{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:20:03Z","timestamp":1793751603277,"version":"4.6.1"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.psyneuen.2019.104485","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T12:29:02Z","timestamp":1571228942000},"page":"104485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Adipokines in anorexia nervosa: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"112","author":[{"given":"Vasilios","family":"Karageorgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki A.","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evdoxia","family":"Tsigkaropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Karavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossetos","family":"Gournellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Soureti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Bellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Douzenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Michopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2019.104485_bib0005","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2174\/092986708785133004","article-title":"Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions","volume":"15","author":"Adeghate","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0010","first-page":"401","article-title":"Anorexia nervosa and bone densitometry","volume":"88","author":"Adkins","year":"2017","journal-title":"Radiol. Technol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0015","series-title":"Diagnostic and Statistical Manual of Mental Disorders","first-page":"338","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0020","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.nut.2013.02.005","article-title":"Plasma klotho levels decrease in both anorexia nervosa and obesity","volume":"29","author":"Amitani","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/09513590.2016.1255881","article-title":"Persistent amenorrhea and decreased DHEAS to cortisol ratio after recovery from anorexia nervosa","volume":"33","author":"Andrisani","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders","volume":"68","author":"Arcelus","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0035","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/oby.2003.137","article-title":"Correlation between serum resistin level and adiposity in obese individuals","volume":"11","author":"Azuma","year":"2003","journal-title":"Obes. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0040","first-page":"431","article-title":"The role of neuropeptides in the disturbed control of appetite and hormone secretion in eating disorders","volume":"24","author":"Baranowska","year":"2003","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0045","doi-asserted-by":"crossref","first-page":"E1188","DOI":"10.1210\/JC.2015-1595","article-title":"Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women","volume":"100","author":"Barja-fern\u00e1ndez","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2012.06.013","article-title":"Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats","volume":"37","author":"Bassi","year":"2012","journal-title":"Peptides"},{"issue":"7280","key":"10.1016\/j.psyneuen.2019.104485_bib0055","first-page":"193","article-title":"Resistin: a new hormone that links obesity with type 2 diabetes","volume":"322","author":"Berger","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0060","series-title":"Plasma Visfatin Concentrations and Fat Depot-Specific mRNA Expression in Humans","author":"Berndt","year":"2005"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0065","doi-asserted-by":"crossref","first-page":"784","DOI":"10.2310\/JIM.0b013e3181b9163d","article-title":"Leptin deficiency: clinical implications and opportunities for therapeutic interventions","volume":"57","author":"Bl\u00fcher","year":"2009","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0070","first-page":"E132","article-title":"Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa","volume":"292","author":"Bossu","year":"2007","journal-title":"Am. J. Physiol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ajhb.20108","article-title":"Serum leptin levels in Ache Amerindian females with normal adiposity are not significantly different from American anorexia nervosa patients","volume":"17","author":"Bribiescas","year":"2005","journal-title":"Am. J. Hum. Biol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0080","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2003-41353","article-title":"Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin","volume":"35","author":"Brichard","year":"2003","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1053\/meta.2003.50067","article-title":"Evidence for metabolic and endocrine abnormalities in subjects recovered from Anorexia nervosa","volume":"52","author":"Brown","year":"2003","journal-title":"Metab. Clin. Exp."},{"issue":"12","key":"10.1016\/j.psyneuen.2019.104485_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189500","article-title":"Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment","volume":"12","author":"Buckert","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s40519-017-0392-y","article-title":"Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with Anorexia nervosa","volume":"23","author":"Carlsson","year":"2018","journal-title":"Eat Weight Disord."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13643-017-0540-5","article-title":"Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies","volume":"6","author":"Catal\u00e1-L\u00f3pez","year":"2017","journal-title":"Syst. Rev."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(05)66830-4","article-title":"Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa","volume":"366","author":"Chan","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0110","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/dmrr.1201","article-title":"Visfatin in overweight\/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review","volume":"27","author":"Chang","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0115","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2012.27.4.377","article-title":"Low resistin level is associated with poor hospitalization-free survival in hemodialysis patients","author":"Chung","year":"2012","journal-title":"J. Korean Med. Sci."},{"issue":"6","key":"10.1016\/j.psyneuen.2019.104485_bib0120","first-page":"e195","article-title":"Sleep disturbances in eating disorders: a review","volume":"162","author":"Cinosi","year":"2011","journal-title":"Clin. Ter."},{"issue":"Suppl 5","key":"10.1016\/j.psyneuen.2019.104485_bib0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000191340","article-title":"Weight regulation, leptin and growth hormone","volume":"48","author":"Considine","year":"1997","journal-title":"Horm. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0130","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ejcn.2016.115","article-title":"Hematological complications in anorexia nervosa","volume":"70","author":"De Filippo","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0015-0282(02)03221-1","article-title":"Menstrual status and serum leptin levels in anorectic and in menstruating women with low body mass indexes","volume":"78","author":"Di Carlo","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0140","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/823481","article-title":"The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis","volume":"2015","author":"Dimova","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0145","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1210\/jc.2008-0746","article-title":"Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa","volume":"93","author":"Dost\u00e1lov\u00e1","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0150","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4088\/JCP.13m08753","article-title":"Appetite regulatory hormones in women with anorexia nervosa: binge-eating\/purging versus restricting type","volume":"76","author":"Eddy","year":"2015","journal-title":"J. Clin. Psychiatry."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00702-008-0151-3","article-title":"Leptin and its associations with measures of psychopathology in patients with anorexia nervosa","volume":"116","author":"Ehrlich","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0165","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00702-008-0033-8","article-title":"Glial and neuronal damage markers in patients with anorexia nervosa","volume":"115","author":"Ehrlich","year":"2008","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.psyneuen.2017.06.015","article-title":"Differentiating constitutional thinness from anorexia nervosa in DSM 5 era","volume":"84","author":"Estour","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/jc.2009-1730","article-title":"Fibroblast growth Factor-21 may mediate growth hormone resistance in anorexia nervosa","volume":"95","author":"Fazeli","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0180","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1017\/S0007114509274733","article-title":"Thin healthy women have a similar low bone mass to women with anorexia nervosa","volume":"102","author":"Fern\u00e1ndez-Garc\u00eda","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/B978-0-12-410473-0.00010-6","article-title":"Clinical and hormonal variables related to bone mass loss in anorexia nervosa patients","volume":"92","author":"Fern\u00e1ndez-Soto","year":"2013","journal-title":"Vitam Horm."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1365-2265.1997.1260938.x","article-title":"Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease","volume":"46","author":"Ferron","year":"1997","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0195","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI9725","article-title":"Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring","volume":"105","author":"Flier","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0200","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00702-010-0551-z","article-title":"Screening for anorexia nervosa via measurement of serum leptin levels","volume":"118","author":"F\u00f6cker","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpsychires.2017.10.008","article-title":"Predictors of long-term recovery in anorexia nervosa and bulimia nervosa: data from a 22-year longitudinal study","volume":"96","author":"Franko","year":"2018","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.psyneuen.2019.104485_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3956(99)00038-2","article-title":"Reduced body fat in long-term followed-up female patients with anorexia nervosa","volume":"34","author":"Frey","year":"2000","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0215","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1743-6109.2011.02514.x","article-title":"Normal inhibin B levels suggest partial preservation of gonadal function in adult male patients with anorexia nervosa","volume":"9","author":"Galusca","year":"2012","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122040","article-title":"Neuropeptide Y and \u03b1-MSH circadian levels in two populations with low body weight: anorexia nervosa and constitutional thinness","volume":"10","author":"Galusca","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0225","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ajcn\/85.4.967","article-title":"Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin","volume":"85","author":"Germain","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0230","first-page":"190","article-title":"Relationship between serum omentin-1 level and bone mineral density in girls with anorexia nervosa","volume":"36","author":"Guo","year":"2013","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0235","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/09513590.2014.888412","article-title":"Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome","volume":"30","author":"Guzel","year":"2014","journal-title":"Gynecol. Endocrinol."},{"issue":"2","key":"10.1016\/j.psyneuen.2019.104485_bib0240","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/sleep\/34.2.147","article-title":"Sleep duration and circulating adipokine levels","volume":"34","author":"Hayes","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0245","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00787-012-0243-3","article-title":"Leptin treatment of patients with anorexia nervosa? The urgent need for initiation of clinical studies","volume":"21","author":"Hebebrand","year":"2012","journal-title":"Eur. Child Adolesc. Psychiatry"},{"issue":"2","key":"10.1016\/j.psyneuen.2019.104485_bib0250","doi-asserted-by":"crossref","first-page":"I","DOI":"10.1016\/j.orcp.2007.03.003","article-title":"Metabolic dysfunction in anorexia nervosa","volume":"1","author":"Heilbronn","year":"2007","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0255","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0260","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/bmj.39343.408449.80","article-title":"Uncertainty in heterogeneity estimates in meta-analyses","volume":"335","author":"Ioannidis","year":"2007","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.psyneuen.2019.104485_bib0265","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF03327507","article-title":"Somatic and psychological factors related to the body mass index of patients with anorexia nervosa","volume":"13","author":"Kawai","year":"2008","journal-title":"Eat. Weight Disord."},{"issue":"2","key":"10.1016\/j.psyneuen.2019.104485_bib0270","doi-asserted-by":"crossref","first-page":"93","DOI":"10.7326\/0003-4819-152-2-201001190-00008","article-title":"Narrative review: the role of leptin in human physiology: emerging clinical applications","volume":"152","author":"Kelesidis","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0275","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0280","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1161\/CIRCULATIONAHA.104.530972","article-title":"Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure","volume":"112","author":"Kistorp","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0285","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbrc.2005.11.039","article-title":"Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes","volume":"339","author":"Kl\u00f6ting","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0290","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/oby.2002.81","article-title":"Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin","volume":"10","author":"Laimer","year":"2002","journal-title":"Obes. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0295","doi-asserted-by":"crossref","first-page":"E1898","DOI":"10.1210\/jc.2012-1702","article-title":"Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa","volume":"97","author":"Lawson","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.psyneuen.2019.104485_bib0300","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2265.2011.04182.x","article-title":"Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat","volume":"76","author":"Lawson","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0305","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bone.2009.09.005","article-title":"Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa","volume":"46","author":"Lawson","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0310","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1012903330944","article-title":"Influence of cortisol status on leptin secretion","volume":"4","author":"Leal-Cerro","year":"2001","journal-title":"Pituitary"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0315","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1098-108X(199911)26:3<283::AID-EAT5>3.0.CO;2-K","article-title":"Body fat, caloric intake, and plasma leptin levels in women with anorexia nervosa","volume":"26","author":"Lear","year":"1999","journal-title":"Int. J. Eat Disord."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0320","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1038\/s41598-017-01674-8","article-title":"A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0325","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0330","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1467-789X.2005.00159.x","article-title":"Adiponectin: action, regulation and association to insulin sensitivity","volume":"6","author":"Lihn","year":"2005","journal-title":"Obes. Rev."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0335","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40337-017-0186-7","article-title":"Feeding and eating disorders in the DSM-5 era: a systematic review of prevalence rates in non-clinical male and female samples","volume":"5","author":"Lindvall Dahlgren","year":"2017","journal-title":"J. Eat. Disord."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0340","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-2003-41286","article-title":"Serum leptin monitoring in anorectic patients during refeeding therapy","volume":"111","author":"Lob","year":"2003","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0345","first-page":"316","article-title":"Genetic variations of circulating adiponectin levels modulate changes in appetite in response to weight-loss diets","volume":"102","author":"Ma","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0350","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-0035-1559632","article-title":"Is serum serotonin involved in the bone loss of young females with anorexia nervosa? Horm","volume":"48","author":"Ma\u00efmoun","year":"2015","journal-title":"Metab. Res."},{"issue":"4","key":"10.1016\/j.psyneuen.2019.104485_bib0355","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF03327490","article-title":"Correlation between psychometric and biological parameters in anorexic and bulimic patients during and after an intensive day hospital treatment","volume":"10","author":"Manara","year":"2005","journal-title":"Eat. Weight Disord."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0360","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/BF03350816","article-title":"Glucose metabolism during ghrelin infusion in patients with anorexia nervosa","volume":"30","author":"Miljic","year":"2007","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0365","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2005-2304","article-title":"Ghrelin has partial or No effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa","volume":"91","author":"Miljic","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0370","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1210\/jc.2008-0170","article-title":"Bone metabolism in adolescent boys with anorexia nervosa","volume":"93","author":"Misra","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0375","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1210\/jc.2003-030088","article-title":"Serum osteoprotegerin in adolescent girls with anorexia nervosa","volume":"88","author":"Misra","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0380","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-1781(00)00144-X","article-title":"Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes","volume":"94","author":"Monteleone","year":"2000","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0385","doi-asserted-by":"crossref","first-page":"E202","DOI":"10.1152\/ajpendo.90865.2008","article-title":"The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling","volume":"297","author":"Morton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0390","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jpsychires.2016.03.003","article-title":"The DSM-5 diagnostic criteria for anorexia nervosa may change its population prevalence and prognostic value","volume":"77","author":"Mustelin","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0395","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2007.08.005","article-title":"Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa","volume":"64","author":"Nakahara","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0400","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ejcn.2010.66","article-title":"Specific adipocytokines profiles in patients with hyperactive and\/or binge\/purge form of anorexia nervosa","volume":"64","author":"Nogueira","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.psyneuen.2019.104485_bib0405","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.metabol.2014.08.004","article-title":"Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism","volume":"64","author":"Park","year":"2015","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0410","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jclinepi.2007.11.010","article-title":"Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry","volume":"61","author":"Peters","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0415","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1210\/jc.2006-1425","article-title":"Effect of human body weight changes on circulating levels of peptide YY and peptide YY3\u201336","volume":"92","author":"Pfluger","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0420","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0425","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nrendo.2016.175","article-title":"The endocrine manifestations of anorexia nervosa: mechanisms and management","volume":"13","author":"Schorr","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0430","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1442-200x.2005.02036.x","article-title":"Factors involved in the regulation of plasma leptin levels in children and adolescents with anorexia nervosa","volume":"47","author":"Shimizu","year":"2005","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0435","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/eje.0.1490331","article-title":"Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance","volume":"149","author":"Silha","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0440","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11920-012-0282-y","article-title":"Epidemiology of eating disorders: incidence, prevalence and mortality rates","volume":"14","author":"Smink","year":"2012","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0445","first-page":"4489","article-title":"The effects of anorexia nervosa on bone metabolism in female adolescents","volume":"84","author":"Soyka","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0450","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0455","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/nu9111210","article-title":"Leptin and physical activity in adult patients with anorexia nervosa: failure to demonstrate a simple linear association","volume":"9","author":"Stengel","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0460","first-page":"2056","article-title":"Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-Insulin-Like growth factor I Axis 1","volume":"84","author":"St\u00f8ving","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.psyneuen.2019.104485_bib0465","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tcm.2010.12.002","article-title":"Omentin: a novel link between inflammation, diabesity, and cardiovascular disease","volume":"20","author":"Tan","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0470","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/jc.2003-031260","article-title":"Adiponectin in anorexia nervosa and bulimia nervosa","volume":"89","author":"Tagami","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0475","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/eat.22166","article-title":"Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration","volume":"46","author":"Terra","year":"2013","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0480","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jc.2002-020645","article-title":"Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women","volume":"88","author":"Tolle","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0485","doi-asserted-by":"crossref","first-page":"1958947","DOI":"10.1155\/2017\/1958947","article-title":"Visfatin triggers anorexia and body weight loss through regulating the inflammatory response in the hypothalamic microglia","volume":"2017","author":"Tu","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0490","first-page":"1","article-title":"Adiponectin and resistin in acutely ill and weight-recovered adolescent anorexia nervosa: association with psychiatric symptoms","volume":"2018","author":"Tyszkiewicz-Nwafor","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0495","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2265.2008.03423.x","article-title":"Leptin concentration indexed to fat mass is increased in untreated anorexia nervosa (AN) patients","volume":"71","author":"Uzum","year":"2009","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0500","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/jcem.87.4.8381","article-title":"Leptin and soluble leptin receptor levels in obese and weight-losing individuals","volume":"87","author":"van Dielen","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.psyneuen.2019.104485_bib0505","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in r with the metafor package","volume":"1","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0510","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40337-017-0153-3","article-title":"Comparative efficacy of pharmacological and non-pharmacological interventions for the acute treatment of adult outpatients with anorexia nervosa: study protocol for the systematic review and network meta-analysis of individual data","volume":"5","author":"Wade","year":"2017","journal-title":"J. Eat. Disord."},{"issue":"8","key":"10.1016\/j.psyneuen.2019.104485_bib0515","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.psyneuen.2019.104485_bib0520","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000318571","article-title":"Preproenkephalin expression in peripheral blood mononuclear cells of acutely underweight and recovered patients with anorexia nervosa","volume":"62","author":"Weiss","year":"2010","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0525","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa040388","article-title":"Recombinant human leptin in women with hypothalamic amenorrhea","volume":"351","author":"Welt","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0530","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.amjmed.2015.06.031","article-title":"Medical complications of anorexia nervosa and bulimia","volume":"129","author":"Westmoreland","year":"2016","journal-title":"Am. J. Med."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0535","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12933-018-0723-y","article-title":"Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study","volume":"17","author":"Yang","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0540","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/db07-1045","article-title":"Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes","volume":"57","author":"Youn","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.psyneuen.2019.104485_bib0545","first-page":"56","article-title":"Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults: a pilot study","author":"Zepf","year":"2012","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.psyneuen.2019.104485_bib0550","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453019309278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453019309278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:07:25Z","timestamp":1759684045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453019309278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":110,"alternative-id":["S0306453019309278"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2019.104485","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipokines in anorexia nervosa: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2019.104485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104485"}}