{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T15:40:42Z","timestamp":1770651642386,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008545","name":"Georgia State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.psyneuen.2016.10.022","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T23:30:55Z","timestamp":1477438255000},"page":"100-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Histone deacetylase and acetyltransferase inhibitors modulate behavioral responses to social stress"],"prefix":"10.1016","volume":"75","author":[{"given":"Katharine E.","family":"McCann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Rosenhauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genna M.F.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Norvelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis C.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim L.","family":"Huhman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2016.10.022_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0753-3322(00)89046-0","article-title":"Environmental stress and psychiatric illness","volume":"54","author":"Agid","year":"2000","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0018-506X(92)90044-V","article-title":"Sex differences in odor-stimulated flank marking in the golden hamster (Mesocricetus auratus)","volume":"26","author":"Albers","year":"1992","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12035-011-8178-0","article-title":"Neuroanatomical profile of antimaniac effects of histone deacetylases inhibitors","volume":"43","author":"Arent","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0020","doi-asserted-by":"crossref","first-page":"51163","DOI":"10.1074\/jbc.M409024200","article-title":"Curcumin, a novel p300\/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone\/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription","volume":"279","author":"Balasubramanyam","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0025","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0031-9384(01)00490-5","article-title":"Social defeat as a stressor in humans","volume":"73","author":"Bjorkqvist","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nlm.2014.02.009","article-title":"Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus","volume":"111","author":"Blank","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn. Memory"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0040","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learn. Memory"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2015.04.030","article-title":"Antidepressant action of HDAC inhibition in the prefrontal cortex","volume":"298","author":"Covington","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0050","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.ne.15.030192.002033","article-title":"The role of the amygdala in fear and anxiety","volume":"15","author":"Davis","year":"1992","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0055","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1523\/JNEUROSCI.5634-11.2012","article-title":"HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience","volume":"32","author":"Espallergues","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1749-6632.2003.tb07077.x","article-title":"The amygdala, fear, and memory","volume":"985","author":"Fanselow","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0065","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0031-9384(87)90114-4","article-title":"Scent marking and the maintenance of dominant\/subordinate status in male golden hamsters","volume":"40","author":"Ferris","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0070","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbr.2015.02.030","article-title":"Dopamine in the nucleus accumbens modulates the memory of social defeat in Syrian hamsters (Mesocricetus auratus)","volume":"286","author":"Gray","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0080","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0085","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2013.07.035","article-title":"Repeated valproate treatment facilitates fear extinction under specific stimulus conditions","volume":"552","author":"Heinrichs","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ilar\/ilu002","article-title":"Social defeat as an animal model for depression","volume":"55","author":"Hollis","year":"2014","journal-title":"ILAR J."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yhbeh.2010.09.005","article-title":"Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus","volume":"59","author":"Hollis","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0306-4530(91)90039-V","article-title":"Plasma cyclic AMP increases in hamsters following exposure to a graded footshock stressor","volume":"16","author":"Huhman","year":"1991","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yhbeh.2003.05.001","article-title":"Conditioned defeat in male and female Syrian hamsters","volume":"44","author":"Huhman","year":"2003","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0110","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.yhbeh.2006.06.022","article-title":"Social conflict models: can they inform us about human psychopathology?","volume":"50","author":"Huhman","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0115","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0006-8993(01)03054-2","article-title":"Activation of GABA(A) receptors in the amygdala blocks the acquisition and expression of conditioned defeat in Syrian hamsters","volume":"920","author":"Jasnow","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0120","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neuroscience.2003.10.015","article-title":"N-methyl-d-aspartate receptors in the amygdala are necessary for the acquisition and expression of conditioned defeat","volume":"123","author":"Jasnow","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0125","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1037\/0735-7044.119.4.1125","article-title":"Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala","volume":"119","author":"Jasnow","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0130","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bcp.2005.01.014","article-title":"Curcumin-induced histone hypoacetylation: the role of reactive oxygen species","volume":"69","author":"Kang","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0135","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Kilgore","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2007.12.005","article-title":"Chronic microinjection of valproic acid into the nucleus accumbens attenuates amphetamine-induced locomotor activity","volume":"432","author":"Kim","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0145","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1037\/0735-7044.121.5.1125","article-title":"Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction","volume":"121","author":"Lattal","year":"2007","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0150","doi-asserted-by":"crossref","first-page":"e54463","DOI":"10.1371\/journal.pone.0054463","article-title":"A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories","volume":"8","author":"Maddox","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0155","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1523\/JNEUROSCI.3308-11.2012","article-title":"Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning","volume":"32","author":"Mahan","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/lm.768208","article-title":"Is the medial amygdala part of the neural circuit modulating conditioned defeat in Syrian hamsters?","volume":"15","author":"Markham","year":"2008","journal-title":"Learn. Memory"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1101\/lm.1633710","article-title":"Role of amygdala and hippocampus in the neural circuit subserving conditioned defeat in Syrian hamsters","volume":"17","author":"Markham","year":"2010","journal-title":"Learn. Memory"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0170","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.neuropharm.2011.09.026","article-title":"The medial prefrontal cortex is both necessary and sufficient for the acquisition of conditioned defeat","volume":"62","author":"Markham","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0175","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.physbeh.2011.09.009","article-title":"The effect of escapable versus inescapable social defeat on conditioned defeat and social recognition in Syrian hamsters","volume":"105","author":"McCann","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.physbeh.2014.02.039","article-title":"Effects of inescapable versus escapable social stress in Syrian hamsters: the importance of stressor duration versus escapability","volume":"129","author":"McCann","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.27.070203.144157","article-title":"The amygdala modulates the consolidation of memories of emotionally arousing experiences","volume":"27","author":"McGaugh","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0190","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/npp.2014.315","article-title":"A diet enriched with curcumin impairs newly acquired and reactivated fear memories","volume":"40","author":"Monsey","year":"2015","journal-title":"Neuropsychopharmac"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0195","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0022-3565(25)32998-8","article-title":"Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse","volume":"220","author":"Nau","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0200","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/scientificamerican0698-42","article-title":"The neurobiology of depression","volume":"278","author":"Nemeroff","year":"1998","journal-title":"Sci. Am."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0205","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nn.3296","article-title":"Implications of memory modulation for post-traumatic stress and fear disorders","volume":"16","author":"Parsons","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0210","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0215","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/FBP.0b013e32836104ea","article-title":"Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior","volume":"24","author":"Ploense","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0220","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbr.2011.03.033","article-title":"Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats","volume":"221","author":"Reolon","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/npp.2010.184","article-title":"Dissociable roles of prelimbic and infralimbic cortices ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear","volume":"36","author":"Sierra-Mercado","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0230","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/adb.12161","article-title":"The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals","volume":"20","author":"Simon-O'Brien","year":"2015","journal-title":"Addict. Biol."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0235","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.psyneuen.2014.08.005","article-title":"Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors","volume":"50","author":"Song","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0240","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-013-1636-4","article-title":"Animal models of social avoidance and social fear","volume":"354","author":"Toth","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0245","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1073\/pnas.262658999","article-title":"An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability","volume":"99","author":"Tremolizzo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0250","first-page":"347","article-title":"Actions of sodium valproate on the central nervous system","volume":"50","author":"Tunnicliff","year":"1999","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.psyneuen.2016.10.022_bib0255","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainresbull.2011.03.007","article-title":"Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim test","volume":"85","author":"Xing","year":"2011","journal-title":"Brain Res. Bull."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016308587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453016308587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:54:52Z","timestamp":1759683292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453016308587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":51,"alternative-id":["S0306453016308587"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.10.022","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone deacetylase and acetyltransferase inhibitors modulate behavioral responses to social stress","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2016.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}