{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:54:47Z","timestamp":1765382087965,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Fondazione Centro Studi sulla Calvizie Cesare Ragazzi Laboratories, Zola Predosa, Bologna, Italy."}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.psyneuen.2018.02.022","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T12:49:42Z","timestamp":1519476582000},"page":"31-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Salivary cortisol and cortisone responses to short-term psychological stress challenge in late adolescent and young women with different hyperandrogenic states"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-3041","authenticated-orcid":false,"given":"Marco","family":"Mezzullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaminia","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-8906","authenticated-orcid":false,"given":"Guido","family":"Di Dalmazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-3369","authenticated-orcid":false,"given":"Alessia","family":"Fazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ibarra-Gasparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-4153","authenticated-orcid":false,"given":"Marianna","family":"Mastroroberto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Guidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Maria","family":"Morselli-Labate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Gambineri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2018.02.022_bib0005","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1515\/cclm-2015-0412","article-title":"Immunoassay or LC-MS\/MS for the measurement of salivary cortisol in children?","volume":"54","author":"Bae","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0010","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1093\/humrep\/der197","article-title":"Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"26","author":"Barry","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0015","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.psyneuen.2008.12.001","article-title":"Disturbed stress responses in women with polycystic ovary syndrome","volume":"34","author":"Benson","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0020","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.psyneuen.2009.01.003","article-title":"Adolescents\u2019 cortisol responses to awakening and social stress; effects of gender, menstrual phase and oral contraceptives. The TRAILS study","volume":"34","author":"Bouma","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2133.1984.tb04020.x","article-title":"The assessment of acne vulgaris \u2013 the Leeds technique","volume":"111","author":"Burke","year":"1984","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0030","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1001\/jama.1992.03480090092034","article-title":"The concept of stress and stress system disorders. Overview of physical and behavioral homeostasis","volume":"267","author":"Chrousos","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0035","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/humrep\/des113","article-title":"Effect of an oral contraceptive on emotional distress, anxiety and depression of women with polycystic ovary syndrome: a prospective study","volume":"27","author":"Cinar","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0040","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dex044","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"32","author":"Cooney","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1043-2760(05)80017-7","article-title":"Stress update: adaptation of the hypothalamic-pituitary adrenalaxis to chronic stress","volume":"4","author":"Dallman","year":"1993","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/AOG.0b013e318202b0a4","article-title":"Increased risk for abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"117","author":"Dokras","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.fertnstert.2011.10.022","article-title":"Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis","volume":"97","author":"Dokras","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/0167482X.2010.501398","article-title":"Quality of life, mental health and self-esteem in hirsute adolescent females","volume":"31","author":"Drosdzol","year":"2010","journal-title":"J. Psychosom. Obstet. Gynaecol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0065","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.steroids.2010.11.005","article-title":"Serum steroid profiling by isotopic dilution-liquid chromatography-mass spectrometry: comparison with current immunoassays and reference intervals in healthy adults","volume":"76","author":"Fanelli","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0070","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1210\/jc.2013-1381","article-title":"Androgen profiling by liquid chromatography-tandem mass spectrometry (LC-MS\/MS) in healthy normal-weight ovulatory and anovulatory late adolescent and young women","volume":"98","author":"Fanelli","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0075","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0080","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0015-0282(99)00601-9","article-title":"Autonomic and neuroendocrine responses to stress in patients with functional hypothalamic secondary amenorrhea","volume":"73","author":"Gallinelli","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0085","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1210\/jc.2012-3537","article-title":"Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on italian high-school students","volume":"98","author":"Gambineri","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0090","series-title":"UpToDate","article-title":"Terminology and evaluation of abnormal uterine bleeding in premenopausal woman","author":"Goodman","year":"2007"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0095","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/cen.12783","article-title":"Psychological aspects of hyperandrogenic states in late adolescent and young women","volume":"83","author":"Guidi","year":"2015","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0100","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jc.2014-3886","article-title":"The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage","volume":"100","author":"Hart","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0105","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology and management","volume":"140","author":"Hatch","year":"1981","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.psyneuen.2008.10.026","article-title":"Salivary cortisol as a biomarker in stress research","volume":"34","author":"Hellhammer","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0115","doi-asserted-by":"crossref","first-page":"14111","DOI":"10.1038\/s41598-017-13927-7","article-title":"Evidence for stress-like alterations in the HPA-axis in women taking oral contraceptives","volume":"7","author":"Hertel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0120","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0024-3205(99)00019-3","article-title":"The awakening cortisol response and blood glucose levels","volume":"64","author":"Hucklebridge","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0125","first-page":"269","article-title":"A symptom questionnaire","volume":"48","author":"Kellner","year":"1987","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0130","first-page":"57","article-title":"Interaction between circadian rhythms and stress","volume":"8","author":"Koch","year":"2016","journal-title":"Neurobiol. Stress."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/01674820802546204","article-title":"Anxiety and depression in adolescents with polycystic ovary syndrome and Mayer-Rokitansky-K\u00fcster-Hauser syndrome","volume":"30","author":"Laggari","year":"2010","journal-title":"J. Psychosom. Obstet. Gynaecol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0140","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0009-8981(87)90183-5","article-title":"The effect of oral contraceptives on plasma-free and salivary cortisol and cortisone","volume":"165","author":"Meulenberg","year":"1987","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jsbmb.2016.04.012","article-title":"Validation of an LC-MS\/MS assay for glucocorticoid status assessment: evaluation of the diurnal fluctuation of cortisol and cortisone and of their association within and between serum and saliva","volume":"163","author":"Mezzullo","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0155","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1055\/s-0031-1283122","article-title":"Hypothalamic-pituitary-adrenocortical axis hypersensitivity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome","volume":"119","author":"Milutinovi\u0107","year":"2011","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0160","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1093\/humrep\/des114","article-title":"Psychological parameters in the reproductive phenotypes of polycystic ovary syndrome","volume":"27","author":"Moran","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/er.2015-1080","article-title":"The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids","volume":"38","author":"Oster","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0170","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2265.1998.00458.x","article-title":"Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution","volume":"48","author":"Pasquali","year":"1998","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0175","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/ijo.2008.129","article-title":"Sex dependent role of glucocorticoids and androgens in the pathophysiology of human obesity","volume":"38","author":"Pasquali","year":"2008","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0180","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1016\/j.jchromb.2009.09.014","article-title":"Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions","volume":"877","author":"Perogamvros","year":"2009","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0185","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cct.2015.01.021","article-title":"Mindfulness-based stress reduction for overweight\/obese women with and without polycystic ovary syndrome: design and methods of a pilot randomized controlled trial","volume":"41","author":"Raja-Khan","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000353263","article-title":"Psychological well-being revisited: advances in the science and practice of eudaimonia","volume":"83","author":"Ryff","year":"2014","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0195","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/pgmj.74.873.408","article-title":"A simple instrument for assessing stress in clinical practice","volume":"74","author":"Sonino","year":"1998","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0200","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/10253890.2014.974030","article-title":"Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial","volume":"18","author":"Stefanaki","year":"2015","journal-title":"Stress"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000216186","article-title":"Salivary cortisol for assessment of hypothalamic-pituitary-adrenal axis function","volume":"16","author":"T\u00f6rnhage","year":"2009","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0210","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1083-3188(02)00205-X","article-title":"Fertility concerns and sexual behavior in adolescent girls with polycystic ovary syndrome: implications for quality of life","volume":"16","author":"Trent","year":"2003","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1367\/A04-130R.1","article-title":"Overweight status of adolescent girls with polycystic ovary syndrome: body mass index as mediator of quality of life","volume":"5","author":"Trent","year":"2005","journal-title":"Ambul. Pediatr."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0220","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archpedi.156.6.556","article-title":"Quality of life in adolescent girls with polycystic ovary syndrome","volume":"156","author":"Trent","year":"2010","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0225","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/humupd\/dms029","article-title":"Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies","volume":"18","author":"Veltman-Verhulst","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0230","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/000456328302000601","article-title":"Salivary cortisol: a better measure of adrenal cortical function than serum cortisol","volume":"20","author":"Vining","year":"1983","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0235","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"Wild","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2018.02.022_bib0240","series-title":"Polycystic Ovary Syndrome","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"Zawadzki","year":"1992"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017314142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453017314142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:58:55Z","timestamp":1759683535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453017314142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":48,"alternative-id":["S0306453017314142"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2018.02.022","relation":{},"ISSN":["0306-4530"],"issn-type":[{"type":"print","value":"0306-4530"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salivary cortisol and cortisone responses to short-term psychological stress challenge in late adolescent and young women with different hyperandrogenic states","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2018.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}