{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:57:59Z","timestamp":1787975879552,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.psyneuen.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T20:23:47Z","timestamp":1460233427000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Tandem mass spectrometry determined maternal cortisone to cortisol ratio and psychiatric morbidity during pregnancy\u2212interaction with birth weight"],"prefix":"10.1016","volume":"69","author":[{"given":"Charlotte","family":"Hellgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Edvinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelien D.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Fornes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Stener-Victorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J. Kumari A.","family":"Ubhayasekera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkistis","family":"Skalkidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Sundstr\u00f6m-Poromaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2016.04.006_bib0005","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1210\/jc.2012-1970","article-title":"Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children","volume":"97","author":"Alexander","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0010","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative RT-PCR data: a model based variance estimation approach to identify genes suited for normalization\u2212applied to bladder- and colon-cancer data-sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1203\/PDR.0b013e31818d6c24","article-title":"Prematurity is related to high placental cortisol in preeclampsia","volume":"65","author":"Aufdenblatten","year":"2009","journal-title":"Pediatr. Res."},{"issue":"Pt. 3","key":"10.1016\/j.psyneuen.2016.04.006_bib0020","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1042\/bj3131007","article-title":"Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2","volume":"313","author":"Brown","year":"1996","journal-title":"Biochem. J."},{"issue":"39","key":"10.1016\/j.psyneuen.2016.04.006_bib0025","first-page":"e391","article-title":"The maternal cortisol awakening response in human pregnancy is associated with the length of gestation","volume":"201","author":"Buss","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0030","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1192\/bjp.150.6.782","article-title":"Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale","volume":"150","author":"Cox","year":"1987","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM197501162920304","article-title":"Total cortisol in amniotic fluid and fetal lung maturation","volume":"292","author":"de Fencl","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1469-7610.2010.02314.x","article-title":"Prenatal maternal stress programs infant stress regulation","volume":"52","author":"Davis","year":"2011","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0140-6736(93)90148-A","article-title":"Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?","volume":"341","author":"Edwards","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.infbeh.2005.12.010","article-title":"Prenatal cortisol, prematurity and low birthweight","volume":"29","author":"Field","year":"2006","journal-title":"Infant. Behav. Dev."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0055","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.psyneuen.2009.10.003","article-title":"Maternal cortisol and offspring birthweight: results from a large prospective cohort study","volume":"35","author":"Goedhart","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.psyneuen.2015.04.009","article-title":"Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels","volume":"58","author":"Hannerfors","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0065","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0029-1212128","article-title":"Administration of glycyrrhetinic acid: significant correlation between serum levels and the cortisol\/cortisone-ratio in serum and urine","volume":"107","author":"Heilmann","year":"1999","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0070","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1016\/j.psyneuen.2013.08.007","article-title":"Cortisol awakening response in late pregnancy in women with previous or ongoing depression","volume":"38","author":"Hellgren","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0075","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/meta.2001.24213","article-title":"Assessing systemic 11beta-hydroxysteroid dehydrogenase with serum cortisone\/cortisol ratios in healthy subjects and patients with diabetes mellitus and chronic renal failure","volume":"50","author":"Homma","year":"2001","journal-title":"Metabolism"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0080","doi-asserted-by":"crossref","first-page":"e0135471","DOI":"10.1371\/journal.pone.0135471","article-title":"Prenatal and postpartum evening salivary cortisol levels in association with peripartum depressive symptoms","volume":"10","author":"Iliadis","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0085","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1210\/jc.2010-2395","article-title":"A longitudinal study of plasma and urinary cortisol in pregnancy and postpartum","volume":"96","author":"Jung","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0143-4004(96)80010-5","article-title":"Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat","volume":"17","author":"Langley-Evans","year":"1996","journal-title":"Placenta"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0095","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.neubiorev.2011.12.006","article-title":"Late gestational maternal serum cortisol is inversely associated with fetal brain growth","volume":"36","author":"Li","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000355761","article-title":"A functional fetal HSD11B2[CA]n microsatellite polymorphism is associated with maternal serum cortisol concentrations in pregnant women","volume":"38","author":"Li","year":"2013","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/dta.168","article-title":"Detection and confirmation of 60 anabolic and androgenic steroids in equine plasma by liquid chromatography-tandem mass spectrometry with instant library searching","volume":"3","author":"Liu","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0110","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0143-4004(03)00103-6","article-title":"Alterations in human placental 11beta-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour","volume":"24","author":"Murphy","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0115","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9378(16)33697-3","article-title":"Conversion of maternal cortisol to cortisone during placental transfer to the human fetus","volume":"118","author":"Murphy","year":"1974","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0120","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.placenta.2013.08.011","article-title":"Postdate pregnancy: changes of placental\/membranes 11beta-hydroxysteroid dehydrogenase mRNA and activity","volume":"34","author":"Novembri","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0125","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.psyneuen.2011.09.014","article-title":"Maternal prenatal anxiety and downregulation of placental 11beta-HSD2","volume":"37","author":"O\u2019Donnell","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.psyneuen.2011.11.011","article-title":"Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function","volume":"37","author":"Pawluski","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0135","first-page":"1","article-title":"Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity","author":"Reynolds","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2012.08.012","article-title":"Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis\u20142012 Curt Richter Award Winner","volume":"38","author":"Reynolds","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/joe.0.1560159","article-title":"Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes","volume":"156","author":"Ricketts","year":"1998","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0150","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1093\/hmg\/ddt182","article-title":"Glucocorticoid receptor is required for foetal heart maturation","volume":"22","author":"Rog-Zielinska","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0155","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3109\/08039488.2011.590606","article-title":"The Swedish validation of Edinburgh Postnatal Depression Scale (EPDS) during pregnancy","volume":"65","author":"Rubertsson","year":"2011","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0160","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.peptides.2005.10.002","article-title":"Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clock","volume":"27","author":"Sandman","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0165","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1067\/mob.2001.113322","article-title":"Twenty-four-hour pattern of cortisol in the human fetus at term","volume":"184","author":"Seron-Ferre","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"Suppl. 20","key":"10.1016\/j.psyneuen.2016.04.006_bib0170","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.psyneuen.2016.04.006_bib0175","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.33549\/physiolres.931505","article-title":"Comparison of total and salivary cortisol in a low-dose ACTH (Synacthen) test: influence of three-month oral contraceptives administration to healthy women","volume":"57","author":"Simunkova","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0180","series-title":"State-trait Anxiety Inventory for Adults","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0185","first-page":"885","article-title":"Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis","volume":"80","author":"Stewart","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0190","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0009-9120(01)00251-X","article-title":"Serum cortisol\/cortisone ratio after Synacthen stimulation","volume":"34","author":"Vogeser","year":"2001","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0195","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000235879","article-title":"Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction","volume":"25","author":"Wachter","year":"2009","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.psyneuen.2016.04.006_bib0200","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-0447.1996.tb09845.x","article-title":"The Edinburgh Postnatal Depression Scale: validation on a Swedish community sample","volume":"94","author":"Wickberg","year":"1996","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016300968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016300968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:51:50Z","timestamp":1759683110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453016300968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":40,"alternative-id":["S0306453016300968"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.04.006","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tandem mass spectrometry determined maternal cortisone to cortisol ratio and psychiatric morbidity during pregnancy\u2212interaction with birth weight","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}