{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:15:06Z","timestamp":1791198906681,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.pt.2010.05.005","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:45:29Z","timestamp":1277081129000},"page":"457-464","source":"Crossref","is-referenced-by-count":46,"title":["The trypanolytic factor\u2013mechanism, impacts and applications"],"prefix":"10.1016","volume":"26","author":[{"given":"Richard J.","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2010.05.005_bib1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.mib.2007.09.014","article-title":"The cell biology of Trypanosoma brucei differentiation","volume":"10","author":"Fenn","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2010.05.005_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/jcs.01649","article-title":"The developmental cell biology of Trypanosoma brucei","volume":"118","author":"Matthews","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pt.2010.05.005_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(03)53002-0","article-title":"Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis","volume":"53","author":"Aksoy","year":"2003","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ana.21429","article-title":"The continuing problem of human African trypanosomiasis (sleeping sickness)","volume":"64","author":"Kennedy","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pt.2010.05.005_bib5","series-title":"Global Burden of Disease in 2002: Data sources, Methods and Results","author":"Mathers","year":"2003"},{"key":"10.1016\/j.pt.2010.05.005_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S1471-4922(02)02422-4","article-title":"A response to the aim of eradicating tsetse from Africa","volume":"18","author":"Rogers","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tig.2006.08.003","article-title":"Switching trypanosome coats: what's in the wardrobe?","volume":"22","author":"Taylor","year":"2006","journal-title":"Trends Genet."},{"key":"10.1016\/j.pt.2010.05.005_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0001-706X(02)00237-1","article-title":"Antigenic variation and the African trypanosome genome","volume":"85","author":"Donelson","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2010.05.005_bib9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.bjp.0707354","article-title":"Human African trypanosomiasis: pharmacological re-engagement with a neglected disease","volume":"152","author":"Barrett","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pt.2010.05.005_bib10","series-title":"Trypanosomes et Trypanosomiases","author":"Laveran","year":"1902"},{"key":"10.1016\/j.pt.2010.05.005_bib11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4269\/ajtmh.2002.67.684","article-title":"The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense","volume":"67","author":"Radwanska","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2010.05.005_bib12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3201\/eid0605.000502","article-title":"Antigenic variation in vector-borne pathogens","volume":"6","author":"Barbour","year":"2000","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.pt.2010.05.005_bib13","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1073\/pnas.75.7.3450","article-title":"Identification of the trypanocidal factor in normal human serum: high density lipoprotein","volume":"75","author":"Rifkin","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2010.05.005_bib14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrmicro1428","article-title":"The trypanolytic factor of human serum","volume":"4","author":"Pays","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2010.05.005_bib15","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1016\/S0021-9258(18)83720-6","article-title":"Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein","volume":"264","author":"Hajduk","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib16","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/0035-9203(91)90365-6","article-title":"Trypanosoma brucei brucei: differences in the trypanocidal activity of human plasma and its relationship to the level of high density lipoproteins","volume":"85","author":"Gillett","year":"1991","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2010.05.005_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.183.3.1023","article-title":"The main lytic factor of Trypanosoma brucei brucei in normal human serum is not high density lipoprotein","volume":"183","author":"Raper","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2010.05.005_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0166-6851(01)00292-4","article-title":"The lysosomal targeting and intracellular metabolism of trypanosome lytic factor by Trypanosoma brucei brucei","volume":"115","author":"Shimamura","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib19","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ijpara.2004.04.008","article-title":"The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness","volume":"34","author":"Vanhamme","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0035-9203(94)90443-X","article-title":"Importance of acidic intracellular compartments in the lysis of Trypanosoma brucei brucei by normal human serum","volume":"88","author":"Lorenz","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2010.05.005_bib21","first-page":"117","article-title":"Haptoglobin-related protein and apolipoprotein AI are components of the two trypanolytic factors in human serum","volume":"86","author":"Tomlinson","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0014-4894(91)90139-N","article-title":"Trypanosoma brucei: cytotoxicity of host high-density lipoprotein is not mediated by apolipoprotein A-I","volume":"72","author":"Rifkin","year":"1991","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib23","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0022-2275(20)41386-0","article-title":"Transgenic mice expressing human apolipoprotein A-I have sera with modest trypanolytic activity in vitro but remain susceptible to infection by Trypanosoma brucei brucei","volume":"33","author":"Owen","year":"1992","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.pt.2010.05.005_bib24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1126\/science.7716520","article-title":"Killing of trypanosomes by the human haptoglobin-related protein","volume":"268","author":"Smith","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.pt.2010.05.005_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0166-6851(95)02551-0","article-title":"Lack of correlation between haptoglobin concentration and trypanolytic activity of normal human serum","volume":"76","author":"Raper","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib26","doi-asserted-by":"crossref","first-page":"30254","DOI":"10.1074\/jbc.M010198200","article-title":"Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes","volume":"276","author":"Drain","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0166-6851(01)00361-9","article-title":"Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei","volume":"118","author":"Bishop","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molbiopara.2004.07.004","article-title":"Characterization of primate trypanosome lytic factors","volume":"138","author":"Lugli","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.126.1.155","article-title":"Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes","volume":"126","author":"Hager","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pt.2010.05.005_bib30","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1074\/jbc.273.7.3884","article-title":"Characterization of the human serum trypanosome toxin, haptoglobin-related protein","volume":"273","author":"Muranjan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-6851(00)00277-2","article-title":"An investigation into the mechanism of trypanosome lysis by human serum factors","volume":"110","author":"Molina-Portela","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib32","first-page":"55","article-title":"The effect of normal human serum on trypanosomes of distinct antigenic type (ETat 1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense","volume":"56","author":"van Meirvenne","year":"1976","journal-title":"Ann. Soc. Belg. Med. Trop."},{"key":"10.1016\/j.pt.2010.05.005_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0166-6851(89)90189-8","article-title":"A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense","volume":"36","author":"De Greef","year":"1989","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0092-8674(00)81706-7","article-title":"A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense","volume":"95","author":"Xong","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.pt.2010.05.005_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/35166","article-title":"The role of transferrin-receptor variation in the host range of Trypanosoma brucei","volume":"391","author":"Bitter","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.pt.2010.05.005_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00242-0","article-title":"The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts","volume":"114","author":"Pays","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib37","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.micinf.2005.10.002","article-title":"The variant surface glycoprotein as a tool for adaptation in African trypanosomes","volume":"8","author":"Pays","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.pt.2010.05.005_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0166-6851(94)90172-4","article-title":"The serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein","volume":"68","author":"De Greef","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/EC.5.1.132-139.2006","article-title":"Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei","volume":"5","author":"Oli","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2010.05.005_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature01461","article-title":"Apolipoprotein L-I is the trypanosome lytic factor of human serum","volume":"422","author":"Vanhamme","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pt.2010.05.005_bib41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1126\/science.1114566","article-title":"Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes","volume":"309","author":"P\u00e9rez-Morga","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pt.2010.05.005_bib42","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1073\/pnas.0609902104","article-title":"Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum","volume":"104","author":"Vanhollebeke","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2010.05.005_bib43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molbiopara.2003.11.006","article-title":"Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera","volume":"134","author":"Poelvoorde","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1567-1348(02)00028-X","article-title":"The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa","volume":"1","author":"Gibson","year":"2002","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pt.2010.05.005_bib45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0166-6851(99)00151-6","article-title":"Expression and localization of serum resistance associated protein in Trypanosoma brucei rhodesiense","volume":"104","author":"Milner","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0031182005007560","article-title":"The SRA gene: the key to understanding the nature of Trypanosoma brucei rhodesiense","volume":"131","author":"Gibson","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2010.05.005_bib47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1112642","article-title":"The genome of the African trypanosome Trypanosoma brucei","volume":"309","author":"Berriman","year":"2005","journal-title":"Science"},{"issue":"Suppl. 1","key":"10.1016\/j.pt.2010.05.005_bib48","first-page":"13","article-title":"Only the serum-resistant bloodstream forms of Trypanosoma brucei rhodesiense express the serum resistance associated (SRA) protein","volume":"72","author":"De Greef","year":"1992","journal-title":"Ann. Soc. Belg. Med. Trop."},{"key":"10.1016\/j.pt.2010.05.005_bib49","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1056\/NEJMoa063265","article-title":"Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I","volume":"355","author":"Vanhollebeke","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2010.05.005_bib50","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1371\/journal.ppat.0030129","article-title":"Hemoglobin is a co-factor of human trypanosome lytic factor","volume":"3","author":"Widener","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2010.05.005_bib51","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1369-5274(00)00226-5","article-title":"Trypanosome lytic factors: novel mediators of human innate immunity","volume":"4","author":"Raper","year":"2001","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2010.05.005_bib52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1550-7408.2006.00228.x","article-title":"African trypanosomes: intracellular trafficking of host defense molecules","volume":"54","author":"Shiflett","year":"2007","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.pt.2010.05.005_bib53","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1550-7408.2007.00285.x","article-title":"Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome","volume":"54","author":"Vanhollebeke","year":"2007","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.pt.2010.05.005_bib54","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2007.08.046","article-title":"Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes","volume":"131","author":"Engstler","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.pt.2010.05.005_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0166-6851(95)02479-4","article-title":"Human serum resistant Trypanosoma brucei rhodesiense accumulates similar amounts of fluorescently-labelled trypanolytic human HDL3 particles as human serum sensitive T.b. brucei","volume":"74","author":"Lorenz","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib56","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1182\/blood-2006-05-022327","article-title":"Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein","volume":"108","author":"Nielsen","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.pt.2010.05.005_bib57","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1074\/jbc.M605684200","article-title":"A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex","volume":"282","author":"Nielsen","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib58","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1126\/science.1156296","article-title":"A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans","volume":"320","author":"Vanhollebeke","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.pt.2010.05.005_bib59","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1016\/j.micinf.2006.08.007","article-title":"On the significance of host antibody response to the Trypanosoma brucei transferrin receptor during chronic infection","volume":"8","author":"Steverding","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.pt.2010.05.005_bib60","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0022-2275(20)42051-6","article-title":"Role of phospholipids in the cytotoxic action of high density lipoprotein on trypanosomes","volume":"32","author":"Rifkin","year":"1991","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.pt.2010.05.005_bib61","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1074\/jbc.M207215200","article-title":"Evidence for a Trypanosoma brucei lipoprotein scavenger receptor","volume":"278","author":"Green","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib62","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1084\/jem.20071463","article-title":"Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model","volume":"205","author":"Molina-Portela","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2010.05.005_bib63","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00018-006-6091-x","article-title":"The function of apolipoproteins L","volume":"63","author":"Vanhollebeke","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.pt.2010.05.005_bib64","doi-asserted-by":"crossref","first-page":"19509","DOI":"10.1073\/pnas.0905669106","article-title":"Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes","volume":"106","author":"Thomson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2010.05.005_bib65","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.085647.108","article-title":"The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host\u2013pathogen interactions","volume":"19","author":"Smith","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.pt.2010.05.005_bib66","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.micinf.2008.07.020","article-title":"Mutual self-defence: the trypanolytic factor story","volume":"10","author":"Pays","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.pt.2010.05.005_bib67","doi-asserted-by":"crossref","first-page":"32578","DOI":"10.1074\/jbc.M503510200","article-title":"Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes","volume":"280","author":"Shiflett","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2010.05.005_bib68","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/IAI.67.4.1910-1916.1999","article-title":"Characterization of a novel trypanosome lytic factor from human serum","volume":"67","author":"Raper","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2010.05.005_bib69","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nm1395","article-title":"Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor","volume":"12","author":"Baral","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2010.05.005_bib70","doi-asserted-by":"crossref","unstructured":"Lecordier, L. et al. (2009) C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. PLoS Pathog. 5, e1000685 DOI:10.1371\/journal.ppat.1000685","DOI":"10.1371\/journal.ppat.1000685"},{"key":"10.1016\/j.pt.2010.05.005_bib71","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2307\/3283852","article-title":"The removal of trypanolytic activity from human serum by Trypanosoma brucei gambiense and its subsequent recovery in trypanosome lysates","volume":"81","author":"Ortiz-Ord\u00f3\u00f1ez","year":"1995","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2010.05.005_bib72","doi-asserted-by":"crossref","unstructured":"Samanovic, M. et al. (2009) Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates leishmania infection. PLoS Pathog. 5, e1000276 10.1371\/journal.ppat.1000276","DOI":"10.1371\/journal.ppat.1000276"}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492210001078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492210001078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T21:05:42Z","timestamp":1635541542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492210001078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1471492210001078"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2010.05.005","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}