{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:51:50Z","timestamp":1791435110781,"version":"4.3.3"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.psyneuen.2017.08.020","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T06:17:16Z","timestamp":1503382636000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Pharmacological challenge studies with acute psychosocial stress"],"prefix":"10.1016","volume":"85","author":[{"given":"Kathryne","family":"Van Hedger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya K.","family":"Bershad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2017.08.020_bib0005","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1162\/jocn.2007.19.3.468","article-title":"Beta-adrenergic modulation of cognitive flexibility during stress","volume":"19","author":"Alexander","year":"2007","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ynstr.2016.11.001","article-title":"The trier social stress test: principles and practice","volume":"6","author":"Allen","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0015","first-page":"8","article-title":"The combined propranolol\/TSST paradigm \u2013 a new method for psychoneuroendocrinology","author":"Andrews","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0020","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.yhbeh.2011.01.004","article-title":"The stress-response-dampening effects of placebo","volume":"59","author":"Balodis","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00213-009-1635-z","article-title":"Effects of MDMA on sociability and neural response to social threat and social reward","volume":"207","author":"Bedi","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0030","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/npp.2011.6","article-title":"Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-na\u00efve social phobia patients","volume":"36","author":"Bergamaschi","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0035","article-title":"Gabapentin therapy in psychiatric disorders","author":"Berlin","year":"2015","journal-title":"Primary Care Companion CNS Disord."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.psyneuen.2014.12.004","article-title":"Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans","volume":"52","author":"Bershad","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0045","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1080\/17470919.2016.1143026","article-title":"Oxytocin receptor gene variation predicts subjective responses to MDMA","volume":"11","author":"Bershad","year":"2016","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0050","article-title":"MDMA does not alter responses to the Trier Social Stress Test in humans","volume":"1\u20138","author":"Bershad","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0055","unstructured":"Bershad, A.K., Miller, M.A., Norman, G., de Wit, H., (under review). Effects of opioid and non-opioid analgesics on responses to acute psychosocial stress."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4603(81)80001-9","article-title":"Alcohol, expectancy and stress: methodological concerns with the expectancy design","volume":"6","author":"Bradlyn","year":"1981","journal-title":"Addict. Behav."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0065","first-page":"538","article-title":"Caffeine and psychiatric symptoms: a review","volume":"97","author":"Broderick","year":"2004","journal-title":"J. Okla. State Med. Assoc."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0070","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.psyneuen.2011.12.010","article-title":"Acute psychosocial stress: does the emotional stress response correspond with physiological responses?","volume":"37","author":"Campbell","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.15288\/qjsa.1972.33.033","article-title":"Alcohol and tension reduction. A review","volume":"33","author":"Cappell","year":"1972","journal-title":"Q. J. Stud. Alcohol"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1176\/appi.ajp.161.2.195","article-title":"Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress","volume":"161","author":"Charney","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0085","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/j.1530-0277.2011.01522.x","article-title":"Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men","volume":"35","author":"Childs","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0090","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/0269881116650388","article-title":"Effects of d-amphetamine upon psychosocial stress responses","volume":"30","author":"Childs","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.drugalcdep.2017.03.030","article-title":"Dose-related effects of delta \u22129-tetrahydrocannabinol on emotional responses to acute stress","volume":"177","author":"Childs","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0100","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.npp.1300856","article-title":"The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress","volume":"31","author":"Chong","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12630-013-9890-1","article-title":"Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial","volume":"60","author":"Clarke","year":"2013","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0110","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/0269881103017002006","article-title":"Effects of gabapentin on anxiety induced by simulated public speaking","volume":"17","author":"de Paris","year":"2003","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0120","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1177\/0269881112472560","article-title":"The 5-HT1D\/1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin","volume":"27","author":"de Rezende","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0125","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/0956797610374741","article-title":"Acetaminophen reduces social pain: behavioral and neural evidence","volume":"21","author":"DeWall","year":"2010","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jesp.2014.09.006","article-title":"Can acetaminophen reduce the pain of decision making?","volume":"56","author":"DeWall","year":"2015","journal-title":"J. Exp. Soc. Psychol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nlm.2014.01.010","article-title":"Retrieval-induced forgetting under psychosocial stress: no reduction by delayed stress and beta-adrenergic blockade","volume":"110","author":"Dreifus","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0140","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tics.2004.05.010","article-title":"Why rejection hurts: a common neural alarm system for physical and social pain","volume":"8","author":"Eisenberger","year":"2004","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0145","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.psyneuen.2006.09.009","article-title":"Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam","volume":"31","author":"Fries","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2013.11.030","article-title":"MDMA decreases the effects of simulated social rejection","volume":"117","author":"Frye","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0155","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1177\/0269881108101782","article-title":"Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation","volume":"24","author":"Garcia-Leal","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0160","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00006842-199705000-00012","article-title":"Smoking status and nicotine administration differentially modify hemodynamic stress reactivity in men and women","volume":"59","author":"Girdler","year":"1997","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0165","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1176\/ajp.138.9.1215","article-title":"Treatment of spontaneous panic attacks with chlomipramine","volume":"138","author":"Gloger","year":"1981","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2017.02.030","article-title":"Meta-analytical assessment of the effects of protocol variations on cortisol responses to the Trier Social Stress Test","volume":"80","author":"Goodman","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0175","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF00432224","article-title":"Effect of metergoline on human anxiety","volume":"86","author":"Graeff","year":"1985","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0180","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/026988118700100305","article-title":"Effect of chlorimipramine and maprotiline on experimental anxiety in humans","volume":"1","author":"Guimar\u00e3es","year":"1987","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/026988119701100305","article-title":"Ritanserin facilitates anxiety in a simulated public-speaking paradigm","volume":"11","author":"Guimar\u00e3es","year":"1997","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0190","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.npp.1300004","article-title":"Acute SSRI administration affects the processing of social cues in healthy volunteers","volume":"28","author":"Harmer","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0195","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF02806003","article-title":"Effect of d \u2212fenfluramine on human experimental anxiety","volume":"127","author":"Hetem","year":"1996","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0200","doi-asserted-by":"crossref","first-page":"e013433","DOI":"10.1136\/bmjopen-2016-013433","article-title":"Biological rationale and potential clinical use of gabapentin and pregabalin in bipolar disorder, insomnia and anxiety: protocol for a systematic review and meta-analysis","volume":"7","author":"Houghton","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0205","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tins.2016.12.006","article-title":"Cannabidiol: swinging the marijuana pendulum from \u2018weed' to medication to treat the opioid epidemic","volume":"40","author":"Hurd","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00213-012-2645-9","article-title":"MDMA enhances mind reading of positive emotions and impairs mind reading of negative emotions","volume":"222","author":"Hysek","year":"2012","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0215","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1152\/jn.00933.2007","article-title":"Facilitation of cortico-amygdala synapses by nicotine: activity-dependent modulation of glutamatergic transmission","volume":"99","author":"Jiang","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0220","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02245463","article-title":"Flumazenil has an anxiolytic effect in simulated stress","volume":"114","author":"Kapczinski","year":"1994","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0225","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1176\/appi.ajp.2016.15121509","article-title":"The phenomenology of major depression and the representativeness and nature of DSM criteria","volume":"173","author":"Kendler","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0230","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/sode.12203","article-title":"Effect of pet dogs on children\u2019s perceived stress and cortisol stress response","volume":"26","author":"Kertes","year":"2017","journal-title":"Soc. Dev."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0235","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1176\/ajp.142.11.1259","article-title":"The self medication hypothesis of addictive disorders: focus on heroin and cocaine dependence","volume":"142","author":"Khantzian","year":"1985","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0240","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/add.12004","article-title":"Addiction as a self-regulation disorder and the role of self-medication","volume":"108","author":"Khantzian","year":"2013","journal-title":"Addiction"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0245","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/npp.2014.12","article-title":"Effects of MDMA and intranasal oxytocin on social and emotional processing","volume":"39","author":"Kirkpatrick","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0250","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000119004","article-title":"The \u2018Trier Social Stress Test\u2019 \u2212 a tool for investigating psychobiological stress responses in a laboratory setting","volume":"28","author":"Kirschbaum","year":"1993","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0255","first-page":"56","article-title":"Ten years of research with the trier social stress test","author":"Kudielka","year":"2007","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0260","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00006842-199005000-00006","article-title":"Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption","volume":"52","author":"Lane","year":"1990","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0265","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(93)91660-K","article-title":"Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex","volume":"612","author":"Lees","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0270","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1037\/0021-843X.89.4.528","article-title":"Alcohol and stress response dampening: pharmacological effects, expectancy, and tension reduction","volume":"89","author":"Levenson","year":"1980","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0275","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2017.04.007","article-title":"Sex differences in salivary cortisol reactivity to the Trier Social Stress Test (TSST): a meta-analysis","volume":"82","author":"Liu","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0280","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.pbb.2006.03.005","article-title":"Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women","volume":"83","author":"Lovallo","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0285","first-page":"1","article-title":"Transdiagnostic neural correlates of affective face processing in anxiety and depression","author":"MacNamara","year":"2017","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0290","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000076045","article-title":"Modulation of neuroendocrine response and non-verbal behavior during psychosocial stress in healthy volunteers by the glutamate release-inhibiting drug lamotrigine","volume":"79","author":"Makatsori","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0295","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0006-3223(00)00964-1","article-title":"Effects of adverse experiences for brain structure and function","volume":"48","author":"McEwen","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0300","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00436092","article-title":"Simulated public speaking as a model of clinical anxiety","volume":"77","author":"McNair","year":"1982","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0305","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/npp.2015.316","article-title":"Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress","volume":"41","author":"Mineur","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0310","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/scan\/nsw057","article-title":"From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain","volume":"1","author":"Mischkowski","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0315","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1590\/S0100-879X2000000500013","article-title":"Effects of tryptophan depletion on anxiety induced by simulated public speaking","volume":"33","author":"Monteiro-dos-Santos","year":"2000","journal-title":"Braz. J. Med Biol. Res."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0320","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0014-2999(75)90297-6","article-title":"Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons","volume":"32","author":"Nyb\u00e4ck","year":"1975","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0325","first-page":"607","article-title":"The biology of social attachments: opiates alleviate separation distress","volume":"13","author":"Panksepp","year":"1978","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0330","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0149-7634(80)90036-6","article-title":"Endogenous opioids and social behavior","volume":"4","author":"Panksepp","year":"1980","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0335","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02245082","article-title":"Individual differences in stress and arousal during cigarette smoking","volume":"115","author":"Parrott","year":"1994","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0340","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/mp.2017.36","article-title":"Identifying fast-onset antidepressants using rodent models","volume":"22","author":"Ramaker","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0345","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/026988119300700305","article-title":"Clomipramine and initial worsening in panic disorder: beyond the \u2018jitteriness syndrome'","volume":"7","author":"Ramos","year":"1993","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0350","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-2007-1000811","article-title":"The stress-, but not corticotropin-releasing hormone-induced activation of the pituitary-adrenal axis in man is blocked by alprazolam","volume":"26","author":"Rohrer","year":"1994","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0355","first-page":"250","article-title":"Does drinking reduce stress?","volume":"23","author":"Sayette","year":"1999","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0360","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1037\/h0046234","article-title":"Cognitive, social, and physiological determinants of emotional state","volume":"69","author":"Schachter","year":"1962","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0365","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/138032a0","article-title":"A syndrome produced by diverse nocuous agents","volume":"138","author":"Selye","year":"1936","journal-title":"Nature"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0370","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1037\/0021-843X.95.2.159","article-title":"Individual differences in the stress-response-dampening effect of alcohol: a dose-response study","volume":"95","author":"Sher","year":"1986","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0375","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s002130100752","article-title":"Opposite effects of nefazodone in two human models of anxiety","volume":"156","author":"Silva","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0380","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s002130100917","article-title":"How does stress increase risk of drug abuse and relapse?","volume":"158","author":"Sinha","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0385","first-page":"1","article-title":"Modelling depression in animals: at the interface of reward and stress pathways","author":"Slattery","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0390","series-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1983"},{"issue":"Suppl. 1","key":"10.1016\/j.psyneuen.2017.08.020_bib0395","first-page":"S39","article-title":"Mechanisms of action of gabapentin","volume":"153","author":"Taylor","year":"1997","journal-title":"Rev. Neurol. (Paris)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0400","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.pnpbp.2004.05.031","article-title":"Can stress cause depression?","volume":"28","author":"van Praag","year":"2004","journal-title":"Prog Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0405","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neulet.2008.10.005","article-title":"Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain","volume":"448","author":"Wallace","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0410","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1007\/s00213-014-3570-x","article-title":"MDMA alters emotional processing and facilitates positive social interaction","volume":"231","author":"Wardle","year":"2014","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0415","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00213-010-2150-y","article-title":"Effect of social stress during acute nicotine abstinence","volume":"218","author":"Wardle","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0420","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1369-1600.2006.00026.x","article-title":"Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress","volume":"12","author":"Zimmermann","year":"2007","journal-title":"Addict. Biol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0425","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.psyneuen.2016.11.036","article-title":"Cortisol stress reactivity across psychiatric disorders: a systematic review and meta-analysis","volume":"77","author":"Zorn","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0430","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/026988119300700112","article-title":"Effects of ipsapirone and cannabidiol on human experimental anxiety","volume":"7","author":"Zuardi","year":"1993","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0435","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3389\/fphar.2017.00259","article-title":"Inverted u-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life","volume":"8","author":"Zuardi","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psyneuen.2017.08.020_bib0440","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1126\/science.1078546","article-title":"COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor","volume":"299","author":"Zubieta","year":"2003","journal-title":"Science"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017305449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017305449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:58:05Z","timestamp":1759683485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453017305449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":88,"alternative-id":["S0306453017305449"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2017.08.020","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological challenge studies with acute psychosocial stress","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2017.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}