{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:54Z","timestamp":1787161614798,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.pt.2008.08.011","type":"journal-article","created":{"date-parts":[[2008,10,18]],"date-time":"2008-10-18T05:02:53Z","timestamp":1224306173000},"page":"497-501","source":"Crossref","is-referenced-by-count":176,"title":["Opisthorchis viverrini: an underestimated parasite in world health"],"prefix":"10.1016","volume":"24","author":[{"given":"Ross H.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paiboon","family":"Sithithaworn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor N.","family":"Petney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2008.08.011_bib1","unstructured":"WHO (2007) AIDS epidemic update. World Health Organisation\u2013United Nations Program on HIV\/AIDS"},{"key":"10.1016\/j.pt.2008.08.011_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.actatropica.2003.02.001","article-title":"Epidemiology of Opisthorchis viverrini","volume":"88","author":"Sithithaworn","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2008.08.011_bib3","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0020-7519(01)00196-5","article-title":"Environmental, cultural and social changes and their influence on parasite infections","volume":"31","author":"Petney","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib4","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2008.08.011_bib5","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","article-title":"Liver fluke induces cholangiocarcinoma","volume":"4","author":"Sripa","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.pt.2008.08.011_bib6","first-page":"537","article-title":"Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention","volume":"2","author":"Parkin","year":"1993","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.pt.2008.08.011_bib7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0020-7519(94)90009-4","article-title":"Parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast Thailand","volume":"24","author":"Sithithaworn","year":"1994","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MOG.0b013e3282fbf9b3","article-title":"Cholangiocarcinoma: lessons from Thailand","volume":"24","author":"Sripa","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.pt.2008.08.011_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0140-6736(90)90591-R","article-title":"Northeast Thailand: a region with high incidence of cholangiocarcinoma","volume":"1","author":"Vatanasapt","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2008.08.011_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actatropica.2003.08.002","article-title":"Pathobiology of opisthorchiasis: an update","volume":"88","author":"Sripa","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2008.08.011_bib11","first-page":"121","article-title":"Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis)","volume":"61","author":"IARC","year":"1994","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.pt.2008.08.011_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0065-308X(07)65004-0","article-title":"The role of helminth infections in carcinogenesis","volume":"65","author":"Mayer","year":"2007","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/MOG.0b013e3280495451","article-title":"Cholangiocarcinoma: emerging approaches to a challenging cancer","volume":"23","author":"Patel","year":"2007","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.pt.2008.08.011_bib14","series-title":"Worms and Human Disease","author":"Muller","year":"2002"},{"key":"10.1016\/j.pt.2008.08.011_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.actatropica.2003.05.001","article-title":"Taxonomy and biology of liver flukes","volume":"88","author":"Kaewkes","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2008.08.011_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0020-7519(86)90091-3","article-title":"Field studies on the transmission of the human liver fluke, Opisthorchis viverrini, in northeast Thailand: population changes of the snail intermediate host","volume":"16","author":"Brockelman","year":"1986","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib17","first-page":"138","article-title":"Opisthorchis viverrini: intensity and rates of infection in cyprinoid fish from an endemic focus in northeast Thailand","volume":"13","author":"Vichasri","year":"1982","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2008.08.011_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.trstmh.2006.02.018","article-title":"Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR","volume":"101","author":"Sayasone","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2008.08.011_bib19","first-page":"1083","article-title":"Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR","volume":"37","author":"Sithithaworn","year":"2006","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2008.08.011_bib20","unstructured":"Jongsuksuntigul, P. (2002) Parasitic disease in northeast Thailand. In Seminar in Parasitic Diseases in northeast Thailand, KlungnanaVitaya, Khon Kaen, Thailand"},{"key":"10.1016\/j.pt.2008.08.011_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.actatropica.2003.01.002","article-title":"Opisthorchiasis control in Thailand","volume":"88","author":"Jongsuksuntigul","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2008.08.011_bib22","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-3156.2004.01234.x","article-title":"Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, northeast Thailand","volume":"9","author":"Sriamporn","year":"2004","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.pt.2008.08.011_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0031182000075107","article-title":"Field trials in the control of Opisthorchis viverrini with an integrated programme in endemic areas of northeast Thailand","volume":"106","author":"Saowakontha","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2008.08.011_bib24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0020-7519(88)90099-9","article-title":"Rate of re-infection by Opisthorchis viverrini in an endemic northeast Thai community after chemotherapy","volume":"18","author":"Upatham","year":"1988","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib25","unstructured":"WHO (2004) Report of joint WHO\/FAO workshop on food-borne trematode infections in Asia. 1\u201358, WHO Regional Office for the Western Pacific"},{"key":"10.1016\/j.pt.2008.08.011_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ijc.2910590412","article-title":"Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand","volume":"59","author":"Haswell-Elkins","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pt.2008.08.011_bib27","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ijc.21146","article-title":"Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand","volume":"117","author":"Honjo","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pt.2008.08.011_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.exppara.2008.01.018","article-title":"TaqMan real-time PCR assay for specific detection of Opisthorchis viverrini DNA in Thai patients with hepatocellular carcinoma and cholangiocarcinoma","volume":"119","author":"Suksumek","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/MCG.0b013e31806daf89","article-title":"Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients","volume":"42","author":"Yachimski","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.pt.2008.08.011_bib30","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0140-6736(05)67530-7","article-title":"Cholangiocarcinoma","volume":"366","author":"Khan","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2008.08.011_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000077991","article-title":"A review and update on cholangiocarcinoma","volume":"66","author":"Olnes","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.pt.2008.08.011_bib32","unstructured":"Khuhaprema, T. et al. (2007) Cancer in Thailand (Vol. IV), 1998\u20132000, Bangkok Medical Publisher"},{"key":"10.1016\/j.pt.2008.08.011_bib33","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1371\/journal.pntd.0000114","article-title":"Measuring the burden of neglected tropical diseases: the global burden of disease framework","volume":"1","author":"Mathers","year":"2007","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2008.08.011_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1471-2164-8-189","article-title":"Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"8","author":"Laha","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pt.2008.08.011_bib35","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/oxfordjournals.molbev.a026204","article-title":"Molecular systematics of the parasitic protozoan Giardia intestinalis","volume":"16","author":"Monis","year":"1999","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.pt.2008.08.011_bib36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00436-006-0304-y","article-title":"Genetic variation in Opisthorchis viverrini (Trematoda: Opisthorchiidae) from northeast Thailand and Laos PDR based on random amplified polymorphic DNA analyses","volume":"100","author":"Sithithaworn","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.pt.2008.08.011_bib37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.actatropica.2006.11.001","article-title":"Genetic markers for the identification and characterization of Opisthorchis viverrini, a medically important food borne trematode in southeast Asia","volume":"100","author":"Saijuntha","year":"2006","journal-title":"Acta Trop."},{"issue":"Suppl 3","key":"10.1016\/j.pt.2008.08.011_bib38","first-page":"43","article-title":"Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR","volume":"37","author":"Saijuntha","year":"2006","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2008.08.011_bib39","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ijpara.2006.12.008","article-title":"Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts","volume":"37","author":"Saijuntha","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib40","unstructured":"Abella, M. (2004) Labour migration in East Asian economics. In Annual Bank Conference on Development Economics., 1\u201319"},{"key":"10.1016\/j.pt.2008.08.011_bib41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2310\/7060.2000.00086","article-title":"Investigation on subclinical aspects related to intestinal parasitic infections among Thai laborers in Taipei","volume":"7","author":"Cheng","year":"2000","journal-title":"J. Travel Med."},{"key":"10.1016\/j.pt.2008.08.011_bib42","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3201\/eid1110.050614","article-title":"Emerging foodborne trematodiasis","volume":"11","author":"Keiser","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.pt.2008.08.011_bib43","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/35016500","article-title":"Effect of aquaculture on world fish supplies","volume":"405","author":"Naylor","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pt.2008.08.011_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1079\/JOH2006364","article-title":"Hosts and parasites as aliens","volume":"80","author":"Taraschewski","year":"2006","journal-title":"J. Helminthol."},{"key":"10.1016\/j.pt.2008.08.011_bib45","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.3201\/eid1012.040410","article-title":"Opisthorchiasis from imported raw fish","volume":"10","author":"Yossepowitch","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.pt.2008.08.011_bib46","unstructured":"WHO (1995) Control of foodborne trematode infections. Report of a WHO Study Group. World Health Organ. Tech. Rep. Ser. 849, 1\u2013157"},{"key":"10.1016\/j.pt.2008.08.011_bib47","unstructured":"Christensen, J.H. et al. L., Mearns, C.G. Men\u00e9ndez, J. R\u00e4is\u00e4nen, A. Rinke, A. Sarr and P. Whetton (2007) Regional Climate Projections. Cambridge University Press"},{"key":"10.1016\/j.pt.2008.08.011_bib48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1079\/JOH2006357","article-title":"Climate disruption and parasite-host dynamics: patterns and processes associated with warming and the frequency of extreme climatic events","volume":"80","author":"Hudson","year":"2006","journal-title":"J. Helminthol."},{"key":"10.1016\/j.pt.2008.08.011_bib49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0031182005008693","article-title":"Global warming and temperature-mediated increases in cercarial emergence in trematode parasites","volume":"132","author":"Poulin","year":"2006","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2008.08.011_bib50","doi-asserted-by":"crossref","first-page":"564","DOI":"10.4269\/ajtmh.2008.78.564","article-title":"Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment","volume":"78","author":"Pinlaor","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2008.08.011_bib51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exppara.2004.07.007","article-title":"Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with Opisthorchis viverrini","volume":"108","author":"Pinlaor","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2008.08.011_bib52","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1158\/1055-9965.EPI-07-2717","article-title":"Urinary 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis","volume":"17","author":"Thanan","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.pt.2008.08.011_bib53","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1055-9965.EPI-08-0191","article-title":"High excretion of etheno adducts in liver fluke-infected patients: protection by praziquantel against DNA damage","volume":"17","author":"Dechakhamphu","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492208002353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492208002353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T15:40:39Z","timestamp":1557848439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492208002353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1471492208002353"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2008.08.011","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}