{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:20:47Z","timestamp":1782206447162,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.psyneuen.2014.02.004","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T04:30:33Z","timestamp":1392352233000},"page":"52-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania"],"prefix":"10.1016","volume":"43","author":[{"given":"Jayashri","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-9110","authenticated-orcid":false,"given":"Ling","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Scarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamsyn E.","family":"Van Rheenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-1222","authenticated-orcid":false,"given":"Roisin","family":"Worsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gurvich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emorfia","family":"Gavrilidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"de Castella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-8096","authenticated-orcid":false,"given":"Paul","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2014.02.004_bib0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0006-3223(94)91193-2","article-title":"The Clinician-Administered Rating Scale for Mania (CARS-M): development, reliability, and validity","volume":"36","author":"Altman","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0010","series-title":"Diagnostics and Statistical Manual of Mental Disorders, text revised","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jad.2010.08.015","article-title":"Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania","volume":"129","author":"Amrollahi","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpsyc.57.1.95","article-title":"A preliminary investigation of a protein kinace C inhibitor in the treatment of acute mania","volume":"57","author":"Bebchuk","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/AOG.0b013e318233beae","article-title":"Continuation rates and complications of intrauterine contraception in women diagnosed with bipolar disorder","volume":"118","author":"Berenson","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0006-8993(84)90325-1","article-title":"Progesterone decreases the concentration of hypothalamic and anterior pituitary estrogen receptors in ovariectomized rats","volume":"304","author":"Blaustein","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0035","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.lfs.2012.12.012","article-title":"Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment?","volume":"93","author":"Buwalda","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0040","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1176\/ajp.144.6.826a","article-title":"Estrogen\u2013progesterone combination: another mood stabilizer?","volume":"144","author":"Chouinard","year":"1987","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0045","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/gyno.1998.5201","article-title":"Ovarian overstimulation and cystic formation in premenopausal tamoxifen exposure: comparison between tamoxifen-treated and nontreated breast cancer patients","volume":"72","author":"Cohen","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1192\/bjp.bp.111.102855","article-title":"Should psychiatrists be prescribing oestrogen therapy to their female patients?","volume":"202","author":"Craig","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0055","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1176\/appi.ajp.2010.09121816","article-title":"Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD","volume":"168","author":"Dias","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0060","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s11920-008-0081-7","article-title":"A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder","volume":"10","author":"DiazGranados","year":"2008","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000106054","article-title":"Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder","volume":"55","author":"Einat","year":"2007","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0070","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4088\/JCP.v63n0403","article-title":"The impact of reproductive events on the course of bipolar disorder in women","volume":"63","author":"Freeman","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0075","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0006-3223(93)90006-Y","article-title":"Altered platelet protein kinase C activity in bipolar affective disorder, manic episode","volume":"33","author":"Friedman","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0080","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","article-title":"Treatment of bipolar disorder","volume":"381","author":"Geddes","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0085","first-page":"153","article-title":"Danazol and the rapid-cycling patient","volume":"47","author":"Goldstein","year":"1986","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0090","series-title":"ECDEU Assessment Manual for Psychopharmacology","first-page":"534","author":"Guy","year":"1976"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0095","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.fertnstert.2012.01.128","article-title":"Executive summary of the stages of reproductive aging workshop+10: addressing the unfinished agenda of staging reproductive aging","volume":"97","author":"Harlow","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0100","series-title":"Multilevel analysis: Techniques and applications","author":"Hox","year":"2010"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0105","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1210\/en.2010-1061","article-title":"Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function","volume":"152","author":"Irwin","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0110","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1001\/archpsyc.65.8.955","article-title":"Estrogen in severe mental illness: a potential new treatment approach","volume":"65","author":"Kulkarni","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0115","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.psyneuen.2005.11.001","article-title":"A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder","volume":"31","author":"Kulkarni","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0920-9964(00)00088-8","article-title":"Estrogen \u2013 a potential treatment for schizophrenia","volume":"48","author":"Kulkarni","year":"2001","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-291X(84)91062-3","article-title":"Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase","volume":"118","author":"Lam","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0200","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1471-0528.1998.tb09940.x","article-title":"A double-blind randomised placebo controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones","volume":"105","author":"Lawrie","year":"1998","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0130","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0006-3223(99)00235-8","article-title":"Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness","volume":"46","author":"Manji","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1399-5618.2012.01026.x","article-title":"Progression of female reproductive stages associated with bipolar illness exacerbation","volume":"14","author":"Marsh","year":"2012","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0140","series-title":"Mplus user's guide","author":"Muth\u00e9n","year":"1998"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0145","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1176\/ajp.145.6.768c","article-title":"Interaction of danazol and carbamazepine","volume":"145","author":"Nelson","year":"1988","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1006426132338","article-title":"Preliminary assessment of cognitive function inbreast cancer patients treated with tamoxifen","volume":"64","author":"Paganini-Hill","year":"2000","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jad.2006.08.013","article-title":"Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder","volume":"99","author":"Payne","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2011.06.012","article-title":"Antimanic-like effect of tamoxifen is not reproduced by acute or chronic administration of medroxyprogesterone or clomiphene","volume":"500","author":"Pereira","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1034\/j.1399-5618.2003.00010.x","article-title":"Menstrual cycle related mood changes in women with bipolar disorder","volume":"5","author":"Rasgon","year":"2003","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2005.08.002","article-title":"Longitudinal evaluation of reproductive function in women treated for bipolar disorder","volume":"89","author":"Rasgon","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side effects","volume":"212","author":"Simpson","year":"1970","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0180","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1004233225855","article-title":"Multilevel analysis of repeated measures data","volume":"32","author":"Van Der Leeden","year":"1998","journal-title":"Qual. Quant."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0185","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/archgenpsychiatry.2007.43","article-title":"Protein kinase c inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen","volume":"65","author":"Yildiz","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0190","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/npp.2010.192","article-title":"Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials","volume":"36","author":"Yildiz","year":"2011","journal-title":"Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.psyneuen.2014.02.004_bib0195","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1399-5618.2007.00530.x","article-title":"Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study","volume":"9","author":"Zarate","year":"2007","journal-title":"Bipolar Disord."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453014000559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453014000559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:45:25Z","timestamp":1759682725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453014000559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":40,"alternative-id":["S0306453014000559"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2014.02.004","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2014.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}