{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:46Z","timestamp":1791262606535,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.pt.2015.11.001","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T22:30:59Z","timestamp":1448749859000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination?"],"prefix":"10.1016","volume":"32","author":[{"given":"David","family":"Berthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone F.","family":"Breni\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bras-Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Loup","family":"Lemesre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jamonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Lejon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Th\u00e9venon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bucheton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2015.11.001_bib0505","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/infdis\/149.3.311","article-title":"Genetic resistance to African trypanosomiasis","volume":"149","author":"Murray","year":"1984","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0510","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20506\/rst.17.1.1088","article-title":"Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis","volume":"17","author":"d\u2019Ieteren","year":"1998","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.pt.2015.11.001_bib0515","series-title":"L\u2019\u00e9levage dans l\u2019Afrique Occiedentale Fran\u00e7aise","author":"Pierre","year":"1906"},{"key":"10.1016\/j.pt.2015.11.001_bib0520","doi-asserted-by":"crossref","first-page":"369","DOI":"10.20506\/rst.9.2.506","article-title":"Trypanotolerance in cattle and prospects for the control of trypanosomiasis by selective breeding","volume":"9","author":"Murray","year":"1990","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.pt.2015.11.001_bib0525","doi-asserted-by":"crossref","first-page":"343","DOI":"10.20506\/rst.24.1.1573","article-title":"Use of molecular markers to enhance resistance of livestock to disease: a global approach","volume":"24","author":"Gibson","year":"2005","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.pt.2015.11.001_bib0530","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0368-1742(58)80025-9","article-title":"Studies of the tolerance of N\u2019dama cattle to trypanosomiasis","volume":"68","author":"Chandler","year":"1958","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.pt.2015.11.001_bib0535","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF02240423","article-title":"Studies on trypanosome-resistant cattle. II. The effect of trypanosomiasis on N\u2019dama, Muturu and Zebu cattle","volume":"5","author":"Roberts","year":"1973","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.pt.2015.11.001_bib0540","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-3024.1991.tb00295.x","article-title":"Susceptibility of N\u2019Dama and Boran cattle to sequential challenges with tsetse-transmitted clones of Trypanosoma congolense","volume":"13","author":"Paling","year":"1991","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.pt.2015.11.001_bib0545","doi-asserted-by":"crossref","first-page":"e0126498","DOI":"10.1371\/journal.pone.0126498","article-title":"A comparison of phenotypic traits related to trypanotolerance in five West African cattle breeds highlights the value of shorthorn taurine breeds","volume":"10","author":"Berthier","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pt.2015.11.001_bib0550","first-page":"99","article-title":"Trypanotolerance. An individual not a breed character","volume":"40","author":"Roelants","year":"1983","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2015.11.001_bib0555","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1111\/j.1365-294X.2004.02311.x","article-title":"Admixture and diversity in West African cattle populations","volume":"13","author":"Freeman","year":"2004","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2015.11.001_bib0560","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1111\/mec.12816","article-title":"Adaptive admixture in the West African bovine hybrid zone: insight from the Borgou population","volume":"23","author":"Flori","year":"2014","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2015.11.001_bib0565","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.pt.2013.08.003","article-title":"Community- and farmer-based management of animal African trypanosomosis in cattle","volume":"29","author":"Bouyer","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0570","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.1232392100","article-title":"Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N\u2019Dama and susceptible East African Boran cattle","volume":"100","author":"Hanotte","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pt.2015.11.001_bib0575","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1126\/science.1186254","article-title":"Ecology. Time to tap Africa's livestock genomes","volume":"328","author":"Hanotte","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pt.2015.11.001_bib0580","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nrmicro3298","article-title":"The molecular arms race between African trypanosomes and humans","volume":"12","author":"Pays","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2015.11.001_bib0585","series-title":"Control and Surveillance of Human African Trypanosomiasis","year":"2013"},{"key":"10.1016\/j.pt.2015.11.001_bib0590","first-page":"257","article-title":"Epidemiology of human African trypanosomiasis","volume":"6","author":"Franco","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.pt.2015.11.001_bib0595","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(09)60829-1","article-title":"Human African trypanosomiasis","volume":"375","author":"Brun","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2015.11.001_bib0600","doi-asserted-by":"crossref","first-page":"e1691","DOI":"10.1371\/journal.pntd.0001691","article-title":"Untreated infections by Trypanosoma brucei gambiense are not 100% fatal","volume":"6","author":"Jamonneau","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0605","doi-asserted-by":"crossref","first-page":"e3349","DOI":"10.1371\/journal.pntd.0003349","article-title":"Human African trypanosomiasis presenting at least 29 years after infection \u2013 what can this teach us about the pathogenesis and control of this neglected tropical disease?","volume":"8","author":"Sudarshi","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0610","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.micinf.2011.05.007","article-title":"Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): perspectives for a better control of sleeping sickness","volume":"13","author":"Ilboudo","year":"2011","journal-title":"Microbes Infect."},{"key":"10.1016\/j.pt.2015.11.001_bib0615","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1365-3156.2000.00623.x","article-title":"Follow-up of card agglutination trypanosomiasis test (CATT) positive but apparently aparasitemic individuals in C\u00f4te d\u2019Ivoire: evidence for a complex and heterogeneous population","volume":"5","author":"Garcia","year":"2000","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.pt.2015.11.001_bib0620","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1017\/S0031182013002102","article-title":"The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy","volume":"141","author":"Franco","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2015.11.001_bib0625","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fcimb.2013.00033","article-title":"Is vector control needed to eliminate gambiense human African trypanosomiasis?","volume":"3","author":"Solano","year":"2013","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.pt.2015.11.001_bib0630","doi-asserted-by":"crossref","first-page":"e0003727","DOI":"10.1371\/journal.pntd.0003727","article-title":"Reducing human\u2013tsetse contact significantly enhances the efficacy of sleeping sickness active screening campaigns: a promising result in the context of elimination","volume":"12","author":"Courtin","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0635","first-page":"29","article-title":"Studies in the epidemiology of East African leishmaniasis. 4. The significance of the positive leishmanin test","volume":"70","author":"Southgate","year":"1967","journal-title":"J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0640","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0035-9203(74)90067-4","article-title":"Studies on Mediterranean leishmaniasis. 2. Asymptomatic cases of visceral leishmaniasis","volume":"68","author":"Pampiglione","year":"1974","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0645","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/infdis\/154.6.1003","article-title":"New perspectives on a subclinical form of visceral leishmaniasis","volume":"154","author":"Badaro","year":"1986","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0650","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0020-7519(00)00136-3","article-title":"The leishmaniases as emerging and reemerging zoonoses","volume":"30","author":"Ashford","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0655","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1128\/JCM.37.6.1953-1957.1999","article-title":"Occurrence of Leishmania infantum parasitemia in asymptomatic blood donors living in an area of endemicity in southern France","volume":"37","author":"Le Fichoux","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.pt.2015.11.001_bib0660","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/0035-9203(94)90214-3","article-title":"Use of the leishmanin skin test and Western blot analysis for epidemiological studies in visceral leishmaniasis areas: experience in a highly endemic focus in Alpes-Maritimes (France)","volume":"88","author":"Marty","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0665","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0035-9203(03)00015-4","article-title":"Detection of Leishmania infantum cryptic infection in asymptomatic blood donors living in an endemic area (Eivissa, Balearic Islands, Spain) by different diagnostic methods","volume":"98","author":"Riera","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0670","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.4269\/ajtmh.2007.77.1051","article-title":"Human asymptomatic infection in visceral leishmaniasis: a seroprevalence study in an urban area of low endemicity. Preliminary results","volume":"77","author":"Barao","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0675","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1756-3305-4-86","article-title":"LeishVet guidelines for the practical management of canine leishmaniosis","volume":"4","author":"Solano-Gallego","year":"2011","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2015.11.001_bib0680","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pt.2008.05.003","article-title":"Canine leishmaniosis \u2013 new concepts and insights on an expanding zoonosis: part two","volume":"24","author":"Miro","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0685","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4269\/ajtmh.1996.55.273","article-title":"Canine leishmaniasis: identification of asymptomatic carriers by polymerase chain reaction and immunoblotting","volume":"55","author":"Berrahal","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0690","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jinf.2004.05.004","article-title":"Human and canine leishmaniasis in asymptomatic and symptomatic population in Northwestern Greece","volume":"50","author":"Papadopoulou","year":"2005","journal-title":"J. Infect."},{"key":"10.1016\/j.pt.2015.11.001_bib0695","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.rvsc.2008.07.014","article-title":"Canine visceral leishmaniasis in urban and rural areas of Northeast Brazil","volume":"86","author":"Queiroz","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.pt.2015.11.001_bib0700","doi-asserted-by":"crossref","first-page":"e2657","DOI":"10.1371\/journal.pntd.0002657","article-title":"Strong association between serological status and probability of progression to clinical visceral leishmaniasis in prospective cohort studies in India and Nepal","volume":"8","author":"Hasker","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0705","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/cid\/cis716","article-title":"A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis","volume":"55","author":"Cunningham","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0710","first-page":"CD009135","article-title":"Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease","volume":"6","author":"Boelaert","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pt.2015.11.001_bib0715","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1128\/JCM.00372-14","article-title":"Molecular tools for diagnosis of visceral leishmaniasis: systematic review and meta-analysis of diagnostic test accuracy","volume":"52","author":"de Ruiter","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.pt.2015.11.001_bib0720","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s40475-014-0027-6","article-title":"Kala-azar (visceral leishmaniasis) elimination in Bangladesh: successes and challenges","volume":"1","author":"Ahmed","year":"2014","journal-title":"Curr. Trop. Med. Rep."},{"key":"10.1016\/j.pt.2015.11.001_bib0725","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1473-3099(10)70320-0","article-title":"Visceral leishmaniasis: elimination with existing interventions","volume":"11","author":"Matlashewski","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0730","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/j.1948-7134.2011.00107.x","article-title":"Research priorities for the control of phlebotomine sand flies","volume":"36","author":"Warburg","year":"2011","journal-title":"J. Vector Ecol."},{"key":"10.1016\/j.pt.2015.11.001_bib0735","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fimmu.2012.00069","article-title":"Vaccines for canine leishmaniasis","volume":"3","author":"Palatnik-de-Sousa","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2015.11.001_bib0740","unstructured":"Lemesre, J-L. (1993) Proc\u00e9d\u00e9 de culture in vitro de diff\u00e9rents stades de parasites tissulaires obtenus et applications biologiques, FR2705358A1"},{"key":"10.1016\/j.pt.2015.11.001_bib0745","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.vetimm.2005.03.001","article-title":"Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis","volume":"106","author":"Holzmuller","year":"2005","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.pt.2015.11.001_bib0750","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.vaccine.2004.11.061","article-title":"Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes","volume":"23","author":"Lemesre","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.pt.2015.11.001_bib0755","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.vaccine.2007.02.083","article-title":"Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial","volume":"25","author":"Lemesre","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.pt.2015.11.001_bib0760","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vetimm.2008.10.309","article-title":"Effective humoral and cellular immunoprotective responses in Li ESAp-MDP vaccinated protected dogs","volume":"128","author":"Bourdoiseau","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.pt.2015.11.001_bib0765","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1297-9716-45-69","article-title":"The protective immune response produced in dogs after primary vaccination with the LiESP\/QA-21 vaccine (CaniLeish\u00ae) remains effective against an experimental challenge one year later","volume":"45","author":"Martin","year":"2014","journal-title":"Vet. Res."},{"key":"10.1016\/j.pt.2015.11.001_bib0770","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.vetpar.2013.05.008","article-title":"Vaccination with LiESP\/QA-21 (CaniLeish\u00ae) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs \u2013 a preliminary xenodiagnosis study","volume":"197","author":"Bongiorno","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0775","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pt.2015.03.007","article-title":"Uniting mathematics and biology for control of visceral leishmaniasis","volume":"31","author":"Rock","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0780","series-title":"American trypanosomiasis. Chagas Disease One Hundred Years of Research","first-page":"669","article-title":"Pathological consequences of host response to parasite","author":"Hontebeyrie","year":"2010"},{"issue":"Suppl. 1","key":"10.1016\/j.pt.2015.11.001_bib0785","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0074-02762007000900018","article-title":"Chagas disease: what is known and what is needed \u2013 a background article","volume":"102","author":"Coura","year":"2007","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.pt.2015.11.001_bib0790","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4269\/ajtmh.1997.57.328","article-title":"The indeterminate phase of Chagas\u2019 disease: ultrastructural characterization of cardiac changes in the canine model","volume":"57","author":"Andrade","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0795","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ijpara.2005.07.003","article-title":"Navigating parasite webs and parasite flow: emerging and re-emerging parasitic zoonoses of wildlife origin","volume":"35","author":"Polley","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0800","doi-asserted-by":"crossref","first-page":"748","DOI":"10.4269\/ajtmh.1998.58.748","article-title":"Influence of humans and domestic animals on the household prevalence of Trypanosoma cruzi in Triatoma infestans populations in northwest Argentina","volume":"58","author":"Gurtler","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0805","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1590\/S0037-86822011000500009","article-title":"Epidemiological factors related to the transmission risk of Trypanosoma cruzi in a Quilombola community, State of Mato Grosso do Sul, Brazil","volume":"44","author":"Cominetti","year":"2011","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.pt.2015.11.001_bib0810","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas\u2019 disease","volume":"373","author":"Bern","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2015.11.001_bib0815","doi-asserted-by":"crossref","first-page":"284729","DOI":"10.1155\/2013\/284729","article-title":"Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes","volume":"2013","author":"Ayo","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.pt.2015.11.001_bib0820","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pt.2006.09.011","article-title":"The future of Chagas disease control","volume":"22","author":"Schofield","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0825","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0301-6226(03)00078-2","article-title":"Population parameters for traits defining trypanotolerance in an F2 cross of N\u2019Dama and Boran cattle","volume":"84","author":"van der Waaij","year":"2003","journal-title":"Livestock Prod. Sci."},{"key":"10.1016\/j.pt.2015.11.001_bib0830","doi-asserted-by":"crossref","first-page":"9304","DOI":"10.1073\/pnas.1013486108","article-title":"Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection","volume":"108","author":"Noyes","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pt.2015.11.001_bib0835","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/1471-2164-10-550","article-title":"A whole genome Bayesian scan for adaptive genetic divergence in West African cattle","volume":"10","author":"Gautier","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pt.2015.11.001_bib0840","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1365-294X.2009.04141.x","article-title":"Detection of selection signatures within candidate regions underlying trypanotolerance in outbred cattle populations","volume":"18","author":"Dayo","year":"2009","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2015.11.001_bib0845","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ng0697-194","article-title":"Localization of genes controlling resistance to trypanosomiasis in mice","volume":"16","author":"Kemp","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pt.2015.11.001_bib0850","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/1471-2164-11-394","article-title":"High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele","volume":"11","author":"Nganga","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pt.2015.11.001_bib0855","doi-asserted-by":"crossref","first-page":"e880","DOI":"10.1371\/journal.pntd.0000880","article-title":"A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice","volume":"4","author":"Goodhead","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0860","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.meegid.2008.02.007","article-title":"Host genetics in African trypanosomiasis","volume":"8","author":"Courtin","year":"2008","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pt.2015.11.001_bib0865","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-3024.2011.01287.x","article-title":"Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections","volume":"33","author":"Bucheton","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.pt.2015.11.001_bib0870","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.meegid.2005.03.002","article-title":"Interest of tumor necrosis factor-\u03b1-308 G\/A and interleukin-10-592 C\/A polymorphisms in human African trypanosomiasis","volume":"6","author":"Courtin","year":"2006","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pt.2015.11.001_bib0875","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.meegid.2006.04.001","article-title":"Association between human African trypanosomiasis and the IL6 gene in a Congolese population","volume":"7","author":"Courtin","year":"2007","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pt.2015.11.001_bib0880","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.meegid.2013.03.004","article-title":"HLA-G 3\u2032 UTR-2 haplotype is associated with human African trypanosomiasis susceptibility","volume":"17","author":"Courtin","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.pt.2015.11.001_bib0885","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1193032","article-title":"Association of trypanolytic ApoL1 variants with kidney disease in African Americans","volume":"329","author":"Genovese","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pt.2015.11.001_bib0890","doi-asserted-by":"crossref","first-page":"941","DOI":"10.4269\/ajtmh.1999.61.941","article-title":"Kala-azar in a high transmission focus: an ethnic and geographic dimension","volume":"61","author":"Ibrahim","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0895","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S1286-4579(02)00027-8","article-title":"The interplay between environmental and host factors during an outbreak of visceral leishmaniasis in eastern Sudan","volume":"4","author":"Bucheton","year":"2002","journal-title":"Microbes Infect."},{"issue":"Suppl.","key":"10.1016\/j.pt.2015.11.001_bib0900","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1017\/S0031182000076678","article-title":"Genetic susceptibility to leishmanial infections: studies in mice and man","volume":"112","author":"Blackwell","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2015.11.001_bib0905","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/sj.gene.6363927","article-title":"Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region","volume":"4","author":"Bucheton","year":"2003","journal-title":"Genes Immun."},{"key":"10.1016\/j.pt.2015.11.001_bib0910","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1086\/379084","article-title":"A major susceptibility locus on chromosome 22q12 plays a critical role in the control of kala-azar","volume":"73","author":"Bucheton","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pt.2015.11.001_bib0915","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.gene.6364355","article-title":"Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis","volume":"8","author":"Bucheton","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.pt.2015.11.001_bib0920","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.4049\/jimmunol.1402047","article-title":"IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis","volume":"194","author":"Oliveira","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2015.11.001_bib0925","doi-asserted-by":"crossref","first-page":"e1000276","DOI":"10.1371\/journal.ppat.1000276","article-title":"Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection","volume":"5","author":"Samanovic","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2015.11.001_bib0930","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ng.2518","article-title":"Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis","volume":"45","author":"Fakiola","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pt.2015.11.001_bib0935","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4269\/ajtmh.1990.43.498","article-title":"Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas\u2019 cardiopathy","volume":"43","author":"Zicker","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2015.11.001_bib0940","doi-asserted-by":"crossref","first-page":"683230","DOI":"10.1155\/2014\/683230","article-title":"Chagas disease cardiomyopathy: immunopathology and genetics","volume":"2014","author":"Cunha-Neto","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.pt.2015.11.001_bib0945","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2334-13-587","article-title":"Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways","volume":"13","author":"Frade","year":"2013","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.pt.2015.11.001_bib0950","doi-asserted-by":"crossref","first-page":"e79629","DOI":"10.1371\/journal.pone.0079629","article-title":"Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects","volume":"8","author":"Deng","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pt.2015.11.001_bib0955","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vetpar.2007.03.004","article-title":"Infectivity of seropositive dogs, showing different clinical forms of leishmaniasis, to Lutzomyia longipalpis phlebotomine sand flies","volume":"147","author":"Michalsky","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.pt.2015.11.001_bib0960","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1051\/parasite\/2011184295","article-title":"Experimental evaluation of xenodiagnosis to detect trypanosomes at low parasitaemia levels in infected hosts","volume":"18","author":"Wombou Toukam","year":"2011","journal-title":"Parasite"},{"key":"10.1016\/j.pt.2015.11.001_bib0965","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1365-3156.2005.01467.x","article-title":"Transmissibility of Trypanosoma brucei during its development in cattle","volume":"10","author":"Van den Bossche","year":"2005","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.pt.2015.11.001_bib0970","series-title":"Tropical Cattle: Origins and Breeding Policies","author":"Payne","year":"1997"},{"key":"10.1016\/j.pt.2015.11.001_bib0975","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/d6040705","article-title":"On the history of cattle genetic resources","volume":"6","author":"Felius","year":"2014","journal-title":"Diversity"},{"key":"10.1016\/j.pt.2015.11.001_bib0980","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2052.2011.02227.x","article-title":"Association studies in QTL regions linked to bovine trypanotolerance in a West African crossbred population","volume":"43","author":"Dayo","year":"2012","journal-title":"Anim. Genet."},{"issue":"Suppl. 1","key":"10.1016\/j.pt.2015.11.001_bib0985","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1186\/1297-9686-35-S1-S35","article-title":"Serial analysis of gene expression (SAGE) in bovine trypanotolerance: preliminary results","volume":"35","author":"Berthier","year":"2003","journal-title":"Genet. Sel. Evol."},{"key":"10.1016\/j.pt.2015.11.001_bib0990","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1196\/annals.1373.039","article-title":"Bovine transcriptome analysis by SAGE technology during an experimental Trypanosoma congolense infection","volume":"1081","author":"Berthier","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pt.2015.11.001_bib0995","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1196\/annals.1428.062","article-title":"Study of bovine trypanotolerance by whole transcriptome analysis","volume":"1149","author":"Berthier","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pt.2015.11.001_bib1000","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2164-10-207","article-title":"Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility","volume":"10","author":"O\u2019Gorman","year":"2009","journal-title":"BMC Genomics"}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492215002354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492215002354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T01:17:43Z","timestamp":1599873463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492215002354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1471492215002354"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2015.11.001","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination?","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2015.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}