavioral symptoms in patients with breast cancer and survivors","volume":"26","author":"Bower","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cyto.2004.04.002","article-title":"Tumour necrosis factor-alpha, interleukin-6, and fasting serum insulin correlate with clinical outcome in metastatic breast cancer patients treated with chemotherapy","volume":"27","author":"Bozcuk","year":"2004","journal-title":"Cytokine"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0035","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.38343.670868.D3","article-title":"Depression and anxiety in women with early breast cancer: five year observational cohort study","volume":"330","author":"Burgess","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0040","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/cncr.21147","article-title":"Psychosocial factors and interleukin-6 among women with advanced ovarian cancer","volume":"104","author":"Costanzo","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0895-4356(02)00585-1","article-title":"How to measure comorbidity. A critical review of available methods","volume":"56","author":"de Groot","year":"2003","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0060","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1213\/01.ANE.0000055362.56604.78","article-title":"The role of interleukin-6 in nociception and pain","volume":"96","author":"de Jongh","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/(SICI)1099-1611(200001\/02)9:1<20::AID-PON425>3.0.CO;2-Y","article-title":"Negative and positive influences of social support on depression in patients with head and neck cancer: a prospective study","volume":"9","author":"de Leeuw","year":"2000","journal-title":"Psycho-Oncology"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0070","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0005-7967(03)00036-6","article-title":"Pain coping and social support as predictors of long-term functional disability and pain in early rheumatoid arthritis","volume":"41","author":"Evers","year":"2003","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0075","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0022-3999(02)00303-3","article-title":"Epidemiologic evidence for the relation between socioeconomic status and depression, obesity, and diabetes","volume":"53","author":"Everson","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0080","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/07347330902775590","article-title":"Social support networks and depression of women suffering from early-stage breast cancer: a case control study","volume":"27","author":"Gagliardi","year":"2009","journal-title":"J. Psychosoc. Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0085","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1200\/JCO.2003.08.097","article-title":"Breast cancer in older women: quality of life and psychosocial adjustment in the 15 months after diagnosis","volume":"21","author":"Ganz","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0090","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/jama.2009.1568","article-title":"Prevalence of and factors associated with persistent pain following breast cancer surgery","volume":"302","author":"Gartner","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(97)00810-0","article-title":"Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy","volume":"237","author":"Geiss","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1200\/JCO.2010.28.4455","article-title":"Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis","volume":"29","author":"Giese-Davis","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0105","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/hec.4730020305","article-title":"The RAND 36-item health survey 1.0","volume":"2","author":"Hays","year":"1993","journal-title":"Health Econ."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0115","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/cncr.22335","article-title":"Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer","volume":"107","author":"Hegel","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0120","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1348\/1359107042304542","article-title":"Social support, anxiety and depression after chemotherapy for ovarian cancer: a prospective study","volume":"9","author":"Hipkins","year":"2004","journal-title":"Br. J. Health Psychol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1099-1611(199803\/04)7:2<101::AID-PON299>3.0.CO;2-3","article-title":"Social support, life stress, pain and emotional adjustment to advanced breast cancer","volume":"7","author":"Koopman","year":"1998","journal-title":"Psycho-Oncology"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0130","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1200\/JCO.2005.04.2846","article-title":"Social networks, social support, and survival after breast cancer diagnosis","volume":"24","author":"Kroenke","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jpainsymman.2009.12.023","article-title":"The association of depression and pain with health-related quality of life, disability, and health care use in cancer patients","volume":"40","author":"Kroenke","year":"2010","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0140","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1017\/S0021932005001203","article-title":"Social networks and inflammatory markers in the Framingham Heart Study","volume":"38","author":"Loucks","year":"2006","journal-title":"J. Biosoc. Sci."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1207\/S15327558IJBM0702_3","article-title":"Interleukin-6 and use of social support in gynecologic cancer patients","volume":"7","author":"Lutgendorf","year":"2000","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0150","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1997.0238","article-title":"Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression","volume":"9","author":"Maes","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbi.2006.07.006","article-title":"Stimulated production of interleukin-8 covaries with psychosocial risk factors for inflammatory disease among middle-aged community volunteers","volume":"21","author":"Marsland","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.psy.0000221371.43607.64","article-title":"Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study","volume":"68","author":"McDade","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0165","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1470-2045(13)70244-4","article-title":"Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis","volume":"14","author":"Mitchell","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/00008483-200311000-00001","article-title":"A short social support measure for patients recovering from myocardial infarction: the ENRICHD Social Support Inventory","volume":"23","author":"Mitchell","year":"2003","journal-title":"J. Cardpulm. Rehabil."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0175","first-page":"585","article-title":"Comparative study of symptoms and neuroendocrine-immune network mediator levels between rheumatoid arthritis patients and healthy subjects","volume":"18","author":"Mukai","year":"2000","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0180","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jpsychores.2008.12.012","article-title":"Social support and cancer progression: a systematic review","volume":"67","author":"Nausheen","year":"2009","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0185","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ejpain.2008.05.015","article-title":"Chronic pain and other sequelae in long-term breast cancer survivors: nationwide survey in Denmark","volume":"13","author":"Peuckmann","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D Scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0200","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jpainsymman.2006.01.008","article-title":"Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer","volume":"32","author":"Reyes-Gibby","year":"2006","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0205","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/jwh.2011.2852","article-title":"Depressive symptoms and health-related quality of life in breast cancer survivors","volume":"21","author":"Reyes-Gibby","year":"2012","journal-title":"J. Womens Health"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0210","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1021\/cr020373d","article-title":"Electrochemiluminescence (ECL)","volume":"104","author":"Richter","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0215","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ijc.10833","article-title":"Circulating interleukin-6 predicts survival in patients with metastatic breast cancer","volume":"103","author":"Salgado","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0220","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/archinte.160.12.1761","article-title":"Association between depression and mortality in older adults: the Cardiovascular Health Study","volume":"160","author":"Schulz","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0225","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jpainsymman.2011.10.021","article-title":"Long-term follow-up of pain and emotional characteristics of women after surgery for breast cancer","volume":"44","author":"Sheridan","year":"2012","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0230","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.pnpbp.2007.05.001","article-title":"Interleukin-6 levels and HPA axis activation in breast cancer patients with major depressive disorder","volume":"31","author":"Soygur","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0235","series-title":"The Oxford Handbook of Psychoneuroimmunology","first-page":"214","article-title":"Social support and immunity","author":"Uchino","year":"2012"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0240","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7525-2-24","article-title":"Testing the performance of the ENRICHD Social Support Instrument in cardiac patients","volume":"2","author":"Vaglio","year":"2004","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0245","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1207\/s15327558ijbm0302_2","article-title":"Psychometric qualities of the RAND 36-Item Health Survey 1.0: a multidimensional measure of general health status","volume":"3","author":"VanderZee","year":"1996","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0250","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00006842-199705000-00011","article-title":"Psychological sequelae of cancer diagnosis: a meta-analytical review of 58 studies after 1980","volume":"59","author":"van\u2019t Spijker","year":"1997","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0255","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.51.1.29","article-title":"The pain of being sick: implications of immune-to-brain communication for understanding pain","volume":"51","author":"Watkins","year":"2000","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.psyneuen.2013.12.016_bib0260","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol. Rev."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453013004526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453013004526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:44:45Z","timestamp":1759682685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453013004526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":52,"alternative-id":["S0306453013004526"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2013.12.016","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Social support predicts inflammation, pain, and depressive symptoms: Longitudinal relationships among breast cancer survivors","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2013.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}