{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:55:53Z","timestamp":1774079753107,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["105216\/Z\/14\/Z"],"award-info":[{"award-number":["105216\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","award":["MR\/L010305\/1"],"award-info":[{"award-number":["MR\/L010305\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005774","name":"University of Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000866","name":"Cardiff University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.psyneuen.2016.09.019","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T05:07:16Z","timestamp":1475212036000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-1799","authenticated-orcid":false,"given":"Trevor","family":"Humby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen S.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Messer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2016.09.019_bib0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/jmedgenet-2013-102151","article-title":"Genome-wide association study of smoking behaviours among Bangladeshi adults","volume":"51","author":"Argos","year":"2014","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jad.2013.12.042","article-title":"A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status","volume":"157","author":"Barbosa","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0015","series-title":"New Insights into Anxiety Disorders","article-title":"Understanding the causes of reduced startle reactivity in stress-related mental disorders","author":"Beck","year":"2013"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fendo.2014.00146","article-title":"An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism","volume":"5","author":"Berbel","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1192\/bjp.bp.110.082990","article-title":"Prevalence of autoimmune thyroid dysfunction in postpartum psychosis","volume":"198","author":"Bergink","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0030","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.biopsych.2012.11.006","article-title":"Immune system dysregulation in first-onset postpartum psychosis","volume":"73","author":"Bergink","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0035","first-page":"437096","article-title":"The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.psyneuen.2015.07.397","article-title":"Programming of maternal behaviour by the placenta: a novel animal model","volume":"61","author":"Creeth","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.molmed.2012.03.001","article-title":"Does steroid sulfatase deficiency influence postpartum psychosis risk?","volume":"18","author":"Davies","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0050","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/ejn.12430","article-title":"Measuring risk-taking in mice: balancing the risk between seeking reward and danger","volume":"39","author":"Dent","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0055","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/bdi.12314","article-title":"Smoking and postpartum psychosis","volume":"17","author":"Di Florio","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0060","series-title":"Psychiatric Disorders in Pregnancy and the Postpartum: Principles and Treatment","first-page":"61","article-title":"Postpartum depression: a common complication of childbirth","author":"Epperson","year":"2006"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0065","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jaad.2009.04.028","article-title":"X-linked ichthyosis: an oculocutaneous genodermatosis","volume":"62","author":"Fernandes","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0070","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.gene.2016.04.022","article-title":"Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections","volume":"586","author":"Gueugnon","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2015.07.002","article-title":"Molecular neurobiological clues to the pathogenesis of bipolar disorder","volume":"36","author":"Harrison","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/B:BEGE.0000017872.25069.44","article-title":"QTL analysis of multiple behavioral measures of anxiety in mice","volume":"34","author":"Henderson","year":"2004","journal-title":"Behav. Genet."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0085","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0006-291X(03)00865-9","article-title":"Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates","volume":"305","author":"Ho","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0090","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/sj.bjc.6602130","article-title":"Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats","volume":"91","author":"Ireson","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0095","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/hmg\/ddh203","article-title":"Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome","volume":"13","author":"Isles","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0100","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1176\/ajp.2007.164.7.1099","article-title":"Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16","volume":"164","author":"Jones","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0105","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1017\/S1461145710001495","article-title":"Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania","volume":"14","author":"Kalinichev","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/YPG.0b013e3280ae6cc3","article-title":"Serotonergic candidate genes and puerperal psychosis: an association study","volume":"17","author":"Kumar","year":"2007","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0115","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/glia.21025","article-title":"NOV\/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins","volume":"58","author":"Le Dreau","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0120","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/mp.2015.40","article-title":"Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database","volume":"21","author":"Li","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-811X-1-1","article-title":"CCN3 and calcium signaling","volume":"1","author":"Lombet","year":"2003","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-444-63486-3.00012-8","article-title":"Neural ECM in addiction, schizophrenia, and mood disorder","volume":"214","author":"Lubbers","year":"2014","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1399-5618.2006.00306.x","article-title":"Duplication 8q22.1-q24.1 associated with bipolar disorder and speech delay","volume":"8","author":"Macayran","year":"2006","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0140","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fncel.2015.00237","article-title":"Matricellular proteins of the Cyr61\/CTGF\/NOV (CCN) family and the nervous system","volume":"9","author":"Malik","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2008.12.008","article-title":"A potential role for adrenal androgens in postpartum psychiatric distress","volume":"143","author":"Marrs","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0447.2005.00595.x","article-title":"Postpartum psychiatric disturbances as an unrecognized onset of CADASIL","volume":"112","author":"Pantoni","year":"2005","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0155","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbrc.2015.04.016","article-title":"CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25","volume":"461","author":"Park","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2011.12.031","article-title":"Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes","volume":"72","author":"Pedroso","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0165","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1478-811X-4-6","article-title":"New insight into CCN3 interactions?nuclear CCN3: fact or fantasy?","volume":"4","author":"Perbal","year":"2006","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0170","first-page":"3394","article-title":"In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE","volume":"60","author":"Purohit","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0175","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/ajmg.b.30529","article-title":"Porcine maternal infanticide as a model for puerperal psychosis","volume":"144B","author":"Quilter","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1534\/g3.115.020982","article-title":"An examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period","volume":"6","author":"Ray","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0185","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-3223(85)90020-4","article-title":"Hypercalcemia in the etiology of puerperal psychosis","volume":"20","author":"Riley","year":"1985","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0190","doi-asserted-by":"crossref","first-page":"e0118510","DOI":"10.1371\/journal.pone.0118510","article-title":"Temporal and spatial transcriptional fingerprints by antipsychotic or propsychotic drugs in mouse brain","volume":"10","author":"Sakuma","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbamcr.2003.12.001","article-title":"Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress","volume":"1691","author":"Schild","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0200","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1089\/jwh.2006.15.352","article-title":"A review of postpartum psychosis","volume":"15","author":"Sit","year":"2006","journal-title":"J. Womens Health (Larchmt)"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0205","doi-asserted-by":"crossref","first-page":"e0142195","DOI":"10.1371\/journal.pone.0142195","article-title":"The effect of acute and chronic social stress on the hippocampal transcriptome in mice","volume":"10","author":"Stankiewicz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0210","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cccn.2003.10.018","article-title":"Serum concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate and their relation to cytokine production during and after normal pregnancy","volume":"340","author":"Tagawa","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0215","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/npp.2011.314","article-title":"Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice","volume":"37","author":"Trent","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0220","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.psyneuen.2012.12.002","article-title":"Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder","volume":"38","author":"Trent","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2040-2392-5-21","article-title":"Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder","volume":"5","author":"Trent","year":"2014","journal-title":"Mol. Autism"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0972-2327.145287","article-title":"Bright splenium of a psychotic mind","volume":"18","author":"Udaya","year":"2015","journal-title":"Ann. Indian Acad. Neurol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0235","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jad.2015.09.064","article-title":"Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression","volume":"189","author":"Veen","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0240","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1677\/jme.0.0320397","article-title":"Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation","volume":"32","author":"Vendrell","year":"2004","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0245","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2010.07.043","article-title":"Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells","volume":"214","author":"Wang","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0250","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1007\/s00018-014-1556-9","article-title":"The role of the CCN family of proteins in female reproduction","volume":"71","author":"Winterhager","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.psyneuen.2016.09.019_bib0255","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1093\/humrep\/det341","article-title":"Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats","volume":"28","author":"Zhang","year":"2013","journal-title":"Hum. Reprod."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016302165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016302165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:57:19Z","timestamp":1759683439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453016302165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":51,"alternative-id":["S0306453016302165"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.09.019","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}