{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:52:39Z","timestamp":1793479959305,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"am","delay-in-days":270,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes OF Health","doi-asserted-by":"crossref","award":["AG050054"],"award-info":[{"award-number":["AG050054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF CAREER 1553067"],"award-info":[{"award-number":["NSF CAREER 1553067"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.psyneuen.2018.12.010","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T12:23:23Z","timestamp":1544531003000},"page":"248-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"special_numbering":"C","title":["Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-2127","authenticated-orcid":false,"given":"Scott A.","family":"Kinlein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler R.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5605-4962","authenticated-orcid":false,"given":"Ilia N.","family":"Karatsoreos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2018.12.010_bib0005","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.yhbeh.2013.03.017","article-title":"Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice","volume":"63","author":"Aliczki","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.0007-1331.2002.00792.x","article-title":"Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint","volume":"14","author":"Bhatnagar","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0015","first-page":"348","article-title":"Anatomic, hematologic, and biochemical features of C57BL\/6NCrl mice maintained on chronic oral corticosterone","volume":"62","author":"Cassano","year":"2012","journal-title":"Comp. Med."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(90)91570-7","article-title":"Afferent connections of the thalamic paraventricular and parataenial nuclei in the rat--a retrograde tracing study with iontophoretic application of fluoro-Gold","volume":"522","author":"Chen","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0025","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ejphar.2007.11.070","article-title":"Central corticosteroid actions: search for gene targets","volume":"583","author":"Datson","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0030","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jpsychires.2005.08.002","article-title":"Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review","volume":"40","author":"de Kloet","year":"2006","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0035","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1365-2826.2010.02000.x","article-title":"Nongenomic actions of adrenal steroids in the central nervous system","volume":"22","author":"Evanson","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0040","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.2174\/138161212803530907","article-title":"The role of life events and HPA axis in anxiety disorders: a review","volume":"18","author":"Faravelli","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172868","article-title":"Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences","volume":"12","author":"Finnell","year":"2017","journal-title":"PloS one"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0050","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2007"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0055","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2012.08.016","article-title":"Neural mechanisms of stress resilience and vulnerability","volume":"75","author":"Franklin","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0060","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1038\/ncomms11937","article-title":"Hypothalamic CRH neurons orchestrate complex behaviours after stress","volume":"7","author":"Fuzesi","year":"2016","journal-title":"Nat. Commun."},{"issue":"Suppl. 1","key":"10.1016\/j.psyneuen.2018.12.010_bib0065","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.psy.0000163456.22154.d2","article-title":"Hypercortisolemia and depression","volume":"67","author":"Gillespie","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","article-title":"Regulation of the hypothalamic-pituitary-adrenocortical stress response","volume":"6","author":"Herman","year":"2016","journal-title":"Comprehens. Physiol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0075","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1210\/en.2011-1652","article-title":"Orexins\/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress","volume":"152","author":"Heydendael","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fnbeh.2014.00073","article-title":"Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood","volume":"8","author":"Hsu","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0085","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1210\/en.2005-1393","article-title":"Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress","volume":"147","author":"Jaferi","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0090","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1124\/pr.112.005892","article-title":"Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes","volume":"64","author":"Joels","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0018-506X(72)90011-6","article-title":"Effects of adrenalectomy on open-field behavior in rats","volume":"3","author":"Joffe","year":"1972","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0100","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/j.pain.0000000000000318","article-title":"Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception","volume":"156","author":"Jurik","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0105","article-title":"Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review","author":"Juruena","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0115","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1210\/en.2009-1436","article-title":"Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse","volume":"151","author":"Karatsoreos","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fpsyt.2015.00031","article-title":"Dysregulated hypothalamic-pituitary-adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress","volume":"6","author":"Kinlein","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0125","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1210\/en.2017-00208","article-title":"Chronic corticosterone treatment during adolescence has significant effects on metabolism and skeletal development in male C57BL6\/N mice","volume":"158","author":"Kinlein","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neubiorev.2015.08.005","article-title":"Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior","volume":"56","author":"Kirouac","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0135","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.bbi.2007.11.006","article-title":"Coping style and immunity in animals: making sense of individual variation","volume":"22","author":"Koolhaas","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cne.21502","article-title":"Projections from the paraventricular nucleus of the thalamus to the forebrain, with special emphasis on the extended amygdala","volume":"506","author":"Li","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00429-011-0360-7","article-title":"Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus","volume":"217","author":"Li","year":"2012","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0150","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pbb.2009.12.016","article-title":"Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus","volume":"95","author":"Li","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","article-title":"Stress, adaptation, and disease. Allostasis and allostatic load","volume":"840","author":"McEwen","year":"1998","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0160","first-page":"1","article-title":"Neurobiological and systemic effects of chronic stress","author":"McEwen","year":"2017","journal-title":"Chronic stress"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0165","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/nn.4086","article-title":"Mechanisms of stress in the brain","volume":"18","author":"McEwen","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0170","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.yhbeh.2005.02.002","article-title":"Behavioral specificity of non-genomic glucocorticoid effects in rats: effects on risk assessment in the elevated plus-maze and the open-field","volume":"48","author":"Mikics","year":"2005","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/00221325.1966.10532787","article-title":"Effect of ACTH on open-field behavior, avoidance, startle, and food and water consumption","volume":"108","author":"Moyer","year":"1966","journal-title":"J. Genetic Psychol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1744-9081-4-23","article-title":"Context and strain-dependent behavioral response to stress","volume":"4","author":"Nosek","year":"2008","journal-title":"Behav. Brain Funct. : BBF"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(95)00749-G","article-title":"Adrenergic innervation of forebrain neurons that project to the paraventricular thalamic nucleus in the rat","volume":"697","author":"Otake","year":"1995","journal-title":"Brain Res."},{"issue":"Suppl 1","key":"10.1016\/j.psyneuen.2018.12.010_bib0190","first-page":"S11","article-title":"Stressor-specific activation of the hypothalamic-pituitary-adrenocortical axis","volume":"49","author":"Pacak","year":"2000","journal-title":"Physiol. Res."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0195","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-4328(02)00124-9","article-title":"Physical and emotional stress have differential effects on preference for saccharine and open field behaviour in rats","volume":"139","author":"Pijlman","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0205","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.psyneuen.2017.10.001","article-title":"Neuroendocrine stress reactivity of male C57BL\/6N mice following chronic oral corticosterone exposure during adulthood or adolescence","volume":"86","author":"Shahanoor","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0210","first-page":"1","article-title":"Exploratory rearing: a context- and stress-sensitive behavior recorded in the open-field test","author":"Sturman","year":"2018","journal-title":"Stress"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0215","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3109\/10253890.2011.586446","article-title":"Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis","volume":"14","author":"Tasker","year":"2011","journal-title":"Stress"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0220","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.clinpsy.3.022806.091520","article-title":"Coping resources, coping processes, and mental health","volume":"3","author":"Taylor","year":"2007","journal-title":"Ann. Rev. Clin. Psychol."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0225","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0306-4522(99)00158-X","article-title":"High versus low reactivity to a novel environment: behavioural, pharmacological and neurochemical assessments","volume":"93","author":"Thiel","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0230","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0235","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(94)90072-8","article-title":"Effect of environmental stressors on time course, variability and form of self-grooming in the rat: handling, social contact, defeat, novelty, restraint and fur moistening","volume":"65","author":"van Erp","year":"1994","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0240","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0245","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.psyneuen.2015.02.005","article-title":"Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients","volume":"55","author":"Zaba","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2018.12.010_bib0250","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnbeh.2014.00125","article-title":"A robust and reliable non-invasive test for stress responsivity in mice","volume":"8","author":"Zimprich","year":"2014","journal-title":"Front. Behav. Neurosci."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453018309156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453018309156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:05:07Z","timestamp":1759683907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453018309156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":50,"alternative-id":["S0306453018309156"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2018.12.010","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2018.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}