{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:44:13Z","timestamp":1793670253540,"version":"4.5.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009408","name":"Brain Canada Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010294","name":"Posluns Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.psyneuen.2022.105751","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T01:22:05Z","timestamp":1648344125000},"page":"105751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["A new angle on mental rotation ability in transgender men: Modulation by ovarian milieu"],"prefix":"10.1016","volume":"141","author":[{"given":"Diana E.","family":"Peragine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Gervais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Simeon-Spezzaferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Einstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.psyneuen.2022.105751_bib1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0306-4530(03)00089-1","article-title":"A single administration of testosterone improves visuospatial ability in young women","volume":"29","author":"Aleman","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.psyneuen.2022.105751_bib2","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1210\/js.2019-00119","article-title":"Testosterone supplementation and cognitive functioning in men\u2014a systematic review and meta-analysis","volume":"3","author":"Buskbjerg","year":"2019","journal-title":"J. Endocr. Soc."},{"issue":"8","key":"10.1016\/j.psyneuen.2022.105751_bib3","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.psyneuen.2010.02.010","article-title":"Cortical activation during mental rotation in male-to-female and female-to-male transsexuals under hormonal treatment","volume":"35","author":"Carrillo","year":"2010","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.psyneuen.2022.105751_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0306-4530(98)00033-X","article-title":"Cognitive ability and cerebral lateralisation in transsexuals","volume":"23","author":"Cohen-Kettenis","year":"1998","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.psyneuen.2022.105751_bib5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1177\/0956797612441220","article-title":"Brief wakeful resting boosts new memories over the long term","volume":"23","author":"Dewar","year":"2012","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.psyneuen.2022.105751_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2020.04.019","article-title":"Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause","volume":"94","author":"Gervais","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.psyneuen.2022.105751_bib7","series-title":"The Oxford Handbook of Evolutionary Psychology and Behavioral Endocrinology","article-title":"Sex differences in cognition: evidence for the organizational-activational hypothesis","author":"Hampson","year":"2019"},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yhbeh.2013.12.016","article-title":"Estradiol and mental rotation: relation to dimensionality, difficulty, or angular disparity?","volume":"65","author":"Hampson","year":"2014","journal-title":"Horm. Behav."},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.psychres.2005.05.014","article-title":"Cross-sex hormone treatment does not change sex-sensitive cognitive performance in gender identity disorder patients","volume":"137","author":"Haraldsen","year":"2005","journal-title":"Psychiatry Res."},{"issue":"5","key":"10.1016\/j.psyneuen.2022.105751_bib10","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10508-008-9445-7","article-title":"Menstrual cycle phase effects on memory and Stroop task performance","volume":"38","author":"Hatta","year":"2009","journal-title":"Arch. Sex. Behav."},{"key":"10.1016\/j.psyneuen.2022.105751_bib11","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1037\/0735-7044.114.6.1245","article-title":"Sex hormones affect spatial abilities during the menstrual cycle","volume":"114","author":"Hausmann","year":"2000","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/00050067708254291","article-title":"The Wechsler Memory Scale: preliminary findings toward an Australian standardisation","volume":"12","author":"Ivison","year":"1977","journal-title":"Aust. Psychol."},{"key":"10.1016\/j.psyneuen.2022.105751_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104721","article-title":"Gender-affirming hormone treatment and cognitive function in transgender young adults: a systematic review and meta-analysis","volume":"119","author":"Karalexi","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.psyneuen.2022.105751_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01542220","article-title":"Physical and hormonal evaluation of transsexual patients: a longitudinal study","volume":"15","author":"Meyer","year":"1986","journal-title":"Arch. Sex. Behav."},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib15","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1210\/jc.2004-1181","article-title":"Testosterone administration in women with anorexia nervosa","volume":"90","author":"Miller","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2022.105751_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0306-4530(95)00051-8","article-title":"A curvilinear relationship between testosterone and spatial cognition in humans: Possible influence of hand preference","volume":"21","author":"Moffat","year":"1996","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2022.105751_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104488","article-title":"Sex difference or hormonal difference in mental rotation? The influence of ovarian milieu","volume":"115","author":"Peragine","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/hbeh.1997.1418","article-title":"Differences in the relationship of menstrual cycle phase to spatial performance on two-and three-dimensional tasks","volume":"32","author":"Phillips","year":"1997","journal-title":"Horm. Behav."},{"key":"10.1016\/j.psyneuen.2022.105751_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2015.10.056","article-title":"Changes in spatial cognition and brain activity after a single dose of testosterone in healthy women","volume":"298","author":"Pintzka","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.psyneuen.2022.105751_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/2229-3485.179436","article-title":"Common pitfalls in statistical analysis: the perils of multiple testing","volume":"7","author":"Ranganathan","year":"2016","journal-title":"Perspect. Clin. Res."},{"key":"10.1016\/j.psyneuen.2022.105751_bib21","series-title":"A Compendium of Neuropsychological Tests","author":"Strauss","year":"2006"},{"issue":"3972","key":"10.1016\/j.psyneuen.2022.105751_bib22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.171.3972.701","article-title":"Mental rotation of three-dimensional objects","volume":"171","author":"Shepard","year":"1971","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.psyneuen.2022.105751_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0306-4530(98)00091-2","article-title":"Activating effects of cross-sex hormones on cognitive functioning: a study of short-term and long-term hormone effects in transsexuals","volume":"24","author":"Slabbekoorn","year":"1999","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.euroneuro.2007.10.002","article-title":"Effects of cross-sex hormones on cerebral activation during language and mental rotation: an fMRI study in transsexuals","volume":"18","author":"Sommer","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.psyneuen.2022.105751_bib25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.beem.2007.04.003","article-title":"Sexual differentiation of the brain and behavior","volume":"21","author":"Swaab","year":"2007","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.psyneuen.2022.105751_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yhbeh.2004.09.003","article-title":"Testing the prenatal androgen hypothesis: Measuring digit ratios, sexual orientation, and spatial abilities in adults","volume":"47","author":"Van Anders","year":"2005","journal-title":"Horm. Behav."},{"issue":"2","key":"10.1016\/j.psyneuen.2022.105751_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2466\/pms.1978.47.2.599","article-title":"Mental rotations, a group test of three-dimensional spatial visualization","volume":"47","author":"Vandenberg","year":"1978","journal-title":"Percept. Mot. Skills"},{"issue":"6","key":"10.1016\/j.psyneuen.2022.105751_bib28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1037\/0735-7044.116.6.982","article-title":"Organizing and activating effects of sex hormones in homosexual transsexuals","volume":"116","author":"Van Goozen","year":"2002","journal-title":"Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.psyneuen.2022.105751_bib29","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1037\/0033-2909.117.2.250","article-title":"Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables","volume":"117","author":"Voyer","year":"1995","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.psyneuen.2022.105751_bib30","series-title":"Wechsler Memory Scale","author":"Wechsler","year":"1945"},{"key":"10.1016\/j.psyneuen.2022.105751_bib31","unstructured":"Wechsler, D., 2009a. Wechsler Memory Scales \u2013 Fourth Edition (WMS-IV): Administration and scoring. San Antonio, TX: Pearson Clinical Assessment."},{"key":"10.1016\/j.psyneuen.2022.105751_bib32","unstructured":"Wechsler, D., 2009b. Wechsler Memory Scales \u2013 Fourth Edition (WMS-IV): Technical and interpretive manual. San Antonio, TX: Pearson Clinical Assessment."}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453022000920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453022000920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:16:21Z","timestamp":1759684581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453022000920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":32,"alternative-id":["S0306453022000920"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2022.105751","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new angle on mental rotation ability in transgender men: Modulation by ovarian milieu","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2022.105751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105751"}}