{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:37:07Z","timestamp":1790627827512,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["31272682"],"award-info":[{"award-number":["31272682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"crossref","award":["418540"],"award-info":[{"award-number":["418540"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.pt.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T03:30:13Z","timestamp":1502422213000},"page":"845-857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Schistosomiasis from a Snail\u2019s Perspective: Advances in Snail Immunity"],"prefix":"10.1016","volume":"33","author":[{"given":"Emmanuel A.","family":"Pila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob R.","family":"Hambrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Hanington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2017.07.006_bib0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S003118200100837X","article-title":"Evolutionary relationships between trematodes and snails emphasizing schistosomes and paragonimids","volume":"123","author":"Blair","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1139\/z03-215","article-title":"Trematodes and snails: an intimate association","volume":"82","author":"Lockyer","year":"2004","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.pt.2017.07.006_bib0015","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0020-7519(01)00204-1","article-title":"The nature and evolution of the association among digeneans, molluscs and fishes","volume":"31","author":"Cribb","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S0031182003003597","article-title":"Compatibility of Schistosoma haematobium, S. intercalatum and their hybrids with Bulinus truncatus and B. forskalii","volume":"127","author":"Webster","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0025","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1179\/000349802125000592","article-title":"Snail\u2013parasite compatibility and prevalence of Schistosoma haematobium on the shores of Lake Kariba, Zambia","volume":"96","author":"Mubila","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1017\/S003118200100806X","article-title":"Bulinus species on Madagascar: molecular evolution, genetic markers and compatibility with Schistosoma haematobium","volume":"123","author":"Stothard","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.actatropica.2013.01.003","article-title":"Use of sentinel snails for the detection of Schistosoma haematobium transmission on Zanzibar and observations on transmission patterns","volume":"128","author":"Allan","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2017.07.006_bib0040","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2017.07.006_bib0045","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.fsi.2015.01.036","article-title":"Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: a review of research progress over the last decade","volume":"46","author":"Coustau","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/bs.apar.2016.08.006","article-title":"The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle","volume":"97","author":"Mitta","year":"2017","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0055","first-page":"189","article-title":"Susceptibility of snails to infection with schistosomes is influenced by temperature and expression of heat shock proteins","volume":"5","author":"Knight","year":"2015","journal-title":"Epidemiology"},{"key":"10.1016\/j.pt.2017.07.006_bib0060","doi-asserted-by":"crossref","first-page":"e1002677","DOI":"10.1371\/journal.ppat.1002677","article-title":"Reversing the resistance phenotype of the Biomphalaria glabrata snail host Schistosoma mansoni infection by temperature modulation","volume":"8","author":"Ittiprasert","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0065","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1590\/S0074-02762006000200016","article-title":"The effects of temperature change on the infection rate of Biomphalaria glabrata with Schistosoma mansoni","volume":"101","author":"Coelho","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"10.1016\/j.pt.2017.07.006_bib0070","first-page":"164","article-title":"The influence of trematode infection on the hemocyte composition in Planorbarius corneus (Gastropoda, Pulmonata)","volume":"13","author":"Ataev","year":"2016","journal-title":"Invertebr. Survival J."},{"key":"10.1016\/j.pt.2017.07.006_bib0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0022-2011(92)90107-F","article-title":"A comparative study of hemocytes from six different snails: morphology and functional aspects","volume":"59","author":"Adema","year":"1992","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.pt.2017.07.006_bib0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.1975.tb35116.x","article-title":"Functional morphology and biochemistry of molluscan phagocytes","volume":"266","author":"Cheng","year":"1975","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pt.2017.07.006_bib0085","doi-asserted-by":"crossref","first-page":"e0123964","DOI":"10.1371\/journal.pone.0123964","article-title":"Immune defenses of the invasive apple snail Pomacea canaliculata (Caenogastropoda, Ampullariidae): phagocytic hemocytes in the circulation and the kidney","volume":"10","author":"Cueto","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.07.006_bib0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1017\/S0031182008005155","article-title":"Flow cytometry analysis of the circulating haemocytes from Biomphalaria glabrata and Biomphalaria tenagophila following Schistosoma mansoni infection","volume":"136","author":"Martins-Souza","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0095","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/jipa.1999.4876","article-title":"Internal defenses of the snail Biomphalaria glabrata","volume":"74","author":"Matricon-Gondran","year":"1999","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.pt.2017.07.006_bib0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.dci.2015.11.010","article-title":"Haematopoiesis in molluscs: a review of haemocyte development and function in gastropods, cephalopods and bivalves","volume":"58","author":"Pila","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0105","series-title":"Biomphalaria Snails and Larval Trematodes","first-page":"159","article-title":"Immunobiology of Biomphalaria\u2013trematode interactions","author":"Yoshino","year":"2010"},{"key":"10.1016\/j.pt.2017.07.006_bib0110","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF00216428","article-title":"Identification of antigenically distinct hemocyte subpopulations in Biomphalaria glabrata (Gastropoda) using monoclonal antibodies to surface membrane markers","volume":"232","author":"Yoshino","year":"1983","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.pt.2017.07.006_bib0115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0022-2011(85)90007-2","article-title":"Surface antigens of Biomphalaria glabrata (Gastropoda) hemocytes: functional heterogeneity in cell subpopulations recognized by a monoclonal antibody","volume":"45","author":"Yoshino","year":"1985","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.pt.2017.07.006_bib0120","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1073\/pnas.1521239113","article-title":"Endogenous growth factor stimulation of hemocyte proliferation induces resistance to Schistosoma mansoni challenge in the snail host","volume":"113","author":"Pila","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2017.07.006_bib0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S0031182000059667","article-title":"Effects of infection with Echinostoma paraensei on the circulating haemocyte population of the host snail Biomphalaria glabrata","volume":"98","author":"Noda","year":"1989","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.dci.2007.09.001","article-title":"Regulation of hydrogen peroxide release in circulating hemocytes of the planorbid snail Biomphalaria glabrata","volume":"32","author":"Humphries","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0135","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1242\/jeb.02561","article-title":"Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation","volume":"209","author":"Lacchini","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.pt.2017.07.006_bib0140","doi-asserted-by":"crossref","first-page":"e45637","DOI":"10.1371\/journal.pone.0045637","article-title":"Schistosoma mansoni in susceptible and resistant snail strains Biomphalaria tenagophila: in vivo tissue response and in vitro hemocyte interactions","volume":"7","author":"Nacif-Pimenta","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.07.006_bib0145","doi-asserted-by":"crossref","first-page":"e93215","DOI":"10.1371\/journal.pone.0093215","article-title":"Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant Biomphalaria glabrata exposed to Schistosoma mansoni excretory\u2013secretory products","volume":"9","author":"Zahoor","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.07.006_bib0150","doi-asserted-by":"crossref","first-page":"e51102","DOI":"10.1371\/journal.pone.0051102","article-title":"Early differential gene expression in haemocytes from resistant and susceptible Biomphalaria glabrata strains in response to Schistosoma mansoni","volume":"7","author":"Lockyer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.07.006_bib0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2307\/3281328","article-title":"Ultrastructure of encapsulation of Schistosoma mansoni mother sporocysts by hemocytes of juveniles of the 10-R2 strain of Biomphalaria glabrata","volume":"68","author":"Loker","year":"1982","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00931716","article-title":"Ultrastructural changes in the body wall of Schistosoma mansoni during the transformation of the miracidium into the mother sporocyst in the snail host Biomphalaria pfeifferi","volume":"56","author":"Meuleman","year":"1978","journal-title":"Z. Parasitenkd."},{"key":"10.1016\/j.pt.2017.07.006_bib0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molbiopara.2007.05.009","article-title":"Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata","volume":"155","author":"Guillou","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0170","doi-asserted-by":"crossref","first-page":"21087","DOI":"10.1073\/pnas.1011242107","article-title":"Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection","volume":"107","author":"Hanington","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2017.07.006_bib0175","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2307\/3280740","article-title":"Macrophagelike hemocytes of resistant Biomphalaria glabrata are cytotoxic for sporocysts of Schistosoma mansoni in vitro","volume":"66","author":"Bayne","year":"1980","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0180","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2307\/3279288","article-title":"Studies on resistance in snails. 4. Induction of ventricular capsules and changes in the amebocyte-producing organ during sensitization of Biomphalaria glabrata snails","volume":"62","author":"Lie","year":"1976","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0185","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijpara.2013.11.004","article-title":"Resistance of Biomphalaria glabrata 13-16-R1 snails to Schistosoma mansoni PR1 is a function of haemocyte abundance and constitutive levels of specific transcripts in haemocytes","volume":"44","author":"Larson","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0190","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijpara.2017.01.005","article-title":"Identification and functional characterization of Oncomelania hupensis macrophage migration inhibitory factor involved in the snail host innate immune response to the parasite Schistosoma japonicum","volume":"47","author":"Huang","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0195","doi-asserted-by":"crossref","first-page":"e1001115","DOI":"10.1371\/journal.ppat.1001115","article-title":"Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni","volume":"6","author":"Baeza Garcia","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0200","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.fsi.2010.04.006","article-title":"Allograft inflammatory factor-1 in disk abalone (Haliotis discus discus): molecular cloning, transcriptional regulation against immune challenge and tissue injury","volume":"29","author":"De Zoysa","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0022-2011(90)90147-X","article-title":"The effect of schistosome excretory-secretory products on Biomphalaria glabrata hemocyte motility","volume":"56","author":"Lodes","year":"1990","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.pt.2017.07.006_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(91)90124-O","article-title":"Isolation and functional characterization of snail hemocyte-modulating polypeptide from primary sporocysts of Schistosoma mansoni","volume":"49","author":"Lodes","year":"1991","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-3305-2-18","article-title":"Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway","volume":"2","author":"Zahoor","year":"2009","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2017.07.006_bib0220","doi-asserted-by":"crossref","first-page":"e0005467","DOI":"10.1371\/journal.pntd.0005467","article-title":"H+ channels in embryonic Biomphalaria glabrata cell membranes: putative roles in snail host\u2013schistosome interactions","volume":"11","author":"Wright","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.07.006_bib0225","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exppara.2012.10.002","article-title":"Circulating Biomphalaria glabrata hemocyte subpopulations possess shared schistosome glycans and receptors capable of binding larval glycoconjugates","volume":"133","author":"Yoshino","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0230","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ijpara.2011.01.007","article-title":"An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni\/Biomphalaria glabrata interactions","volume":"41","author":"Mon\u00e9","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0235","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1645\/0022-3395(2001)087[0292:KOSMSB]2.0.CO;2","article-title":"Killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata: role of reactive oxygen species","volume":"87","author":"Hahn","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0240","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S0031182000080732","article-title":"Schistosomicidal activities of Lymnaea stagnalis haemocytes: the role of oxygen radicals","volume":"109","author":"Adema","year":"1994","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0245","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1645\/0022-3395(2001)087[0778:IONOIK]2.0.CO;2","article-title":"Involvement of nitric oxide in killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata","volume":"87","author":"Hahn","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0250","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.dci.2006.12.005","article-title":"Variation in expression of Biomphalaria glabrata SOD1: a potential controlling factor in susceptibility\/resistance to Schistosoma mansoni","volume":"31","author":"Bender","year":"2007","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0255","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2009.01.005","article-title":"Successful parasitism of vector snail Biomphalaria glabrata by the human blood fluke (trematode) Schistosoma mansoni: a 2009 assessment","volume":"165","author":"Bayne","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0260","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jip.2008.06.002","article-title":"Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails","volume":"99","author":"Hanelt","year":"2008","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.pt.2017.07.006_bib0265","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molbiopara.2006.09.009","article-title":"Identification of genes involved in interactions between Biomphalaria glabrata and Schistosoma mansoni by suppression subtractive hybridization","volume":"151","author":"Lockyer","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0270","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2307\/3279358","article-title":"The origin of amebocytes in Biomphalaria glabrata","volume":"61","author":"Lie","year":"1975","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0275","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.dci.2013.09.016","article-title":"Activation of an innate immune response in the schistosome-transmitting snail Biomphalaria glabrata by specific bacterial PAMPs","volume":"42","author":"Sullivan","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0280","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.dci.2011.03.032","article-title":"Effect of crude lipopolysaccharide from Escherichia coli O127:B8 on the amebocyte-producing organ of Biomphalaria glabrata (Mollusca)","volume":"35","author":"Sullivan","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0285","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1645\/GE-3266","article-title":"Mitotic responses to extracts of miracidia and cercariae of Schistosoma mansoni in the amebocyte-producing organ of the snail intermediate host Biomphalaria glabrata","volume":"90","author":"Sullivan","year":"2004","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0290","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2307\/3283654","article-title":"Effects of excretory-secretory products of Echinostoma paraensei larvae on the hematopoietic organ of M-line Biomphalaria glabrata snails","volume":"78","author":"Noda","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0295","article-title":"Whole genome analysis of a schistosomiasis-transmitting freshwater snail","author":"Adema","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2017.07.006_bib0300","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0005-2736(00)00364-3","article-title":"Characterization of an insulin receptor-related receptor in Biomphalaria glabrata embryonic cells","volume":"1510","author":"Lardans","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2017.07.006_bib0305","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.ijpara.2009.12.005","article-title":"Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei","volume":"40","author":"Hanington","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0310","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cne.20732","article-title":"Epidermal growth factor-dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis: role of phagocyte survival","volume":"492","author":"Hermann","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pt.2017.07.006_bib0315","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fsi.2005.12.008","article-title":"Modulation of mitogen-activated protein kinases (MAPK) activity in response to different immune stimuli in haemocytes of the common periwinkle Littorina littorea","volume":"21","author":"Iakovleva","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0320","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF00932715","article-title":"Possible role of reactive forms of oxygen in in vitro killing of Schistosoma mansoni sporocysts by hemocytes of Lymnaea stagnalis","volume":"75","author":"Dikkeboom","year":"1988","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.pt.2017.07.006_bib0325","doi-asserted-by":"crossref","first-page":"e1005513","DOI":"10.1371\/journal.ppat.1005513","article-title":"A novel Toll-like receptor (TLR) influences compatibility between the gastropod Biomphalaria glabrata, and the digenean trematode Schistosoma mansoni","volume":"12","author":"Pila","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0330","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molbiopara.2007.11.003","article-title":"Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata\/Schistosoma mansoni model: new candidates identified by a global comparative proteomics approach","volume":"157","author":"Roger","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0335","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.dci.2014.10.009","article-title":"A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata","volume":"48","author":"Dheilly","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0340","doi-asserted-by":"crossref","first-page":"e1005067","DOI":"10.1371\/journal.pgen.1005067","article-title":"Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites","volume":"11","author":"Tennessen","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2017.07.006_bib0345","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.molimm.2011.05.017","article-title":"Identification and characterization of five transcription factors that are associated with evolutionarily conserved immune signaling pathways in the schistosome-transmitting snail Biomphalaria glabrata","volume":"48","author":"Zhang","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0350","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.dci.2015.08.004","article-title":"Identification of nuclear factor kappaB (NF-\u03baB) binding motifs in Biomphalaria glabrata","volume":"53","author":"Humphries","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0355","doi-asserted-by":"crossref","first-page":"e0005362","DOI":"10.1371\/journal.pntd.0005362","article-title":"Schistosome infectivity in the snail, Biomphalaria glabrata, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein","volume":"11","author":"Allan","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.07.006_bib0360","doi-asserted-by":"crossref","first-page":"e1006081","DOI":"10.1371\/journal.ppat.1006081","article-title":"Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni","volume":"13","author":"Wu","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0365","doi-asserted-by":"crossref","first-page":"e1005361","DOI":"10.1371\/journal.ppat.1005361","article-title":"A shift from cellular to humoral responses contributes to innate immune memory in the vector snail Biomphalaria glabrata","volume":"12","author":"Pinaud","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0370","doi-asserted-by":"crossref","first-page":"e1591","DOI":"10.1371\/journal.pntd.0001591","article-title":"A somatically diversified defense factor, FREP3, is a determinant of snail resistance to schistosome infection","volume":"6","author":"Hanington","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.07.006_bib0375","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/S0031182098002923","article-title":"Failure of Schistosoma mansoni to reinfect Biomphalaria glabrata snails: acquired humoral resistance or intra-specific larval antagonism?","volume":"117","author":"Sire","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.07.006_bib0380","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0020-7519(83)90041-3","article-title":"Acquired resistance in snails. Induction of resistance to Schistosoma mansoni in Biomphalaria glabrata","volume":"13","author":"Lie","year":"1983","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0385","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0020-7519(79)90009-2","article-title":"Acquired resistance to echinostomes in four Biomphalaria glabrata strains","volume":"9","author":"Lie","year":"1979","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0390","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0020-7519(75)90062-4","article-title":"Studies on resistance in snails: specific resistance induced by irradiated miracidia of Echinostoma lindoense in Biomphalaria glabrata snails","volume":"5","author":"Lie","year":"1975","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.07.006_bib0395","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pbio.0040004","article-title":"Identification of Drosophila gene products required for phagocytosis of Candida albicans","volume":"4","author":"Stroschein-Stevenson","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2017.07.006_bib0400","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(04)00173-4","article-title":"Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae","volume":"116","author":"Blandin","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.pt.2017.07.006_bib0405","doi-asserted-by":"crossref","first-page":"e813","DOI":"10.1371\/journal.pntd.0000813","article-title":"A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host\/parasite model","volume":"4","author":"Mon\u00e9","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.07.006_bib0410","doi-asserted-by":"crossref","first-page":"e1003216","DOI":"10.1371\/journal.ppat.1003216","article-title":"Biomphalysin, a new \u03b2 pore-forming toxin involved in Biomphalaria glabrata immune defense against Schistosoma mansoni","volume":"9","author":"Galinier","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0415","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mib.2006.12.008","article-title":"Pore-forming toxins and cellular non-immune defenses (CNIDs)","volume":"10","author":"Aroian","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2017.07.006_bib0420","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1462-5822.1999.00009.x","article-title":"Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas","volume":"1","author":"Nelson","year":"1999","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.pt.2017.07.006_bib0425","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000321882","article-title":"The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation","volume":"3","author":"Hanington","year":"2011","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.pt.2017.07.006_bib0430","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1073\/pnas.94.16.8691","article-title":"A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection","volume":"94","author":"Adema","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2017.07.006_bib0435","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00251-001-0386-8","article-title":"Parasite-responsive IgSF members in the snail Biomphalaria glabrata: characterization of novel genes with tandemly arranged IgSF domains and a fibrinogen domain","volume":"53","author":"Zhang","year":"2001","journal-title":"Immunogenetics"},{"key":"10.1016\/j.pt.2017.07.006_bib0440","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0145-305X(02)00091-5","article-title":"The FREP gene family in the snail Biomphalaria glabrata: additional members, and evidence consistent with alternative splicing and FREP retrosequences","volume":"27","author":"Zhang","year":"2003","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0445","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0378-1119(01)00444-9","article-title":"Structure of two FREP genes that combine IgSF and fibrinogen domains, with comments on diversity of the FREP gene family in the snail Biomphalaria glabrata","volume":"269","author":"Leonard","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.pt.2017.07.006_bib0450","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.1088069","article-title":"Diversification of Ig superfamily genes in an invertebrate","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pt.2017.07.006_bib0455","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1753425908093800","article-title":"Expression profiling and binding properties of fibrinogen-related proteins (FREPs), plasma proteins from the schistosome snail host Biomphalaria glabrata","volume":"14","author":"Zhang","year":"2008","journal-title":"Innate Immun."},{"key":"10.1016\/j.pt.2017.07.006_bib0460","doi-asserted-by":"crossref","first-page":"e0005398","DOI":"10.1371\/journal.pntd.0005398","article-title":"A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni","volume":"11","author":"Galinier","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.07.006_bib0465","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molimm.2009.10.019","article-title":"Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes)","volume":"47","author":"Adema","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0470","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-319-20819-0_5","article-title":"Fibrinogen-related proteins (FREPs) in mollusks","volume":"57","author":"Adema","year":"2015","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.pt.2017.07.006_bib0475","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fsi.2015.03.005","article-title":"The role of fibrinogen-related proteins in the gastropod immune response","volume":"46","author":"Gordy","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.pt.2017.07.006_bib0480","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/1471-2164-9-634","article-title":"Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni","volume":"9","author":"Lockyer","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pt.2017.07.006_bib0485","doi-asserted-by":"crossref","first-page":"E6736","DOI":"10.1073\/pnas.1521077112","article-title":"Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi","volume":"112","author":"Gantz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2017.07.006_bib0490","doi-asserted-by":"crossref","first-page":"e1002458","DOI":"10.1371\/journal.ppat.1002458","article-title":"Engineered Anopheles immunity to Plasmodium infection","volume":"7","author":"Dong","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0495","doi-asserted-by":"crossref","first-page":"e1002017","DOI":"10.1371\/journal.ppat.1002017","article-title":"Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi","volume":"7","author":"Isaacs","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0500","doi-asserted-by":"crossref","first-page":"e1004116","DOI":"10.1371\/journal.ppat.1004116","article-title":"Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis","volume":"10","author":"Carneiro","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.07.006_bib0505","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00436-004-1241-2","article-title":"A new description of the reproductive system of Schistosoma mansoni (Trematoda: Schistosomatidae) analyzed by confocal laser scanning microscopy","volume":"95","author":"Neves","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.pt.2017.07.006_bib0510","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2017.07.006_bib0515","doi-asserted-by":"crossref","first-page":"163","DOI":"10.7257\/1053-816X.2013.33.4.163","article-title":"Schistosomiasis","volume":"33","author":"Jenkins-Holick","year":"2013","journal-title":"Urol. Nurs."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492217301861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492217301861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T07:48:50Z","timestamp":1570002530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492217301861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":103,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1471492217301861"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2017.07.006","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schistosomiasis from a Snail\u2019s Perspective: Advances in Snail Immunity","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2017.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}