{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:27:00Z","timestamp":1770272820536,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC1001900"],"award-info":[{"award-number":["2017YFC1001900"]}]},{"name":"National Key R&D Program of China","award":["2017YFC1001900"],"award-info":[{"award-number":["2017YFC1001900"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070576"],"award-info":[{"award-number":["81070576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["12JCZDJC24700"],"award-info":[{"award-number":["12JCZDJC24700"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.psyneuen.2017.11.010","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T15:00:30Z","timestamp":1511362830000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["T4 and waist:hip ratio as biomarkers of antipsychotic-induced weight gain in Han Chinese inpatients with schizophrenia"],"prefix":"10.1016","volume":"88","author":[{"given":"Shen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2017.11.010_bib0005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.psychres.2008.10.007","article-title":"Understanding the relationship between baseline BMI and subsequent weight change in antipsychotic trials: effect modification or regression to the mean?","volume":"170","author":"Allison","year":"2009","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jcp.20273","article-title":"Differential effects of thyroid hormones on energy metabolism of rat slow- and fast-twitch muscles","volume":"203","author":"Bahi","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0015","doi-asserted-by":"crossref","first-page":"e94112","DOI":"10.1371\/journal.pone.0094112","article-title":"Almost all antipsychotics result in weight gain: a meta-analysis","volume":"9","author":"Bak","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmed.2010.10.010","article-title":"Antipsychotic drugs and obesity","volume":"17","author":"Correll","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0025","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jamapsychiatry.2014.1314","article-title":"Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study","volume":"71","author":"Correll","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.eurpsy.2009.01.005","article-title":"Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC)","volume":"24","author":"De Hert","year":"2009","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrendo.2011.156","article-title":"Metabolic and cardiovascular adverse effects associated with antipsychotic drugs","volume":"8","author":"De Hert","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0040","doi-asserted-by":"crossref","DOI":"10.2174\/1871530317666170320105221","article-title":"Thyroid hormones, metabolic syndrome and its components","author":"Delitala","year":"2017","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0045","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1210\/jc.2006-0478","article-title":"Insulin action in adipose tissue and muscle in hypothyroidism","volume":"91","author":"Dimitriadis","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.psyneuen.2015.12.024","article-title":"A low TSH profile predicts olanzapine-induced weight gain and relief by adjunctive topiramate in healthy male volunteers","volume":"66","author":"Evers","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0055","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4088\/JCP.v69n0401","article-title":"Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges","volume":"69","author":"Fleischhacker","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0060","first-page":"434","article-title":"The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects","volume":"102","author":"Gu","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0065","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.psyneuen.2010.12.018","article-title":"Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia","volume":"36","author":"Guest","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0070","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.psyneuen.2012.09.009","article-title":"Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies","volume":"38","author":"Harris","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0075","series-title":"Handbook of Experimental Pharmacology","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-3-642-25761-2_6","article-title":"Metabolic consequences of antipsychotic therapy: preclinical and clinical perspectives on diabetes, diabetic ketoacidosis, and obesity","author":"Heal","year":"2012"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0080","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2165\/00023210-200620050-00004","article-title":"Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia","volume":"20","author":"Horacek","year":"2006","journal-title":"CNS Drugs"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00213-013-3073-1","article-title":"A randomized, 12-week study of the effects of extended-release paliperidone (paliperidone ER) and olanzapine on metabolic profile, weight, insulin resistance, and beta-cell function in schizophrenic patients","volume":"230","author":"Hu","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000351249","article-title":"Thyroid hormones and the metabolic syndrome","volume":"2","author":"Iwen","year":"2013","journal-title":"Eur. Thyroid J."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0095","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4306\/pi.2015.12.2.242","article-title":"Metabolic disturbances independent of body mass in patients with schizophrenia taking atypical antipsychotics","volume":"12","author":"Kang","year":"2015","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0100","first-page":"488","article-title":"Comparison of fasting blood sugar and serum lipid profile changes after treatment with atypical antipsychotics olanzapine and risperidone","volume":"53","author":"Kaushal","year":"2012","journal-title":"Singapore Med. J."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0105","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.schres.2015.11.002","article-title":"Early insulin resistance predicts weight gain and waist circumference increase in first-episode psychosis\u2014a one year follow-up study","volume":"169","author":"Keinanen","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0110","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1055\/s-0034-1367060","article-title":"Triiodothyronine induces proliferation of pancreatic beta-cells through the MAPK\/ERK pathway","volume":"122","author":"Kim","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0115","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(13)60733-3","article-title":"Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis","volume":"382","author":"Leucht","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0120","doi-asserted-by":"crossref","first-page":"45203","DOI":"10.1038\/srep45203","article-title":"TOX and ADIPOQ gene polymorphisms are associated with antipsychotic-Induced weight gain in han chinese","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0125","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1586\/ern.10.85","article-title":"Management of antipsychotic-related weight gain","volume":"10","author":"Maayan","year":"2010","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0130","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1530\/EJE-08-0797","article-title":"Studies of insulin resistance in patients with clinical and subclinical hypothyroidism","volume":"160","author":"Maratou","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0135","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1176\/ajp.2007.164.7.1050","article-title":"Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis: a randomized, double-blind 52-week comparison","volume":"164","author":"McEvoy","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0140","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s00228-014-1762-2","article-title":"Effects of second-generation antipsychotics on selected markers of one-carbon metabolism and metabolic syndrome components in first-episode schizophrenia patients","volume":"70","author":"Misiak","year":"2014","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.psyneuen.2017.11.010_bib0145","first-page":"20","article-title":"Metabolic considerations in the use of antipsychotic medications: a review of recent evidence","volume":"68","author":"Newcomer","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0150","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.euroneuro.2009.03.003","article-title":"Tolerability of outpatient antipsychotic treatment: 36-month results from the european schizophrenia outpatient health outcomes (SOHO) study","volume":"19","author":"Novick","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/dme.12589","article-title":"Positive association of free triiodothyronine with pancreatic beta-cell function in people with prediabetes","volume":"32","author":"Oda","year":"2015","journal-title":"Diabetic Med."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0160","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2015.1737","article-title":"Premature mortality among adults with schizophrenia in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0165","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00213-012-2850-6","article-title":"Comparison of metabolic effects of ziprasidone versus olanzapine treatment in patients with first-episode schizophrenia","volume":"225","author":"Ou","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S1461145713001053","article-title":"Course of weight gain and metabolic abnormalities in first treated episode of psychosis: the first year is a critical period for development of cardiovascular risk factors","volume":"17","author":"Perez-Iglesias","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0175","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.schres.2008.01.004","article-title":"Metabolic syndrome in first episode schizophrenia\u2014a randomized double-blind controlled, short-term prospective study","volume":"101","author":"Saddichha","year":"2008","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/15622975.2013.817685","article-title":"Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain","volume":"16","author":"Schwarz","year":"2015","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0185","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11920-014-0473-9","article-title":"Antipsychotic induced weight gain: genetics, epigenetics, and biomarkers reviewed","volume":"16","author":"Shams","year":"2014","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0190","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1176\/appi.ajp.2008.08050756","article-title":"Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study","volume":"165","author":"Sikich","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0195","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-0447.2008.01334.x","article-title":"Which comes first: atypical antipsychotic treatment or cardiometabolic risk?","volume":"119","author":"Stahl","year":"2009","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1359786806071243","article-title":"Review of the evidence for the long-term efficacy of atypical antipsychotic agents in the treatment of patients with schizophrenia and related psychoses","volume":"20","author":"Turner","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0205","doi-asserted-by":"crossref","first-page":"e1417","DOI":"10.4088\/JCP.14m09358","article-title":"Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment","volume":"76","author":"Vandenberghe","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0210","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0215","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/ajcn\/81.3.555","article-title":"Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men","volume":"81","author":"Wang","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0220","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.schres.2013.07.051","article-title":"The comparison of glycometabolism parameters and lipid profiles between drug-naive, first-episode schizophrenia patients and healthy controls","volume":"150","author":"Wu","year":"2013","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0225","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/schbul\/sbv179","article-title":"Genome-wide association study suggested the PTPRD polymorphisms were associated with weight gain effects of atypical antipsychotic medications","volume":"42","author":"Yu","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0230","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/schbul\/sbw058","article-title":"Pharmacogenetic associations of antipsychotic drug-related weight gain: a systematic review and meta-analysis","volume":"42","author":"Zhang","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0235","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11126-015-9385-z","article-title":"Quality of life and hormonal, biochemical, and anthropometric profile between olanzapine and risperidone users","volume":"87","author":"de Araujo","year":"2016","journal-title":"Psychiatr. Q."},{"key":"10.1016\/j.psyneuen.2017.11.010_bib0240","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2869.2010.00871.x","article-title":"Sleep onset and cardiovascular activity in primary insomnia","volume":"20","author":"de Zambotti","year":"2011","journal-title":"J. Sleep Res."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017311769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017311769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:58:34Z","timestamp":1759683514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453017311769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":48,"alternative-id":["S0306453017311769"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2017.11.010","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T4 and waist:hip ratio as biomarkers of antipsychotic-induced weight gain in Han Chinese inpatients with schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2017.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}