{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:25:00Z","timestamp":1789129500151,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006254","name":"Ruhr-Universit\u00e4t Bochum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU 2479\/3-2"],"award-info":[{"award-number":["KU 2479\/3-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.psyneuen.2022.105993","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T13:06:01Z","timestamp":1669727161000},"page":"105993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Mitochondrial DNA as a marker for treatment-response in post-traumatic stress disorder"],"prefix":"10.1016","volume":"148","author":[{"given":"E.M.","family":"Hummel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Piovesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Herpertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kumsta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psyneuen.2022.105993_bib1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4088\/JCP.11r07237","article-title":"The psychiatric manifestations of mitochondrial disorders: a case and review of the literature","volume":"73","author":"Anglin","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib2","series-title":"Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)","author":"APA","year":"2013"},{"key":"10.1016\/j.psyneuen.2022.105993_bib3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/YCO.0000000000000167","article-title":"Epidemiology of posttraumatic stress disorder: prevalence, correlates and consequences","volume":"28","author":"Atwoli","year":"2015","journal-title":"Curr. Opin. Psychiatr."},{"key":"10.1016\/j.psyneuen.2022.105993_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nm.3261","article-title":"Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs","volume":"19","author":"Bacman","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib5","first-page":"1","article-title":"Circulating inflammatory markers, cell-free mitochondrial DNA, cortisol, endocannabinoids, and N-acylethanolamines in female depressed outpatients","author":"Behnke","year":"2022","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pnpbp.2015.06.012","article-title":"Mitochondrial DNA copy number is reduced in male combat veterans with PTSD","volume":"64","author":"Bersani","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/NMD.0b013e3181594ca0","article-title":"Cortisol, dehydroepiandrosterone, and estradiol measured over 24\u2009h in women with childhood sexual abuse-related posttraumatic stress disorder","volume":"195","author":"Bremner","year":"2007","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.psyneuen.2022.105993_bib8","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.cub.2015.10.065","article-title":"Genetic control over mtDNA and its relationship to major depressive disorder","volume":"25","author":"Cai","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mito.2020.06.004","article-title":"Thinking outside the nucleus: mitochondrial DNA copy number in health and disease","volume":"53","author":"Castellani","year":"2020","journal-title":"Mitochondrion"},{"key":"10.1016\/j.psyneuen.2022.105993_bib10","first-page":"10","article-title":"Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2022.105993_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jpsychires.2020.11.016","article-title":"Differences in mitochondrial DNA copy number between patients with bipolar I and II disorders","volume":"145","author":"Chung","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.psyneuen.2022.105993_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.psyneuen.2022.105993_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-clinpsy-082719-104030","article-title":"Stress and psychiatric disorders: the role of mitochondria","volume":"16","author":"Daniels","year":"2020","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib14","first-page":"11","article-title":"Blood-based mitochondrial respiratory chain function in major depression","author":"Fernstrom","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259591","article-title":"Plasma circulating cell-free mitochondrial DNA in depressive disorders","volume":"16","author":"Fernstrom","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2022.105993_bib16","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/1873-3468.14021","article-title":"Mitochondrial DNA copy number in human disease: the more the better?","volume":"595","author":"Filograna","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.psyneuen.2022.105993_bib17","first-page":"5","article-title":"Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder","author":"Flaquer","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib18","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41593-019-0447-7","article-title":"Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans","volume":"22","author":"Gelernter","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.psyneuen.2022.105993_bib19","doi-asserted-by":"crossref","first-page":"24778","DOI":"10.1073\/pnas.2005885117","article-title":"Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells","volume":"117","author":"Gumpp","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.psyneuen.2022.105993_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mito.2020.12.009","article-title":"Mitochondrial bioenergetics in leukocytes and oxidative stress in blood serum of mild to moderately depressed women","volume":"58","author":"Gumpp","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.psyneuen.2022.105993_bib21","article-title":"Investigating mitochondrial bioenergetics in peripheral blood mononuclear cells of women with childhood maltreatment from post-parturition period to one-year follow-up","author":"Gumpp","year":"2022","journal-title":"Psychol. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib22","doi-asserted-by":"crossref","first-page":"10614","DOI":"10.1073\/pnas.88.23.10614","article-title":"Introduction of disease-related mitochondrial-DNA deletions into hela-cells lacking mitochondrial-DNA results in mitochondrial dysfunction","volume":"88","author":"Hayashi","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.psyneuen.2022.105993_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/nature20127","article-title":"A cannabinoid link between mitochondria and memory","volume":"539","author":"Hebert-Chatelain","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.psyneuen.2022.105993_bib24","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"key":"10.1016\/j.psyneuen.2022.105993_bib25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41398-018-0264-x","article-title":"Cell-free DNA release under psychosocial and physical stress conditions","volume":"8","author":"Hummel","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib26","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jaac.2019.09.031","article-title":"Depressive symptoms predict change in telomere length and mitochondrial DNA copy number across adolescence","volume":"59","author":"Humphreys","year":"2020","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molmed.2020.02.006","article-title":"Therapeutic manipulation of mtDNA heteroplasmy: a shifting perspective","volume":"26","author":"Jackson","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jcb.21625","article-title":"Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth","volume":"103","author":"Jeng","year":"2008","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.psyneuen.2022.105993_bib29","series-title":"Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)","author":"Jonas","year":"2013"},{"key":"10.1016\/j.psyneuen.2022.105993_bib30","first-page":"370","article-title":"Mitochondrial dysfunction and psychiatric disorders","volume":"32","author":"Jou","year":"2009","journal-title":"Chang Gung Med. J."},{"key":"10.1016\/j.psyneuen.2022.105993_bib31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.biopsych.2017.09.010","article-title":"What can mitochondrial DNA analysis tell us about mood disorders?","volume":"83","author":"Kasahara","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib32","first-page":"9","article-title":"Inflammation in post-traumatic stress disorder (PTSD): a review of potential correlates of PTSD with a neurological perspective","author":"Kim","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.psyneuen.2022.105993_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.psyneuen.2011.07.003","article-title":"Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: a meta-analysis","volume":"37","author":"Klaassens","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2022.105993_bib34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12888-017-1541-6","article-title":"The German version of the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): psychometric properties and diagnostic utility","volume":"17","author":"Kruger-Gottschalk","year":"2017","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/papt.12227","article-title":"The role of epigenetics for understanding mental health difficulties and its implications for psychotherapy research","volume":"92","author":"Kumsta","year":"2019","journal-title":"Psychol. Psychother."},{"key":"10.1016\/j.psyneuen.2022.105993_bib36","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s00216-011-4764-2","article-title":"Mitochondrial ROS production under cellular stress: comparison of different detection methods","volume":"400","author":"Kuznetsov","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.psyneuen.2022.105993_bib37","doi-asserted-by":"crossref","first-page":"1314165","DOI":"10.1080\/20008198.2017.1314165","article-title":"The neurobiology of PTSD","volume":"8","author":"Lanius","year":"2017","journal-title":"Eur. J. Psychotraumatol."},{"issue":"Suppl 1","key":"10.1016\/j.psyneuen.2022.105993_bib38","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.arr.2010.08.009","article-title":"Somatic mutations of mitochondrial DNA in aging and cancer progression","volume":"9","author":"Lee","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.psyneuen.2022.105993_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13148-020-0820-0","article-title":"An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci","volume":"12","author":"Logue","year":"2020","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.psyneuen.2022.105993_bib40","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jn\/nxab418","article-title":"Diet quality scores are positively associated with whole blood-derived mitochondrial DNA copy number in the Framingham heart study","volume":"152","author":"Ma","year":"2022","journal-title":"J. Nutr."},{"key":"10.1016\/j.psyneuen.2022.105993_bib41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1192\/bjp.bp.106.024877","article-title":"Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis","volume":"191","author":"Meewisse","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.mito.2009.12.131","article-title":"The locus ceruleus contains mitochondrial DNA deletions in Alzheimer's Disease","volume":"10","author":"Miller","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.psyneuen.2022.105993_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/cei.13351","article-title":"From early adversities to immune activation in psychiatric disorders: the role of the sympathetic nervous system","volume":"197","author":"Mondelli","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104784","article-title":"Targeted bisulfite sequencing: a novel tool for the assessment of DNA methylation with high sensitivity and increased coverage","volume":"120","author":"Moser","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2022.105993_bib45","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1093\/brain\/awn252","article-title":"Resistance training in patients with single, large-scale deletions of mitochondrial DNA","volume":"131","author":"Murphy","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.psyneuen.2022.105993_bib46","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/mnfr.200700075","article-title":"Medication-induced mitochondrial damage and disease","volume":"52","author":"Neustadt","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.psyneuen.2022.105993_bib47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.psyneuen.2004.10.005","article-title":"PTSD symptoms predict waking salivary cortisol levels in police officers","volume":"30","author":"Neylan","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.psyneuen.2022.105993_bib48","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1016\/j.biopsych.2015.12.019","article-title":"The amount of mitochondrial DNA in blood reflects the course of a depressive episode","volume":"80","author":"Nicod","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib49","first-page":"8","article-title":"Sex and gender differences in post-traumatic stress disorder: an update","author":"Olff","year":"2017","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib50","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2741\/4529","article-title":"Current strategies towards therapeutic manipulation of mtDNA heteroplasmy","volume":"22","author":"Pereira","year":"2017","journal-title":"Front. Biosci. -Landmark"},{"key":"10.1016\/j.psyneuen.2022.105993_bib51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jalz.2013.04.508","article-title":"Mitochondrial DNA deletions in Alzheimer's brains: a review","volume":"10","author":"Phillips","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.psyneuen.2022.105993_bib52","first-page":"4","article-title":"Simultaneous quantification of mitochondrial DNA copy number and deletion ratio: a multiplex real-time PCR assay","author":"Phillips","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psyneuen.2022.105993_bib53","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/PSY.0000000000000544","article-title":"Psychological stress and mitochondria: a conceptual framework","volume":"80","author":"Picard","year":"2018","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PSY.0000000000000545","article-title":"Psychological stress and mitochondria: a systematic review","volume":"80","author":"Picard","year":"2018","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib55","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrendo.2014.22","article-title":"Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids","volume":"10","author":"Picard","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mito.2016.07.003","article-title":"The rise of mitochondria in medicine","volume":"30","author":"Picard","year":"2016","journal-title":"Mitochondrion"},{"key":"10.1016\/j.psyneuen.2022.105993_bib57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","article-title":"An energetic view of stress: focus on mitochondria","volume":"49","author":"Picard","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cobeha.2019.04.015","article-title":"Mitochondrial psychobiology: foundations and applications","volume":"28","author":"Picard","year":"2019","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.psyneuen.2022.105993_bib59","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10545-018-0168-1","article-title":"The role of suboptimal mitochondrial function in vulnerability to post-traumatic stress disorder","volume":"41","author":"Preston","year":"2018","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.psyneuen.2022.105993_bib60","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.bbamcr.2011.05.014","article-title":"Glucocorticoids induce mitochondrial gene transcription in HepG2 cells Role of the mitochondrial glucocorticoid receptor","volume":"1813","author":"Psarra","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.psyneuen.2022.105993_bib61","first-page":"12","article-title":"The mitochondrion as a primary site of action of regulatory agents involved in neuroimmunomodulation","volume":"1088","author":"Psarra","year":"2006","journal-title":"Neuroendocr. Immune Cross"},{"key":"10.1016\/j.psyneuen.2022.105993_bib62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2005.11.025","article-title":"The mitochondrion as a primary site of action of steroid and thyroid hormones: presence and action of steroid and thyroid hormone receptors in mitochondria of animal cells","volume":"246","author":"Psarra","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib63","doi-asserted-by":"crossref","first-page":"E118","DOI":"10.5489\/cuaj.932","article-title":"3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores","volume":"4","author":"Reguly","year":"2010","journal-title":"Can. Urol. Assoc. J."},{"key":"10.1016\/j.psyneuen.2022.105993_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.schres.2017.01.056","article-title":"Postmortem studies on mitochondria in schizophrenia","volume":"187","author":"Roberts","year":"2017","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.psyneuen.2022.105993_bib65","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2003.11.018","article-title":"Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder","volume":"55","author":"Rohleder","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib66","first-page":"157","article-title":"Mitochondrial complex I deficiency in schizophrenia and bipolar disorder and medication influence","volume":"3","author":"Rollins","year":"2018","journal-title":"Mol. Neuropsychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib67","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ana.20240","article-title":"Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells","volume":"56","author":"Santra","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/07853890801923753","article-title":"Mitochondrial involvement in psychiatric disorders","volume":"40","author":"Shao","year":"2008","journal-title":"Ann. Med."},{"key":"10.1016\/j.psyneuen.2022.105993_bib69","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1038\/s41467-020-19615-x","article-title":"Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR","volume":"11","author":"Smith","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psyneuen.2022.105993_bib70","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10545-010-9122-6","article-title":"Altering the balance between healthy and mutated mitochondrial DNA","volume":"34","author":"Smith","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.psyneuen.2022.105993_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100180","article-title":"HPA axis function and diurnal cortisol in post-traumatic stress disorder: a systematic review","volume":"11","author":"Speer","year":"2019","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.psyneuen.2022.105993_bib72","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41588-020-00767-x","article-title":"Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program","volume":"53","author":"Stein","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.psyneuen.2022.105993_bib73","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/hmg\/8.6.1047","article-title":"Gene shifting: a novel therapy for mitochondrial myopathy","volume":"8","author":"Taivassalo","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.psyneuen.2022.105993_bib74","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/brain\/awl282","article-title":"Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions","volume":"129","author":"Taivassalo","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.psyneuen.2022.105993_bib75","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mito.2021.04.002","article-title":"Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations","volume":"59","author":"Trumpff","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.psyneuen.2022.105993_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237235","article-title":"Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults","volume":"15","author":"Vyas","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.psyneuen.2022.105993_bib77","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1146\/annurev.bi.61.070192.005523","article-title":"Diseases of the mitochondrial-DNA","volume":"61","author":"Wallace","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.psyneuen.2022.105993_bib78","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.psyneuen.2022.105993_bib79","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.euroneuro.2017.06.001","article-title":"Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients","volume":"27","author":"Wang","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib80","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.4088\/JCP.12r08225","article-title":"Meta-analysis of the efficacy of treatments for posttraumatic stress disorder","volume":"74","author":"Watts","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib81","unstructured":"Weathers, F.W., Keane, T.M., Palmieri, P.A., Marx, B.P., Schnurr, P.P., 2013. PTSD Checklist for DSM-5 (PCL-5). PTSD: National Center for PTSD 2013;10(4)."},{"key":"10.1016\/j.psyneuen.2022.105993_bib82","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.5665\/sleep.5068","article-title":"Mitochondrial DNA copy number in sleep duration discordant monozygotic twins","volume":"38","author":"Wrede","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.psyneuen.2022.105993_bib83","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ajcn\/nqy286","article-title":"Fruit and vegetable consumption, cigarette smoke, and leukocyte mitochondrial DNA copy number","volume":"109","author":"Wu","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.psyneuen.2022.105993_bib84","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.biopsych.2013.04.013","article-title":"Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder","volume":"74","author":"Xie","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.psyneuen.2022.105993_bib85","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/3-540-28082-0_13","article-title":"Neuroendocrine aspects of PTSD","author":"Yehuda","year":"2005","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.psyneuen.2022.105993_bib86","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00005053-199006000-00004","article-title":"Low urinary cortisol excretion in patients with posttraumatic stress disorder","volume":"178","author":"Yehuda","year":"1990","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.psyneuen.2022.105993_bib87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-3223(95)00451-3","article-title":"Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis","volume":"40","author":"Yehuda","year":"1996","journal-title":"Biol. Psychiatry"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453022003341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453022003341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:19:04Z","timestamp":1759684744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453022003341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":87,"alternative-id":["S0306453022003341"],"URL":"https:\/\/doi.org\/10.1016\/j.psyneuen.2022.105993","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial DNA as a marker for treatment-response in post-traumatic stress disorder","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psyneuen.2022.105993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105993"}}